EP1425383A4 - Stabilisation de cellules et de specimens biologiques pour l'analyse - Google Patents

Stabilisation de cellules et de specimens biologiques pour l'analyse

Info

Publication number
EP1425383A4
EP1425383A4 EP02768676A EP02768676A EP1425383A4 EP 1425383 A4 EP1425383 A4 EP 1425383A4 EP 02768676 A EP02768676 A EP 02768676A EP 02768676 A EP02768676 A EP 02768676A EP 1425383 A4 EP1425383 A4 EP 1425383A4
Authority
EP
European Patent Office
Prior art keywords
analysis
damage
cells
vitro
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02768676A
Other languages
German (de)
English (en)
Other versions
EP1425383A2 (fr
Inventor
Galla Chandra Rao
Melissa Hermann
Herman Rutner
Leon Terstappen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunivest Corp
Original Assignee
Immunivest Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26979228&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1425383(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunivest Corp filed Critical Immunivest Corp
Publication of EP1425383A2 publication Critical patent/EP1425383A2/fr
Publication of EP1425383A4 publication Critical patent/EP1425383A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
EP02768676A 2001-08-23 2002-08-23 Stabilisation de cellules et de specimens biologiques pour l'analyse Withdrawn EP1425383A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31415101P 2001-08-23 2001-08-23
US314151P 2001-08-23
US36962802P 2002-04-03 2002-04-03
US369628P 2002-04-03
PCT/US2002/026867 WO2003018757A2 (fr) 2001-08-23 2002-08-23 Stabilisation de cellules et de specimens biologiques pour l'analyse

Publications (2)

Publication Number Publication Date
EP1425383A2 EP1425383A2 (fr) 2004-06-09
EP1425383A4 true EP1425383A4 (fr) 2005-11-09

Family

ID=26979228

Family Applications (2)

Application Number Title Priority Date Filing Date
EP02761478A Expired - Lifetime EP1425294B2 (fr) 2001-08-23 2002-08-23 Analyse de cellules tumorales en circulation, de fragments et de debris associes
EP02768676A Withdrawn EP1425383A4 (fr) 2001-08-23 2002-08-23 Stabilisation de cellules et de specimens biologiques pour l'analyse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP02761478A Expired - Lifetime EP1425294B2 (fr) 2001-08-23 2002-08-23 Analyse de cellules tumorales en circulation, de fragments et de debris associes

Country Status (11)

