EE05402B1 - Meetod bensimidasooli-tüüpi ühendite valmistamiseks ning k?rvalsaadusena moodustunud sulfoonide eemaldamiseks - Google Patents

Meetod bensimidasooli-tüüpi ühendite valmistamiseks ning k?rvalsaadusena moodustunud sulfoonide eemaldamiseks

Info

Publication number
EE05402B1
EE05402B1 EEP200400052A EEP200400052A EE05402B1 EE 05402 B1 EE05402 B1 EE 05402B1 EE P200400052 A EEP200400052 A EE P200400052A EE P200400052 A EEP200400052 A EE P200400052A EE 05402 B1 EE05402 B1 EE 05402B1
Authority
EE
Estonia
Prior art keywords
benzimidazole
preparation
sulfones
removal
products
Prior art date
Application number
EEP200400052A
Other languages
English (en)
Estonian (et)
Inventor
Laurent Maria Broeckx Rudy
De Smaele Dirk
Marcel Herman Leurs Stefan
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200400052A publication Critical patent/EE200400052A/xx
Publication of EE05402B1 publication Critical patent/EE05402B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Extraction Or Liquid Replacement (AREA)
EEP200400052A 2001-07-16 2002-07-09 Meetod bensimidasooli-tüüpi ühendite valmistamiseks ning k?rvalsaadusena moodustunud sulfoonide eemaldamiseks EE05402B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202696 2001-07-16
PCT/EP2002/007693 WO2003008406A1 (fr) 2001-07-16 2002-07-09 Procede ameliore de preparation de composes de type benzimidazole

Publications (2)

Publication Number Publication Date
EE200400052A EE200400052A (et) 2004-04-15
EE05402B1 true EE05402B1 (et) 2011-04-15

Family

ID=8180641

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200400052A EE05402B1 (et) 2001-07-16 2002-07-09 Meetod bensimidasooli-tüüpi ühendite valmistamiseks ning k?rvalsaadusena moodustunud sulfoonide eemaldamiseks

Country Status (23)

Country Link
US (1) US6919459B2 (fr)
EP (1) EP1409478B1 (fr)
JP (1) JP4320250B2 (fr)
KR (1) KR100914175B1 (fr)
CN (1) CN1235899C (fr)
AT (1) ATE321758T1 (fr)
AU (1) AU2002321204B2 (fr)
BR (1) BRPI0211101B8 (fr)
CA (1) CA2450433C (fr)
CZ (1) CZ304526B6 (fr)
DE (1) DE60210292T2 (fr)
EA (1) EA005773B1 (fr)
EE (1) EE05402B1 (fr)
ES (1) ES2261703T3 (fr)
HK (1) HK1069168A1 (fr)
HU (1) HU230155B1 (fr)
IL (2) IL159854A0 (fr)
MX (1) MXPA04000433A (fr)
NO (1) NO324257B1 (fr)
NZ (1) NZ530168A (fr)
PL (1) PL208291B1 (fr)
SK (1) SK287245B6 (fr)
WO (1) WO2003008406A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1556043A1 (fr) * 2002-10-22 2005-07-27 Ranbaxy Laboratories, Ltd. Forme amorphe de sels d'esomeprazole
EP1615913A2 (fr) * 2003-06-10 2006-01-18 Teva Pharmaceutical Industries Limited Procede de preparation de benzimidazoles 2- (pyridinyl)methyl]sulfinyle substitues et nouveau derives chlorures de pantoprazole
WO2006019151A1 (fr) * 2004-08-20 2006-02-23 Eisai R & D Management Co., Ltd. Procédé pour la fabrication d’un dérivé de benzimidazole
WO2006049486A1 (fr) * 2004-11-08 2006-05-11 Dishman Pharmaceuticals And Chemicals Ltd. Méthode de synthèse de 2-(2-pyridylméthoylsulphinyl)-1h-benzimidazoles substitués
EP1681056A1 (fr) 2005-01-14 2006-07-19 Krka Tovarna Zdravil, D.D., Novo Mesto Procédé de préparation du lansoprazole
GB0525710D0 (en) * 2005-12-17 2006-01-25 Pliva Hrvatska D O O An improved process for preparing of substituted 2-benzimidazolesulfoxide compounds
EP1801110A1 (fr) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Sel d'arginine d'ésoméprazole
EP1818331A1 (fr) 2006-02-14 2007-08-15 EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. Procédé pour la préparation de 2-[{4-(3-méthoxypropoxy)-3-méthyl-2-pyridinyl}méthylsulfinyl]-1H-benzimidazole essentiellement exempte d'impurité sulfone
WO2007129328A2 (fr) * 2006-05-09 2007-11-15 Cadila Healthcare Limited Méthode de préparation de benzimidazones substitués 2-[pyridinyl]sulfinyle
WO2007138468A2 (fr) * 2006-06-01 2007-12-06 Wockhardt Ltd Procédés de préparation de lansoprazole
WO2008017020A2 (fr) * 2006-08-03 2008-02-07 Dr. Reddy's Laboratories Limited Procédé de preparation d'inhibiteurs de la pompe à protons
EP2069329A4 (fr) * 2006-10-06 2010-04-07 Reddys Lab Ltd Dr Procédé pour la préparation de dérivés de benzimidazole, et de leurs sels
EP1947099A1 (fr) 2007-01-18 2008-07-23 LEK Pharmaceuticals D.D. Procédé pour l'élimination de solvant des sels d'oméprazole
BRPI0813191B1 (pt) * 2007-06-15 2021-09-08 Emcure Pharmaceuticals Limited Processo de sulfoxidação de compostos biologicamente ativos
US8247568B2 (en) * 2007-06-21 2012-08-21 Matrix Laboratories Ltd Process for the preparation of pure rabeprazole
EP2022789A1 (fr) * 2007-08-06 2009-02-11 Farmaprojects, S.A. Procédé pour la préparation d'un inhibiteur de la sécrétion d'acide gastrique
WO2009066317A2 (fr) * 2007-08-20 2009-05-28 Macleods Pharmaceuticals Limited Procédé de préparation de pantoprazole sodique
EP2030973A1 (fr) * 2007-08-31 2009-03-04 KRKA, tovarna zdravil, d.d., Novo mesto Procédé pour la préparation de 2-sulfinyl-1H-benzimidazoles
US8071781B2 (en) * 2008-11-11 2011-12-06 Syn-Tech Chem. & Pharm. Co., Ltd. Process for preparing rabeprazole sodium
EP2542576B1 (fr) * 2010-03-02 2016-04-20 Seattle Genetics, Inc. Procédés pour cribler des anticorps
CN104418837A (zh) * 2013-08-19 2015-03-18 长沙市如虹医药科技有限公司 一种氧化硫醚成亚砜的方法
CN104402867A (zh) * 2014-11-07 2015-03-11 烟台万润精细化工股份有限公司 一种制备埃索美拉唑杂质h和b的方法
CN104402866A (zh) * 2014-11-07 2015-03-11 烟台万润精细化工股份有限公司 一种制备埃索美拉唑杂质j和k的方法
CN104530006B (zh) * 2015-01-06 2018-05-11 江苏奥赛康药业股份有限公司 兰索拉唑的制备方法
CN104744440B (zh) * 2015-03-12 2016-09-07 常州康丽制药有限公司 雷贝拉唑硫醚的回收方法
CN110487918B (zh) * 2018-05-14 2022-02-08 中国医学科学院药物研究所 泮托拉唑钠及其起始原料中基因毒性杂质的分析方法
CN109354587B (zh) * 2018-10-18 2020-09-18 成都天台山制药有限公司 泮托拉唑钠的制备方法和泮托拉唑钠

