ES2188961T3 - Derivados de piperidina 1,4-disustituidos fluorados. - Google Patents
Derivados de piperidina 1,4-disustituidos fluorados.Info
- Publication number
- ES2188961T3 ES2188961T3 ES97933037T ES97933037T ES2188961T3 ES 2188961 T3 ES2188961 T3 ES 2188961T3 ES 97933037 T ES97933037 T ES 97933037T ES 97933037 T ES97933037 T ES 97933037T ES 2188961 T3 ES2188961 T3 ES 2188961T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- present
- atoms
- arilo
- hydrogen atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A NUEVOS DERIVADOS FLUORADOS DE PIPERIDINA DISUSTITUIDOS EN POSICIONES 1,4, REPRESENTADOS MEDIANTE LA FORMULA GENERAL [I]: Y A SALES FARMACEUTICAS DE LOS MISMOS, DONDE: AR REPRESENTA UN GRUPO ARILO O HETEROARILO, CON 1 A 2 HETEROATOMOS SELECCIONADOS A PARTIR DEL GRUPO FORMADO POR NITROGENO, OXIGENO Y AZUFRE (ENTRE 1 Y 3 ATOMOS DE HIDROGENO DEL ANILLO DE DICHO GRUPO ARILO O HETEROARILO PUEDEN ESTAR SUSTITUIDOS POR ARILO INFERIOR, ETC.); R 1 REPRESENTA CICLOALQUILO C 3 - C 6 , CUYOS 1-4 ATOMOS DE HIDROGENO PUEDEN ESTAR SUSTITUIDOS POR UN ATOMO O VARIOS DE FLUOR; R SUP,2 REPRESENTA GRUPOS HIDROCARBONADOS C 5 - C 15 AL IFATICOS, SATURADOS O INSATURADOS, CUYOS 1 A 6 ATOMOS DE HIDROGENO PUEDEN ESTAR SUSTITUIDOS POR UNO O VARIOS ATOMOS DE FLUOR, POR UN GRUPO ARALQUILO, ARILALQUENILO, HETEROARILALQUILO O HETEROARILALQUENILO CON 1 A 2 HETEROATOMOS, SELECCIONADOS A PARTIR DEL GRUPO FORMADO POR NITROGENO, OXIGENO Y AZUFRE (OPCIONALMENTE DE 1 A 3 ATOMOS DE HIDROGENO DELANILLO EN DICHO GRUPO ARALQUILO, ARILALQUENILO, HETEROARILALQUILO O HETEROARILALQUENILO, PUEDEN ESTAR SUSITUIDOS POR ALQUILO INFERIOR, TRIFLUOROMETILO, CIANO, HIDROXILO, NITRO, ALCOXICARBONILO INFERIOR, HALOGENO, ALCOXI INFERIOR O AMINO, ETC.; Y X REPRESENTA O O NH, CON LA CONDICION DE QUE UNO DE R 1 Y R 2 CONTENGA UNO O MAS ATOMOS DE FLUOR]. LOS COMPUESTOS DE LA PRESENTE INVENCION PRESENTAN UNA ACTIVIDAD ANTAGONISTA SELECTIVA PARA LOS RECEPTORES MUSCARINICOS M 3 , Y PRESENTAN UNA EXCELENTE ACTIVIDAD ORAL, DURACION DE ACCION Y FARMACOCINETICA, DE FORMA QUE PRESENTAN ESCASOS EFECTOS SECUNDARIOS Y SON SEGUROS Y EFECTIVOS. POR TANTO, DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO O PROFILAXIS DE ENFERMEDADES RESPIRATORIAS, URINARIAS Y DIGESTIVAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21943696 | 1996-08-01 | ||
JP5397997 | 1997-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2188961T3 true ES2188961T3 (es) | 2003-07-01 |
Family
ID=26394715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97933037T Expired - Lifetime ES2188961T3 (es) | 1996-08-01 | 1997-07-28 | Derivados de piperidina 1,4-disustituidos fluorados. |
Country Status (29)
Country | Link |
---|---|
US (2) | US5948792A (es) |
EP (1) | EP0930298B1 (es) |
JP (1) | JP3063164B2 (es) |
KR (1) | KR20000022214A (es) |
CN (1) | CN1226888A (es) |
AR (3) | AR008272A1 (es) |
AT (1) | ATE229941T1 (es) |
AU (1) | AU716050B2 (es) |
BG (1) | BG103114A (es) |
BR (1) | BR9711108A (es) |
CA (1) | CA2261680C (es) |
CO (1) | CO4960641A1 (es) |
CZ (1) | CZ33199A3 (es) |
DE (1) | DE69718026T2 (es) |
EE (1) | EE9900038A (es) |
ES (1) | ES2188961T3 (es) |
HR (1) | HRP970426A2 (es) |
HU (1) | HUP9902381A3 (es) |
ID (1) | ID17259A (es) |
IL (1) | IL127685A0 (es) |
IS (1) | IS4960A (es) |
NO (1) | NO990472L (es) |
NZ (1) | NZ333842A (es) |
PE (1) | PE92198A1 (es) |
PL (1) | PL331431A1 (es) |
