SG11202011274YA - Chemical compositions and methods of using same - Google Patents

Chemical compositions and methods of using same

Info

Publication number
SG11202011274YA
SG11202011274YA SG11202011274YA SG11202011274YA SG11202011274YA SG 11202011274Y A SG11202011274Y A SG 11202011274YA SG 11202011274Y A SG11202011274Y A SG 11202011274YA SG 11202011274Y A SG11202011274Y A SG 11202011274YA SG 11202011274Y A SG11202011274Y A SG 11202011274YA
Authority
SG
Singapore
Prior art keywords
methods
same
chemical compositions
compositions
chemical
Prior art date
Application number
SG11202011274YA
Inventor
Dwayne Dunaway
Elizabeth Manrao
Joseph Beechem
Rustem Khafizov
Sanghamithra Korukonda
Yi Deng
Dae Kim
Mark Gregory
Margaret Hoang
Matthew Walsh
Gavin Meredith
Mark Mcelwain
Peter Skene
Cassandra Burke
Original Assignee
Nanostring Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanostring Technologies Inc filed Critical Nanostring Technologies Inc
Publication of SG11202011274YA publication Critical patent/SG11202011274YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
SG11202011274YA 2018-05-14 2019-05-14 Chemical compositions and methods of using same SG11202011274YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862671091P 2018-05-14 2018-05-14
US201962836327P 2019-04-19 2019-04-19
PCT/US2019/032168 WO2019222178A1 (en) 2018-05-14 2019-05-14 Chemical compositions and methods of using same

Publications (1)

Publication Number Publication Date
SG11202011274YA true SG11202011274YA (en) 2020-12-30

Family

ID=67002349

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202011274YA SG11202011274YA (en) 2018-05-14 2019-05-14 Chemical compositions and methods of using same

Country Status (9)

Country Link
US (2) US11549139B2 (en)
EP (1) EP3794146A1 (en)
JP (1) JP2021523723A (en)
KR (1) KR20210061962A (en)
CN (1) CN112703255A (en)
AU (1) AU2019271028A1 (en)
CA (1) CA3099909A1 (en)
SG (1) SG11202011274YA (en)
WO (1) WO2019222178A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102298387B1 (en) * 2014-11-21 2021-09-07 나노스트링 테크놀로지스, 인크. Enzyme- and amplification-free sequencing
AU2017361521B2 (en) * 2016-11-21 2020-08-27 Nanostring Technologies, Inc. Chemical compositions and methods of using same
WO2022060967A1 (en) * 2020-09-16 2022-03-24 Nanostring Technologies, Inc. Chemical compositions and methods of using the same
WO2022216824A1 (en) * 2021-04-06 2022-10-13 Akoya Biosciences, Inc. Detection of labeled analytes in biological samples
EP4216220A1 (en) * 2022-01-25 2023-07-26 Leica Microsystems CMS GmbH Data storage device and method for storing data

