EP0347028A3 - Kalziumphosphatmineralzusammensetzungen sowie Verfahren zu deren Herstellung - Google Patents

Kalziumphosphatmineralzusammensetzungen sowie Verfahren zu deren Herstellung Download PDF

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Publication number
EP0347028A3
EP0347028A3 EP19890303806 EP89303806A EP0347028A3 EP 0347028 A3 EP0347028 A3 EP 0347028A3 EP 19890303806 EP19890303806 EP 19890303806 EP 89303806 A EP89303806 A EP 89303806A EP 0347028 A3 EP0347028 A3 EP 0347028A3
Authority
EP
European Patent Office
Prior art keywords
calcium phosphate
methods
preparing same
phosphate mineral
mineral compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19890303806
Other languages
English (en)
French (fr)
Other versions
EP0347028A2 (de
EP0347028B1 (de
Inventor
Brent R. Constantz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norian Corp
Original Assignee
Norian Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22674214&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0347028(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Norian Corp filed Critical Norian Corp
Publication of EP0347028A2 publication Critical patent/EP0347028A2/de
Publication of EP0347028A3 publication Critical patent/EP0347028A3/de
Application granted granted Critical
Publication of EP0347028B1 publication Critical patent/EP0347028B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/30—Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/54—Filling; Sealing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A61K6/74—Fillers comprising phosphorus-containing compounds
    • A61K6/75—Apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/864—Phosphate cements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/873—Carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/876—Calcium oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C01B25/322—Preparation by neutralisation of orthophosphoric acid
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C01B25/327—After-treatment
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/455—Phosphates containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/901—Method of manufacturing prosthetic device

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Composite Materials (AREA)
  • Environmental & Geological Engineering (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP89303806A 1988-04-20 1989-04-18 Kalziumphosphatmineralzusammensetzungen sowie Verfahren zu deren Herstellung Expired - Lifetime EP0347028B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US183770 1988-04-20
US07/183,770 US4880610A (en) 1988-04-20 1988-04-20 In situ calcium phosphate minerals--method and composition

Publications (3)

Publication Number Publication Date
EP0347028A2 EP0347028A2 (de) 1989-12-20
EP0347028A3 true EP0347028A3 (de) 1991-09-11
EP0347028B1 EP0347028B1 (de) 1998-09-16

Family

ID=22674214

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89303806A Expired - Lifetime EP0347028B1 (de) 1988-04-20 1989-04-18 Kalziumphosphatmineralzusammensetzungen sowie Verfahren zu deren Herstellung

Country Status (5)

Country Link
US (3) US4880610A (de)
EP (1) EP0347028B1 (de)
JP (1) JP2863544B2 (de)
CA (1) CA1332495C (de)
DE (1) DE68928816T2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2158189C1 (ru) * 1999-03-30 2000-10-27 Закрытое акционерное общество Клиническое научно-производственное объединение "Биотехника" Способ нанесения гидроксиапатитовых покрытий

Families Citing this family (256)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053212A (en) * 1988-04-20 1991-10-01 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US5962028A (en) * 1988-04-20 1999-10-05 Norian Corporation Carbonated hydroxyapatite compositions and uses
US5129905A (en) * 1988-04-20 1992-07-14 Norian Corporation Methods for in situ prepared calcium phosphate minerals
US5047031A (en) * 1988-04-20 1991-09-10 Norian Corporation In situ calcium phosphate minerals method
US6002065A (en) * 1988-04-20 1999-12-14 Norian Corporation Kits for preparing calcium phosphate minerals
GB8813033D0 (en) * 1988-06-02 1988-07-06 Geistlich Soehne Ag Chemical compound
US5275564A (en) * 1988-08-25 1994-01-04 American Dental Laser, Inc. Dental laser assembly
US5009898A (en) * 1988-09-29 1991-04-23 Kabushiki Kaisha Sangi Antimicrobial hydroxyapatite powders and methods for preparing them
US5034059A (en) * 1989-02-17 1991-07-23 Norian Corporation Composition comprising octacalcium phosphate crystals and polypeptide
US5037639A (en) * 1989-05-24 1991-08-06 American Dental Association Health Foundation Methods and compositions for mineralizing calcified tissues
US5460803A (en) * 1989-05-24 1995-10-24 American Dental Association Health Foundation Methods and compositions for mineralizing and fluoridating calcified tissues
US5534244A (en) * 1989-05-24 1996-07-09 Tung; Ming S. Methods and compositions for mineralizing and/or fluoridating calcified tissues with amorphous strontium compounds
