AR008272A1 - Derivados de piperidina 1,4-disustituida que contienen fluor, composicion farmaceutica compuesta de los mismos y un proceso para su preparacion - Google Patents
Derivados de piperidina 1,4-disustituida que contienen fluor, composicion farmaceutica compuesta de los mismos y un proceso para su preparacionInfo
- Publication number
- AR008272A1 AR008272A1 ARP970103516A ARP970103516A AR008272A1 AR 008272 A1 AR008272 A1 AR 008272A1 AR P970103516 A ARP970103516 A AR P970103516A AR P970103516 A ARP970103516 A AR P970103516A AR 008272 A1 AR008272 A1 AR 008272A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- substituted
- hydrogen atoms
- fluorine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de piperidina 1,4-disustituida que contienen flúor, un proceso para prepararlos y composiciones farmacéuticas que los contienen que se usancomo medicina, especialmente en el tratamiento o profilaxis de varias enfermedades delo s sistemas respiratorios, urinarias y digestsivas. Los nuevosderivados están representados por la fórmula general (I) y sus sales farmacéuticamente aceptables donde: Ar representa un grupo de arilo o un grupode heteroarilo que tieneentre 1 y 2 heteroátomos seleccionados de un grupo formado por nitrógeno, oxígeno y azufre (cualquiera de 1 a 3 átomos dehidrógeno sobre el anillo de dicho grupo de arilo o heteroarilo puede ser sustituido por un alquilo inferior,trifluormetilo, ciano, hidroxilo, nitroalcoxicaarbonilo inferior, halógeno, alcoxi inferior, amino o alquilamino inferior); R1 es cicloalquilo C3-C6 cuyos 1 a 4 átomos de hidrógeno puedenestar sustituidos con átomo(s) de flúor; R2 son gruposalifáticos satura dos o no saturados de C5-C15 cualquiera de cuyos 1 a 6 átomos de hidrógeno puedensustituirse con átomo(s) de flúor, grupos de aralquilo, arilalquenilo, heteroarilalquilo heteroarilalquenilo que tienen entre 1 y 2heteroátomosseleccionados del grupo formado por nitrógeno, oxígeno y azufre (opcionalmente cualquiera de 1 a 3 átomos de hidrógeno en el anillo en dicho grupo aralquilo,arilalquenilo, heteroarilquilo, o heteroarilalquenilo puede estar sustituídocon un alquilo inferior, t rifluorometilo, ciano, hidroxilo, nitroalcoxicarbonilo inferior, halógeno, alcoxi inferior, amino o alquilamino inferior), y X es O o NH, con la condición de que ppor lo menos uno de R1 y R2contenga uno o más átomosde flúor. Los compuestos no solo tienen un antagonismo potente y selectivo para los receptores M3 muscarínicos sino también tienen
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21943696 | 1996-08-01 | ||
JP5397997 | 1997-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR008272A1 true AR008272A1 (es) | 1999-12-29 |
Family
ID=26394715
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970103516A AR008272A1 (es) | 1996-08-01 | 1997-08-01 | Derivados de piperidina 1,4-disustituida que contienen fluor, composicion farmaceutica compuesta de los mismos y un proceso para su preparacion |
ARP980104218A AR016877A2 (es) | 1996-08-01 | 1998-08-25 | 6-ter-butiloxicarbonilaminopiridinas 2-sustituidas y sus sales |
ARP980104219A AR017021A1 (es) | 1996-08-01 | 1998-08-25 | Acido 2-hidroxiacetico |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980104218A AR016877A2 (es) | 1996-08-01 | 1998-08-25 | 6-ter-butiloxicarbonilaminopiridinas 2-sustituidas y sus sales |
ARP980104219A AR017021A1 (es) | 1996-08-01 | 1998-08-25 | Acido 2-hidroxiacetico |
Country Status (29)
Country | Link |
---|---|
US (2) | US5948792A (es) |