Family Cites Families (248)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230558A (en) 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4318846A (en) 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4757141A (en) 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US5985549A (en) 1985-10-22 1999-11-16 University Of Massachusetts Non-isotopic in-situ hybridization method for detection of nucleic acids
US5091519A (en) 1986-05-01 1992-02-25 Amoco Corporation Nucleotide compositions with linking groups
US4811218A (en) 1986-06-02 1989-03-07 Applied Biosystems, Inc. Real time scanning electrophoresis apparatus for DNA sequencing
US5151507A (en) 1986-07-02 1992-09-29 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US5066580A (en) 1988-08-31 1991-11-19 Becton Dickinson And Company Xanthene dyes that emit to the red of fluorescein
US6242184B1 (en) 1988-10-18 2001-06-05 University Of Massachusetts In-situ hybridization of single-copy and multiple-copy nucleic acid sequences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
US6277569B1 (en) 1990-09-20 2001-08-21 Vysis, Inc. Methods for multiple direct label probe detection of multiple chromosomes or regions thereof by in situ hybridization
US5491224A (en) 1990-09-20 1996-02-13 Bittner; Michael L. Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture
US6037120A (en) 1995-10-12 2000-03-14 Benner; Steven Albert Recognition of oligonucleotides containing non-standard base pairs
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
US6140496A (en) 1990-10-09 2000-10-31 Benner; Steven Albert Precursors for deoxyribonucleotides containing non-standard nucleosides
US5320814A (en) 1991-01-25 1994-06-14 Trustees Of Tufts College Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample
DE69333073T2 (en) 1992-02-12 2004-04-15 Chromagen, Inc., San Diego USES OF FLUORESCENT N-NUCLEOSIDES AND THEIR ANALOGS
AU4292893A (en) 1992-04-21 1993-11-18 Regents Of The University Of California, The Multicolor in situ hybridization methods for genetic testing
US5386024A (en) 1993-02-10 1995-01-31 Gen-Probe Incorporated Method to prepare nucleic acids from a biological sample using low pH and acid protease
US5543838A (en) 1993-08-31 1996-08-06 Xerox Corporation Signal multiplexing system for an image sensor array
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US5783387A (en) 1995-02-06 1998-07-21 The Regents Of The University Of California Method for identifying and quantifying nucleic acid sequence aberrations
US5780227A (en) 1995-06-07 1998-07-14 Sheridan; Patrick J. Oligonucleotide probe conjugated to a purified hydrophilic alkaline phosphatase and uses thereof
US5945515A (en) 1995-07-31 1999-08-31 Chomczynski; Piotr Product and process for isolating DNA, RNA and proteins
AU6898296A (en) 1995-08-14 1997-03-12 Ely Michael Rabani Methods and devices for parallel multiplex polynucleotide sequencing
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
AU7398996A (en) 1995-10-11 1997-04-30 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US6007994A (en) 1995-12-22 1999-12-28 Yale University Multiparametric fluorescence in situ hybridization
US6387707B1 (en) 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US7144119B2 (en) 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US5847162A (en) 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US5800996A (en) 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5853993A (en) 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
US20020034737A1 (en) 1997-03-04 2002-03-21 Hyseq, Inc. Methods and compositions for detection or quantification of nucleic acid species
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
JP4209471B2 (en) 1997-02-20 2009-01-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Plasmon resonant particles, methods, and apparatus
US5888778A (en) 1997-06-16 1999-03-30 Exact Laboratories, Inc. High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers
US20050037397A1 (en) 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
KR20010031140A (en) 1997-10-14 2001-04-16 루미넥스 코포레이션 Precision fluorescently dyed particles and methods of making and using same
US6322901B1 (en) 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US6673914B1 (en) 1998-01-22 2004-01-06 John Wayne Cancer Institute Human tumor-associated gene
JP2002503814A (en) 1998-02-12 2002-02-05 イムニベスト・コーポレイション Methods and reagents for rapid and efficient isolation of circulating cancer cells
US6225285B1 (en) 1998-03-11 2001-05-01 Exelixis Pharmaceuticals, Inc. Semaphorin K1