SK (1) | SK12299A3 (es) |
TR (2) | TR200001482T2 (es) |
WO (1) | WO1998005641A1 (es) |
YU (1) | YU1299A (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6180823B1 (en) | 1998-11-06 | 2001-01-30 | Sepracor Inc. | Stereoselective process for alkyl phenylglycolic acids |
US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
AU4194500A (en) | 1999-04-08 | 2000-11-14 | Banyu Pharmaceutical Co., Ltd. | Diastereoselective preparation of michael adducts |
WO2000066579A1 (fr) * | 1999-04-28 | 2000-11-09 | Banyu Pharmaceutical Co., Ltd. | Methodes de preparation de derives de piperidylmethylpyridine |
AU6686700A (en) * | 1999-08-23 | 2001-03-19 | H. Lundbeck A/S | Treatment of urinary incontinence |
UA73543C2 (uk) | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
CA2392028C (en) | 1999-12-07 | 2009-08-18 | Theravance, Inc. | Carbamate derivatives having muscarinic receptor antagonist activity |
DE60033964T2 (de) * | 1999-12-17 | 2007-11-29 | Sanofi-Aventis | Phenoxypropanolamin-derivate, ihre herstellung und therapeutische verwendung |
US6403818B1 (en) | 2000-02-28 | 2002-06-11 | Eisai Co., Ltd. | Process for producing α-hydroxy-carbonyl compound |
US6469172B2 (en) | 2000-03-08 | 2002-10-22 | Merck & Co., Inc. | Process for the preparation of chemical compounds |
US6403584B1 (en) * | 2000-06-22 | 2002-06-11 | Merck & Co., Inc. | Substituted nipecotyl derivatives as inhibitors of cell adhesion |
EP1302458A4 (en) * | 2000-07-11 | 2005-10-19 | Banyu Pharma Co Ltd | ESTERDERIVATE |
RU2296762C2 (ru) | 2000-12-22 | 2007-04-10 | Альмиралль Продесфарма Аг | Карбаматы хинуклидина, способы их получения и фармацевтическая композиция на их основе |
BR0116624A (pt) * | 2000-12-28 | 2003-12-23 | Almirall Prodesfarma Ag | Composto, processo para produzir o mesmo, composição farmacêutica, uso do composto ou da composição farmacêutica, e, produto de combinação |
DE10111843A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von inflammatorischen Erkrankungen |
WO2003026564A2 (en) * | 2001-09-27 | 2003-04-03 | Pharmacia Ab | Pharmaceutical compositions for the treatment of urinary disorders |
ES2203327B1 (es) | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
ES2204295B1 (es) * | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
EA200500173A1 (ru) * | 2002-07-08 | 2005-08-25 | Рэнбакси Лабораториз Лимитед | Производные 3,6-дизамещенного азабицикло[3.1.0]гексана в качестве антагонистов мускариновых рецепторов |
EP1546098B1 (en) | 2002-07-31 | 2008-05-28 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
US6583103B1 (en) | 2002-08-09 | 2003-06-24 | S.C. Johnson & Son, Inc. | Two part cleaning formula resulting in an effervescent liquid |
WO2004014363A1 (en) | 2002-08-09 | 2004-02-19 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist |
WO2004018422A1 (en) | 2002-08-23 | 2004-03-04 | Ranbaxy Laboratories Limited | Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists |
CA2502532A1 (en) * | 2002-10-29 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Quaternary ammonium compounds as muscarinic receptor antagonists |
TW200800953A (en) | 2002-10-30 | 2008-01-01 | Theravance Inc | Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine |
EP1572648B1 (en) | 2002-12-10 | 2008-07-09 | Ranbaxy Laboratories, Ltd. | 3,6-disubstituted azabicyclo (3.1.0)-hexane derivatives as muscarinic receptor antagonists |
