ES2058238T3 - Estructuras adn con contenido de una secuencia conductora de factor alfa de kluyveromyces para dirigir la secrecion de polipeptidos heterologos. - Google Patents

Estructuras adn con contenido de una secuencia conductora de factor alfa de kluyveromyces para dirigir la secrecion de polipeptidos heterologos.

Info

Publication number
ES2058238T3
ES2058238T3 ES88201631T ES88201631T ES2058238T3 ES 2058238 T3 ES2058238 T3 ES 2058238T3 ES 88201631 T ES88201631 T ES 88201631T ES 88201631 T ES88201631 T ES 88201631T ES 2058238 T3 ES2058238 T3 ES 2058238T3
Authority
ES
Spain
Prior art keywords
polypeptides
heterological
secretion
direct
content
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88201631T
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English (en)
Inventor
Den Berg Johannes A Dr Van
Anthony J Dr Brake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Novartis Vaccines and Diagnostics Inc
Original Assignee
Gist Brocades NV
Chiron Corp
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Filing date
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Application filed by Gist Brocades NV, Chiron Corp filed Critical Gist Brocades NV
Application granted granted Critical
Publication of ES2058238T3 publication Critical patent/ES2058238T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION SE REFIERE A BLOQUES ESTRUCTURALES DE DNA QUE SON UTILES PARA PROPORCIONAR EXPRESION SECRETORIA DE POLIPEPTIDOS HETEROLOGOS EN LEVADURAS, QUE COMPRENDEN UNA SECUENCIA GUIA DEL FACTOR ALFA UNIDA AL POLIPEPTIDO HETEROLOGO POR UNA SEÑAL DE PROCESADO DE LA LEVADURA. SE DAN EJEMPLOS DE BLOQUES QUE EMPLEAN LA GUIA DEL FACTOR ALFA DE K.LACTIS Y SECUENCIAS DE LA SEÑAL DE PROCESADO, CON Y SIN NINGUN GRUPO ESPACIADOR, UNIDO A PROQUIMOSINA.
ES88201631T 1987-07-28 1988-07-28 Estructuras adn con contenido de una secuencia conductora de factor alfa de kluyveromyces para dirigir la secrecion de polipeptidos heterologos. Expired - Lifetime ES2058238T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/078,551 US5010182A (en) 1987-07-28 1987-07-28 DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides

Publications (1)

Publication Number Publication Date
ES2058238T3 true ES2058238T3 (es) 1994-11-01

Family

ID=22144759

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88201631T Expired - Lifetime ES2058238T3 (es) 1987-07-28 1988-07-28 Estructuras adn con contenido de una secuencia conductora de factor alfa de kluyveromyces para dirigir la secrecion de polipeptidos heterologos.

Country Status (19)

Country Link
US (1) US5010182A (es)
EP (1) EP0301669B1 (es)
JP (1) JP2680054B2 (es)
KR (1) KR970004940B1 (es)
CN (1) CN1045620C (es)
AT (1) ATE90727T1 (es)
AU (1) AU623860B2 (es)
CA (1) CA1327762C (es)
DE (1) DE3881776T2 (es)
DK (1) DK175365B1 (es)
ES (1) ES2058238T3 (es)
FI (1) FI101232B1 (es)
HU (1) HU213015B (es)
IE (1) IE62261B1 (es)
IL (1) IL87255A (es)
NO (1) NO180381C (es)
NZ (1) NZ225596A (es)
PT (1) PT88115B (es)
ZA (1) ZA885535B (es)

Families Citing this family (160)

* Cited by examiner, † Cited by third party
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EP0301669A1 (en) 1989-02-01
CN1032367A (zh) 1989-04-12
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ATE90727T1 (de) 1993-07-15
NO883346D0 (no) 1988-07-28
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HU213015B (en) 1997-01-28
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EP0301669B1 (en) 1993-06-16
DK175365B1 (da) 2004-09-13
FI101232B1 (fi) 1998-05-15
PT88115A (pt) 1989-06-30
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FI883541A (fi) 1989-01-29
NO180381B (no) 1996-12-30

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