ATE423314T1 (en) 1998-06-24 2009-03-15 Illumina Inc DECODING OF MATRIXED SENSORS BY MICROPARTICLES
US6306643B1 (en) 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US6251303B1 (en) 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
EP0990903B1 (en) 1998-09-18 2003-03-12 Massachusetts Institute Of Technology Biological applications of semiconductor nanocrystals
US6426513B1 (en) 1998-09-18 2002-07-30 Massachusetts Institute Of Technology Water-soluble thiol-capped nanocrystals
US6465193B2 (en) 1998-12-11 2002-10-15 The Regents Of The University Of California Targeted molecular bar codes and methods for using the same
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6511824B1 (en) 1999-03-17 2003-01-28 Exelixis, Inc. Nucleic acids and polypeptides of invertebrate TWIK channels and methods of use
JP2003517283A (en) 1999-04-08 2003-05-27 オアシス バイオサイエンシーズ インコーポレイティッド Amplification and sequencing of primer pairs and their use
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
WO2000065094A2 (en) 1999-04-22 2000-11-02 The Albert Einstein College Of Medicine Of Yeshiva University Assay of gene expression patterns by multi-fluor fish
ATE439452T1 (en) 1999-05-07 2009-08-15 Life Technologies Corp METHOD FOR DETECTING ANALYTES USING SEMICONDUCTOR NANOCRYSTALS
US20020051971A1 (en) 1999-05-21 2002-05-02 John R. Stuelpnagel Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6316200B1 (en) 2000-06-08 2001-11-13 Becton, Dickinson And Company Probes and methods for detection of nucleic acids
AU5764500A (en) 1999-06-25 2001-01-31 Motorola, Inc. Novel methods and products for arrayed microsphere analysis
CA2382436C (en) 1999-08-30 2011-05-17 Illumina, Inc. Methods for improving signal detection from an array
US6379888B1 (en) 1999-09-27 2002-04-30 Becton, Dickinson And Company Universal probes and methods for detection of nucleic acids
US6428957B1 (en) 1999-11-08 2002-08-06 Agilent Technologies, Inc. Systems tools and methods of assaying biological materials using spatially-addressable arrays
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
EP1257805B1 (en) 2000-02-10 2015-10-14 Illumina, Inc. Composition comprising a substrate with multiple assay locations for bead-based simultaneous processing of multiple samples, apparatus comprising the composition, and manufacturing method for the composition
US20020028457A1 (en) 2000-02-16 2002-03-07 Quantum Dot Corporation Single target counting assays using semiconductor nanocrystals
EP1257355A2 (en) 2000-02-22 2002-11-20 Genospectra, Inc. Microarray fabrication techniques and apparatus
US20030186426A1 (en) 2000-03-15 2003-10-02 The Regents Of The University Of California Multichannel flow cell for interacting single optically trapped, DNA molecules with different chemical species
US6734420B2 (en) 2000-04-06 2004-05-11 Quantum Dot Corporation Differentiable spectral bar code methods and systems
IL152727A0 (en) 2000-05-16 2003-06-24 Childrens Mercy Hospital Single copy genomic hybridization probes and method of generating same
US7033758B2 (en) 2000-06-02 2006-04-25 Bayer Corporation Highly sensitive gene detection and localization using in situ branched-DNA hybridization
US7763421B2 (en) 2000-06-05 2010-07-27 Ventana Medical Systems, Inc. Methods for producing nucleic acid hybridization probes that amplify hybridization signal by promoting network formation
AU2001278133A1 (en) 2000-08-01 2002-02-13 Surromed, Inc. Methods for solid phase nanoextraction and desorption
US6649138B2 (en) 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US6777244B2 (en) 2000-12-06 2004-08-17 Hrl Laboratories, Llc Compact sensor using microcavity structures
US6576291B2 (en) 2000-12-08 2003-06-10 Massachusetts Institute Of Technology Preparation of nanocrystallites
EP1351970A2 (en) 2000-12-12 2003-10-15 Invitrogen Corporation Compositions and methods for the release of nucleic acid molecules from solid matrices
EP1370690B1 (en) 2001-03-16 2012-03-14 Kalim Mir Arrays and methods of use
CN1559006A (en) 2001-05-21 2004-12-29 埃克来拉生物科学公司 Methods and compositions for analyzing proteins
US20040161741A1 (en) 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
WO2003092043A2 (en) 2001-07-20 2003-11-06 Quantum Dot Corporation Luminescent nanoparticles and methods for their preparation
EP1425383A4 (en) 2001-08-23 2005-11-09 Immunivest Corp Stabilization of cells and biological specimens for analysis
US7863012B2 (en) 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
EP1432786B1 (en) 2001-09-06 2009-07-22 Genomic Profiling Systems, Inc. Rapid detection of replicating cells
