EP1425383A4 - Stabilisierung von zellen und biologischen präparaten zur analyse - Google Patents

Stabilisierung von zellen und biologischen präparaten zur analyse

Info

Publication number
EP1425383A4
EP1425383A4 EP02768676A EP02768676A EP1425383A4 EP 1425383 A4 EP1425383 A4 EP 1425383A4 EP 02768676 A EP02768676 A EP 02768676A EP 02768676 A EP02768676 A EP 02768676A EP 1425383 A4 EP1425383 A4 EP 1425383A4
Authority
EP
European Patent Office
Prior art keywords
analysis
damage
cells
vitro
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02768676A
Other languages
English (en)
French (fr)
Other versions
EP1425383A2 (de
Inventor
Galla Chandra Rao
Melissa Hermann
Herman Rutner
Leon Terstappen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunivest Corp
Original Assignee
Immunivest Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26979228&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1425383(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunivest Corp filed Critical Immunivest Corp
Publication of EP1425383A2 publication Critical patent/EP1425383A2/de
Publication of EP1425383A4 publication Critical patent/EP1425383A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
EP02768676A 2001-08-23 2002-08-23 Stabilisierung von zellen und biologischen präparaten zur analyse Withdrawn EP1425383A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31415101P 2001-08-23 2001-08-23
US314151P 2001-08-23
US36962802P 2002-04-03 2002-04-03
US369628P 2002-04-03
PCT/US2002/026867 WO2003018757A2 (en) 2001-08-23 2002-08-23 Stabilization of cells and biological specimens for analysis

Publications (2)

Publication Number Publication Date
EP1425383A2 EP1425383A2 (de) 2004-06-09
EP1425383A4 true EP1425383A4 (de) 2005-11-09

Family

ID=26979228

Family Applications (2)

Application Number Title Priority Date Filing Date
EP02768676A Withdrawn EP1425383A4 (de) 2001-08-23 2002-08-23 Stabilisierung von zellen und biologischen präparaten zur analyse
EP02761478A Expired - Lifetime EP1425294B2 (de) 2001-08-23 2002-08-23 Analyse zirkulierender tumorzellen, fragmente und trümmer

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP02761478A Expired - Lifetime EP1425294B2 (de) 2001-08-23 2002-08-23 Analyse zirkulierender tumorzellen, fragmente und trümmer

Country Status (11)