EP (1) | EP0930298B1 (es) |
JP (1) | JP3063164B2 (es) |
KR (1) | KR20000022214A (es) |
CN (1) | CN1226888A (es) |
AR (3) | AR008272A1 (es) |
AT (1) | ATE229941T1 (es) |
AU (1) | AU716050B2 (es) |
BG (1) | BG103114A (es) |
BR (1) | BR9711108A (es) |
CA (1) | CA2261680C (es) |
CO (1) | CO4960641A1 (es) |
CZ (1) | CZ33199A3 (es) |
DE (1) | DE69718026T2 (es) |
EE (1) | EE9900038A (es) |
ES (1) | ES2188961T3 (es) |
HR (1) | HRP970426A2 (es) |
HU (1) | HUP9902381A3 (es) |
ID (1) | ID17259A (es) |
IL (1) | IL127685A0 (es) |
IS (1) | IS4960A (es) |
NO (1) | NO990472L (es) |
NZ (1) | NZ333842A (es) |
PE (1) | PE92198A1 (es) |
PL (1) | PL331431A1 (es) |
SK (1) | SK12299A3 (es) |
TR (2) | TR199900204T2 (es) |
WO (1) | WO1998005641A1 (es) |
YU (1) | YU1299A (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6180823B1 (en) | 1998-11-06 | 2001-01-30 | Sepracor Inc. | Stereoselective process for alkyl phenylglycolic acids |
US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
AU4194500A (en) | 1999-04-08 | 2000-11-14 | Banyu Pharmaceutical Co., Ltd. | Diastereoselective preparation of michael adducts |
AU4314700A (en) * | 1999-04-28 | 2000-11-17 | Banyu Pharmaceutical Co., Ltd. | Processes for the preparation of piperidylmethylpyridine derivatives |
AR025353A1 (es) * | 1999-08-23 | 2002-11-20 | Lundbeck & Co As H | Tratamiento de la incontinencia urinaria |
ATE299494T1 (de) * | 1999-12-07 | 2005-07-15 | Theravance Inc | Carbamat-derivate als muscarin-rezeptor antonisten |
UA73543C2 (uk) | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
AU2525801A (en) * | 1999-12-17 | 2001-06-25 | Sanofi-Synthelabo | Phenoxypropanolamines, method for producing them and pharmaceutical compositionscontaining them |
US6403818B1 (en) | 2000-02-28 | 2002-06-11 | Eisai Co., Ltd. | Process for producing α-hydroxy-carbonyl compound |
US6469172B2 (en) | 2000-03-08 | 2002-10-22 | Merck & Co., Inc. | Process for the preparation of chemical compounds |
US6403584B1 (en) * | 2000-06-22 | 2002-06-11 | Merck & Co., Inc. | Substituted nipecotyl derivatives as inhibitors of cell adhesion |
AU2001271027B2 (en) * | 2000-07-11 | 2005-07-07 | Msd K.K. | Ester derivatives |
KR100869722B1 (ko) | 2000-12-22 | 2008-11-21 | 알미랄 에이쥐 | 퀴누클리딘 카르바메이트 유도체 및 m3 길항제로서 그의사용 |
ATE334128T1 (de) | 2000-12-28 | 2006-08-15 | Almirall Prodesfarma Ag | Neue chinuclidinderivate und medizinische zusammensetzungen, die diese verbindungen enthalten |
DE10111843A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von inflammatorischen Erkrankungen |
WO2003026564A2 (en) * | 2001-09-27 | 2003-04-03 | Pharmacia Ab | Pharmaceutical compositions for the treatment of urinary disorders |
ES2203327B1 (es) * | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
ES2204295B1 (es) * | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
CN1668585A (zh) | 2002-07-08 | 2005-09-14 | 兰贝克赛实验室有限公司 | 用作蝇蕈碱受体拮抗剂的3,6-二取代氮杂双环[3.1.0]己烷衍生物 |
US7265147B2 (en) | 2002-07-31 | 2007-09-04 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
US7410993B2 (en) | 2002-08-09 | 2008-08-12 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane deriviatives useful as muscarinic receptor antagonists |
US6583103B1 (en) | 2002-08-09 | 2003-06-24 | S.C. Johnson & Son, Inc. | Two part cleaning formula resulting in an effervescent liquid |
US7288562B2 (en) | 2002-08-23 | 2007-10-30 | Ranbaxy Laboratories Limited | Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists |
JP2006506392A (ja) * | 2002-10-29 | 2006-02-23 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | ムスカリン受容体アンタゴニストとしての第四級アンモニウム化合物 |
TWI295669B (en) | 2002-10-30 | 2008-04-11 | Theravance Inc | Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds |
JP2006518707A (ja) * | 2002-12-10 | 2006-08-17 | ランバクシー ラボラトリーズ リミテッド | ムスカリン様受容体アンタゴニストとしての3,6−二置換アザビシクロ[3.1.0]ヘキサン誘導体 |
DE60332387D1 (de) | 2002-12-13 | 2010-06-10 | Warner Lambert Co | Alpha-2-delta-ligand zur behandlung vonsymptomen der unteren harnwege |
WO2004056767A1 (en) * | 2002-12-23 | 2004-07-08 | Ranbaxy Laboratories Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
ATE386738T1 (de) | 2002-12-23 | 2008-03-15 | Ranbaxy Lab Ltd | Flavaxat-derivate als muscarin-rezeptor antagonisten |
US7488748B2 (en) * | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
AU2003214520A1 (en) | 2003-04-09 | 2004-11-01 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
AU2003214535B2 (en) | 2003-04-10 | 2009-09-03 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
EP1615887A1 (en) | 2003-04-10 | 2006-01-18 | Ranbaxy Laboratories, Ltd. | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
WO2004089900A1 (en) | 2003-04-11 | 2004-10-21 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as muscarinic receptor antagonists |
WO2004091597A2 (en) * | 2003-04-15 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Method of treating irritable bowel syndrome (ibs) |
WO2005007645A1 (en) | 2003-07-11 | 2005-01-27 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
CA2543858C (en) | 2003-11-21 | 2014-04-15 | Theravance, Inc. | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
JP4707560B2 (ja) * | 2003-12-29 | 2011-06-22 | Msd株式会社 | 新規2−ヘテロアリール置換ベンズイミダゾール誘導体 |
US20080319002A1 (en) * | 2004-06-16 | 2008-12-25 | Ranbaxy Laboratories Limited | Xanthine Derivatives a Useful as Muscarinic Receptor Antagonists |
EP1781607A2 (en) * | 2004-08-19 | 2007-05-09 | Ranbaxy Laboratories Limited | Pyrrolidine derivatives as muscarinic receptor antagonists |
WO2006032994A2 (en) * | 2004-09-24 | 2006-03-30 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
EP1797040A1 (en) * | 2004-09-29 | 2007-06-20 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
BRPI0517232A (pt) | 2004-11-02 | 2008-10-07 | Banyu Pharma Co Ltd | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, ativador da glicocinase, e, agentes terapêuticos e/ou profiláticos para diabetes e para obesidade |
WO2006054162A1 (en) * | 2004-11-19 | 2006-05-26 | Ranbaxy Laboratories Limited | Azabicyclic muscarinic receptor antagonists |
US20100035954A1 (en) * | 2004-12-15 | 2010-02-11 | Mohammad Salman | Acid addition salts of muscarinic receptor antagonists |
WO2006117754A1 (en) * | 2005-05-03 | 2006-11-09 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives as muscarinic receptor antagonists |
CA2623958C (en) * | 2005-09-30 | 2013-05-28 | Banyu Pharmaceutical Co., Ltd. | 2-heteroaryl-substituted indole derivative |
WO2007039884A1 (en) * | 2005-10-05 | 2007-04-12 | Ranbaxy Laboratories Limited | 3 -azabicyclooctane derivatives as muscarinic receptor antagonists |
JP2009512676A (ja) | 2005-10-19 | 2009-03-26 | ランバクシー ラボラトリーズ リミテッド | ムスカリン性受容体アンタゴニストの医薬組成物 |
GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
JP2008081492A (ja) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 |
US20090010923A1 (en) * | 2007-04-24 | 2009-01-08 | University Of Maryland, Baltimore | Treatment of cancer with anti-muscarinic receptor agents |