Country Link
EP (2) EP1425294B2 (fr)
JP (3) JP2005501236A (fr)
KR (2) KR20040053115A (fr)
CN (2) CN1596265A (fr)
AT (1) ATE401574T1 (fr)
AU (2) AU2008288601B2 (fr)
BR (2) BR0212125A (fr)
CA (2) CA2457894C (fr)
DE (1) DE60227678D1 (fr)
IL (2) IL160209A0 (fr)
WO (2) WO2003018757A2 (fr)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003018757A2 (fr) * 2001-08-23 2003-03-06 Immunivest Corporation Stabilisation de cellules et de specimens biologiques pour l'analyse
US7863012B2 (en) 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
CA2484876C (fr) 2002-05-13 2011-11-22 Becton, Dickinson And Company Systeme de prelevement d'echantillon comprenant un inhibiteur de protease
ATE531257T1 (de) 2002-09-27 2011-11-15 Gen Hospital Corp Mikrofluidische vorrichtung zur zelltrennung und verwendungen davon
CA2445204C (fr) 2002-10-16 2014-08-12 Streck Laboratories, Inc. Methode et dispositif de prelevement et de conservation de cellules aux fins d'analyse
WO2004076643A2 (fr) 2003-02-27 2004-09-10 Immunivest Corporation Cellules tumorales circulantes (ctc): evaluation precoce du temps d'evolution, de la survie et de la reaction aux therapies des patients cancereux metastasiques
JP4629675B2 (ja) * 2003-09-18 2011-02-09 ベリデックス・リミテッド・ライアビリティ・カンパニー オペレーター不要のプログラム可能な試料調製および分析システム
EP1861509B1 (fr) * 2005-03-14 2015-09-09 Janssen Diagnostics, LLC Méthode de prédiction de survie sans progression et de survie globale, à chaque instant du suivi, au cours du traitement de patientes atteintes du cancer du sein métastatique, utilisant des cellules tumorales circulantes
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
CN104673905B (zh) 2005-06-20 2016-09-07 领先细胞医疗诊断有限公司 检测单个细胞中的核酸和鉴定异质大细胞群中罕见细胞的方法
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
WO2011050103A1 (fr) 2009-10-21 2011-04-28 The Scripps Research Institute Méthodes d'utilisation de cellules non rares pour détecter des cellules rares
US8337755B2 (en) 2006-03-13 2012-12-25 Veridex, Llc Operator independent programmable sample preparation and analysis system
KR101467136B1 (ko) * 2006-06-02 2014-12-01 화이자 프로덕츠 인코포레이티드 순환 종양 세포 분석
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
EP2029779A4 (fr) 2006-06-14 2010-01-20 Living Microsystems Inc Utilisation de génotypage snp fortement parallèle pour diagnostic fétal
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
CA2657621A1 (fr) 2006-07-14 2008-01-17 Aviva Biosciences Corporation Procedes et compositions servant a detecter des cellules rares dans un echantillon biologique
CN101669031A (zh) * 2007-02-27 2010-03-10 森托科隆股份公司 使用与细胞外标记物结合的试剂组多重检测肿瘤细胞
WO2008128243A1 (fr) 2007-04-16 2008-10-23 Immunivest Corporation Procédé rapide semi-automatisé pour détecter des cellules infectées de virus dans des spécimens directs
US8003314B2 (en) 2007-04-16 2011-08-23 Diagnostic Hybrids, Inc. Methods for direct fluorescent antibody virus detection in liquids
US7828968B2 (en) 2007-08-30 2010-11-09 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
US8110101B2 (en) 2007-08-30 2012-02-07 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
WO2009076560A2 (fr) 2007-12-12 2009-06-18 The Board Of Trustees Of The Leland Stanford Junior University Procédé et appareil pour la séparation magnétique de cellules
EP2952589B1 (fr) 2008-09-20 2018-02-14 The Board of Trustees of The Leland Stanford Junior University Diagnostic non invasif d'une aneuploïdie foetale par séquençage
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
DE202010018569U1 (de) 2009-02-18 2017-09-26 Streck Inc. Konservierung zellfreier Nukleinsäuren
US20130023433A1 (en) 2009-09-28 2013-01-24 Yuling Luo Methods of detecting nucleic acid sequences with high specificity
EP2529030B1 (fr) 2010-01-29 2019-03-13 Advanced Cell Diagnostics, Inc. Methode de detection d'acides nucleiques in situ
JPWO2011099565A1 (ja) * 2010-02-10 2013-06-17 シスメックス株式会社 血液中癌細胞の検出方法及びそれに用いるプログラム
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
EP2854058A3 (fr) 2010-05-18 2015-10-28 Natera, Inc. Procédés pour une classification de ploïdie prénatale non invasive
US10179937B2 (en) 2014-04-21 2019-01-15 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
DE102010020785A1 (de) * 2010-05-18 2011-11-24 Siemens Aktiengesellschaft Vorrichtung und Verfahren zum Erkennen von magnetisch markierten Mikroobjekten
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US20120252038A1 (en) * 2011-04-01 2012-10-04 Chianese David A Steroid receptor assays
EP2704740B1 (fr) 2011-05-04 2016-10-05 Streck, Inc. Virus grippal porcin inactivé et procédés de préparation