AU2002360272A1 (en) 2001-10-10 2003-04-22 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
AU2002351276A1 (en) 2001-12-10 2003-07-09 James O. Bowlby Jr. Tsunami chain reaction - geometric dna amplification
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US8394944B2 (en) 2002-09-20 2013-03-12 Siemens Healthcare Diagnostics Inc. Dual-purpose primers and probes for providing enhanced hybridization assays by disruption of secondary structure formation
US20090246879A1 (en) 2002-12-20 2009-10-01 Callida Genomics Materials and Methods Relating to Nano-Tags and Nano-Brands
JP4283578B2 (en) 2003-03-31 2009-06-24 学校法人片柳学園 Target sequence detection method using probe nucleic acid containing mismatch amplification substance, probe nucleic acid and target sequence detection assay kit
DK1620568T3 (en) 2003-04-24 2009-03-30 Afshin Ahmadian Analysis for allele-specific mutation detection
US7385043B1 (en) 2003-04-30 2008-06-10 The Public Health Research Institute Of The City Of New York, Inc. Homogeneous multiplex screening assays and kits
US7250371B2 (en) 2003-08-26 2007-07-31 Lam Research Corporation Reduction of feature critical dimensions
US20050048498A1 (en) 2003-08-29 2005-03-03 Applera Corporation Compositions, methods, and kits for assembling probes
US20050064435A1 (en) 2003-09-24 2005-03-24 Xing Su Programmable molecular barcodes
US7402399B2 (en) 2003-10-14 2008-07-22 Monogram Biosciences, Inc. Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
WO2005054516A2 (en) 2003-11-26 2005-06-16 Advandx, Inc. Peptide nucleic acid probes for analysis of certain staphylococcus species
US7381529B2 (en) 2003-12-31 2008-06-03 Intel Corporation Methods and compositions for detecting nucleic acids using scanning probe microscopy and nanocodes
US7462475B2 (en) 2004-05-20 2008-12-09 Dna Poleymerase Technology, Inc. Use of whole blood in PCR reactions
US20070154889A1 (en) 2004-06-25 2007-07-05 Veridex, Llc Methods and reagents for the detection of melanoma
US20060073501A1 (en) 2004-09-10 2006-04-06 Van Den Boom Dirk J Methods for long-range sequence analysis of nucleic acids
ATE452208T1 (en) 2004-10-08 2010-01-15 Sysmex Corp METHOD FOR DETECTING A TARGET SUBSTANCE USING A NUCLEIC ACID PROBE
JP4839051B2 (en) 2004-10-08 2011-12-14 シスメックス株式会社 Method for detecting a test substance using a nucleic acid probe
US7829278B2 (en) 2004-10-28 2010-11-09 Board Of Trustees Of The University Of Illinois Polynucleotide barcoding
US20060134917A1 (en) 2004-12-16 2006-06-22 Lam Research Corporation Reduction of etch mask feature critical dimensions
AU2006210553A1 (en) 2005-02-01 2006-08-10 Ab Advanced Genetic Analysis Corporation Reagents, methods and libraries for bead-based sequencing
US8063196B2 (en) 2005-02-01 2011-11-22 Siemens Healthcare Diagnostics Inc. Highly orthogonal universal sequences for use in nucleic acid assays
US7524631B2 (en) 2005-02-02 2009-04-28 Patterson Bruce K HPV E6, E7 mRNA assay and methods of use thereof
US8628918B2 (en) 2005-05-09 2014-01-14 Affymetrix, Inc. Multiplex capture of nucleic acids
ATE502120T1 (en) 2005-05-12 2011-04-15 Affymetrix Inc MULTIPLEX ASSAY FOR BRANCHED CHAIN DNA
US20070048759A1 (en) 2005-06-10 2007-03-01 Dan Luo Detection of target molecules with labeled nucleic acid detection molecules
US7842793B2 (en) 2005-06-14 2010-11-30 The California Institute Of Technology Methods of making nucleic acid nanostructures
ES2565670T3 (en) 2005-06-20 2016-04-06 Advanced Cell Diagnostics, Inc. Nucleic acid detection methods in individual cells and identification of rare cells in large populations of heterogeneous cells
WO2007015168A2 (en) 2005-07-01 2007-02-08 Dako Denmark A/S Monomeric and polymeric linkers useful for conjugating biological molecules and other substances
US7927798B2 (en) 2005-10-05 2011-04-19 Panomics, Inc. Detection of nucleic acids from whole blood
US8017360B2 (en) 2005-11-10 2011-09-13 Panomics, Inc. Detection of nucleic acids through amplification of surrogate nucleic acids
WO2007061876A2 (en) 2005-11-23 2007-05-31 University Of Utah Research Foundation Methods and compositions involving intrinsic genes
WO2007076132A2 (en) 2005-12-23 2007-07-05 Nanostring Technologies, Inc. Compositions comprising oriented, immobilized macromolecules and methods for their preparation
JP5537034B2 (en) 2005-12-23 2014-07-02 ナノストリング テクノロジーズ，インコーポレーテッド Nanoreporter and method for producing and using the same
JP2009538123A (en) 2006-04-19 2009-11-05 アプライド バイオシステムズ， エルエルシー Reagents, methods and libraries for gel-free bead-based sequencing
