ATE38097T1 - Stabilisierte, ein enzymkonjugat enthaltende zusammensetzung. - Google Patents

Stabilisierte, ein enzymkonjugat enthaltende zusammensetzung.

Info

Publication number
ATE38097T1
ATE38097T1 AT85101109T AT85101109T ATE38097T1 AT E38097 T1 ATE38097 T1 AT E38097T1 AT 85101109 T AT85101109 T AT 85101109T AT 85101109 T AT85101109 T AT 85101109T AT E38097 T1 ATE38097 T1 AT E38097T1
Authority
AT
Austria
Prior art keywords
enzyme conjugate
composition containing
stabilized composition
polyethylene glycol
calcium salt
Prior art date
Application number
AT85101109T
Other languages
English (en)
Inventor
Mark Anthony Anawis
Roger Elmer Lindberg
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE38097T1 publication Critical patent/ATE38097T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/535Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/18Multi-enzyme systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
AT85101109T 1984-02-03 1985-02-02 Stabilisierte, ein enzymkonjugat enthaltende zusammensetzung. ATE38097T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57682484A 1984-02-03 1984-02-03
EP85101109A EP0152847B1 (de) 1984-02-03 1985-02-02 Stabilisierte, ein Enzymkonjugat enthaltende Zusammensetzung

Publications (1)

Publication Number Publication Date
ATE38097T1 true ATE38097T1 (de) 1988-11-15

Family

ID=24306158

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85101109T ATE38097T1 (de) 1984-02-03 1985-02-02 Stabilisierte, ein enzymkonjugat enthaltende zusammensetzung.

Country Status (14)

Country Link
EP (1) EP0152847B1 (de)
JP (1) JPH06104064B2 (de)
KR (1) KR900002840B1 (de)
AT (1) ATE38097T1 (de)
AU (1) AU578065B2 (de)
CA (1) CA1249782A (de)
DE (1) DE3565722D1 (de)
DK (1) DK44185A (de)
ES (1) ES8609728A1 (de)
GR (1) GR850292B (de)
IE (1) IE57714B1 (de)
IL (1) IL74177A (de)
NZ (1) NZ210990A (de)
ZA (1) ZA85705B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766106A (en) * 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US5206344A (en) * 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US4810638A (en) * 1986-07-24 1989-03-07 Miles Inc. Enzyme-labeled antibody reagent with polyalkyleneglycol linking group
IE64284B1 (en) * 1987-08-03 1995-07-26 Ddi Pharmaceuticals Conjugates of superoxide dismutase
DE3726634A1 (de) * 1987-08-11 1989-02-23 Biotest Ag Stabilisiertes peroxidasepraeparat
FR2626373B1 (fr) * 1988-01-22 1993-10-15 Stabiligen Procede de preparation d'un traceur stable et traceur obtenu
DE3901458A1 (de) 1989-01-19 1990-07-26 Behringwerke Ag Verwendung von zwei- oder dreiwertigen kationen in immunchemischen tests
DK131792D0 (de) * 1992-10-28 1992-10-28 Novo Nordisk As
DK1400551T3 (da) 1998-08-28 2007-10-15 Amylin Pharmaceuticals Inc Polyamidkæder med præcis længde og deres konjugater med proteiner
EP1458758A2 (de) * 2001-12-21 2004-09-22 Maxygen Aps Adiponectin-fragmente und -konjugate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3065827D1 (en) * 1979-08-23 1984-01-12 Ivan Endre Modrovich Method of stabilizing an enzyme solution for use in total cholesterol determination, stabilized solution and test kit therefor
GB2057572B (en) * 1979-08-30 1984-03-07 White W T Device for metering fluid flow
GB2067572A (en) * 1980-01-21 1981-07-30 Abbott Lab Partially oxidized enzyme conjugates
FR2537991A1 (fr) * 1982-12-20 1984-06-22 Sanders Procede pour stabiliser des enzymes liquides, enzymes liquides ainsi stabilisees et aliment renfermant de telles enzymes notamment pour des animaux monogastriques

Also Published As

Publication number Publication date
GR850292B (de) 1985-06-05
DK44185A (da) 1985-08-04
DE3565722D1 (en) 1988-11-24
NZ210990A (en) 1988-02-29
KR900002840B1 (ko) 1990-05-01
IE57714B1 (en) 1993-03-10
KR860006542A (ko) 1986-09-13
AU578065B2 (en) 1988-10-13
IE850250L (en) 1985-08-03
ES8609728A1 (es) 1986-09-01
ZA85705B (en) 1985-09-25
DK44185D0 (da) 1985-01-31
IL74177A0 (en) 1985-04-30
JPH06104064B2 (ja) 1994-12-21
EP0152847A1 (de) 1985-08-28
AU3829185A (en) 1985-08-08
JPS60184385A (ja) 1985-09-19
ES540059A0 (es) 1986-09-01
EP0152847B1 (de) 1988-10-19
IL74177A (en) 1989-09-10
CA1249782A (en) 1989-02-07

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