WO2013016600A2 (fr) * 2011-07-28 2013-01-31 The Trustees Of The University Of Pennsylvania Méthodes et réactifs pour le diagnostic d'états pathologiques et la caractérisation de cellules tumorales associées à des liquides séreux
JP6155269B2 (ja) 2011-09-26 2017-06-28 プレアナリティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 細胞外核酸の安定化および単離
US11021733B2 (en) 2011-09-26 2021-06-01 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
KR102037891B1 (ko) * 2012-03-09 2019-10-30 한국전자통신연구원 다중 분리 장치 및 혈중 암세포 분리 방법
EP2848935A4 (fr) * 2012-05-10 2015-12-09 Konica Minolta Inc Procédé d'élimination des globules rouges ainsi que tube de centrifugation pour prélèvement sanguin
US10724074B2 (en) 2012-09-25 2020-07-28 Qiagen Gmbh Stabilisation of biological samples
EP2971279B1 (fr) 2013-03-15 2019-11-13 The Trustees of Princeton University Méthodes et dispositifs de purification à rendement élevé
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
US11493428B2 (en) 2013-03-15 2022-11-08 Gpb Scientific, Inc. On-chip microfluidic processing of particles
CN105121643A (zh) * 2013-03-18 2015-12-02 凯杰有限公司 细胞外核酸的稳定化和分离
EP3447141B1 (fr) 2013-03-18 2020-08-05 PreAnalytiX GmbH Stabilisation d'échantillons biologiques
WO2015013244A1 (fr) * 2013-07-24 2015-01-29 Streck, Inc. Compositions et méthodes de stabilisation de cellules tumorales circulantes
US10053692B2 (en) 2013-10-21 2018-08-21 The General Hospital Corporation Methods relating to circulating tumor cell clusters and the treatment of cancer
WO2015112955A1 (fr) 2014-01-27 2015-07-30 Epic Sciences, Inc. Diagnostics de cellules tumorales circulantes pour biomarqueurs du cancer de la prostate
EP3108246B1 (fr) 2014-02-21 2019-10-09 Epic Sciences, Inc. Méthodes pour analyser des cellules circulantes rares
EP4218411A3 (fr) * 2014-03-18 2023-08-23 PreAnalytiX GmbH Stabilisation et isolement d'acides nucléiques extracellulaires
CN103940997B (zh) * 2014-03-21 2017-01-04 上海柏慧康生物科技有限公司 一种乳腺癌循环肿瘤细胞检测系统及试剂盒
CN103980365A (zh) * 2014-06-03 2014-08-13 国家纳米科学中心 一种表面固载炭疽致死因子的磁性纳米粒子、其制备方法及用途
EP3164204B1 (fr) * 2014-07-02 2021-03-10 Siemens Healthcare Diagnostics Inc. Séparation d'acides nucléiques sélective
WO2016137915A1 (fr) * 2015-02-24 2016-09-01 Siemens Healthcare Diagnostics Inc. Préfixation permettant d'augmenter la récupération de cellules rares
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
WO2016183106A1 (fr) 2015-05-11 2016-11-17 Natera, Inc. Procédés et compositions pour la détermination de la ploïdie
US20170097361A1 (en) * 2015-07-15 2017-04-06 Streck, Inc. Method and device for stabilizing of proteins
JP6617495B2 (ja) * 2015-09-18 2019-12-11 東ソー株式会社 腫瘍細胞の検出方法
US20180328848A1 (en) * 2015-11-04 2018-11-15 Axon Dx, Llc Cell detection, capture, analysis, aggregation, and output methods and apparatus
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
CA3005694A1 (fr) 2015-11-20 2017-05-26 Qiagen Gmbh Procede de preparation de compositions sterilisees d'acides nucleiques extracellulaires
CN105372109A (zh) * 2015-12-15 2016-03-02 苏州药明康德新药开发股份有限公司 添加稳定剂的生物基质的制备方法
WO2017152028A1 (fr) * 2016-03-04 2017-09-08 Janssen Diagnostics, Llc Conservation de composants cellulaires de cellules avec un conservateur
WO2017155894A1 (fr) 2016-03-07 2017-09-14 Cfgenome, Llc Témoins moléculaires non invasifs
JP2017219479A (ja) 2016-06-09 2017-12-14 住友電気工業株式会社 微小粒子計測装置及び分析方法
US11506655B2 (en) 2016-07-29 2022-11-22 Streck, Inc. Suspension composition for hematology analysis control
WO2018067517A1 (fr) 2016-10-04 2018-04-12 Natera, Inc. Procédés pour caractériser une variation de nombre de copies à l'aide d'un séquençage de ligature de proximité
US10415080B2 (en) 2016-11-21 2019-09-17 Nanostring Technologies, Inc. Chemical compositions and methods of using same
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
RU2764245C2 (ru) * 2017-08-02 2022-01-14 Зарштедт Аг Унд Ко. Кг Способ и состав для стабилизации нуклеиновых кислот, свободных от клеток, и клеток
JP7393328B2 (ja) 2017-09-01 2023-12-06 ジーピービー・サイエンティフィック・インコーポレイテッド マイクロ流体を使用した治療的に活性な細胞を調製する方法
EP3697209A4 (fr) * 2017-10-19 2021-07-28 Streck, Inc. Compositions pour l'hémolyse et la régulation de la coagulation et la stabilisation de vésicules extracellulaires
SG11202011274YA (en) 2018-05-14 2020-12-30 Nanostring Technologies Inc Chemical compositions and methods of using same
JP7334468B2 (ja) * 2018-05-29 2023-08-29 東ソー株式会社 血液試料保存剤
JP7036670B2 (ja) 2018-05-31 2022-03-15 アークレイ株式会社 血液中の稀少細胞検査、該検査ための血液処理方法及び採血管
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN108865976B (zh) * 2018-07-19 2022-06-28 复旦大学附属中山医院 一种离散汲取收集外泌体(exosome)的方法及试剂
CN110250159A (zh) * 2019-05-28 2019-09-20 天津中科生物科技有限公司 一种细胞保护液及其制备方法和应用
JP7355473B1 (ja) 2022-03-25 2023-10-03 積水メディカル株式会社 循環腫瘍細胞分離キット、循環腫瘍細胞分離容器及び循環腫瘍細胞の分離方法