AU2003303041B2 (en) | 2002-12-13 | 2008-07-24 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
AU2002347552A1 (en) | 2002-12-23 | 2004-07-14 | Ranbaxy Laboratories Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
ATE386738T1 (de) | 2002-12-23 | 2008-03-15 | Ranbaxy Lab Ltd | Flavaxat-derivate als muscarin-rezeptor antagonisten |
US7488748B2 (en) * | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
WO2004089898A1 (en) | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
AU2003223010A1 (en) * | 2003-04-10 | 2004-11-01 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
CN100406009C (zh) | 2003-04-10 | 2008-07-30 | 兰贝克赛实验室有限公司 | 作为毒蕈碱受体拮抗剂的取代的氮杂双环己烷衍生物 |
US20070021487A1 (en) | 2003-04-11 | 2007-01-25 | Mohammad Salman | Azabicyclo derivatives as muscarinic receptor antagonists |
WO2004091597A2 (en) * | 2003-04-15 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Method of treating irritable bowel syndrome (ibs) |
EP1644356A1 (en) | 2003-07-11 | 2006-04-12 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
US7345060B2 (en) | 2003-11-21 | 2008-03-18 | Theravance, Inc. | Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
KR20060105872A (ko) * | 2003-12-29 | 2006-10-11 | 반유 세이야꾸 가부시끼가이샤 | 신규한 2-헤테로아릴 치환된 벤즈이미다졸 유도체 |
ATE419246T1 (de) * | 2004-06-16 | 2009-01-15 | Ranbaxy Lab Ltd | Als antagonisten des muscarinrezeptors geeignete xanthinderivate |
WO2006018708A2 (en) * | 2004-08-19 | 2006-02-23 | Ranbaxy Laboratories Limited | Pyrrolidine derivatives as muscarinic receptor antagonists |
US20080280883A1 (en) * | 2004-09-24 | 2008-11-13 | Mohammad Salman | Muscarinic Receptor Antagonists |
US20090105221A1 (en) * | 2004-09-29 | 2009-04-23 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
US7932394B2 (en) | 2004-11-02 | 2011-04-26 | Msd K.K. | Aryloxy-substituted benzimidazole derivatives |
WO2006054162A1 (en) * | 2004-11-19 | 2006-05-26 | Ranbaxy Laboratories Limited | Azabicyclic muscarinic receptor antagonists |
WO2006064304A1 (en) * | 2004-12-15 | 2006-06-22 | Ranbaxy Laboratories Limited | Acid addition salts of muscarinic receptor antagonists |
EP1888525A1 (en) * | 2005-05-03 | 2008-02-20 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives as muscarinic receptor antagonists |
CA2623958C (en) * | 2005-09-30 | 2013-05-28 | Banyu Pharmaceutical Co., Ltd. | 2-heteroaryl-substituted indole derivative |
WO2007039884A1 (en) * | 2005-10-05 | 2007-04-12 | Ranbaxy Laboratories Limited | 3 -azabicyclooctane derivatives as muscarinic receptor antagonists |
CA2626612A1 (en) | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
JP2008081492A (ja) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 |
US20090010923A1 (en) * | 2007-04-24 | 2009-01-08 | University Of Maryland, Baltimore | Treatment of cancer with anti-muscarinic receptor agents |
WO2009035542A2 (en) * | 2007-09-07 | 2009-03-19 | Theravance, Inc. | Guanidine-containing compounds useful as muscarinic receptor antagonists |
NZ585516A (en) * | 2007-12-21 | 2012-07-27 | Hoffmann La Roche | Anti-cd20 antibody formulation |
CN104876854B (zh) * | 2015-04-16 | 2017-03-01 | 御盛隆堂药业有限责任公司 | 羟基乙酸酯衍生物及其用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6018661B2 (ja) * | 1976-01-01 | 1985-05-11 | 太田製薬株式会社 | 1−(1,3−ジオキソラン−4−イルメチル)ピペリジノ−ル誘導体 |
JPS5679688A (en) * | 1979-12-04 | 1981-06-30 | Ota Seiyaku Kk | 4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production |