US5322675A (en) * 1990-11-09 1994-06-21 Director-General Of Agency Of Industrial Science And Technology Method of preparing calcium phosphate
US5164187A (en) * 1990-04-05 1992-11-17 Norian Corporation Hydroxyapatite prosthesis coatings
JP3748567B2 (ja) * 1990-07-27 2006-02-22 ノリアン コーポレイション 水酸化リン灰石への前駆体としてのカルシウム及びホスフェート源の均質混合物
US5231169A (en) * 1990-10-17 1993-07-27 Norian Corporation Mineralized collagen
US5310464A (en) * 1991-01-04 1994-05-10 Redepenning Jody G Electrocrystallization of strongly adherent brushite coatings on prosthetic alloys
US5205921A (en) * 1991-02-04 1993-04-27 Queen's University At Kingston Method for depositing bioactive coatings on conductive substrates
JPH06315629A (ja) * 1991-11-15 1994-11-15 Central Glass Co Ltd 除タンパク用充填剤およびこれを充填したカートリッジ
DK0573491T3 (da) * 1991-12-30 2002-05-21 Norian Corp Mineraliseret kollagen
US5258044A (en) * 1992-01-30 1993-11-02 Etex Corporation Electrophoretic deposition of calcium phosphate material on implants
US5270351A (en) * 1992-06-15 1993-12-14 American Dental Association Health Foundation Adhesion-promoting agents incorporating polyvalent cations
US5944721A (en) * 1997-12-08 1999-08-31 Huebner; Randall J. Method for repairing fractured bone
US5522893A (en) * 1993-03-12 1996-06-04 American Dental Association Health Foundation Calcium phosphate hydroxyapatite precursor and methods for making and using the same
US5427768A (en) * 1993-06-23 1995-06-27 American Dental Association Health Foundation Carbonated solutions for treating, mineralizing and fluoridating calcified tissues and methods for their use
WO1995003369A1 (en) * 1993-07-22 1995-02-02 Norian Corporation Storage stable partially neutralized acid compositions and uses
US5476647A (en) * 1993-09-13 1995-12-19 American Dental Association Health Foundation Complex calcium and fluoride containing mouth rinses, dentifrices, and chewable tablets
US5525148A (en) * 1993-09-24 1996-06-11 American Dental Association Health Foundation Self-setting calcium phosphate cements and methods for preparing and using them
US5472734A (en) * 1993-09-29 1995-12-05 Aluminum Company Of America Apatite coating on aluminum sheet and method of manufacture
US5514137A (en) * 1993-12-06 1996-05-07 Coutts; Richard D. Fixation of orthopedic devices
US5503164A (en) * 1994-01-28 1996-04-02 Osteogenics, Inc. Device and method for repair of craniomaxillofacial bone defects including burr holes
WO1998020939A2 (en) 1996-11-15 1998-05-22 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
US20050043808A1 (en) * 1994-05-06 2005-02-24 Advanced Bio Surfaces, Inc. Knee joint prosthesis
US5556429A (en) * 1994-05-06 1996-09-17 Advanced Bio Surfaces, Inc. Joint resurfacing system
US5496399A (en) * 1994-08-23 1996-03-05 Norian Corporation Storage stable calcium phosphate cements
US5678233A (en) * 1994-09-14 1997-10-14 Brown; Paul W. Method of immobilizing toxic or radioactive inorganic wastes and associated products
AU713540B2 (en) * 1994-10-25 1999-12-02 Osteonics Corp. Interlocking structural elements and method for bone repair, augmentation and replacement
US5550172A (en) * 1995-02-07 1996-08-27 Ethicon, Inc. Utilization of biocompatible adhesive/sealant materials for securing surgical devices
US5624493A (en) * 1995-04-19 1997-04-29 The United States Of America As Represented By The Department Of Energy Quick-setting concrete and a method for making quick-setting concrete
US5676976A (en) * 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6117456A (en) * 1995-05-19 2000-09-12 Etex Corporation Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US6287341B1 (en) 1995-05-19 2001-09-11 Etex Corporation Orthopedic and dental ceramic implants
US6027742A (en) 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US6132463A (en) * 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US6541037B1 (en) 1995-05-19 2003-04-01 Etex Corporation Delivery vehicle
US7150879B1 (en) 1995-05-19 2006-12-19 Etex Corporation Neutral self-setting calcium phosphate paste
US5652056A (en) * 1995-08-25 1997-07-29 Pepin; John N. Hydroxyapatite filament
US5648097A (en) * 1995-10-04 1997-07-15 Biotek, Inc. Calcium mineral-based microparticles and method for the production thereof
US5783217A (en) * 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture
DE19613081A1 (de) * 1996-04-02 1997-10-09 Franz Prof Dr Med Copf Prothesenteil für eine Schaftprothese und Materialkit zur Verwendung mit einem solchen
US6143948A (en) * 1996-05-10 2000-11-07 Isotis B.V. Device for incorporation and release of biologically active agents
CA2205104A1 (en) * 1996-05-10 1997-11-10 Eugenia Ribeiro De Sousa Fidalgo Leitao Device for incorporation and release of biologically active agents
FR2749756B1 (fr) * 1996-06-14 1998-09-11 Bioland Procede de preparation d'un materiau composite implantable, materiau obtenu, implant comprenant ce materiau et kit de mise en oeuvre
US6953594B2 (en) 1996-10-10 2005-10-11 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
ES2299183T3 (es) 1996-10-16 2008-05-16 Etex Corporation Composiciones bioceramicas.
