GB959261A - Ergoline i derivatives - Google Patents
Ergoline i derivativesInfo
- Publication number
- GB959261A GB959261A GB1998762A GB1998762A GB959261A GB 959261 A GB959261 A GB 959261A GB 1998762 A GB1998762 A GB 1998762A GB 1998762 A GB1998762 A GB 1998762A GB 959261 A GB959261 A GB 959261A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- cycloaliphatic
- methyl
- hydrogen
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention comprises D-6-methyl- and 1,6-dimethyl-8-aminomethyl-ergoline I derivatives of general formula: <FORM:0959261/C2/1> wherein R1 is hydrogen or methyl and R is hydrogen or the radical of an aliphatic, cycloaliphatic, aromatic, aralkyl, aralkenyl, heterocyclyl-alkyl, cycloaliphatic-alkyl or heterocyclic carboxylic, dicarboxylic, carbamic, carbonic or sulphonic acid, having from 1 to 10 carbon atoms substituted or not by aryloxy groups or halogen atoms, by free or monoalkylated or dialkylated amino groups, by nitro, hydroxy, alkyl, alkoxy, thioether or sulphonic groups; and their preparation by reduction of the corresponding dihydro-D-lysergamides and, if desired, subsequent acylation with the chloride or anhydride of the appropriate acid. Pharmaceutical compositions comprise compounds of the invention with a therapeutically acceptable carrier. Oral and parenteral administration (tablets, powders, pills, liquids) are mentioned. The compounds have oxytocic, antienteraminic, adrenolytic, hypotensive and sedative properties. Specifications 670,991 and 811,964 are referred to.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT980861 | 1961-05-29 | ||
IT1617861 | 1961-09-07 | ||
IT85562A IT1051702B (en) | 1962-01-18 | 1962-01-18 | REFINEMENTS RELATED TO 6 METHYL AND 1.6 DIMETHYL ERGOLINE DERIVATIVES 1 |
IT1570063A IT1051709B (en) | 1963-07-26 | 1963-07-26 | 1-methyl-n-carbobenzoxy-dihydrolysergamine |
Publications (1)
Publication Number | Publication Date |
---|---|
GB959261A true GB959261A (en) | 1964-05-27 |
Family
ID=27452643
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1998762A Expired GB959261A (en) | 1961-05-29 | 1962-05-24 | Ergoline i derivatives |
GB3069464A Expired GB1004310A (en) | 1961-05-29 | 1964-08-04 | 1,6-dimethyl-ergoline i derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3069464A Expired GB1004310A (en) | 1961-05-29 | 1964-08-04 | 1,6-dimethyl-ergoline i derivatives |
Country Status (10)
Country | Link |
---|---|
BE (1) | BE650930A (en) |
BR (2) | BR6239435D0 (en) |
CH (1) | CH430737A (en) |
DE (2) | DE1470217A1 (en) |
FI (2) | FI45660C (en) |
FR (3) | FR1326772A (en) |
GB (2) | GB959261A (en) |
NL (3) | NL6408237A (en) |
NO (1) | NO118975B (en) |
SE (2) | SE315903B (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4299836A (en) * | 1979-07-12 | 1981-11-10 | Richter Gedeon Vegyeszeti Gyar Rt. | Novel ergol-8-ene and ergolin compounds and process for preparing same |
US4382940A (en) * | 1979-12-06 | 1983-05-10 | Farmitalia Carlo Erba S.P.A. | Ercoline derivatives and therapeutic compositions having CNS affecting activity |
US4766128A (en) * | 1983-03-14 | 1988-08-23 | Schering Aktiengesellschaft | Optionally 11- to 13-substituted ergoline compounds useful as medicinal agents |
EP0411494A2 (en) * | 1989-08-04 | 1991-02-06 | POLI INDUSTRIA CHIMICA S.p.A. | Ergoline derivatives having dopaminergic activity |
US7572883B2 (en) | 2001-06-08 | 2009-08-11 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Somatostatin-dopamine chimeric analogs |