Country Link
EP (2) EP1425383A4 (de)
JP (3) JP2005502863A (de)
KR (2) KR20040030984A (de)
CN (2) CN1571634A (de)
AT (1) ATE401574T1 (de)
AU (2) AU2008288601B2 (de)
BR (2) BR0212125A (de)
CA (2) CA2457894C (de)
DE (1) DE60227678D1 (de)
IL (2) IL160209A0 (de)
WO (2) WO2003018757A2 (de)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7863012B2 (en) 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
CN1571634A (zh) * 2001-08-23 2005-01-26 免疫公司 用于分析的细胞和生物学标本的稳定
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
CA2484876C (en) 2002-05-13 2011-11-22 Becton, Dickinson And Company Protease inhibitor sample collection system
EP2359689B1 (de) 2002-09-27 2015-08-26 The General Hospital Corporation Mikrofluid-Vorrichtung zur Zelltrennung, sowie Verwendung derselben
ES2784011T3 (es) 2002-10-16 2020-09-21 Streck Inc Procedimiento y dispositivo para recoger y preservar las células para su análisis
WO2004076643A2 (en) 2003-02-27 2004-09-10 Immunivest Corporation CIRCULATING TUMOR CELLS (CTC’s): EARLY ASSESSMENT OF TIME TO PROGRESSION SURVIVAL AND RESPONSE TO THERAPY IN METASTATIC CANCER PATIENTS
EP1673611A4 (de) * 2003-09-18 2011-11-30 Immunivest Corp Operatorunabhängige programmierbare probenpräparations- und analysesystem
DK1861509T3 (da) * 2005-03-14 2015-12-07 Janssen Diagnostics Llc Fremgangsmåde til forudsigelse af progressionsfri og overordnet overlevelse for hvert opfølgningstidspunkt under behandling af patienter med metastatisk brystkræft under anvendelse af cirkulerende tumorceller
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
EP2500439B2 (de) 2005-06-20 2017-08-16 Advanced Cell Diagnostics, Inc. Verfahren zum Nachweis von Nukleinsäuren in einzelnen Zellen und zur Identifikation seltener Zellen aus großen heterogenen Zellpopulationen
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US8337755B2 (en) 2006-03-13 2012-12-25 Veridex, Llc Operator independent programmable sample preparation and analysis system
NZ573187A (en) * 2006-06-02 2011-11-25 Pfizer Prod Inc Circulating tumor cell assay for predicting efficacy of 1gf-1r antagonist therapy
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
EP2029779A4 (de) 2006-06-14 2010-01-20 Living Microsystems Inc Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
CN101583722A (zh) 2006-07-14 2009-11-18 阿维瓦生物科学股份有限公司 从生物学样品检测稀有细胞的方法和组合物
JP5409395B2 (ja) * 2007-02-27 2014-02-05 セントクローネ インターナショナル エービー 細胞外マーカーに結合する剤のパネルを用いる腫瘍細胞の多重検出
WO2008128243A1 (en) 2007-04-16 2008-10-23 Immunivest Corporation A rapid, semi-automated method to detect respiratory virus infected cells in direct specimens
US8003314B2 (en) 2007-04-16 2011-08-23 Diagnostic Hybrids, Inc. Methods for direct fluorescent antibody virus detection in liquids
US7828968B2 (en) 2007-08-30 2010-11-09 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
US8110101B2 (en) 2007-08-30 2012-02-07 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
EP2229441B1 (de) 2007-12-12 2014-10-01 The Board of Trustees of The Leland Stanford Junior University Verfahren und vorrichtung zur magnetischen trennung von zellen
US20100112575A1 (en) 2008-09-20 2010-05-06 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive Diagnosis of Fetal Aneuploidy by Sequencing
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
DE202010018569U1 (de) 2009-02-18 2017-09-26 Streck Inc. Konservierung zellfreier Nukleinsäuren
WO2011038403A1 (en) 2009-09-28 2011-03-31 Yuling Luo Methods of detecting nucleic acid sequences with high specificity
CN115060882A (zh) * 2009-10-21 2022-09-16 斯克里普斯研究所 用非稀有细胞检测稀有细胞的方法
US20130171621A1 (en) 2010-01-29 2013-07-04 Advanced Cell Diagnostics Inc. Methods of in situ detection of nucleic acids
WO2011099565A1 (ja) * 2010-02-10 2011-08-18 シスメックス株式会社 血液中癌細胞の検出方法及びそれに用いるプログラム
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
AU2011255641A1 (en) 2010-05-18 2012-12-06 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
DE102010020785A1 (de) * 2010-05-18 2011-11-24 Siemens Aktiengesellschaft Vorrichtung und Verfahren zum Erkennen von magnetisch markierten Mikroobjekten
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US20120252038A1 (en) * 2011-04-01 2012-10-04 Chianese David A Steroid receptor assays
WO2012151391A2 (en) 2011-05-04 2012-11-08 Streck, Inc. Inactivated virus compositions and methods of preparing such compositions
US20140295426A1 (en) * 2011-07-28 2014-10-02 Veridex Llc Methods for Diagnosing Cancer by Characterization of Tumor Cells Associated with Pleural or Serous Fluids
WO2013045458A1 (en) 2011-09-26 2013-04-04 Preanalytix Gmbh Stabilisation and isolation of extracellular nucleic acids
US11021733B2 (en) 2011-09-26 2021-06-01 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
KR102037891B1 (ko) * 2012-03-09 2019-10-30 한국전자통신연구원 다중 분리 장치 및 혈중 암세포 분리 방법
US20150148212A1 (en) 2012-05-10 2015-05-28 Konica Minolta, Inc. Process for removing red blood cells and centrifugal tube for blood collection
CN104755628B (zh) 2012-09-25 2019-03-01 凯杰有限公司 生物样品的稳定化
CN105264127B (zh) 2013-03-15 2019-04-09 Gpb科学有限责任公司 颗粒的片上微流体处理
US10324011B2 (en) 2013-03-15 2019-06-18 The Trustees Of Princeton University Methods and devices for high throughput purification
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
US11525155B2 (en) 2013-03-18 2022-12-13 Qiagen Gmbh Stabilisation of biological samples
EP2976426A1 (de) * 2013-03-18 2016-01-27 Qiagen GmbH Stabilisierung und isolierung extrazellulärer nukleinsäuren
ES2938048T3 (es) 2013-07-24 2023-04-04 Streck Llc Composiciones y procedimientos para estabilizar las células tumorales circulantes
CN105899679A (zh) * 2013-10-21 2016-08-24 通用医疗公司 与循环肿瘤细胞簇有关的方法以及癌症的治疗
EA201691496A1 (ru) 2014-01-27 2016-12-30 Эпик Сайенсиз, Инк. Диагностика биомаркеров рака предстательной железы с помощью циркулирующих опухолевых клеток
WO2015127008A1 (en) 2014-02-21 2015-08-27 Epic Sciences, Inc. Methods for analyzing rare circulating cells
WO2015140218A1 (en) * 2014-03-18 2015-09-24 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
CN103940997B (zh) * 2014-03-21 2017-01-04 上海柏慧康生物科技有限公司 一种乳腺癌循环肿瘤细胞检测系统及试剂盒
CN106460070B (zh) 2014-04-21 2021-10-08 纳特拉公司 检测染色体片段中的突变和倍性
CN103980365A (zh) * 2014-06-03 2014-08-13 国家纳米科学中心 一种表面固载炭疽致死因子的磁性纳米粒子、其制备方法及用途
ES2872344T3 (es) * 2014-07-02 2021-11-02 Siemens Healthcare Diagnostics Inc Separación selectiva de ácidos nucleicos
US10564075B2 (en) 2015-02-24 2020-02-18 Siemens Healthcare Diagnostics Inc. Prefixation for increased rare cell recovery
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
CA2936167A1 (en) * 2015-07-15 2017-01-15 Streck, Inc. Method and device for stabilizing of proteins
JP6617495B2 (ja) * 2015-09-18 2019-12-11 東ソー株式会社 腫瘍細胞の検出方法
US20180328848A1 (en) * 2015-11-04 2018-11-15 Axon Dx, Llc Cell detection, capture, analysis, aggregation, and output methods and apparatus
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
CN114457068A (zh) 2015-11-20 2022-05-10 凯杰有限公司 用于稳定细胞外核酸的已灭菌组合物的制备方法
CN105372109A (zh) * 2015-12-15 2016-03-02 苏州药明康德新药开发股份有限公司 添加稳定剂的生物基质的制备方法
US10945428B2 (en) 2016-03-04 2021-03-16 Menarini Silicon Biosystems S.P.A. Preservation of cellular components from cells with a preservative
JP7064665B2 (ja) * 2016-03-07 2022-05-11 ファーザー フラナガンズ ボーイズ ホーム ドゥーイング ビジネス アズ ボーイズ タウン ナショナル リサーチ ホスピタル 非侵襲的分子対照
JP2017219479A (ja) 2016-06-09 2017-12-14 住友電気工業株式会社 微小粒子計測装置及び分析方法
EP3491381A1 (de) 2016-07-29 2019-06-05 Streck, Inc. Suspensionszusammensetzung zur kontrolle einer hämatologischen analyse
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
SG10202100951SA (en) 2016-11-21 2021-03-30 Nanostring Technologies Inc Chemical compositions and methods of using same
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
WO2019025387A1 (de) * 2017-08-02 2019-02-07 Sarstedt Ag & Co. Kg Verfahren und zusammensetzung zur stabilisierung zellfreier nukleinsäuren und zellen
EP3675876A4 (de) 2017-09-01 2021-06-02 GPB Scientific, Inc. Verfahren zur herstellung therapeutisch aktiver zellen unter verwendung von mikrofluidik
EP3697209A4 (de) * 2017-10-19 2021-07-28 Streck, Inc. Zusammensetzungen zur hämolyse- und gerinnungsregulierung sowie stabilisierung von extrazellulären vesikeln
CA3099909A1 (en) 2018-05-14 2019-11-21 Nanostring Technologies, Inc. Chemical compositions and methods of using same
JP7334468B2 (ja) * 2018-05-29 2023-08-29 東ソー株式会社 血液試料保存剤
JP7036670B2 (ja) 2018-05-31 2022-03-15 アークレイ株式会社 血液中の稀少細胞検査、該検査ための血液処理方法及び採血管
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN108865976B (zh) * 2018-07-19 2022-06-28 复旦大学附属中山医院 一种离散汲取收集外泌体(exosome)的方法及试剂
CN110250159A (zh) * 2019-05-28 2019-09-20 天津中科生物科技有限公司 一种细胞保护液及其制备方法和应用
JP7355473B1 (ja) 2022-03-25 2023-10-03 積水メディカル株式会社 循環腫瘍細胞分離キット、循環腫瘍細胞分離容器及び循環腫瘍細胞の分離方法

