TNSN91056A1 - Derives de benzeneacetamides - Google Patents

Derives de benzeneacetamides

Info

Publication number
TNSN91056A1
TNSN91056A1 TNTNSN91056A TNSN91056A TNSN91056A1 TN SN91056 A1 TNSN91056 A1 TN SN91056A1 TN TNSN91056 A TNTNSN91056 A TN TNSN91056A TN SN91056 A TNSN91056 A TN SN91056A TN SN91056 A1 TNSN91056 A1 TN SN91056A1
Authority
TN
Tunisia
Prior art keywords
represent
radical
alkyl
hydrogen atom
hydrogen
Prior art date
Application number
TNTNSN91056A
Other languages
English (en)
Inventor
Henri Paul Van Daele Georges
Gustaaf Celine Verdonck Marc
Rene Marie Andre Bosmans Jean-Paul
Adriaan Jan Janssen Paul
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of TNSN91056A1 publication Critical patent/TNSN91056A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Abstract

DERIVES DE BENZENEACETAMIDES COMPOSE MEDICA DE FORMULE 1 , SES SELS D ADDITION AVEC DES ACIDES PHARMACEUTIQUEMENT ACCEPTABLES ET SES FORMES STEREOCHIMIQUEMENT ISOMERS , FORMULE DANS LAQUELLE : R1 ET R2 REPRESENTENT CHACUN INDEPENDAMMENT UN ATOME D HYGIENNE , UN RADICAL ALKYLE ENC1-6 OU CYCLOALKYLE EN C3-6 , OU BIEN R1 ET R2 CONJOINTEMENT AVEC L ATOME D AZOTE PORTANT LESDITES RADICAUX R1 ET R2 PEUVENT FORMER UN GROUPE PYRROLIDINYLE , PIPERIDINYLE , MORPHOLINYLE , PIPERAZINLYNE OU 4-ALKYL (C1-4) PIPERAZINYLE, X REPRESENTE O OU S , R3 EST UN ATOME D HYDROGENE OU UN RADICAL ALKYLE EN C1 -6 , R4 , R5 ET R6 REPRESENTENT CHACUN INDEPENDAMENT UN ATOME D HYDROGENE OU UN RADICAL HALO , ALKYLE EN C1-6 ALKYLOXY EN C1-6 NITRO , TRIFLUOROMETHYLE , CYANO, AMINOMETHYLE , CARBOXYLE, ALKYL ( c1-4) OXYXCARBONYLE OU HYDROXY; R7 EST UN ATOME D HYDROGENE OU UN RADICAL HALO , ET R8 ,R9 ET R10 REPRESENTENT CHACUN INDEPENDAMENT UN ATOME D HYDROGENE OU UN RADICAL HALO , ALKYLE EN C1 -6 , ALKYLOXY EN C1-6 , NITRO , HYDROXY , TRIFLUOROMETHYL ,2,2,2 - TRIFLUORETHOXY ,( TRIFLUOROMETHYL ) CARBONYLE, AMINOCARBONYLE, ( CYCLOPROPYL) CARBNYLE OU UN RADICAL ALKYLE (C1-6) -( C=Y) -DANS LAQUEL = y REPRESENTE = 0 , = N-OH , = N-OCH3 , = N- NH2 OU = N-N (CH3)2 ; A LA CONDITION QUE: (1) R1 SOIT AUTRE QUE N-PROPYLE QUAND R2 A R7 , R9 ET R 10 REPRESENTENT DES ATOMES D HYDROGENE , R8 REPRESENTE 4- ETHOXY ET X REPRESENTE UN ATOME D OXYGENE ET : (2) X EST AUTRE QUE LE SOUFFRE QUAND R1, R2, R3 ET R6 A R10 REPRESENTENT CHACUN DES ATOMES D'HYDROGENE ET R4 ET R5 REPRESENTENT 3,4-DIMETHOXY. (I) COMPOSES NOUVEAUX, COMPOSOITIONS PHARMACEUTIQUES CONTENANT LES COMPOSES DE FORMULE I ET PROCEDE DE PREPARATION DE CES COMPOSOITIONS
TNTNSN91056A 1990-07-10 1991-07-10 Derives de benzeneacetamides TNSN91056A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90201857 1990-07-10
EP91200646 1991-03-22

Publications (1)

