GB1100444A - 13-alkyl 17-halogenoalkynyl steroid 3-alcohols and their esters - Google Patents

13-alkyl 17-halogenoalkynyl steroid 3-alcohols and their esters

Info

Publication number
GB1100444A
GB1100444A GB4001767A GB4001767A GB1100444A GB 1100444 A GB1100444 A GB 1100444A GB 4001767 A GB4001767 A GB 4001767A GB 4001767 A GB4001767 A GB 4001767A GB 1100444 A GB1100444 A GB 1100444A
Authority
GB
United Kingdom
Prior art keywords
alkyl
trans
halogenoalkynyl
steroid
alcohols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4001767A
Inventor
Gordon Alan Hughes
Herchel Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK448162AA external-priority patent/DK113641B/en
Application filed by Individual filed Critical Individual
Priority claimed from GB3206463A external-priority patent/GB1100441A/en
Publication of GB1100444A publication Critical patent/GB1100444A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pressure-Spray And Ultrasonic-Wave- Spray Burners (AREA)

Abstract

Novel steroids and D-homo-steroids of the formula <FORM:1100444/C2/1> (wherein each R is H or alkyl; R1 is alkyl of 2 or more carbon atoms; R2 is haloalk-1-ynyl trans to R1; R3 is H, alkyl with or without substituents, tetrahydropyranyl or acyl; Q is methylene or ethylene; Y is H or acyl; and the H atoms at the ring C junctions and R1 are trans-anti-trans; and there is a D 5(10) or D 4 double bond present) are prepared by reduction of the 3-ones and, if desired, acylation. The compounds of the invention are stated to possess progestational and pituitary gonadotropic inhibiting activity, and may be made up into pharmaceutical compositions with suitable carriers.
GB4001767A 1962-10-17 1963-08-14 13-alkyl 17-halogenoalkynyl steroid 3-alcohols and their esters Expired GB1100444A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK448162AA DK113641B (en) 1961-10-19 1962-10-17 Process for the production of steroid ketones.
GB3206463A GB1100441A (en) 1963-08-14 1963-08-14 13-alkyl 17-halogenoalkynyl-steroid 3-ketones and their derivatives
DK400464A DK134161B (en) 1962-10-17 1964-08-13 Analogous method for the production of steroid ketones.

Publications (1)

Publication Number Publication Date
GB1100444A true GB1100444A (en) 1968-01-24

Family

ID=27221920

Family Applications (2)

Application Number Title Priority Date Filing Date
GB4001767A Expired GB1100444A (en) 1962-10-17 1963-08-14 13-alkyl 17-halogenoalkynyl steroid 3-alcohols and their esters
GB4001667A Expired GB1100443A (en) 1962-10-17 1963-08-14 17ª‡-chloroethynyl-13ª‰-ethylgonenolone

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB4001667A Expired GB1100443A (en) 1962-10-17 1963-08-14 17ª‡-chloroethynyl-13ª‰-ethylgonenolone

Country Status (14)

Country Link
JP (1) JPS4837029B1 (en)
AT (3) AT301045B (en)
BE (1) BE651797A (en)
BR (1) BR6461643D0 (en)
CH (1) CH498819A (en)
DE (4) DE1793641C2 (en)
DK (3) DK134161B (en)
FR (2) FR1566154A (en)
GB (2) GB1100444A (en)
IL (1) IL21826A (en)
IN (2) IN95058B (en)
NL (2) NL139307B (en)
NO (3) NO126016B (en)
SE (5) SE350256B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2913381A1 (en) * 1979-03-30 1980-10-16 Schering Ag 11-METHYLENESTEROIDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
JPS57106714U (en) * 1980-12-23 1982-07-01
DE3214689A1 (en) * 1982-04-16 1983-10-27 Schering AG, 1000 Berlin und 4709 Bergkamen 11SS CHLORINE STEROIDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
EP2675820A1 (en) * 2011-02-17 2013-12-25 Lupin Limited An improved process for preparation of levonorgestrel