ES2620398T3 (en) 2006-05-22 2017-06-28 Nanostring Technologies, Inc. Systems and methods to analyze nanoindicators
US7745129B1 (en) 2006-07-12 2010-06-29 Kenneth David Schatz Methods for sequencing of a necleic acid
JP2008043332A (en) 2006-08-17 2008-02-28 Panomics Inc Quantitative determination of nucleic acid from tissue slide
WO2008039998A2 (en) 2006-09-28 2008-04-03 President And Fellows Of Harvard College Methods for sequencing dna
US7629125B2 (en) 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
WO2008069884A2 (en) 2006-12-01 2008-06-12 Panomics, Inc. Two-stage nucleic acid amplification using an amplification oligomer
US7883869B2 (en) 2006-12-01 2011-02-08 The Trustees Of Columbia University In The City Of New York Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
WO2008124847A2 (en) 2007-04-10 2008-10-16 Nanostring Technologies, Inc. Methods and computer systems for identifying target-specific sequences for use in nanoreporters
ES2391906T3 (en) 2007-09-12 2012-11-30 Institut Pasteur Polynucleotide suitable for a single cell based indicator assay to control gene expression patterns with high spatio-temporal resolution
WO2009046149A1 (en) 2007-10-01 2009-04-09 Applied Biosystems Inc. Chase ligation sequencing
WO2009046445A1 (en) 2007-10-04 2009-04-09 Halcyon Molecular Sequencing nucleic acid polymers with electron microscopy
US8114681B2 (en) 2007-10-05 2012-02-14 Affymetrix, Inc. Highly multiplexed particle-based assays
EP2227563B1 (en) 2007-12-05 2012-06-06 Complete Genomics, Inc. Efficient base determination in sequencing reactions
CN101586150B (en) 2008-05-23 2016-09-28 陕西佰美基因股份有限公司 Detection probe, general oligonucleotide chip and nucleic acid detection method and application thereof
US20090298709A1 (en) 2008-05-28 2009-12-03 Affymetrix, Inc. Assays for determining telomere length and repeated sequence copy number
DK2297359T3 (en) 2008-05-30 2014-02-24 Univ Utah Res Found Gene expression profiles to predict the outcome of breast cancer
CA2733609C (en) 2008-08-14 2018-03-06 Nanostring Technologies, Inc. Stable nanoreporters
US8309306B2 (en) 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
WO2010056577A1 (en) 2008-11-17 2010-05-20 Magic Technologies, Inc. Methods and compositions in particle-based detection of target molecules using linking molecules
WO2010060103A1 (en) 2008-11-24 2010-05-27 Loma Linda University Biomarkers for the detection of head and neck tumors
US8685646B2 (en) 2008-12-18 2014-04-01 Siemens Healthcare Diagnostics Inc. Methods and reagents for shortening incubation times in hybridization assays
EP2373812B1 (en) 2008-12-19 2016-11-09 President and Fellows of Harvard College Particle-assisted nucleic acid sequencing
WO2010081114A2 (en) 2009-01-12 2010-07-15 20/20 Genesystems, Inc. Oligonucleotide-coated affinity membranes and uses thereof
US8404444B2 (en) 2009-02-25 2013-03-26 Diacarta Llc Method for predicting the level of damage to cells by measuring free circulating Alu nucleic acid
CN103952482A (en) 2009-04-02 2014-07-30 弗卢伊蒂格姆公司 Multi-primer amplification method for barcoding of target nucleic acids
CN102858995B (en) 2009-09-10 2016-10-26 森特瑞隆技术控股公司 Targeting sequence measurement
US20130023433A1 (en) 2009-09-28 2013-01-24 Yuling Luo Methods of detecting nucleic acid sequences with high specificity
AU2010306862B2 (en) 2009-10-13 2015-08-27 Nanostring Technologies, Inc. Protein detection via nanoreporters
WO2011084168A1 (en) 2010-01-08 2011-07-14 The Regents Of The University Of California Bioassays based on polymeric sequence probes
US20130171621A1 (en) 2010-01-29 2013-07-04 Advanced Cell Diagnostics Inc. Methods of in situ detection of nucleic acids
CA2785529C (en) 2010-02-11 2019-01-08 Nanostring Technologies, Inc. Compositions and methods for the detection of small rnas
WO2011100669A2 (en) 2010-02-15 2011-08-18 North Carolina State University Office Of Technology Transfer Lable-free multiplexing bioassays using fluorescent conjugated polymers and barcoded nanoparticles
WO2011106583A1 (en) 2010-02-26 2011-09-01 Ventana Medical Systems, Inc. Polytag probes
EP2547795B1 (en) 2010-03-16 2015-01-14 Nanostring Technologies, Inc Compositions and methods for the detection of genomic features
US20130203055A1 (en) 2010-06-03 2013-08-08 Joan Aurich-Costa Methods and kits for in situ detection of nucleotide sequences
WO2011156434A2 (en) 2010-06-07 2011-12-15 Firefly Bioworks, Inc. Nucleic acid detection and quantification by post-hybridization labeling and universal encoding
US20120003648A1 (en) 2010-07-01 2012-01-05 Affymetrix, Inc. Signal Multiplexing and Signal Amplification