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2475737A1 (fr) * 1980-02-07 1981-08-14 Pasteur Institut Perfectionnements apportes aux procedes de conservation d'hematies par lyophilisation en vue de leur utilisation dans des reactions d'hemagglutination et hematies non agglutinables spontanement obtenues par ce procede
US4404181A (en) * 1981-10-15 1983-09-13 Cambridge Chemical Products, Inc. Extended-life tissue fixative composition and method of using the same
EP0161770A2 (de) * 1984-05-14 1985-11-21 Becton Dickinson and Company Auflösungsmittel zur Bestimmung von peripherischen Blutzellen
WO1993005650A1 (en) * 1991-09-20 1993-04-01 Camiener Gerald W Methods and compositions with aldehyde stabilizing solution
WO1994018828A1 (en) * 1993-02-25 1994-09-01 Abbott Laboratories Multipurpose reagent system for rapid lysis of whole blood samples
WO1997008557A1 (en) * 1995-08-28 1997-03-06 Miltenyi Biotech Gmbh Efficient enrichment and detection of disseminated tumor cells
WO1997045729A1 (en) * 1996-05-24 1997-12-04 Northern General Hospital Nhs Trust Specimen collection fluid
US5849517A (en) * 1991-05-08 1998-12-15 Streck Laboratories, Inc. Method and composition for preserving antigens and nucleic acids and process for utilizing cytological material produced by same
US6197523B1 (en) * 1997-11-24 2001-03-06 Robert A. Levine Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4040785A (en) * 1976-10-18 1977-08-09 Technicon Instruments Corporation Lysable blood preservative composition
US4320111A (en) * 1977-06-14 1982-03-16 American Home Products Corporation Immunologic compositions methods of preparation and use
FR2523810B1 (fr) * 1982-03-23 1988-11-25 Carpentier Alain Tissu biologique greffable et procede pour sa preparation
FR2528848A1 (fr) * 1982-06-16 1983-12-23 Sanofi Sa Nouveau derive de thieno-pyridone, son procede de preparation et son application therapeutique
EP0156537A3 (de) * 1984-03-02 1987-05-13 Board Of Regents University Of Texas System Biologische magnetische Flüssigkeiten
US4788139A (en) * 1987-08-06 1988-11-29 Streck Laboratories, Inc. Platelet aggregation reagent, reagent container and method of determining platelet aggregation in EDTA-anticoagulated blood
US5385707A (en) * 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
US5698271A (en) * 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
US6670197B2 (en) * 1997-11-24 2003-12-30 David L. Rimm Method for assaying whole blood for the presence or absence of circulating cancer or other target cell fragments
EP1062515B1 (de) * 1998-02-12 2009-11-25 Immunivest Corporation Verfahren und reagenzien zur raschen und effizienten isolierung zirkulierender krebszellen
US6960449B2 (en) * 1999-02-10 2005-11-01 Cell Works Diagnostics, Inc. Class characterization of circulating cancer cells isolated from body fluids and methods of use
AU7351800A (en) * 1999-09-13 2001-04-17 Neil H. Bander A method for isolation of prostatic epithelial cells from semen
CN1571634A (zh) * 2001-08-23 2005-01-26 免疫公司 用于分析的细胞和生物学标本的稳定