BRPI0816219B8 (pt) | 2007-09-07 | 2021-05-25 | Theravance Biopharma R&D Ip Llc | compostos contendo guanidina úteis como antagonistas de receptor muscarínico, composição farmacêutica e uso |
RS53551B1 (en) * | 2007-12-21 | 2015-02-27 | F. Hoffmann La Roche Ag | ANTIBODY FORMULATION |
CN104876854B (zh) * | 2015-04-16 | 2017-03-01 | 御盛隆堂药业有限责任公司 | 羟基乙酸酯衍生物及其用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6018661B2 (ja) * | 1976-01-01 | 1985-05-11 | 太田製薬株式会社 | 1−(1,3−ジオキソラン−4−イルメチル)ピペリジノ−ル誘導体 |
JPS5679688A (en) * | 1979-12-04 | 1981-06-30 | Ota Seiyaku Kk | 4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production |
IT1231238B (it) * | 1987-09-21 | 1991-11-26 | Angeli Inst Spa | Derivati ammidinici |
GB8825505D0 (en) * | 1988-11-01 | 1988-12-07 | Pfizer Ltd | Therapeutic agents |
GB9023023D0 (en) * | 1990-10-23 | 1990-12-05 | Barlow Richard B | Pharmaceutical compositions |
CA2123728A1 (en) * | 1993-05-21 | 1994-11-22 | Noriyoshi Sueda | Urea derivatives and their use as acat inhibitors |
WO1995006635A1 (fr) * | 1993-09-02 | 1995-03-09 | Yamanouchi Pharmaceutical Co., Ltd. | Derive de carbamate et medicament le contenant |
JP3294961B2 (ja) * | 1993-12-10 | 2002-06-24 | 杏林製薬株式会社 | 新規イミダゾール誘導体及びその製造法 |
JPH07258250A (ja) * | 1994-03-25 | 1995-10-09 | Yamanouchi Pharmaceut Co Ltd | エステル誘導体 |
CA2218479C (en) * | 1995-04-28 | 2008-01-15 | Banyu Pharmaceutical Co., Ltd. | 1,4-di-substituted piperidine derivatives |
CA2179574A1 (en) * | 1995-06-26 | 1996-12-27 | Tomomi Okada | Substituted piperidine derivative and medicine comprising the same |
AU7145996A (en) * | 1995-10-13 | 1997-04-30 | Banyu Pharmaceutical Co., Ltd. | Substituted heteroaromatic derivatives |
-
1997
- 1997-07-24 PE PE1997000659A patent/PE92198A1/es not_active Application Discontinuation
- 1997-07-28 EP EP97933037A patent/EP0930298B1/en not_active Expired - Lifetime
- 1997-07-28 KR KR1019980710633A patent/KR20000022214A/ko not_active Application Discontinuation
- 1997-07-28 EE EEP199900038A patent/EE9900038A/xx unknown
- 1997-07-28 CN CN97196911A patent/CN1226888A/zh active Pending
- 1997-07-28 ES ES97933037T patent/ES2188961T3/es not_active Expired - Lifetime
- 1997-07-28 IL IL12768597A patent/IL127685A0/xx unknown
- 1997-07-28 AU AU36351/97A patent/AU716050B2/en not_active Ceased
- 1997-07-28 TR TR1999/00204T patent/TR199900204T2/xx unknown
- 1997-07-28 JP JP10507794A patent/JP3063164B2/ja not_active Expired - Fee Related
- 1997-07-28 PL PL97331431A patent/PL331431A1/xx unknown
- 1997-07-28 CZ CZ99331A patent/CZ33199A3/cs unknown
- 1997-07-28 TR TR2000/01482T patent/TR200001482T2/xx unknown
- 1997-07-28 BR BR9711108A patent/BR9711108A/pt not_active IP Right Cessation
- 1997-07-28 YU YU1299A patent/YU1299A/sh unknown
- 1997-07-28 SK SK122-99A patent/SK12299A3/sk unknown
- 1997-07-28 AT AT97933037T patent/ATE229941T1/de not_active IP Right Cessation
- 1997-07-28 HU HU9902381A patent/HUP9902381A3/hu unknown
- 1997-07-28 DE DE69718026T patent/DE69718026T2/de not_active Expired - Lifetime
- 1997-07-28 CA CA002261680A patent/CA2261680C/en not_active Expired - Fee Related
- 1997-07-28 WO PCT/JP1997/002600 patent/WO1998005641A1/ja not_active Application Discontinuation
- 1997-07-30 HR HR53,979/97A patent/HRP970426A2/hr not_active Application Discontinuation
- 1997-07-31 US US08/903,768 patent/US5948792A/en not_active Expired - Lifetime
- 1997-07-31 ID IDP972666A patent/ID17259A/id unknown
- 1997-08-01 CO CO97044382A patent/CO4960641A1/es unknown
- 1997-08-01 AR ARP970103516A patent/AR008272A1/es not_active Application Discontinuation