US20120052498A1 (en) 2010-07-01 2012-03-01 Affymetrix, Inc. Detection of Nucleic Acids
US20120004132A1 (en) 2010-07-02 2012-01-05 Affymetrix, Inc. Detection of Nucleic Acids and Proteins
CN103109187B (en) 2010-07-07 2015-03-25 密执安大学评议会 Diagnosis and treatment of breast cancer
US20120071343A1 (en) 2010-09-20 2012-03-22 Advanced Cell Diagnostics, Inc Biomarkers for differentiating melanoma from benign nevus in the skin
CN102445964A (en) 2010-10-06 2012-05-09 鸿富锦精密工业（深圳）有限公司 Computer case and hard disk module thereof
DK2625320T3 (en) 2010-10-08 2019-07-01 Harvard College HIGH-THROUGHPUT SINGLE COVERAGE CODING
US10669569B2 (en) 2010-10-15 2020-06-02 Navinci Diagnostics Ab Dynamic range methods
US8658361B2 (en) 2010-10-21 2014-02-25 Advanced Cell Diagnostics, Inc. Ultra sensitive method for in situ detection of nucleic acids
JP5978220B2 (en) 2010-10-29 2016-08-24 プレジデント アンド フェローズ オブ ハーバード カレッジ Nucleic acid nanostructure barcode probe
US8865404B2 (en) 2010-11-05 2014-10-21 President And Fellows Of Harvard College Methods for sequencing nucleic acid molecules
US8859201B2 (en) 2010-11-16 2014-10-14 Nabsys, Inc. Methods for sequencing a biomolecule by detecting relative positions of hybridized probes
US20120172246A1 (en) 2010-12-31 2012-07-05 Affymetrix, Inc. Detection of Nucleic Acids
US20120178081A1 (en) 2010-12-31 2012-07-12 Affymetrix. Inc. Methods of Labeling Cells, Labeled Cells, and uses Thereof
DK2668290T3 (en) 2011-01-28 2017-09-18 Advanced Cell Diagnostics Inc RNASCOPE® HPV ASSAY FOR DETERMINING HPV STATUS OF CANCER AND HEALTH CANCER AND LESSIONS
US20120295801A1 (en) 2011-02-17 2012-11-22 President And Fellows Of Harvard College High-Throughput In Situ Hybridization
JP5971769B2 (en) 2011-03-15 2016-08-17 ザ ユニバーシティー オブ ノースカロライナ アット チャペル ヒル Methods of treating breast cancer using anthracycline therapy
US9758834B2 (en) 2011-03-28 2017-09-12 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
US20150086981A1 (en) 2011-05-04 2015-03-26 Genovoxx Gmbh Nucleoside-triphosphate conjugate and methods for the use thereof
US20130017971A1 (en) 2011-06-24 2013-01-17 Nanostring Technologies, Inc. Multivariate Diagnostic Assays and Methods for Using Same
WO2013006495A2 (en) 2011-07-01 2013-01-10 Dana-Farber Cancer Institute, Inc. Methods of predicting prognosis in cancer
ITPD20110324A1 (en) 2011-10-12 2013-04-13 Innovation Factory S C A R L METHOD FOR DETECTION OF GALFA15 AS A TUMOR MARKER IN PANCREATIC CARCINOMA
EP2766498B1 (en) 2011-10-14 2019-06-19 President and Fellows of Harvard College Sequencing by structure assembly
US9670549B2 (en) 2011-11-10 2017-06-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gene expression signatures of neoplasm responsiveness to therapy
EP2785873A4 (en) 2011-11-30 2015-11-11 Univ North Carolina Methods of treating breast cancer with taxane therapy
EP4249605A3 (en) 2011-12-22 2023-11-15 President And Fellows Of Harvard College Methods for analyte detection
US11021737B2 (en) 2011-12-22 2021-06-01 President And Fellows Of Harvard College Compositions and methods for analyte detection
US10385392B2 (en) 2011-12-30 2019-08-20 Abbott Molecular Inc. Nucleic acid hybridization probes
US9096902B2 (en) 2012-03-22 2015-08-04 The Regents Of The University Of California Genetic barcodes
US20140178869A1 (en) 2012-04-05 2014-06-26 Advanced Cell Diagnostics, Inc. Detection of immunoglobulin light chain restriction by rna in situ hybridization
CN104704128A (en) 2012-05-22 2015-06-10 纳米线科技公司 NANO46 genes and methods to predict breast cancer outcome
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
CA2877378A1 (en) 2012-06-29 2014-01-03 Nanostring Technologies, Inc. Methods of treating breast cancer with gemcitabine therapy
US9347106B2 (en) 2012-07-18 2016-05-24 The Regents Of The University Of California Multiplex assay for the detection of citrus pathogens
US20140120083A1 (en) 2012-11-01 2014-05-01 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
US20150283142A1 (en) 2013-03-15 2015-10-08 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
US20140154681A1 (en) 2012-11-12 2014-06-05 Nanostring Technologies, Inc. Methods to Predict Breast Cancer Outcome
US9713612B2 (en) 2013-03-12 2017-07-25 Curegenix, Inc. Compounds for treatment of cancer
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
PT2968586T (en) 2013-03-14 2018-11-13 Ethris Gmbh Cftr mrna compositions and related methods and uses
TW201522637A (en) 2013-03-15 2015-06-16 Jackson Lab Isolation of non-embryonic stem cells and uses thereof