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2475737A1 (fr) * 1980-02-07 1981-08-14 Pasteur Institut Perfectionnements apportes aux procedes de conservation d'hematies par lyophilisation en vue de leur utilisation dans des reactions d'hemagglutination et hematies non agglutinables spontanement obtenues par ce procede
US4404181A (en) * 1981-10-15 1983-09-13 Cambridge Chemical Products, Inc. Extended-life tissue fixative composition and method of using the same
EP0161770A2 (fr) * 1984-05-14 1985-11-21 Becton Dickinson and Company Agent de lyse pour l'analyse de cellules sanguines périphériques
WO1993005650A1 (fr) * 1991-09-20 1993-04-01 Camiener Gerald W Procedes et compositions comportant une solution de stabilisation a l'aldehyde
WO1994018828A1 (fr) * 1993-02-25 1994-09-01 Abbott Laboratories Systeme de reactifs polyvalent de lyse rapide d'echantillon de sang total
WO1997008557A1 (fr) * 1995-08-28 1997-03-06 Miltenyi Biotech Gmbh Procede efficace d'enrichissement et de detection de cellules tumorales disseminees
WO1997045729A1 (fr) * 1996-05-24 1997-12-04 Northern General Hospital Nhs Trust Liquide servant a recueillir un specimen
US5849517A (en) * 1991-05-08 1998-12-15 Streck Laboratories, Inc. Method and composition for preserving antigens and nucleic acids and process for utilizing cytological material produced by same
US6197523B1 (en) * 1997-11-24 2001-03-06 Robert A. Levine Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4040785A (en) * 1976-10-18 1977-08-09 Technicon Instruments Corporation Lysable blood preservative composition
US4320111A (en) * 1977-06-14 1982-03-16 American Home Products Corporation Immunologic compositions methods of preparation and use
FR2523810B1 (fr) * 1982-03-23 1988-11-25 Carpentier Alain Tissu biologique greffable et procede pour sa preparation
FR2528848A1 (fr) * 1982-06-16 1983-12-23 Sanofi Sa Nouveau derive de thieno-pyridone, son procede de preparation et son application therapeutique
EP0156537A3 (fr) * 1984-03-02 1987-05-13 Board Of Regents University Of Texas System Fluide magnétique biologique
US4788139A (en) * 1987-08-06 1988-11-29 Streck Laboratories, Inc. Platelet aggregation reagent, reagent container and method of determining platelet aggregation in EDTA-anticoagulated blood
US5385707A (en) * 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
US5698271A (en) * 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
US6670197B2 (en) * 1997-11-24 2003-12-30 David L. Rimm Method for assaying whole blood for the presence or absence of circulating cancer or other target cell fragments
AU760560B2 (en) * 1998-02-12 2003-05-15 Board Of Regents, The University Of Texas System Methods and reagents for the rapid and efficient isolation of circulating cancer cells
AU2876900A (en) * 1999-02-10 2000-08-29 Cell Works Inc. Class characterization of circulating cancer cells isolated from body fluids andmethods of use
WO2001019956A2 (fr) * 1999-09-13 2001-03-22 Bander Neil H Procede d'isolement de cellules epitheliales prostatiques du sperme
WO2003018757A2 (fr) * 2001-08-23 2003-03-06 Immunivest Corporation Stabilisation de cellules et de specimens biologiques pour l'analyse