US7517539B1 (en) 1996-10-16 2009-04-14 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
US8728536B2 (en) 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
DE69729647T2 (de) * 1996-10-16 2005-07-07 Etex Corp., Cambridge Verfahren zur Herstellung von wenigkristallinem Calciumphosphat und Verfahren zu dessen Verwendung
US5939039A (en) * 1997-01-16 1999-08-17 Orthovita, Inc. Methods for production of calcium phosphate
WO1999034772A1 (en) * 1998-01-09 1999-07-15 Enamelon, Inc. Solid products and methods for the remineralization and prevention of demineralization of teeth
US6736849B2 (en) 1998-03-11 2004-05-18 Depuy Products, Inc. Surface-mineralized spinal implants
US6139585A (en) * 1998-03-11 2000-10-31 Depuy Orthopaedics, Inc. Bioactive ceramic coating and method
DE19816858A1 (de) 1998-04-16 1999-10-21 Merck Patent Gmbh Tricalciumphosphathaltige Biozementpasten mit Kohäsionspromotoren
KR100563476B1 (ko) * 1998-07-03 2006-03-27 이진용 골재생재료
US5968253A (en) * 1998-07-31 1999-10-19 Norian Corporation Calcium phosphate cements comprising antimicrobial agents
PT1112095E (pt) * 1998-09-11 2003-04-30 Axel Stemberger Implantes biologicamente activos
EP1123081B1 (de) * 1998-10-19 2002-12-11 SYNTHES AG Chur Aushärtbarer keramischer hydraulischer zement
US6224635B1 (en) * 1998-11-06 2001-05-01 Hospital For Joint Diseases Implantation of surgical implants with calcium sulfate
US6383519B1 (en) * 1999-01-26 2002-05-07 Vita Special Purpose Corporation Inorganic shaped bodies and methods for their production and use
US6840995B2 (en) * 1999-07-14 2005-01-11 Calcitec, Inc. Process for producing fast-setting, bioresorbable calcium phosphate cements
US7270705B2 (en) 1999-07-14 2007-09-18 Jiin-Huey Chern Lin Method of increasing working time of tetracalcium phosphate cement paste
US7094282B2 (en) * 2000-07-13 2006-08-22 Calcitec, Inc. Calcium phosphate cement, use and preparation thereof
US6379453B1 (en) 1999-07-14 2002-04-30 Jiin-Huey Chern Process for producing fast-setting, bioresorbable calcium phosphate cements
US7169373B2 (en) * 1999-07-14 2007-01-30 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same
US6960249B2 (en) * 1999-07-14 2005-11-01 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface
US6458162B1 (en) 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
DE19938704C1 (de) 1999-08-14 2001-10-31 Ivoclar Vivadent Ag Verfahren zur Herstellung von Reaktionssystemen zur Implantation in den menschlichen und tierischen Körper als Knochenersatz, die u.a. Calcium und Phosphor enthalten
US6458763B1 (en) 1999-09-17 2002-10-01 Depuy Orthopeadics Bone sialoprotein-based compositions for enhancing connective tissue repair
US7758882B2 (en) 2000-01-31 2010-07-20 Indiana University Research And Technology Corporation Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods
US6723334B1 (en) * 2000-03-01 2004-04-20 Iowa State University Research Foundation, Inc. Biologically compatible bone cements and orthopedic methods
US6630153B2 (en) * 2001-02-23 2003-10-07 Smith & Nephew, Inc. Manufacture of bone graft substitutes
TWI291352B (en) * 2000-07-13 2007-12-21 Calcitec Inc Calcium phosphate cement, use and preparation thereof
US7156915B2 (en) * 2000-07-13 2007-01-02 Calcitec, Inc. Tetracalcium phosphate (TTCP) with surface whiskers and method of making same
US7182928B2 (en) * 2000-07-13 2007-02-27 Calcitec, Inc. Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same
US6551273B1 (en) 2000-08-23 2003-04-22 Scimed Life Systems, Inc. Catheter having a shaft keeper
JP2004521666A (ja) 2000-08-28 2004-07-22 アドバンスト バイオ サーフェイシズ，インコーポレイティド 哺乳動物の関節を増強する方法およびシステム
US6679886B2 (en) 2000-09-01 2004-01-20 Synthes (Usa) Tools and methods for creating cavities in bone
US6599516B1 (en) 2000-09-14 2003-07-29 Etex Corporation Malleable implant containing solid element that resorbs or fractures to provide access channels
AU1331302A (en) * 2000-10-16 2002-04-29 Univ South Carolina Res Found Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using such cement
US7052517B2 (en) * 2000-10-24 2006-05-30 Vita Special Purpose Corporation Delivery device for biological composites and method of preparation thereof
US6736799B1 (en) 2000-10-24 2004-05-18 Vita Licensing, Inc. Delivery device for biological composites and method of preparation thereof
US6547866B1 (en) * 2000-10-30 2003-04-15 Howmedica Osteonics Corp. Porous calcium phosphate cement
DE10057616B4 (de) 2000-11-21 2006-09-14 Stryker Trauma Gmbh Verfahren zum Mischen und Applizieren von fließfähigem Knochenzement sowie Mischvorrichtung für Knochenzement
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US6558709B2 (en) 2001-01-05 2003-05-06 Howmedica Osteonics Corp. Calcium phosphate composition and method of preparing same
US7294187B2 (en) 2001-01-24 2007-11-13 Ada Foundation Rapid-hardening calcium phosphate cement compositions
US7709029B2 (en) * 2001-01-24 2010-05-04 Ada Foundation Calcium-containing restoration materials
US6793725B2 (en) 2001-01-24 2004-09-21 Ada Foundation Premixed calcium phosphate cement pastes
US6592251B2 (en) 2001-01-26 2003-07-15 Howmedica Osteonics Corp. Cement mixing and dispensing device
US6494611B2 (en) 2001-01-26 2002-12-17 Howmedica Osteonics Corp. Apparatus for mixing a liquid and dry powdered components
WO2002083194A1 (en) * 2001-04-12 2002-10-24 Therics, Inc. Method and apparatus for engineered regenerative biostructures
US20050177237A1 (en) * 2001-04-12 2005-08-11 Ben Shappley Spinal cage insert, filler piece and method of manufacturing
US7235079B2 (en) 2004-11-18 2007-06-26 Acumed Llc Composite bone fasteners