Publication Number Publication Date
TNSN91056A1 true TNSN91056A1 (fr) 1992-10-25

Family

ID=26125946

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN91056A TNSN91056A1 (fr) 1990-07-10 1991-07-10 Derives de benzeneacetamides

Country Status (42)

Country Link
US (2) US5684049A (fr)
EP (1) EP0538301B1 (fr)
JP (1) JPH0819068B2 (fr)
KR (1) KR0183446B1 (fr)
CN (2) CN1028990C (fr)
AP (1) AP311A (fr)
AT (1) ATE144765T1 (fr)
AU (1) AU643056B2 (fr)
BG (1) BG61809B1 (fr)
CA (1) CA2084508A1 (fr)
CZ (1) CZ279901B6 (fr)
DE (1) DE69122963T2 (fr)
DK (1) DK0538301T3 (fr)
DZ (1) DZ1514A1 (fr)
ES (1) ES2095942T3 (fr)
FI (1) FI930070A (fr)
GR (1) GR3021829T3 (fr)
HR (1) HRP930485A2 (fr)
HU (2) HUT64013A (fr)
IE (1) IE75693B1 (fr)
IL (3) IL98756A (fr)
LT (1) LT3602B (fr)
LV (1) LV10086B (fr)
MA (1) MA22208A1 (fr)
MX (1) MX9100100A (fr)
MY (1) MY108580A (fr)
NO (1) NO303777B1 (fr)
NZ (1) NZ238763A (fr)
OA (1) OA09770A (fr)
PH (1) PH30977A (fr)
PL (1) PL167076B1 (fr)
PT (1) PT98259B (fr)
RO (1) RO112855B1 (fr)
RU (1) RU2087465C1 (fr)
SG (1) SG48829A1 (fr)
SI (1) SI9111204A (fr)
SK (1) SK279639B6 (fr)
TN (1) TNSN91056A1 (fr)
TW (1) TW204337B (fr)
WO (1) WO1992000952A1 (fr)
YU (1) YU120491A (fr)
ZA (1) ZA915334B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE149484T1 (de) * 1991-12-30 1997-03-15 Janssen Pharmaceutica Nv Alpha-substituierte benzenmethanamin-derivate
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
ATE141254T1 (de) * 1992-07-06 1996-08-15 American Cyanamid Co O-nitrophenyl cyclopropyl keton, herbizides zwischenprodukt und verfahren zu seiner herstellung
JP2669937B2 (ja) * 1993-02-22 1997-10-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノート シヤツプ ジドブジンに対するｈｉｖ−１株の耐性を逆転させる方法
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
GB9403408D0 (en) * 1994-02-23 1994-04-13 Wellcome Found Therapeutic benzonitriles
IL112739A0 (en) * 1994-02-23 1995-05-26 Wellcome Found Ayrlthiobenzonitrile compounds, their preparation and pharmaceutical compositions containing them
GB9403449D0 (en) * 1994-02-23 1994-04-13 Wellcome Found Therapeutic benzonitriles
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
EP0872233A1 (fr) * 1997-04-14 1998-10-21 Janssen Pharmaceutica N.V. Médicaments antirétroviraux à biodisponibilité améliorée
BR9911385A (pt) * 1998-06-19 2001-03-13 Us Health Composição, processos para dissociar um ìon de metal de uma proteìna contendo dedo de zinco, para inativar um vìrus e para selecionar um composto capaz de dissociar um ìon de metal quelado com um dedo de zinco de uma proteìna viral, vìrus isolado e inativado, kit para selecionar um composto capaz de dissociar um ìon de metal de um dedo de zinco de uma proteìna viral, composição viricida, e, formulação farmacêutica.
SK285240B6 (sk) 1999-09-24 2006-09-07 Janssen Pharmaceutica N. V. Antivírusové prostriedky
DE60136187D1 (de) * 2000-08-11 2008-11-27 Japan Tobacco Inc Calciumrezeptor-antagonisten
JP4713026B2 (ja) * 2000-08-11 2011-06-29 日本たばこ産業株式会社 カルシウム受容体拮抗薬
CN1946680B (zh) * 2004-04-23 2011-04-06 弗·哈夫曼-拉罗切有限公司 非核苷逆转录酶抑制剂
US7625949B2 (en) 2004-04-23 2009-12-01 Roche Palo Alto Llc Methods for treating retroviral infections
WO2007146719A2 (fr) * 2006-06-08 2007-12-21 Bristol-Myers Squibb Company Inhibiteurs de facteur viia de benzamide utiles en tant qu'anticoagulants
RU2449985C2 (ru) * 2010-03-31 2012-05-10 Федеральное государственное унитарное предприятие "Российский научный центр "Прикладная химия" Способ получения n,n-диметилацетамида
CN102675212B (zh) * 2012-05-09 2014-11-05 昆明理工大学 N-取代苯基-2-((1h-苯并咪唑-2-基)巯基)乙酰胺类衍生物及其用途
CN104000807B (zh) * 2014-05-28 2016-05-18 中山大学 苯基-酰胺类化合物在制备抗hiv-1病毒药物中的应用
CN105367437B (zh) * 2015-10-12 2017-08-01 湖北文理学院 一种2‑芳氨基乙酰胺类化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1423430A (en) * 1973-03-29 1976-02-04 Wyeth John & Brother Ltd Thioamides
US4246429A (en) * 1978-06-23 1981-01-20 Janssen Pharmaceutica, N.V. Novel α-amino-phenylacetic acid derivatives
CH637828A5 (en) * 1978-11-15 1983-08-31 Koehler Franz Dr Chemie Kg Cytostatics
ATE149484T1 (de) * 1991-12-30 1997-03-15 Janssen Pharmaceutica Nv Alpha-substituierte benzenmethanamin-derivate

