GB1004310A - 1,6-dimethyl-ergoline i derivatives - Google Patents

1,6-dimethyl-ergoline i derivatives

Info

Publication number
GB1004310A
GB1004310A GB3069464A GB3069464A GB1004310A GB 1004310 A GB1004310 A GB 1004310A GB 3069464 A GB3069464 A GB 3069464A GB 3069464 A GB3069464 A GB 3069464A GB 1004310 A GB1004310 A GB 1004310A
Authority
GB
United Kingdom
Prior art keywords
dihydrolysergamine
methyl
ergoline
dimethyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3069464A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT85562A external-priority patent/IT1051702B/en
Priority claimed from IT1570063A external-priority patent/IT1051709B/en
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of GB1004310A publication Critical patent/GB1004310A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Abstract

The invention comprises 1-methyl-N-carbobenzoxy - dihydrolysergamine, its non - toxic acid addition salts, and its preparation by reaction of 1-methyl-dihydrolysergamine with carbobenzoxy chloride in the presence of a tertiary amine. The compounds of the invention have anticephalea, antiallergic and anti-inflammatory properties and may be used in pharmaceutical compositions in combination with a carrier, for example in forms suitable for oral, parenteral or rectal administration, such as tablets, powders, pills, capsules or elixirs.
GB3069464A 1961-05-29 1964-08-04 1,6-dimethyl-ergoline i derivatives Expired GB1004310A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT980861 1961-05-29
IT1617861 1961-09-07
IT85562A IT1051702B (en) 1962-01-18 1962-01-18 REFINEMENTS RELATED TO 6 METHYL AND 1.6 DIMETHYL ERGOLINE DERIVATIVES 1
IT1570063A IT1051709B (en) 1963-07-26 1963-07-26 1-methyl-n-carbobenzoxy-dihydrolysergamine

Publications (1)

Publication Number Publication Date
GB1004310A true GB1004310A (en) 1965-09-15

Family

ID=27452643

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1998762A Expired GB959261A (en) 1961-05-29 1962-05-24 Ergoline i derivatives
GB3069464A Expired GB1004310A (en) 1961-05-29 1964-08-04 1,6-dimethyl-ergoline i derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB1998762A Expired GB959261A (en) 1961-05-29 1962-05-24 Ergoline i derivatives

Country Status (10)

Country Link
BE (1) BE650930A (en)
BR (2) BR6239435D0 (en)
CH (1) CH430737A (en)
DE (2) DE1470217A1 (en)
FI (2) FI45660C (en)
FR (3) FR1326772A (en)
GB (2) GB959261A (en)
NL (3) NL6408237A (en)
NO (1) NO118975B (en)
SE (2) SE315903B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7572883B2 (en) 2001-06-08 2009-08-11 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Somatostatin-dopamine chimeric analogs

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1513322A (en) * 1976-01-09 1978-06-07 Farmaceutici Italia Heterocyclic ergoline derivatives
HU180467B (en) * 1979-07-12 1983-03-28 Gyogyszerkutato Intezet Process for producing new ergol-8-ene- and ergoline-sceleted compounds
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity
DE3309493A1 (en) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen NEW ERGOLIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE AS A MEDICINAL PRODUCT
IT1232692B (en) * 1989-08-04 1992-03-04 Poli Ind Chimica Spa ERGOLINIC DERIVATIVES WITH DOPAMINERGIC ACTIVITY
TWI523863B (en) 2012-11-01 2016-03-01 艾普森藥品公司 Somatostatin-dopamine chimeric analogs

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7572883B2 (en) 2001-06-08 2009-08-11 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Somatostatin-dopamine chimeric analogs
US7579435B2 (en) 2001-06-08 2009-08-25 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Somatostatin-dopamine chimeric analogs
US8178651B2 (en) 2001-06-08 2012-05-15 Ipsen Pharma, S.A.S. Somatostatin-dopamine chimeric analogs
US8324386B2 (en) 2001-06-08 2012-12-04 Ipsen Pharma S.A.S. Somatostatin-dopamine chimeric analogs

Also Published As

Publication number Publication date
FI45660B (en) 1972-05-02
FI46507B (en) 1973-01-02
GB959261A (en) 1964-05-27
DE1470217A1 (en) 1969-12-11
FR1326772A (en) 1963-04-01
BE650930A (en) 1964-11-16
FI46507C (en) 1973-04-10
DE1470285A1 (en) 1970-07-02
CH430737A (en) 1967-02-28
SE315903B (en) 1969-10-13
FR98F (en)
SE324784B (en) 1970-06-15
FR2075M (en) 1963-10-14
NL278401A (en)
NL6408237A (en) 1965-01-27
NO118975B (en) 1970-03-09
BR6461039D0 (en) 1973-08-14
BR6239435D0 (en) 1973-06-14
FI45660C (en) 1972-08-10
NL128196C (en)

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