KR0183446B1 - 에이치아이브이-억제성 벤젠아세트아미드 유도체 - Google Patents

에이치아이브이-억제성 벤젠아세트아미드 유도체 Download PDF

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Publication number
KR0183446B1
KR0183446B1 KR1019930700032A KR930700032A KR0183446B1 KR 0183446 B1 KR0183446 B1 KR 0183446B1 KR 1019930700032 A KR1019930700032 A KR 1019930700032A KR 930700032 A KR930700032 A KR 930700032A KR 0183446 B1 KR0183446 B1 KR 0183446B1
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South Korea
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hydrogen
alkyl
parts
formula
compound
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Expired - Fee Related
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English (en)
Korean (ko)
Inventor
헨리 파울 반 댈레 게오르게스
구스타프 셀리네 베르돈크 마르크
레네 마리에 안드레 보스만스 예안-파울
안드리안 얀 얀센 파울
조성환
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디르크 반테
얀센 파마슈티카 엔.브이
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
KR1019930700032A 1990-07-10 1991-07-04 에이치아이브이-억제성 벤젠아세트아미드 유도체 Expired - Fee Related KR0183446B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP90201857 1990-07-10
EP90201857.1 1990-07-10
EP91200646 1991-03-22
BE91200646.7 1991-03-22
PCT/EP1991/001254 WO1992000952A1 (en) 1990-07-10 1991-07-04 Hiv-inhibiting benzeneacetamide derivatives

Publications (1)

Publication Number Publication Date
KR0183446B1 true KR0183446B1 (ko) 1999-05-15

Family

ID=26125946

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930700032A Expired - Fee Related KR0183446B1 (ko) 1990-07-10 1991-07-04 에이치아이브이-억제성 벤젠아세트아미드 유도체

Country Status (42)

Country Link
US (2) US5556886A (enExample)
EP (1) EP0538301B1 (enExample)
JP (1) JPH0819068B2 (enExample)
KR (1) KR0183446B1 (enExample)
CN (2) CN1028990C (enExample)
AP (1) AP311A (enExample)
AT (1) ATE144765T1 (enExample)
AU (1) AU643056B2 (enExample)
BG (1) BG61809B1 (enExample)
CA (1) CA2084508A1 (enExample)
CZ (1) CZ279901B6 (enExample)
DE (1) DE69122963T2 (enExample)
DK (1) DK0538301T3 (enExample)
DZ (1) DZ1514A1 (enExample)
ES (1) ES2095942T3 (enExample)
FI (1) FI930070A7 (enExample)
GR (1) GR3021829T3 (enExample)
HR (1) HRP930485A2 (enExample)
HU (2) HUT64013A (enExample)
IE (1) IE75693B1 (enExample)
IL (3) IL111924A (enExample)
LT (1) LT3602B (enExample)
LV (1) LV10086B (enExample)
MA (1) MA22208A1 (enExample)
MX (1) MX9100100A (enExample)
MY (1) MY108580A (enExample)
NO (1) NO303777B1 (enExample)
NZ (1) NZ238763A (enExample)
OA (1) OA09770A (enExample)
PH (1) PH30977A (enExample)
PL (1) PL167076B1 (enExample)
PT (1) PT98259B (enExample)
RO (1) RO112855B1 (enExample)
RU (1) RU2087465C1 (enExample)
SG (1) SG48829A1 (enExample)
SI (1) SI9111204A (enExample)
SK (1) SK279639B6 (enExample)
TN (1) TNSN91056A1 (enExample)
TW (1) TW204337B (enExample)
WO (1) WO1992000952A1 (enExample)
YU (1) YU120491A (enExample)
ZA (1) ZA915334B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2125676A1 (en) * 1991-12-30 1993-07-08 Marcel August Constant Janssen .alpha.-substituted benzenemethanamine derivatives
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
DK0577945T3 (da) * 1992-07-06 1996-09-02 American Cyanamid Co Herbicidmellemproduktet o-nitrophenyl-cyclopropyl-keton og fremgangsmåde til fremstilling deraf
AU676021B2 (en) * 1993-02-22 1997-02-27 Janssen Pharmaceutica N.V. Method of reversing resistance of HIV-1 strains to zidovudine
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
IL112739A0 (en) * 1994-02-23 1995-05-26 Wellcome Found Ayrlthiobenzonitrile compounds, their preparation and pharmaceutical compositions containing them
GB9403408D0 (en) * 1994-02-23 1994-04-13 Wellcome Found Therapeutic benzonitriles
GB9403449D0 (en) * 1994-02-23 1994-04-13 Wellcome Found Therapeutic benzonitriles
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
EP0872233A1 (en) * 1997-04-14 1998-10-21 Janssen Pharmaceutica N.V. Antiretroviral compositions with improved bioavailability
ES2221197T3 (es) * 1997-08-22 2004-12-16 F. Hoffmann-La Roche Ag Derivados de n-alcanoilfenilalanina.
BR9911385A (pt) * 1998-06-19 2001-03-13 Us Health Composição, processos para dissociar um ìon de metal de uma proteìna contendo dedo de zinco, para inativar um vìrus e para selecionar um composto capaz de dissociar um ìon de metal quelado com um dedo de zinco de uma proteìna viral, vìrus isolado e inativado, kit para selecionar um composto capaz de dissociar um ìon de metal de um dedo de zinco de uma proteìna viral, composição viricida, e, formulação farmacêutica.
EE04991B1 (et) 1999-09-24 2008-04-15 Janssen Pharmaceutica N.V. Osake, ravimvorm, nende valmistamismeetodid, osakeste kasutamine ning farmatseutiline pakend
DE60136187D1 (de) 2000-08-11 2008-11-27 Japan Tobacco Inc Calciumrezeptor-antagonisten
RU2389719C3 (ru) * 2004-04-23 2018-04-18 Ф.Хоффманн-Ля Рош Аг Ненуклеозидные ингибиторы обратной транскриптазы
US7625949B2 (en) 2004-04-23 2009-12-01 Roche Palo Alto Llc Methods for treating retroviral infections
WO2007146719A2 (en) * 2006-06-08 2007-12-21 Bristol-Myers Squibb Company 2-aminocarbonylphenylamino-2-phenylacetamides as factor viia inhibitors useful as anticoagulants
RU2449985C2 (ru) * 2010-03-31 2012-05-10 Федеральное государственное унитарное предприятие "Российский научный центр "Прикладная химия" Способ получения n,n-диметилацетамида
CN102675212B (zh) * 2012-05-09 2014-11-05 昆明理工大学 N-取代苯基-2-((1h-苯并咪唑-2-基)巯基)乙酰胺类衍生物及其用途
CN104000807B (zh) * 2014-05-28 2016-05-18 中山大学 苯基-酰胺类化合物在制备抗hiv-1病毒药物中的应用
CN105367437B (zh) * 2015-10-12 2017-08-01 湖北文理学院 一种2‑芳氨基乙酰胺类化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1423430A (en) * 1973-03-29 1976-02-04 Wyeth John & Brother Ltd Thioamides
US4246429A (en) * 1978-06-23 1981-01-20 Janssen Pharmaceutica, N.V. Novel α-amino-phenylacetic acid derivatives
CH637828A5 (en) * 1978-11-15 1983-08-31 Koehler Franz Dr Chemie Kg Cytostatics
CA2125676A1 (en) * 1991-12-30 1993-07-08 Marcel August Constant Janssen .alpha.-substituted benzenemethanamine derivatives