US6616742B2 (en) 2001-08-30 2003-09-09 Cana Lab Corporation Process for preparing a paste from calcium phosphate cement
DE10161827A1 (de) * 2001-12-15 2003-06-26 Dot Gmbh Verfahren zur Beschichtung eines Substrats mit Calciumphosphat
AU2002364193A1 (en) * 2001-12-19 2003-07-09 Advanced Bio Surfaces, Inc. Bone smoothing method and system
US6840961B2 (en) * 2001-12-21 2005-01-11 Etex Corporation Machinable preformed calcium phosphate bone substitute material implants
US20040247641A1 (en) * 2002-01-22 2004-12-09 Felt Jeffrey C. Interpositional arthroplasty system & method
KR20030070713A (ko) * 2002-02-26 2003-09-02 김현만 고형표면의 칼슘포스페이트 결정박막 형성방법
AU2003228587A1 (en) 2002-04-18 2003-11-03 University Of Florida Biomimetic organic/inorganic composites, processes for their production, and methods of use
US7514249B2 (en) * 2002-04-18 2009-04-07 The University Of Florida Research Foundation, Inc. Biomimetic organic/inorganic composites
US7455854B2 (en) * 2002-04-18 2008-11-25 University Of Florida Research Foundation, Inc. Method for producing a mineral fiber
US20030216777A1 (en) * 2002-05-16 2003-11-20 Yin-Chun Tien Method of enhancing healing of interfacial gap between bone and tendon or ligament
DE60305036T2 (de) * 2002-06-19 2006-10-12 Dr. H.C. Robert Mathys Stiftung Hydraulischer zement auf basis von calciumphosphat für chirurgische anwendungen
EP1523291B1 (de) * 2002-07-11 2008-06-18 Advanced Bio Surfaces, Inc. Vorrichtung zur zwischenpositionierungs-arthroplastik
NZ538196A (en) * 2002-08-12 2007-05-31 Osteotech Inc Synthesis of a bone-polymer composite material for forming osteoimplants
GB0222291D0 (en) * 2002-09-26 2002-10-30 Smith & Nephew Adhesive bone cement
IL153699A (en) * 2002-12-26 2008-11-26 Prochon Biotech Ltd The composition for transplantation basically
US20050251267A1 (en) * 2004-05-04 2005-11-10 John Winterbottom Cell permeable structural implant
US20040141903A1 (en) * 2003-01-17 2004-07-22 Howmedica Osteonics Corp. Calcium phosphate cement precursors
FR2850282B1 (fr) * 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
US7507257B2 (en) * 2003-02-04 2009-03-24 Wright Medical Technology, Inc. Injectable resorbable bone graft material, powder for forming same and methods relating thereto for treating bone defects
WO2004069890A2 (en) 2003-02-04 2004-08-19 Osteotech, Inc. Polyurethanes for osteoimplants
US7985414B2 (en) * 2003-02-04 2011-07-26 Warsaw Orthopedic, Inc. Polyurethanes for osteoimplants
CA2521623C (en) 2003-04-11 2015-03-17 Etex Corporation Osteoinductive bone material
US7067169B2 (en) * 2003-06-04 2006-06-27 Chemat Technology Inc. Coated implants and methods of coating
US20040250730A1 (en) * 2003-06-12 2004-12-16 David Delaney Calcium phosphate cements prepared from silicate-phosphate solutions
US20040254668A1 (en) * 2003-06-16 2004-12-16 Jang Bor Z. Macro-porous hydroxyapatite scaffold compositions and freeform fabrication method thereof
US20040250729A1 (en) * 2003-06-16 2004-12-16 Jang Bor Z. Fast-setting carbonated hydroxyapatite compositions and uses
US20040262809A1 (en) * 2003-06-30 2004-12-30 Smith Todd S. Crosslinked polymeric composite for orthopaedic implants
IL156945A0 (en) * 2003-07-15 2004-02-08 Itzhak Tavori Device and a method for orthopedic delivery of bone reconstruction medium
US7118705B2 (en) * 2003-08-05 2006-10-10 Calcitec, Inc. Method for making a molded calcium phosphate article
US7163651B2 (en) * 2004-02-19 2007-01-16 Calcitec, Inc. Method for making a porous calcium phosphate article
TWI275386B (en) * 2003-08-05 2007-03-11 Cana Lab Corp Methods for preparing medical implants from calcium phosphate cement and medical implants
US6994726B2 (en) * 2004-05-25 2006-02-07 Calcitec, Inc. Dual function prosthetic bone implant and method for preparing the same
US8029755B2 (en) 2003-08-06 2011-10-04 Angstrom Medica Tricalcium phosphates, their composites, implants incorporating them, and method for their production
AU2004273794A1 (en) * 2003-09-05 2005-03-31 Norian Corporation Bone cement compositions having fiber-reinforcement and/or increased flowability
JP2007507306A (ja) * 2003-09-30 2007-03-29 ジンテーズ　アクチエンゲゼルシャフト　クール 整形外科用インプラントの抗微生物ヒアルロン酸被覆物
US9199005B2 (en) * 2003-10-01 2015-12-01 New York University Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
US7419680B2 (en) 2003-10-01 2008-09-02 New York University Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
EP1686934B1 (de) * 2003-11-07 2020-03-18 Vivex Biologics Group, Inc. Injizierbare knochensubstitut
EP1701672A4 (de) 2003-12-19 2011-04-27 Osteotech Inc Aus gewebe erhaltenes maschengeflecht für die orthopädische regeneration
WO2005065396A2 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
US8012210B2 (en) 2004-01-16 2011-09-06 Warsaw Orthopedic, Inc. Implant frames for use with settable materials and related methods of use
KR20070004656A (ko) * 2004-01-30 2007-01-09 오스테오테크, 인코포레이티드 척추 융합을 위한 임플란트 적층
US7189263B2 (en) * 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
US7351280B2 (en) * 2004-02-10 2008-04-01 New York University Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment
JP2007533376A (ja) 2004-04-15 2007-11-22 エテックス コーポレーション 遅延凝固リン酸カルシウムペースト
US9220595B2 (en) * 2004-06-23 2015-12-29 Orthovita, Inc. Shapeable bone graft substitute and instruments for delivery thereof
US7384430B2 (en) 2004-06-30 2008-06-10 Depuy Products, Inc. Low crystalline polymeric material for orthopaedic implants and an associated method
ES2246726B2 (es) 2004-08-12 2007-11-01 Universitat Politecnica De Catalunya Espuma de fosfato de calcio autofraguable e inyectable.