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2475737A1 (fr) * 1980-02-07 1981-08-14 Pasteur Institut Perfectionnements apportes aux procedes de conservation d'hematies par lyophilisation en vue de leur utilisation dans des reactions d'hemagglutination et hematies non agglutinables spontanement obtenues par ce procede
US4404181A (en) * 1981-10-15 1983-09-13 Cambridge Chemical Products, Inc. Extended-life tissue fixative composition and method of using the same
EP0161770A2 (de) * 1984-05-14 1985-11-21 Becton Dickinson and Company Auflösungsmittel zur Bestimmung von peripherischen Blutzellen
US5849517A (en) * 1991-05-08 1998-12-15 Streck Laboratories, Inc. Method and composition for preserving antigens and nucleic acids and process for utilizing cytological material produced by same
WO1993005650A1 (en) * 1991-09-20 1993-04-01 Camiener Gerald W Methods and compositions with aldehyde stabilizing solution
WO1994018828A1 (en) * 1993-02-25 1994-09-01 Abbott Laboratories Multipurpose reagent system for rapid lysis of whole blood samples
WO1997008557A1 (en) * 1995-08-28 1997-03-06 Miltenyi Biotech Gmbh Efficient enrichment and detection of disseminated tumor cells
WO1997045729A1 (en) * 1996-05-24 1997-12-04 Northern General Hospital Nhs Trust Specimen collection fluid
US6197523B1 (en) * 1997-11-24 2001-03-06 Robert A. Levine Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood

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CA2457894C (en) 2014-07-08
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WO2003019141A3 (en) 2004-04-01
ATE401574T1 (de) 2008-08-15
CA2457894A1 (en) 2003-03-06
AU2009200013B2 (en) 2012-03-08
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IL160209A0 (en) 2004-07-25
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EP1425294A4 (de) 2005-11-16
DE60227678D1 (de) 2008-08-28
CN1571634A (zh) 2005-01-26
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KR20040053115A (ko) 2004-06-23
BR0212125A (pt) 2005-06-28
AU2008288601B2 (en) 2012-05-31
EP1425294B2 (de) 2012-12-12
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