Also Published As

Publication number Publication date
FI930070A0 (fi) 1993-01-08
OA09770A (fr) 1993-11-30
NO930047L (no) 1993-01-07
IE75693B1 (en) 1997-09-10
HUT64013A (en) 1993-11-29
IL111924A0 (en) 1995-03-15
PH30977A (en) 1997-12-23
AP9100288A0 (en) 1991-07-31
YU120491A (sh) 1994-06-10
IL98756A0 (en) 1992-07-15
KR0183446B1 (ko) 1999-05-15
HRP930485A2 (en) 1996-06-30
SI9111204A (en) 1995-04-30
JPH0819068B2 (ja) 1996-02-28
CZ279901B6 (cs) 1995-08-16
SK210291A3 (en) 1995-07-11
WO1992000952A1 (fr) 1992-01-23
JPH05507931A (ja) 1993-11-11
CS210291A3 (en) 1992-02-19
HU9300032D0 (en) 1993-04-28
US5556886A (en) 1996-09-17
NO303777B1 (no) 1998-08-31
FI930070A (fi) 1993-01-08
US5684049A (en) 1997-11-04
RO112855B1 (ro) 1998-01-30
CN1107835A (zh) 1995-09-06
PL167076B1 (pl) 1995-07-31
RU2087465C1 (ru) 1997-08-20
IL98756A (en) 1996-06-18
HU211873A9 (en) 1995-12-28
NZ238763A (en) 1993-10-26
PL297608A1 (fr) 1992-07-13
PT98259A (pt) 1992-04-30
GR3021829T3 (en) 1997-02-28
DE69122963T2 (de) 1997-03-13
IE912208A1 (en) 1992-01-15
IL111924A (en) 1996-12-05
EP0538301B1 (fr) 1996-10-30
LT3602B (en) 1995-12-27
ES2095942T3 (es) 1997-03-01
NO930047D0 (no) 1993-01-07
AP311A (en) 1994-02-01
DE69122963D1 (de) 1996-12-05
DZ1514A1 (fr) 2004-09-13
DK0538301T3 (da) 1996-11-25
TW204337B (fr) 1993-04-21
CN1028990C (zh) 1995-06-21
MA22208A1 (fr) 1992-04-01
MX9100100A (es) 1992-02-28
CN1058958A (zh) 1992-02-26
SK279639B6 (sk) 1999-01-11
BG61809B1 (bg) 1998-06-30
EP0538301A1 (fr) 1993-04-28
CA2084508A1 (fr) 1992-01-11
CN1033142C (zh) 1996-10-30
LV10086A (lv) 1994-05-10
BG97265A (bg) 1994-03-24
ATE144765T1 (de) 1996-11-15
AU643056B2 (en) 1993-11-04
LV10086B (en) 1995-02-20
ZA915334B (en) 1993-03-31
AU8212091A (en) 1992-02-04
MY108580A (en) 1996-10-31
SG48829A1 (en) 1998-05-18
LTIP848A (en) 1995-02-27
PT98259B (pt) 1998-12-31

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