US7785648B2 (en) * 2004-09-22 2010-08-31 New York University Adherent apatite coating on titanium substrate using chemical deposition
US20060110422A1 (en) * 2004-11-19 2006-05-25 Tas Ahmet C Conversion of calcite powders into macro- and microporous calcium phosphate scaffolds for medical applications
US20060282169A1 (en) * 2004-12-17 2006-12-14 Felt Jeffrey C System and method for upper extremity joint arthroplasty
US7879275B2 (en) 2004-12-30 2011-02-01 Depuy Products, Inc. Orthopaedic bearing and method for making the same
US7896921B2 (en) 2004-12-30 2011-03-01 Depuy Products, Inc. Orthopaedic bearing and method for making the same
US7883653B2 (en) 2004-12-30 2011-02-08 Depuy Products, Inc. Method of making an implantable orthopaedic bearing
US8480629B2 (en) 2005-01-28 2013-07-09 Boston Scientific Scimed, Inc. Universal utility board for use with medical devices and methods of use
US7591853B2 (en) 2005-03-09 2009-09-22 Vertebral Technologies, Inc. Rail-based modular disc nucleus prosthesis
US7416602B2 (en) * 2005-04-08 2008-08-26 Howmedica Leibinger, Inc. Calcium phosphate cement
US7459018B2 (en) * 2005-04-08 2008-12-02 Howmedica Leibinger Inc. Injectable calcium phosphate cement
US8814567B2 (en) 2005-05-26 2014-08-26 Zimmer Dental, Inc. Dental implant prosthetic device with improved osseointegration and esthetic features
WO2007027794A1 (en) 2005-08-30 2007-03-08 Zimmer Dental, Inc. Dental implant with improved osseointegration features
US8562346B2 (en) 2005-08-30 2013-10-22 Zimmer Dental, Inc. Dental implant for a jaw with reduced bone volume and improved osseointegration features
US8025903B2 (en) 2005-09-09 2011-09-27 Wright Medical Technology, Inc. Composite bone graft substitute cement and articles produced therefrom
CN103349793B (zh) 2005-09-09 2016-02-10 阿格诺沃斯健康关爱公司 复合骨移植替代物水泥以及由其制得的制品
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
CN101365499A (zh) 2005-11-01 2009-02-11 骨骼技术股份有限公司 骨基质组合物和方法
CN101340935B (zh) 2005-11-14 2013-05-08 拜奥美特3i有限责任公司 于植入物表面上淀积纳米粒子
US20070122445A1 (en) * 2005-11-28 2007-05-31 Shalaby Shalaby W Absorbable fatigue-enduring phosphate composites
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
CA2637606C (en) 2006-01-19 2013-03-19 Osteotech, Inc. Porous osteoimplant
CZ301206B6 (cs) * 2006-01-19 2009-12-09 Ceská hlava s.r.o. Prípravek pro prevenci a lécbu iniciálního zubního kazu
AU2007207429A1 (en) 2006-01-19 2007-07-26 Warsaw Orthopedic, Inc. Injectable and moldable bone substitute materials
US20070185495A1 (en) * 2006-01-30 2007-08-09 Howmedica International S. De R. L. Plug-in syringe stand
WO2007117499A2 (en) * 2006-04-05 2007-10-18 University Of Nebraska Bioresorbable polymer reconstituted bone and methods of formation thereof
WO2007119240A2 (en) * 2006-04-17 2007-10-25 Hepacore Ltd. Methods for bone regeneration using endothelial progenitor cell preparations
US8048118B2 (en) * 2006-04-28 2011-11-01 Warsaw Orthopedic, Inc. Adjustable interspinous process brace
EP2422822A1 (de) 2006-06-29 2012-02-29 Orthovita, Inc. Bioaktiver Knochentransplantatersatz
US8946200B2 (en) * 2006-11-02 2015-02-03 Southwest Research Institute Pharmaceutically active nanosuspensions
EP1917924A1 (de) * 2006-11-02 2008-05-07 Stryker Trauma GmbH Implantierungsvorrichtung
US8388626B2 (en) * 2006-11-08 2013-03-05 Warsaw Orthopedic, Inc. Methods of employing calcium phosphate cement compositions and osteoinductive proteins to effect vertebrae interbody fusion absent an interbody device
US9737414B2 (en) 2006-11-21 2017-08-22 Vertebral Technologies, Inc. Methods and apparatus for minimally invasive modular interbody fusion devices
DE102006058669B4 (de) * 2006-12-13 2009-04-09 Kaczmarek, André, Dr. Tri-calciumphosphat- und/oder hydroxylapatithaltiges selbstaushärtendes Reparaturmaterial für iatrogene Verletzungen der Zahngewebe mit einer Polyphosphatmatrix und einem calciumhydroxidhaltigem Medium
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US8268010B2 (en) * 2007-01-12 2012-09-18 Warsaw Orthopedic, Inc. System and method for forming bone filling materials with microparticles
US8926623B2 (en) * 2007-01-12 2015-01-06 Warsaw Orthopedic, Inc. System and method for forming porous bone filling material
US8840618B2 (en) * 2007-01-12 2014-09-23 Warsaw Orthopedic, Inc. System and method for pressure mixing bone filling material
EP1958649A1 (de) * 2007-02-14 2008-08-20 Graftys Injizierbarer Kalzium-Phospat-Zement zur Freisetzung eines Knochenschwund-Inhibitors
JP2010529091A (ja) 2007-06-06 2010-08-26 インノテーレ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 水硬性セメントをベースとするインプラント材料ならびにその使用
CA2690457C (en) 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
CA3062443C (en) 2007-06-15 2022-03-15 Warsaw Orthopedic, Inc. Method of treating tissue
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
WO2009009684A1 (en) 2007-07-10 2009-01-15 Osteotech, Inc. Delivery system
US20090061389A1 (en) 2007-08-30 2009-03-05 Matthew Lomicka Dental implant prosthetic device with improved osseointegration and shape for resisting rotation
US8202539B2 (en) * 2007-10-19 2012-06-19 Warsaw Orthopedic, Inc. Demineralized bone matrix compositions and methods
AU2008340390B2 (en) 2007-11-09 2014-12-11 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
EP2240116B1 (de) 2008-01-28 2015-07-01 Biomet 3I, LLC Implantatoberfläche mit erhöhter hydrophilie
US8404850B2 (en) * 2008-03-13 2013-03-26 Southwest Research Institute Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors
WO2009120969A2 (en) * 2008-03-28 2009-10-01 Osteotech, Inc. Bone anchors for orthopedic applications
US20110125158A1 (en) 2008-05-01 2011-05-26 Ashish Dhar Diwan Systems, methods and apparatuses for formation and insertion of tissue prostheses
US9095396B2 (en) 2008-07-02 2015-08-04 Zimmer Dental, Inc. Porous implant with non-porous threads
US8231387B2 (en) 2008-07-02 2012-07-31 Zimmer, Inc. Porous implant with non-porous threads
US8562348B2 (en) 2008-07-02 2013-10-22 Zimmer Dental, Inc. Modular implant with secured porous portion
US8899982B2 (en) 2008-07-02 2014-12-02 Zimmer Dental, Inc. Implant with structure for securing a porous portion
US8722706B2 (en) * 2008-08-15 2014-05-13 Southwest Research Institute Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts
US8309134B2 (en) * 2008-10-03 2012-11-13 Southwest Research Institute Modified calcium phosphate nanoparticle formation
WO2012134540A2 (en) 2010-10-22 2012-10-04 Vanderbilt University Injectable synthetic pur composite
AU2009317974A1 (en) * 2008-10-30 2010-05-27 Vanderbilt University Bone/polyurethane composites and methods thereof
US20100114314A1 (en) 2008-11-06 2010-05-06 Matthew Lomicka Expandable bone implant
TWI501793B (zh) * 2008-11-12 2015-10-01 Howmedica Osteonics Corp 以磷酸四鈣為主之有機磷組合物及方法
WO2010093959A2 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery systems, tools, and methods of use
EP2228080A1 (de) 2009-03-03 2010-09-15 Graftys Galliierte Calciumphosphat-Biomaterialien
US8623311B2 (en) 2009-03-03 2014-01-07 Graftys Gallium-doped phosphocalcic compounds
US8894958B2 (en) * 2009-03-03 2014-11-25 Centre National De La Recherche Scientifique (C.N.R.S.) Galliated calcium phosphate biomaterials
US9707058B2 (en) 2009-07-10 2017-07-18 Zimmer Dental, Inc. Patient-specific implants with improved osseointegration
EP3342432B1 (de) 2009-08-03 2021-07-07 Warsaw Orthopedic, Inc. Knochenmatrix-zusammensetzungen und -verfahren
US8602782B2 (en) 2009-11-24 2013-12-10 Zimmer Dental, Inc. Porous implant device with improved core
JP5095034B2 (ja) 2009-12-18 2012-12-12 ハウメディカ・オステオニクス・コーポレイション 照射後貯蔵安定性の直接注入可能なデュアルペースト型骨セメントを製造するシステムおよびリン酸カルシウム組成物
US20110151027A1 (en) * 2009-12-21 2011-06-23 Theodore D Clineff Strontium-doped calcium phosphate bone graft materials
US9028873B2 (en) * 2010-02-08 2015-05-12 Southwest Research Institute Nanoparticles for drug delivery to the central nervous system
US8641418B2 (en) 2010-03-29 2014-02-04 Biomet 3I, Llc Titanium nano-scale etching on an implant surface
AU2011250934B2 (en) 2010-05-11 2016-02-25 Howmedica Osteonics Corp., Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
TWI579007B (zh) 2010-07-02 2017-04-21 艾格諾福斯保健公司 骨再生材料之用途
WO2012027711A2 (en) 2010-08-26 2012-03-01 University Of Louisville Research Foundation, Inc. Compositions and methods for treating bone defects
