ES8609728A1 - Una composicion de conjugado de enzima estabilizado - Google Patents

Una composicion de conjugado de enzima estabilizado

Info

Publication number
ES8609728A1
ES8609728A1 ES540059A ES540059A ES8609728A1 ES 8609728 A1 ES8609728 A1 ES 8609728A1 ES 540059 A ES540059 A ES 540059A ES 540059 A ES540059 A ES 540059A ES 8609728 A1 ES8609728 A1 ES 8609728A1
Authority
ES
Spain
Prior art keywords
enzyme conjugate
conjugate composition
stabilized enzyme
composition
polyethylene glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540059A
Other languages
English (en)
Other versions
ES540059A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of ES8609728A1 publication Critical patent/ES8609728A1/es
Publication of ES540059A0 publication Critical patent/ES540059A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/18—Multi-enzyme systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

METODO DE PREPARACION DE COMPOSICIONES DE CONJUGADO DE ENZIMA QUE CONTIENEN ADEMAS UNA SAL DE CALCIO Y UN POLIETILENGLICOL. CONSISTE EN MEZCLAR, A UNA TEMPERATURA COMPRENDIDA ENTRE 15JC Y 30JC, UNA DISOLUCION TAMPONADA DE CONJUGADO DE ENZIMA, CUYA CONCENTRACION NO ES SUPERIOR A 1 M/ML, CON 0,1 A 10% P/V DE UN POLIETILENGLICOL QUE TIENE UN PESO MOLECULAR COMPRENDIDO ENTRE 1.000 Y 20.000; Y TRATAMIENTO DE LA MEZCLA RESULTANTE CON 0,05 A 1% P/V DE UNA SAL DE CALCIO, TAL COMO CLORURO CALCICO O PROPIONATO CALCICO. ESTAS COMPOSICIONES TIENEN APLICACIONES EN DIAGNOSTICOS CLINICOS.
ES540059A 1984-02-03 1985-02-01 Una composicion de conjugado de enzima estabilizado Expired ES8609728A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57682484A 1984-02-03 1984-02-03

Publications (2)

Publication Number Publication Date
ES8609728A1 true ES8609728A1 (es) 1986-09-01
ES540059A0 ES540059A0 (es) 1986-09-01

Family

ID=24306158

Family Applications (1)

Application Number Title Priority Date Filing Date
ES540059A Expired ES8609728A1 (es) 1984-02-03 1985-02-01 Una composicion de conjugado de enzima estabilizado

Country Status (14)

Country Link
EP (1) EP0152847B1 (es)
JP (1) JPH06104064B2 (es)
KR (1) KR900002840B1 (es)
AT (1) ATE38097T1 (es)
AU (1) AU578065B2 (es)
CA (1) CA1249782A (es)
DE (1) DE3565722D1 (es)
DK (1) DK44185A (es)
ES (1) ES8609728A1 (es)
GR (1) GR850292B (es)
IE (1) IE57714B1 (es)
IL (1) IL74177A (es)
NZ (1) NZ210990A (es)
ZA (1) ZA85705B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206344A (en) * 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US4766106A (en) * 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4810638A (en) * 1986-07-24 1989-03-07 Miles Inc. Enzyme-labeled antibody reagent with polyalkyleneglycol linking group
IE64284B1 (en) * 1987-08-03 1995-07-26 Ddi Pharmaceuticals Conjugates of superoxide dismutase
DE3726634A1 (de) * 1987-08-11 1989-02-23 Biotest Ag Stabilisiertes peroxidasepraeparat
FR2626373B1 (fr) * 1988-01-22 1993-10-15 Stabiligen Procede de preparation d'un traceur stable et traceur obtenu
DE3901458A1 (de) 1989-01-19 1990-07-26 Behringwerke Ag Verwendung von zwei- oder dreiwertigen kationen in immunchemischen tests
DK131792D0 (es) * 1992-10-28 1992-10-28 Novo Nordisk As
DK1400551T3 (da) 1998-08-28 2007-10-15 Amylin Pharmaceuticals Inc Polyamidkæder med præcis længde og deres konjugater med proteiner
CA2468619A1 (en) * 2001-12-21 2003-07-10 Maxygen Aps Adiponectin fragments and conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024578B1 (en) * 1979-08-23 1983-12-07 Ivan Endre Modrovich Method of stabilizing an enzyme solution for use in total cholesterol determination, stabilized solution and test kit therefor
GB2057572B (en) * 1979-08-30 1984-03-07 White W T Device for metering fluid flow
GB2067572A (en) * 1980-01-21 1981-07-30 Abbott Lab Partially oxidized enzyme conjugates
FR2537991A1 (fr) * 1982-12-20 1984-06-22 Sanders Procede pour stabiliser des enzymes liquides, enzymes liquides ainsi stabilisees et aliment renfermant de telles enzymes notamment pour des animaux monogastriques

Also Published As

Publication number Publication date
DK44185A (da) 1985-08-04
IL74177A (en) 1989-09-10
KR900002840B1 (ko) 1990-05-01
AU3829185A (en) 1985-08-08
EP0152847B1 (en) 1988-10-19
CA1249782A (en) 1989-02-07
DE3565722D1 (en) 1988-11-24
DK44185D0 (da) 1985-01-31
GR850292B (es) 1985-06-05
ZA85705B (en) 1985-09-25
IE850250L (en) 1985-08-03
AU578065B2 (en) 1988-10-13
EP0152847A1 (en) 1985-08-28
JPS60184385A (ja) 1985-09-19
NZ210990A (en) 1988-02-29
IE57714B1 (en) 1993-03-10
IL74177A0 (en) 1985-04-30
KR860006542A (ko) 1986-09-13
JPH06104064B2 (ja) 1994-12-21
ES540059A0 (es) 1986-09-01
ATE38097T1 (de) 1988-11-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519