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9002043D0 (sv) 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
KR960002912B1 (ko) * 1993-02-19 1996-02-28 영진약품공업주식회사 신규한 벤즈이미다졸 유도체
ES2094694B1 (es) 1995-02-01 1997-12-16 Esteve Quimica Sa Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
CN1053444C (zh) * 1996-03-20 2000-06-14 常州市第四制药厂 奥美拉唑的一种精制方法
SK283805B6 (sk) * 1996-09-09 2004-02-03 Slovakofarma, A. S. Spôsob prípravy omeprazolu
SI20019A (sl) * 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola

Also Published As

Publication number Publication date
HK1069168A1 (en) 2005-05-13
ES2261703T3 (es) 2006-11-16
EE200400052A (et) 2004-04-15
EP1409478B1 (fr) 2006-03-29
IL159854A (en) 2008-11-03
PL208291B1 (pl) 2011-04-29
NO324257B1 (no) 2007-09-17
SK287245B6 (sk) 2010-04-07
BRPI0211101B8 (pt) 2021-05-25
US6919459B2 (en) 2005-07-19
WO2003008406A1 (fr) 2003-01-30
BR0211101A (pt) 2004-06-22
HU230155B1 (hu) 2015-09-28
CN1235899C (zh) 2006-01-11
NO20040074L (no) 2004-01-08
EP1409478A1 (fr) 2004-04-21
NZ530168A (en) 2004-08-27
CA2450433C (fr) 2010-05-25
JP2005500333A (ja) 2005-01-06
DE60210292T2 (de) 2006-12-07
AU2002321204B2 (en) 2008-05-08
CZ304526B6 (cs) 2014-06-18
KR20040016877A (ko) 2004-02-25
EA200400185A1 (ru) 2004-06-24
KR100914175B1 (ko) 2009-08-27
IL159854A0 (en) 2004-06-20
JP4320250B2 (ja) 2009-08-26
BR0211101B1 (pt) 2013-12-17
US20040209918A1 (en) 2004-10-21
CZ2004208A3 (cs) 2005-03-16
ATE321758T1 (de) 2006-04-15
MXPA04000433A (es) 2004-03-18
DE60210292D1 (de) 2006-05-18
SK922004A3 (en) 2004-08-03
HUP0400610A2 (hu) 2004-08-30
CA2450433A1 (fr) 2003-01-30
EA005773B1 (ru) 2005-06-30
CN1525970A (zh) 2004-09-01
PL367006A1 (en) 2005-02-07
HUP0400610A3 (en) 2012-09-28

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