Also Published As

Publication number Publication date
IL98756A0 (en) 1992-07-15
ATE144765T1 (de) 1996-11-15
AU643056B2 (en) 1993-11-04
JPH0819068B2 (ja) 1996-02-28
US5684049A (en) 1997-11-04
HRP930485A2 (en) 1996-06-30
SI9111204A (en) 1995-04-30
RU2087465C1 (ru) 1997-08-20
YU120491A (sh) 1994-06-10
PT98259A (pt) 1992-04-30
MY108580A (en) 1996-10-31
CN1028990C (zh) 1995-06-21
TW204337B (enExample) 1993-04-21
NZ238763A (en) 1993-10-26
SK279639B6 (sk) 1999-01-11
DE69122963T2 (de) 1997-03-13
ES2095942T3 (es) 1997-03-01
OA09770A (fr) 1993-11-30
PT98259B (pt) 1998-12-31
WO1992000952A1 (en) 1992-01-23
GR3021829T3 (en) 1997-02-28
PL297608A1 (enExample) 1992-07-13
FI930070A0 (fi) 1993-01-08
AU8212091A (en) 1992-02-04
NO930047L (no) 1993-01-07
JPH05507931A (ja) 1993-11-11
EP0538301B1 (en) 1996-10-30
NO930047D0 (no) 1993-01-07
SK210291A3 (en) 1995-07-11
DK0538301T3 (da) 1996-11-25
BG97265A (bg) 1994-03-24
DE69122963D1 (de) 1996-12-05
SG48829A1 (en) 1998-05-18
EP0538301A1 (en) 1993-04-28
CN1033142C (zh) 1996-10-30
RO112855B1 (ro) 1998-01-30
LT3602B (en) 1995-12-27
IL111924A (en) 1996-12-05
HU211873A9 (en) 1995-12-28
MA22208A1 (fr) 1992-04-01
LV10086A (lv) 1994-05-10
LTIP848A (en) 1995-02-27
AP311A (en) 1994-02-01
FI930070A7 (fi) 1993-01-08
HU9300032D0 (en) 1993-04-28
LV10086B (en) 1995-02-20
PH30977A (en) 1997-12-23
PL167076B1 (pl) 1995-07-31
ZA915334B (en) 1993-03-31
IL98756A (en) 1996-06-18
CZ279901B6 (cs) 1995-08-16
HUT64013A (en) 1993-11-29
IL111924A0 (en) 1995-03-15
IE75693B1 (en) 1997-09-10
US5556886A (en) 1996-09-17
NO303777B1 (no) 1998-08-31
DZ1514A1 (fr) 2004-09-13
IE912208A1 (en) 1992-01-15
CS210291A3 (en) 1992-02-19
MX9100100A (es) 1992-02-28
CA2084508A1 (en) 1992-01-11
AP9100288A0 (en) 1991-07-31
CN1058958A (zh) 1992-02-26
BG61809B1 (bg) 1998-06-30
CN1107835A (zh) 1995-09-06
TNSN91056A1 (fr) 1992-10-25

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Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20011217

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000