Also Published As

Publication number Publication date
NO126016B (en) 1972-12-11
BR6461643D0 (en) 1973-08-09
IN137555B (en) 1975-08-16
DE1618872A1 (en) 1972-06-15
NL139307B (en) 1973-07-16
SE335119B (en) 1971-05-17
DK127475B (en) 1973-11-12
AT301045B (en) 1972-08-25
FR4915M (en) 1967-03-20
NL6409391A (en) 1965-02-15
DE1793641C2 (en) 1973-12-20
DK134161C (en) 1977-02-21
BE651797A (en)
IL21826A (en) 1968-12-26
DE1468988B1 (en) 1971-11-25
NL7308508A (en) 1973-09-25
GB1100443A (en) 1968-01-24
DE1618871C3 (en) 1974-02-21
SE334879B (en) 1971-05-10
DE1793641B1 (en) 1973-05-24
SE331470B (en) 1971-01-04
CH498819A (en) 1970-11-15
DK134161B (en) 1976-09-20
DE1618871B2 (en) 1973-07-26
DK127598B (en) 1973-12-03
DE1618872B2 (en) 1974-03-07
NO129905B (en) 1974-06-10
FR1566154A (en) 1969-05-09
SE350256B (en) 1972-10-23
JPS4837029B1 (en) 1973-11-08
SE335120B (en) 1971-05-17
IN95058B (en) 1975-08-16
DE1618871A1 (en) 1972-08-10
NO127193B (en) 1973-05-21
AT269376B (en) 1969-03-10
DE1618872C3 (en) 1974-10-24
AT301039B (en) 1972-08-25

Similar Documents

Publication Publication Date Title
GB1104462A (en) 7ª‡-methyl-steroids of the oestrane series
GB1100444A (en) 13-alkyl 17-halogenoalkynyl steroid 3-alcohols and their esters
ES386297A1 (en) Evomonoside derivative
GB1399162A (en) 6-keto-delta1,3,5-10-steroids and process for the manufacture of 6-keto-delta1,3,5-10-steroids
ES433049A1 (en) Novel 11{62 -alkyl steroids of the estrane series
NL179059C (en) PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH ANTI-INFLAMMATORY EFFECTS, FORMED MEDICINAL PRODUCT AND METHOD FOR PREPARING MEDICINAL COMPOUNDS, SUITABLE FOR USE IN THIS PROCESS
GB1070751A (en) 17-esters of 17-hydroxy-21-desoxy-steroids
GB1341601A (en) 4,14-estradiene compounds
GB1363460A (en) Rofluoropregnenes
GB1085035A (en) New 3,3-methylene-19-nor-steroids
ES347684A1 (en) 1-adamantyl and 1-adamantylmethyl carbonates of testosterone and selected derivatives
GB1082574A (en) Steroid esters
ES443115A1 (en) Novel ester of 19-nor-testosterone
ES386465A1 (en) Neriifolin derivatives
GB1206872A (en) 6beta-HYDROXY-7alpha-METHYL-ANDROSTANE COMPOUNDS
ES391857A1 (en) Steroid derivatives and the preparation thereof
GB983125A (en) Preparation of 9(11)-dehydro spirostanes and 3-esters thereof
GB1074468A (en) Carbalkoxyhtdrazones of the androstane adn estrane series
GB1363033A (en) Derivatives of 22-fluoro-digoxins
GB1130190A (en) Improvements in or relating to steroid intermediates and the production thereof
GB1094806A (en) Unsaturated steroid compounds and processes for their preparation
GB1274032A (en) NOVEL 1-OXA-17alpha-METHYL-A-NOR-GONA-3,9-DIEN-2-ONES, PROCESSES FOR THEIR PREPARATION, AND COMPOSITIONS INCORPORATING THEM
GB1145393A (en) Improvements in or relating to 17-‡-(alka-1&#39;,3&#39;-diynyl)-steroids
ES375061A1 (en) Sulphamido-steroids and the preparation thereof
ES347230A1 (en) Estratrienes, Processes for their Preparation, and Compositions Incorporating them