US8952128B2 (en) | 2012-11-01 | 2015-02-10 | Ipsen Pharma S.A.S. | Somatostatin-dopamine chimeric analogs |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1513322A (en) * | 1976-01-09 | 1978-06-07 | Farmaceutici Italia | Heterocyclic ergoline derivatives |
-
0
- NL NL278401D patent/NL278401A/xx unknown
- NL NL128196D patent/NL128196C/xx active
- FR FR98D patent/FR98F/fr active Active
-
1962
- 1962-05-23 DE DE19621470217 patent/DE1470217A1/en not_active Withdrawn
- 1962-05-24 CH CH628462A patent/CH430737A/en unknown
- 1962-05-24 GB GB1998762A patent/GB959261A/en not_active Expired
- 1962-05-24 FI FI104462A patent/FI45660C/en active
- 1962-05-25 FR FR898776A patent/FR1326772A/fr not_active Expired
- 1962-05-28 SE SE597162A patent/SE315903B/xx unknown
- 1962-05-28 BR BR13943562A patent/BR6239435D0/en unknown
- 1962-05-28 FR FR898966A patent/FR2075M/en active Active
-
1964
- 1964-07-17 NL NL6408237A patent/NL6408237A/xx unknown
- 1964-07-21 FI FI156364A patent/FI46507C/en active
- 1964-07-21 SE SE884364A patent/SE324784B/xx unknown
- 1964-07-22 DE DE19641470285 patent/DE1470285A1/en not_active Withdrawn
- 1964-07-22 BR BR16103964A patent/BR6461039D0/en unknown
- 1964-07-23 NO NO15411664A patent/NO118975B/no unknown
- 1964-07-24 BE BE650930A patent/BE650930A/xx unknown
- 1964-08-04 GB GB3069464A patent/GB1004310A/en not_active Expired
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4299836A (en) * | 1979-07-12 | 1981-11-10 | Richter Gedeon Vegyeszeti Gyar Rt. | Novel ergol-8-ene and ergolin compounds and process for preparing same |
US4382940A (en) * | 1979-12-06 | 1983-05-10 | Farmitalia Carlo Erba S.P.A. | Ercoline derivatives and therapeutic compositions having CNS affecting activity |
US4766128A (en) * | 1983-03-14 | 1988-08-23 | Schering Aktiengesellschaft | Optionally 11- to 13-substituted ergoline compounds useful as medicinal agents |
EP0411494A2 (en) * | 1989-08-04 | 1991-02-06 | POLI INDUSTRIA CHIMICA S.p.A. | Ergoline derivatives having dopaminergic activity |
EP0411494A3 (en) * | 1989-08-04 | 1991-04-24 | Poli Industria Chimica S.P.A. | Ergoline derivatives having dopaminergic activity |
US7572883B2 (en) | 2001-06-08 | 2009-08-11 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Somatostatin-dopamine chimeric analogs |
US7579435B2 (en) | 2001-06-08 | 2009-08-25 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Somatostatin-dopamine chimeric analogs |
US8178651B2 (en) | 2001-06-08 | 2012-05-15 | Ipsen Pharma, S.A.S. | Somatostatin-dopamine chimeric analogs |
US8324386B2 (en) | 2001-06-08 | 2012-12-04 | Ipsen Pharma S.A.S. | Somatostatin-dopamine chimeric analogs |
US8952128B2 (en) | 2012-11-01 | 2015-02-10 | Ipsen Pharma S.A.S. | Somatostatin-dopamine chimeric analogs |
US9603942B2 (en) | 2012-11-01 | 2017-03-28 | Ipsen Pharma S.A.S. | Somatostatin-dopamine chimeric analogs |
US9731027B2 (en) | 2012-11-01 | 2017-08-15 | Ipsen Pharma S.A.S. | Somatostatin-dopamine chimeric analogs |
Also Published As
Publication number | Publication date |
---|---|
FR1326772A (en) | 1963-04-01 |
SE324784B (en) | 1970-06-15 |
NL6408237A (en) | 1965-01-27 |
FI45660B (en) | 1972-05-02 |
FR98F (en) | |
FI46507C (en) | 1973-04-10 |
FI45660C (en) | 1972-08-10 |
GB1004310A (en) | 1965-09-15 |
SE315903B (en) | 1969-10-13 |
NO118975B (en) | 1970-03-09 |
CH430737A (en) | 1967-02-28 |
BR6461039D0 (en) | 1973-08-14 |
DE1470285A1 (en) | 1970-07-02 |
BE650930A (en) | 1964-11-16 |
NL278401A (en) | |
FR2075M (en) | 1963-10-14 |
BR6239435D0 (en) | 1973-06-14 |
NL128196C (en) | |
FI46507B (en) | 1973-01-02 |
DE1470217A1 (en) | 1969-12-11 |
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