-
1998
- 1998-08-25 AR ARP980104218A patent/AR016877A2/es unknown
- 1998-08-25 AR ARP980104219A patent/AR017021A1/es unknown
-
1999
- 1999-01-25 BG BG103114A patent/BG103114A/xx unknown
- 1999-01-28 NZ NZ333842A patent/NZ333842A/en unknown
- 1999-01-29 IS IS4960A patent/IS4960A/is unknown
- 1999-02-01 NO NO990472A patent/NO990472L/no not_active Application Discontinuation
- 1999-04-13 US US09/290,607 patent/US6040449A/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR008272A1 (es) | Derivados de piperidina 1,4-disustituida que contienen fluor, composicion farmaceutica compuesta de los mismos y un proceso para su preparacion | |
ES2127919T3 (es) | 4-amino-piridinas, procedimiento para su preparacion, asi como medicamentos que contienen estos compuestos. | |
AR016817A1 (es) | Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento | |
AR034268A1 (es) | Compuestos derivados de piperidina, su uso en preparacion de medicamentos, composicion farmaceutica, metodo de tratamiento y proceso para su preparacion | |
ES2081966T3 (es) | Derivados heterociclicos benzocondensados que contienen n. | |
ES2112332T3 (es) | Derivados de substitucion de oxigeno de productos de adicion de nucleofilo-oxido nitrico utilizados como promedicamentos donadores de oxido nitrico. | |
KR950700265A (ko) | 고지혈증 치료에 유용한 벤조티아제핀 화합물(hypolipidaemic ben zothiazepine compounds) | |
ES2058527T3 (es) | Derivados de pirimidina condensados procedimiento y compuestos intermedios para su preparacion y composiciones farmaceuticas que los contienen. | |
AU8794291A (en) | New oxazolopyridine derivatives, processes for preparing these and pharmaceutical compositions containing them | |
CO5590895A2 (es) | Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos | |
MX9206939A (es) | Derivados de piperazina, procedimiento para su preparacion y composicion farmaceutica que los comprende | |
ES2118203T3 (es) | Nuevos derivados benzopiranicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. | |
DK161146C (da) | Analogifremgangsmaade til fremstilling af (2-halogenergolinyl)-n',n'-diethylurinstofderivater samt farmaceutisk acceptable syreadditionssalte heraf | |
KR910002854A (ko) | 벤즈아진 화합물 및 그의 의약 용도 | |
PE20040750A1 (es) | Derivados de n-(1-acetilpiperidin-4-il)-4-benzidril-2-isopropilpiperazin-1-carboxamida como inhibidores de 17beta-hidroxiesteroide deshidrogenasa de tipo 3 | |
MX9306310A (es) | Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
ES2071666T3 (es) | Derivados de pirazoloisoquinolina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. | |
IT1271411B (it) | Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare | |
IL111375A (en) | N-substituted azabicycloalkane derivatives and pharmaceutical compositions containing them | |
MX9306394A (es) | Derivados de benzofurano, proceso para su preparacion y composicion farmaceutica que los contiene | |
DE69015787D1 (de) | Thiophenderivate, Verfahren zu deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen. | |
AR034400A1 (es) | Piranoindoles, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos para el tratamiento de glaucoma | |
DK0556813T3 (da) | Amfotere tricykliske forbindelser som antihistaminske og antiallergiske midler | |
AR029741A1 (es) | Uso de compuestos heterociclicos n-sustituidos para la preparacion de medicamentos para la profilaxis y la terapia de la isquemia cerebral y la apoplejia | |
DE58902884D1 (de) | Thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |