GB1060466A - Improvements in or relating to novel anthracene derivatives - Google Patents

Improvements in or relating to novel anthracene derivatives

Info

Publication number
GB1060466A
GB1060466A GB4680063A GB4680063A GB1060466A GB 1060466 A GB1060466 A GB 1060466A GB 4680063 A GB4680063 A GB 4680063A GB 4680063 A GB4680063 A GB 4680063A GB 1060466 A GB1060466 A GB 1060466A
Authority
GB
United Kingdom
Prior art keywords
general formula
prepared
compound
mixture
physiologically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4680063A
Inventor
Ernst Jucker
Anton Ebnoether
Andre Stoll
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz Patent Ltd
Sandoz AG
Original Assignee
Sandoz Patent Ltd
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1497262A external-priority patent/CH419125A/en
Application filed by Sandoz Patent Ltd, Sandoz AG filed Critical Sandoz Patent Ltd
Publication of GB1060466A publication Critical patent/GB1060466A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Novel compounds of the general Formula I <FORM:1060466/C2/1> (wherein each of R1 and R2 represents a C1- 4 alkyl or C2- 4 alkenyl radical and R3 represents a C1- 4 alkyl radical), and their acid addition salts, are prepared by splitting off the elements of water from a compound of the general Formula IV <FORM:1060466/C2/2> by the action of a concentrated mineral acid, a strong organic acid, SOCl2, POCl3, ZnCl2 or acetic anhydride, or a mixture thereof (especially a mixture of acetic anhydride and concentrated HCl), and, if desired, converting the product into a salt with an inorganic or organic acid. Substituted 9 - hydroxydihydroanthracenes (IV) are prepared by a Grignard reaction from 10-R1-10-R2-anthrones-(9). Pharmaceutical compositions having antihistaminic, cough inhibiting, bronchodilatory, serotonin inhibiting, anticholinergic and/or sedative properties, for enteral or parenteral administration, comprise a compound of general Formula I, or a physiologically acceptable acid addition salt thereof, and a physiologically acceptable carrier.
GB4680063A 1962-12-20 1963-11-27 Improvements in or relating to novel anthracene derivatives Expired GB1060466A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1497262A CH419125A (en) 1962-12-20 1962-12-20 Process for the preparation of new carbocyclic compounds
CH887863 1963-07-16

Publications (1)

Publication Number Publication Date
GB1060466A true GB1060466A (en) 1967-03-01

Family

ID=25703892

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4680063A Expired GB1060466A (en) 1962-12-20 1963-11-27 Improvements in or relating to novel anthracene derivatives

Country Status (5)

Country Link
AT (1) AT243266B (en)
DE (1) DE1470259A1 (en)
DK (1) DK105025C (en)
ES (1) ES294657A1 (en)
GB (1) GB1060466A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7736712B2 (en) * 2002-03-18 2010-06-15 Consort Medical Plc Seal material for a dispensing apparatus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7736712B2 (en) * 2002-03-18 2010-06-15 Consort Medical Plc Seal material for a dispensing apparatus

Also Published As

Publication number Publication date
DE1470259A1 (en) 1969-06-04
ES294657A1 (en) 1964-06-01
DK105025C (en) 1966-08-08
AT243266B (en) 1965-11-10

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