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2475737A1 (fr) * 1980-02-07 1981-08-14 Pasteur Institut Perfectionnements apportes aux procedes de conservation d'hematies par lyophilisation en vue de leur utilisation dans des reactions d'hemagglutination et hematies non agglutinables spontanement obtenues par ce procede
US4404181A (en) * 1981-10-15 1983-09-13 Cambridge Chemical Products, Inc. Extended-life tissue fixative composition and method of using the same
EP0161770A2 (fr) * 1984-05-14 1985-11-21 Becton Dickinson and Company Agent de lyse pour l'analyse de cellules sanguines périphériques
US5849517A (en) * 1991-05-08 1998-12-15 Streck Laboratories, Inc. Method and composition for preserving antigens and nucleic acids and process for utilizing cytological material produced by same
WO1993005650A1 (fr) * 1991-09-20 1993-04-01 Camiener Gerald W Procedes et compositions comportant une solution de stabilisation a l'aldehyde
WO1994018828A1 (fr) * 1993-02-25 1994-09-01 Abbott Laboratories Systeme de reactifs polyvalent de lyse rapide d'echantillon de sang total
WO1997008557A1 (fr) * 1995-08-28 1997-03-06 Miltenyi Biotech Gmbh Procede efficace d'enrichissement et de detection de cellules tumorales disseminees
WO1997045729A1 (fr) * 1996-05-24 1997-12-04 Northern General Hospital Nhs Trust Liquide servant a recueillir un specimen
US6197523B1 (en) * 1997-11-24 2001-03-06 Robert A. Levine Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood

Also Published As

Publication number Publication date
IL160209A0 (en) 2004-07-25
EP1425294B2 (fr) 2012-12-12
CA2457891A1 (fr) 2003-03-06
EP1425294A4 (fr) 2005-11-16
AU2009200013B2 (en) 2012-03-08
EP1425383A2 (fr) 2004-06-09
KR20040053115A (ko) 2004-06-23
JP2009109514A (ja) 2009-05-21
WO2003018757A2 (fr) 2003-03-06
ATE401574T1 (de) 2008-08-15
IL160210A0 (en) 2004-07-25
EP1425294B1 (fr) 2008-07-16
AU2009200013A1 (en) 2009-02-05
BR0212125A (pt) 2005-06-28
BR0212124A (pt) 2004-07-20
KR20040030984A (ko) 2004-04-09
WO2003018757A3 (fr) 2003-09-12
JP2005502863A (ja) 2005-01-27
DE60227678D1 (de) 2008-08-28
WO2003019141A2 (fr) 2003-03-06
WO2003019141A3 (fr) 2004-04-01
CN1596265A (zh) 2005-03-16
EP1425294A2 (fr) 2004-06-09
AU2008288601A1 (en) 2009-04-02
AU2008288601B2 (en) 2012-05-31
CA2457894C (fr) 2014-07-08
CA2457894A1 (fr) 2003-03-06
CA2457891C (fr) 2019-10-01
CN1571634A (zh) 2005-01-26
JP2005501236A (ja) 2005-01-13

Similar Documents

Publication Publication Date Title
IL160210A0 (en) Stabilization of cells and biological specimens for analysis
Lazar et al. Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived LNCaP cell line
EP2169387B1 (fr) Procédé multiparamètre haute sensibilité pour l'analyse d'événements rares dans un échantillon biologique
NZ333830A (en) Method for assessing chemosensitivity of a biopsy sample
WO2008109414A3 (fr) Utilisation de la fluorescence endogène pour identifier les cellules de tumeur du sein métastatiques envahissantes
de Paz et al. The relationship between ram sperm head morphometry and fertility depends on the procedures of acquisition and analysis used
Kervarrec et al. Merkel cell carcinomas infiltrated with CD33+ myeloid cells and CD8+ T cells are associated with improved outcome
Baker et al. Rapid cervical cytology screening
Subramanian et al. Significance of bone marrow fibrosis in multiple myeloma
Teman et al. Quantification of fibrosis and osteosclerosis in myeloproliferative neoplasms: a computer-assisted image study
WO2003023354A3 (fr) Identification et quantification des types de lymphocytes sur la base de la morphologie de leurs noyaux au moyen de systemes de disques biologiques optiques
Pijanka et al. Spectroscopic signatures of single, isolated cancer cell nuclei using synchrotron infrared microscopy
Cattan et al. Circulating gastrin, endocrine cells, histamine content, and histidine decarboxylase activity in atrophic gastritis
Böttger et al. DNA image cytometry. A prognostic tool in squamous cell carcinoma of the esophagus?
Simons et al. Effects of histological staining on the analysis of human DNA from archived slides
Gong et al. Clonal status and clinicopathological features of Langerhans cell histiocytosis
Zver et al. Minimal residual disease detection in cryopreserved ovarian tissue by multicolor flow cytometry in acute myeloid leukemia
WO2011033290A3 (fr) Essai par fluorescence double
Toman What are the advantages and disadvantages of fluorescence microscopy
Zver et al. Validation of an automated technique for ovarian cortex dissociation: isolation of viable ovarian cells and their qualification by multicolor flow cytometry
Shen et al. Accurate and noninvasive embryos screening during in vitro fertilization (IVF) assisted by Raman analysis ofembryos culture medium
Balasubramanian et al. Isolation and characterization of circulating tumor cells (CTCs) from peripheral blood specimens of patients with advanced solid tumor malignancies (using ApoStream (TM) instrumentation)
Zickuhr et al. Spatial Metabolomics co-registered with Multiplex Phenotyping for the Evaluation of Human Kidney Tissue
Dao et al. Using micro-synchrotron radiation x-ray fluorescence (µ-SRXRF) for trace metal imaging in the development of MRI contrast agents for prostate cancer imaging
HK1049204A1 (en) Cytological imaging system and method

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20040315

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 01N 1/02 A

A4 Supplementary search report drawn up and despatched

Effective date: 20050927

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 01N 1/02 B

Ipc: 7G 01N 33/574 B

Ipc: 7G 01N 33/543 A

17Q First examination report despatched

Effective date: 20060623

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20080508