MA33231B1 (fr) 2010-09-20 2012-05-02 Univ Hassan Ii Mohammedia Ciments macroporeux a base de bioverre, bioactif, bioresorbable a usage biomedical
WO2012062360A1 (en) 2010-11-10 2012-05-18 Stryker Trauma Gmbh Polymeric bone foam composition and method
US8613938B2 (en) 2010-11-15 2013-12-24 Zimmer Orthobiologics, Inc. Bone void fillers
EP2648740B1 (de) * 2010-12-06 2022-02-09 Massachusetts Institute of Technology Tricalciumphosphat-bindende peptide und ihre verwendung
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US9050163B2 (en) 2011-03-21 2015-06-09 Endo Pharmaceuticals Inc. Urethral anastomosis device and method
US8765189B2 (en) 2011-05-13 2014-07-01 Howmedica Osteonic Corp. Organophosphorous and multivalent metal compound compositions and methods
US9510953B2 (en) 2012-03-16 2016-12-06 Vertebral Technologies, Inc. Modular segmented disc nucleus implant
ES2671740T3 (es) 2012-03-20 2018-06-08 Biomet 3I, Llc Superficie de tratamiento para una superficie de implante
CA2885352A1 (en) 2012-09-18 2014-03-27 Endo Pharmaceuticals Inc. Urethral anastomosis device and method
WO2014159186A1 (en) 2013-03-14 2014-10-02 Endo Pharmaceuticals Inc. Urethral anastomosis device
CN103204485B (zh) * 2013-04-25 2015-02-11 连云港树人科创食品添加剂有限公司 一种食品级磷酸三钙生产方法
AU2014331971B2 (en) 2013-10-08 2018-07-19 Vivorte, Inc. Processed bone particle compositions and related methods
US9168114B2 (en) 2013-10-17 2015-10-27 B & D Dental Corp. Method of making a dental prosthesis
FR3021045B1 (fr) * 2014-05-16 2020-02-21 Solvay Sa Procede de production d'un reactif phosphocalcique, reactif obtenu et son utilisation
ES2555235B1 (es) * 2014-06-25 2016-10-05 Universitat Politècnica De Catalunya Nuevo proceso de fabricación en un solo paso de biomateriales espumados
US9820792B2 (en) 2014-08-22 2017-11-21 Kyphon SÀRL Bone cement mixing and delivery device
US9820791B2 (en) 2014-08-22 2017-11-21 Kyphon SÀRL Methods of filling bone using bone cement mixing and delivery devices
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10219986B2 (en) 2015-03-04 2019-03-05 Modern Ideas LLC Stabilized calcium phosphate and methods of forming same
WO2017209823A2 (en) 2016-03-14 2017-12-07 The University Of Chicago Injectable pastes based on oppositely charged polymer/calcium phosphate hybrid nanoparticles
US11020160B2 (en) 2016-03-21 2021-06-01 Warsaw Orthopedic, Inc. Surgical injection system and method
EP3231453B1 (de) 2016-04-14 2019-12-25 Immundiagnostik AG Bone-sialopreotein(bsp)-funktionalisierte knochenersatzkörper
WO2019014576A1 (en) 2017-07-14 2019-01-17 The University Of Chicago LYOPHILIZED FORMULATIONS COMPRISING NANOPARTICLES AND METHODS OF LYOPHILIZATION
JP7521152B2 (ja) 2017-09-08 2024-07-24 エクスタント メディカル ホールディングス，インコーポレイテッド． 椎間インプラント、器具、及び方法
USD907771S1 (en) 2017-10-09 2021-01-12 Pioneer Surgical Technology, Inc. Intervertebral implant
CN113166202B (zh) 2018-10-12 2024-09-13 治疗调适公司 包括β-磷酸三钙-结合序列的多肽及其用途
MX2022004336A (es) * 2019-10-09 2022-04-26 Solidia Technologies Inc Metodos para la formacion de materiales compuestos curados con ph mejorado y composiciones y sistemas relacionados.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3379541A (en) * 1964-02-18 1968-04-23 Monsanto Co Alkaline earth metal hydroxylapatites, processes for preparing the same and compositions containing the same
US3647371A (en) * 1968-08-07 1972-03-07 Monsanto Co Method for preparation of dicalcium phosphate

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2012436A (en) * 1932-09-06 1935-08-27 Southern Mineral Products Corp Process of making monocalcium phosphate
DE1206293B (de) * 1960-01-16 1965-12-02 Knapsack Ag Verfahren zur Herstellung eines im wesentlichen aus Dicalciumphosphat bestehenden Mineralstoffbeifutters
DE1259861B (de) * 1965-06-16 1968-02-01 Knapsack Ag Verfahren zur Herstellung von stabilisiertem Dicalciumphosphat-Dihydrat
US3467495A (en) * 1965-12-23 1969-09-16 Int Minerals & Chem Corp Preparation of calcium phosphates
GB1111216A (en) * 1966-02-04 1968-04-24 Albright & Wilson Mfg Ltd Production of alkali metal phosphates
GB1395037A (en) * 1972-10-10 1975-05-21 Doulton & Co Ltd Bone china
US4048300A (en) * 1973-01-11 1977-09-13 Colgate-Palmolive Company Dental preparation containing materials having calcium and phosphate components