US20140357509A1 (en) 2013-03-28 2014-12-04 Advanced Cell Diagnostics, Inc. Differentiation between transient and persistent high-risk hpv infection by in situ hybridization
KR102368591B1 (en) 2013-04-30 2022-02-25 캘리포니아 인스티튜트 오브 테크놀로지 Multiplex labeling of molecules by sequential hybridization barcoding
WO2014182598A1 (en) 2013-05-06 2014-11-13 Physicians Choice Laboratory Services, Llc Diagnostic assay combining cellular and cell free nucleic acid
EP2996789B1 (en) 2013-05-17 2019-07-17 Siemens Healthcare Diagnostics Inc. Particle release and collection
DK3003309T3 (en) 2013-05-30 2020-12-14 Infinity Pharmaceuticals Inc Treatment of cancer with PI3 kinase isoform modulators
JP2016521575A (en) 2013-06-14 2016-07-25 ナノストリング テクノロジーズ，インコーポレイティド Multiplexable tag-based reporter system
US10697005B2 (en) 2013-06-26 2020-06-30 Ramesh Vallabhaneni Method and system for tracking specific in situ hybridizations in biological samples using molecular barcodes
US20150051117A1 (en) 2013-08-16 2015-02-19 President And Fellows Of Harvard College Assembly of Nucleic Acid Sequences in Emulsions
EP3338793A1 (en) 2013-08-28 2018-06-27 AbbVie Stemcentrx LLC Novel sez6 modulators and methods of use
US20150105298A1 (en) 2013-10-10 2015-04-16 The Research Foundation For The State University Of New York Multi-oligomer in situ hybridization probes
WO2015061461A1 (en) 2013-10-22 2015-04-30 Shire Human Genetic Therapies, Inc. Cns delivery of mrna and uses thereof
US9629804B2 (en) 2013-10-22 2017-04-25 Shire Human Genetic Therapies, Inc. Lipid formulations for delivery of messenger RNA
WO2015084726A1 (en) 2013-12-02 2015-06-11 Qbase, LLC Event detection through text analysis template models
CA2932476A1 (en) 2013-12-12 2015-06-18 Stemcentrx, Inc. Novel anti-dpep3 antibodies and methods of use
WO2015095766A2 (en) 2013-12-20 2015-06-25 Stem Centrx, Inc. Novel anti-lingo1 antibodies and methods of use
WO2015100459A2 (en) 2013-12-27 2015-07-02 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
EP3094751A4 (en) 2014-01-14 2017-06-07 Santa Maria Biotherapeutics, Inc. Activin inhibitor response prediction and uses for treatment
WO2015120273A1 (en) 2014-02-07 2015-08-13 The General Hospital Corporation Differential diagnosis of hepatic neoplasms
US20150232935A1 (en) 2014-02-14 2015-08-20 The General Hospital Corporation Methods for diagnosing igg4-related disease
JP2017514143A (en) 2014-02-21 2017-06-01 アッヴィ・ステムセントルクス・エル・エル・シー Anti-DLL3 antibodies and drug conjugates for use in melanoma
JP6825915B2 (en) 2014-02-24 2021-02-03 ヴェンタナ メディカル システムズ， インク． Automatic RNA detection using a labeled 2'-O-methyl RNA oligonucleotide probe and signal amplification system
US20150247205A1 (en) 2014-02-28 2015-09-03 The General Hospital Corporation Diagnosis of multiple myeloma and lymphoma
WO2015136509A2 (en) 2014-03-14 2015-09-17 Genesis Theranostix Korlatolt Felelossegu Tarsasag Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy
AU2015231294B2 (en) 2014-03-18 2020-10-29 University Of Massachusetts rAAV-based compositions and methods for treating amyotrophic lateral sclerosis
BR112016021383A2 (en) 2014-03-24 2017-10-03 Genentech Inc METHOD TO IDENTIFY A PATIENT WITH CANCER WHO IS LIKE OR LESS LIKELY TO RESPOND TO TREATMENT WITH A CMET ANTAGONIST, METHOD TO IDENTIFY A PATIENT WITH PREVIOUSLY TREATED CANCER, METHOD TO DETERMINE THE EXPRESSION OF THE HGF BIOMARKER, ANTI-C-MET ANTAGONIST AND ITS USE, DIAGNOSTIC KIT AND ITS PREPARATION METHOD
US10858698B2 (en) 2014-03-25 2020-12-08 President And Fellows Of Harvard College Barcoded protein array for multiplex single-molecule interaction profiling
CN106715768B (en) 2014-07-30 2020-06-16 哈佛学院院长及董事 System and method for assaying nucleic acids
KR102298387B1 (en) 2014-11-21 2021-09-07 나노스트링 테크놀로지스, 인크. Enzyme- and amplification-free sequencing
EP3283629A4 (en) 2015-04-17 2018-08-29 President and Fellows of Harvard College Barcoding systems and methods for gene sequencing and other applications
AU2016349288A1 (en) 2015-11-03 2018-05-31 President And Fellows Of Harvard College Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
WO2017161251A1 (en) 2016-03-17 2017-09-21 President And Fellows Of Harvard College Methods for detecting and identifying genomic nucleic acids
CA3023566A1 (en) 2016-05-16 2017-11-23 Nanostring Technologies, Inc. Methods for detecting target nucleic acids in a sample
WO2017222453A1 (en) 2016-06-21 2017-12-28 Hauling Thomas Nucleic acid sequencing
AU2017361521B2 (en) 2016-11-21 2020-08-27 Nanostring Technologies, Inc. Chemical compositions and methods of using same