IT1231238B (it) * | 1987-09-21 | 1991-11-26 | Angeli Inst Spa | Derivati ammidinici |
GB8825505D0 (en) * | 1988-11-01 | 1988-12-07 | Pfizer Ltd | Therapeutic agents |
GB9023023D0 (en) * | 1990-10-23 | 1990-12-05 | Barlow Richard B | Pharmaceutical compositions |
CA2123728A1 (en) * | 1993-05-21 | 1994-11-22 | Noriyoshi Sueda | Urea derivatives and their use as acat inhibitors |
AU7545894A (en) * | 1993-09-02 | 1995-03-22 | Yamanouchi Pharmaceutical Co., Ltd. | Carbamate derivative and medicine containing the same |
JP3294961B2 (ja) * | 1993-12-10 | 2002-06-24 | 杏林製薬株式会社 | 新規イミダゾール誘導体及びその製造法 |
JPH07258250A (ja) * | 1994-03-25 | 1995-10-09 | Yamanouchi Pharmaceut Co Ltd | エステル誘導体 |
ATE269305T1 (de) * | 1995-04-28 | 2004-07-15 | Banyu Pharma Co Ltd | 1,4-disubstituierte piperidinderivate |
CA2179574A1 (en) * | 1995-06-26 | 1996-12-27 | Tomomi Okada | Substituted piperidine derivative and medicine comprising the same |
ATE205490T1 (de) * | 1995-10-13 | 2001-09-15 | Banyu Pharma Co Ltd | Substituierte heteroaromatische derivate |
-
1997
- 1997-07-24 PE PE1997000659A patent/PE92198A1/es not_active Application Discontinuation
- 1997-07-28 TR TR2000/01482T patent/TR200001482T2/xx unknown
- 1997-07-28 HU HU9902381A patent/HUP9902381A3/hu unknown
- 1997-07-28 EE EEP199900038A patent/EE9900038A/xx unknown
- 1997-07-28 TR TR1999/00204T patent/TR199900204T2/xx unknown
- 1997-07-28 YU YU1299A patent/YU1299A/sh unknown
- 1997-07-28 EP EP97933037A patent/EP0930298B1/en not_active Expired - Lifetime
- 1997-07-28 KR KR1019980710633A patent/KR20000022214A/ko not_active Application Discontinuation
- 1997-07-28 CA CA002261680A patent/CA2261680C/en not_active Expired - Fee Related
- 1997-07-28 IL IL12768597A patent/IL127685A0/xx unknown
- 1997-07-28 CZ CZ99331A patent/CZ33199A3/cs unknown
- 1997-07-28 SK SK122-99A patent/SK12299A3/sk unknown
- 1997-07-28 CN CN97196911A patent/CN1226888A/zh active Pending
- 1997-07-28 AT AT97933037T patent/ATE229941T1/de not_active IP Right Cessation
- 1997-07-28 BR BR9711108A patent/BR9711108A/pt not_active IP Right Cessation
- 1997-07-28 WO PCT/JP1997/002600 patent/WO1998005641A1/ja not_active Application Discontinuation
- 1997-07-28 DE DE69718026T patent/DE69718026T2/de not_active Expired - Lifetime
- 1997-07-28 AU AU36351/97A patent/AU716050B2/en not_active Ceased
- 1997-07-28 ES ES97933037T patent/ES2188961T3/es not_active Expired - Lifetime
- 1997-07-28 JP JP10507794A patent/JP3063164B2/ja not_active Expired - Fee Related
- 1997-07-28 PL PL97331431A patent/PL331431A1/xx unknown
- 1997-07-30 HR HR53,979/97A patent/HRP970426A2/hr not_active Application Discontinuation
- 1997-07-31 ID IDP972666A patent/ID17259A/id unknown
- 1997-07-31 US US08/903,768 patent/US5948792A/en not_active Expired - Lifetime
- 1997-08-01 CO CO97044382A patent/CO4960641A1/es unknown
- 1997-08-01 AR ARP970103516A patent/AR008272A1/es not_active Application Discontinuation
-
1998
- 1998-08-25 AR ARP980104218A patent/AR016877A2/es unknown
- 1998-08-25 AR ARP980104219A patent/AR017021A1/es unknown
-
1999
- 1999-01-25 BG BG103114A patent/BG103114A/xx unknown
- 1999-01-28 NZ NZ333842A patent/NZ333842A/en unknown
- 1999-01-29 IS IS4960A patent/IS4960A/is unknown
- 1999-02-01 NO NO990472A patent/NO990472L/no not_active Application Discontinuation
- 1999-04-13 US US09/290,607 patent/US6040449A/en not_active Expired - Fee Related
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