GB1450157A (en) * 1973-03-06 1976-09-22 Colgate Palmolive Co Dental powder cement and filling material
US4101637A (en) * 1975-10-29 1978-07-18 J. R. Simplot Company Direct granulation process for triple superphosphate
JPS5946911B2 (ja) * 1976-12-16 1984-11-15 住友化学工業株式会社 インプラント
US4274879A (en) * 1979-03-05 1981-06-23 Tate & Lyle Limited Synthetic bone ash
JPS5654841A (en) * 1979-10-08 1981-05-15 Mitsubishi Mining & Cement Co Bone broken portion and filler for void portion and method of treating bone of animal using said filler
US4324772A (en) * 1980-11-19 1982-04-13 Monsanto Company Process for producing hydroxyapatite
US4518430A (en) * 1982-04-29 1985-05-21 American Dental Association Health Foundation Dental resptorative cement pastes
USRE33161E (en) * 1982-04-29 1990-02-06 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
GB2129410B (en) * 1982-11-04 1986-11-12 Baslini Ind Chim Production of calcium phosphates
SU1331501A1 (ru) * 1983-06-22 1987-08-23 Центральный институт усовершенствования врачей Способ получени искусственных костных трансплантатов
DE3433210C1 (de) * 1984-09-10 1986-06-05 Hans Dr.med. Dr.med.dent. 8000 München Scheicher Mittel zur Fuellung von Knochen- und Zahndefekten,zum Knochenaufbau,fuer Knochenkontaktschichten und fuer Knochen- und Zahnwurzelersatz und Verwendung von Carbonatapatit fuer diesen Zweck
US5007930A (en) * 1985-02-19 1991-04-16 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
US5034352A (en) * 1985-06-25 1991-07-23 Lifecore Biomedical, Inc. Calcium phosphate materials
JPS62182146A (ja) * 1985-10-11 1987-08-10 三井東圧化学株式会社 硬化性材料
HU203198B (en) * 1987-10-26 1991-06-28 Sandoz Ag Process for producing pharmaceutical compositions having immunity-inhibiting, monokin-, particularly interleukin-1-inhibiting effect
JPH0645487B2 (ja) * 1989-05-19 1994-06-15 徳山曹達株式会社 硬化材
JPH03110999A (ja) * 1989-09-25 1991-05-10 Sharp Corp ４チャンネル・ステレオ強調回路
JPH03174349A (ja) * 1989-12-01 1991-07-29 Mitsubishi Materials Corp 水硬性リン酸カルシウムセメント
US5262166A (en) * 1991-04-17 1993-11-16 Lty Medical Inc Resorbable bioactive phosphate containing cements
JP3000718B2 (ja) * 1991-05-28 2000-01-17 三菱マテリアル株式会社 薬物徐放性リン酸カルシウムセメント
JP3000719B2 (ja) * 1991-05-28 2000-01-17 三菱マテリアル株式会社 水硬性リン酸カルシウムセメント
JPH059383A (ja) * 1991-06-29 1993-01-19 Dainippon Ink & Chem Inc ポリアリーレンサルフアイド樹脂組成物
JPH0523386A (ja) * 1991-07-23 1993-02-02 Mitsubishi Materials Corp リン酸カルシウムセメント
US5338356A (en) * 1991-10-29 1994-08-16 Mitsubishi Materials Corporation Calcium phosphate granular cement and method for producing same
JPH05319891A (ja) * 1992-05-19 1993-12-03 Mitsubishi Materials Corp 球状α型第３リン酸カルシウム及び水硬性リン酸カルシウムセメント組成物
JPH0645494A (ja) * 1992-07-22 1994-02-18 Nec Corp 半導体集積回路用パッケージ
EP0639366A1 (de) * 1993-08-19 1995-02-22 Kingstar Technology Limited (Uk) Hydroxylapatit Zement als Zahn- oder Knochenersatz
US5336642A (en) * 1993-09-01 1994-08-09 Corning Incorporated Canasite-apatite glass-ceramics
US6201039B1 (en) * 1993-09-21 2001-03-13 The Penn State Research Foundation Bone substitute composition comprising hydroxyapatite and a method of production therefor
CA2143733A1 (en) * 1994-03-02 1995-09-03 Yoshikazu Umezu Alpha-tricalcium phosphate ceramic and production method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3379541A (en) * 1964-02-18 1968-04-23 Monsanto Co Alkaline earth metal hydroxylapatites, processes for preparing the same and compositions containing the same
US3647371A (en) * 1968-08-07 1972-03-07 Monsanto Co Method for preparation of dicalcium phosphate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2158189C1 (ru) * 1999-03-30 2000-10-27 Закрытое акционерное общество Клиническое научно-производственное объединение "Биотехника" Способ нанесения гидроксиапатитовых покрытий

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US4880610A (en) 1989-11-14
US5820632A (en) 1998-10-13
CA1332495C (en) 1994-10-18
JPH0222113A (ja) 1990-01-25
DE68928816T2 (de) 1999-03-18
EP0347028A2 (de) 1989-12-20
US5336264A (en) 1994-08-09
EP0347028B1 (de) 1998-09-16
DE68928816D1 (de) 1998-10-22
JP2863544B2 (ja) 1999-03-03

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