Also Published As

Publication number Publication date
JP2021523723A (en) 2021-09-09
AU2019271028A1 (en) 2020-12-03
KR20210061962A (en) 2021-05-28
US20190345548A1 (en) 2019-11-14
US11549139B2 (en) 2023-01-10
CA3099909A1 (en) 2019-11-21
US20230220461A1 (en) 2023-07-13
WO2019222178A1 (en) 2019-11-21
EP3794146A1 (en) 2021-03-24
CN112703255A (en) 2021-04-23

Similar Documents

Publication Publication Date Title
SG10202100951SA (en) Chemical compositions and methods of using same
GB2582482B (en) CASZ compositions and methods of use
ZA202007839B (en) Polymerases, compositions, and methods of use
ZA202007838B (en) Polymerases, compositions, and methods of use
HK1256726A1 (en) Carrier-binding agent compositions and methods of making and using the same
GB2582100B (en) CAS12C Compositions and methods of use
EP3576782A4 (en) Construct-peptide compositions and methods of use thereof
EP3435956A4 (en) Photo-stabilized compositions and methods of use
ZA201903165B (en) Coating compositions and methods of use thereof
SG11202011274YA (en) Chemical compositions and methods of using same
ZA202104969B (en) Compositions comprising 15-hepe and methods of using the same
ZA201906169B (en) Synthekine compositions and methods of use
ZA202100780B (en) Bismuth-thiol compositions and methods of use
IL276135A (en) Compositions and methods of use
IL283387A (en) Diarylhydantoin compounds and methods of use thereof
ZA202004531B (en) Compositions containing thymohydroquinone and their method of preparation
EP3402443A4 (en) Devices and compositions and methods of use thereof
SG11202011227VA (en) Compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds and methods of use thereof
IL282939A (en) Mixtures and compositions comprising 5-fluoro-4-imino-3- methyl-1-tosyl-3,4- dihydropyrimidin-2-one, and methods of use thereof
HK1250345A1 (en) Compositions comprising 15-oxo-epa or 15-oxo-dgla and methods of making and using same
HK1247136A1 (en) Compositions comprising 15-hepe and methods of using the same
SG11202011041YA (en) Combination compositions comprising bisfluoroalkyl-1,4- benzodiazepinone compounds and methods of use thereof
IL277801A (en) Oxytocin compositions and methods of use
IL274563A (en) Methods of using and compositions containing dulaglutide
IL261794A (en) Compositions and methods of their use