GB1100444A - 13-alkyl 17-halogenoalkynyl steroid 3-alcohols and their esters - Google Patents
13-alkyl 17-halogenoalkynyl steroid 3-alcohols and their estersInfo
- Publication number
- GB1100444A GB1100444A GB4001767A GB4001767A GB1100444A GB 1100444 A GB1100444 A GB 1100444A GB 4001767 A GB4001767 A GB 4001767A GB 4001767 A GB4001767 A GB 4001767A GB 1100444 A GB1100444 A GB 1100444A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- trans
- halogenoalkynyl
- steroid
- alcohols
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pressure-Spray And Ultrasonic-Wave- Spray Burners (AREA)
Abstract
Novel steroids and D-homo-steroids of the formula <FORM:1100444/C2/1> (wherein each R is H or alkyl; R1 is alkyl of 2 or more carbon atoms; R2 is haloalk-1-ynyl trans to R1; R3 is H, alkyl with or without substituents, tetrahydropyranyl or acyl; Q is methylene or ethylene; Y is H or acyl; and the H atoms at the ring C junctions and R1 are trans-anti-trans; and there is a D 5(10) or D 4 double bond present) are prepared by reduction of the 3-ones and, if desired, acylation. The compounds of the invention are stated to possess progestational and pituitary gonadotropic inhibiting activity, and may be made up into pharmaceutical compositions with suitable carriers.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK448162AA DK113641B (en) | 1961-10-19 | 1962-10-17 | Process for the production of steroid ketones. |
GB3206463A GB1100441A (en) | 1963-08-14 | 1963-08-14 | 13-alkyl 17-halogenoalkynyl-steroid 3-ketones and their derivatives |
DK400464A DK134161B (en) | 1962-10-17 | 1964-08-13 | Analogous method for the production of steroid ketones. |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1100444A true GB1100444A (en) | 1968-01-24 |
Family
ID=27221920
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4001667A Expired GB1100443A (en) | 1962-10-17 | 1963-08-14 | 17ª‡-chloroethynyl-13ª‰-ethylgonenolone |
GB4001767A Expired GB1100444A (en) | 1962-10-17 | 1963-08-14 | 13-alkyl 17-halogenoalkynyl steroid 3-alcohols and their esters |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4001667A Expired GB1100443A (en) | 1962-10-17 | 1963-08-14 | 17ª‡-chloroethynyl-13ª‰-ethylgonenolone |
Country Status (14)
Country | Link |
---|---|
JP (1) | JPS4837029B1 (en) |
AT (3) | AT301039B (en) |
BE (1) | BE651797A (en) |
BR (1) | BR6461643D0 (en) |
CH (1) | CH498819A (en) |
DE (4) | DE1468988B1 (en) |
DK (3) | DK134161B (en) |
FR (2) | FR1566154A (en) |
GB (2) | GB1100443A (en) |
IL (1) | IL21826A (en) |
IN (2) | IN95058B (en) |
NL (2) | NL139307B (en) |
NO (3) | NO126016B (en) |
SE (5) | SE350256B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2913381A1 (en) * | 1979-03-30 | 1980-10-16 | Schering Ag | 11-METHYLENESTEROIDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
JPS57106714U (en) * | 1980-12-23 | 1982-07-01 | ||
DE3214689A1 (en) * | 1982-04-16 | 1983-10-27 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11SS CHLORINE STEROIDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
US20130324748A1 (en) * | 2011-02-17 | 2013-12-05 | Lupin Limited | Process for preparation of levonorgestrel |
-
0
- BE BE651797D patent/BE651797A/xx unknown
-
1963
- 1963-08-14 GB GB4001667A patent/GB1100443A/en not_active Expired
- 1963-08-14 GB GB4001767A patent/GB1100444A/en not_active Expired
-
1964
- 1964-08-03 IL IL2182664A patent/IL21826A/en unknown
- 1964-08-05 NO NO15427664A patent/NO126016B/no unknown
- 1964-08-05 IN IN95058A patent/IN95058B/en unknown
- 1964-08-10 DE DE19641468988 patent/DE1468988B1/en active Pending
- 1964-08-10 DE DE19641618871 patent/DE1618871C3/en not_active Expired
- 1964-08-10 DE DE19641618872 patent/DE1618872C3/en not_active Expired
- 1964-08-10 BR BR16164364A patent/BR6461643D0/en unknown
- 1964-08-10 DE DE19641793641 patent/DE1793641C2/en not_active Expired
- 1964-08-12 CH CH1052964A patent/CH498819A/en not_active IP Right Cessation
- 1964-08-13 DK DK400464A patent/DK134161B/en unknown
- 1964-08-13 AT AT292768A patent/AT301039B/en not_active IP Right Cessation
- 1964-08-13 FR FR1566154D patent/FR1566154A/fr not_active Expired
- 1964-08-13 AT AT227470A patent/AT301045B/en not_active IP Right Cessation
- 1964-08-13 AT AT696964A patent/AT269376B/en active
- 1964-08-14 NL NL6409391A patent/NL139307B/en unknown
- 1964-08-14 SE SE843170A patent/SE350256B/xx unknown
- 1964-08-14 SE SE983464A patent/SE331470B/xx unknown
- 1964-11-12 FR FR994684A patent/FR4915M/fr not_active Expired
-
1966
- 1966-11-25 NO NO16575366A patent/NO127193B/no unknown
-
1968
- 1968-03-29 SE SE04238/68A patent/SE335120B/xx unknown
- 1968-03-29 SE SE04239/68A patent/SE334879B/xx unknown
- 1968-03-29 SE SE04237/68A patent/SE335119B/xx unknown
-
1969
- 1969-12-10 DK DK655269A patent/DK127598B/en unknown
-
1971
- 1971-08-02 JP JP5758471A patent/JPS4837029B1/ja active Pending
- 1971-12-30 NO NO495971A patent/NO129905B/no unknown
-
1972
- 1972-05-03 DK DK220272A patent/DK127475B/en unknown
-
1973
- 1973-06-19 NL NL7308508A patent/NL7308508A/xx unknown
-
1974
- 1974-05-03 IN IN137555A patent/IN137555B/en unknown
Also Published As
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