KR880005126A - 알킬설피닐 치환된 2- 페닐이미다조[4,5-c] 피리딘의 제조방법 - Google Patents

알킬설피닐 치환된 2- 페닐이미다조[4,5-c] 피리딘의 제조방법 Download PDF

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KR880005126A
KR880005126A KR870011039A KR870011039A KR880005126A KR 880005126 A KR880005126 A KR 880005126A KR 870011039 A KR870011039 A KR 870011039A KR 870011039 A KR870011039 A KR 870011039A KR 880005126 A KR880005126 A KR 880005126A
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South Korea
Prior art keywords
hydrogen
amino
pyridinyl
alkyl
pyridine
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KR870011039A
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English (en)
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앤 고에드 제인
마이클 그린 제임스
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메리 앤 터커
일라이 릴리 앤드 캄파니
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Publication of KR880005126A publication Critical patent/KR880005126A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

알킬설피닐 치환된 2-페닐이미다조[4,5-c] 피리딘의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 일반식(III)의 N-(3-아미노-4-피리디닐)-알킬티오벤즈아미드를 약 -20℃ 내지 약 50℃의 온도에서 저급 알카노산 용매중에서 산화제와 반응시킴을 특징으로 하여, 일반식(Ia) 또는 (Ib)의 알킬설피닐 2-페닐이미다조[4,5-c]피리딘을 제조하는 방법.
    상기식에서, R1은 수소, C1-C4알킬, C1-C4알콕시 또는 할로겐이고 : R3는 22, 42또는 62위치의 C1-C4알킬설피닐이며 : R2및 R4는 독립적으로 수소, 히드록시, 할로, 시아노, 트리플루오로메틸, C1-C4알킬, C1-C4알콕시, C2-C4알케닐옥시, C2-C4알키닐옥시, C1-C4히드록시알킬옥시, 시아노메톡시, 아미노, 모노- 또는 디- C1-C4-알킬아미노이고 : R5는 22, 42또는 62위치의 C1-C4알킬티오이다.
  2. 제1항에 있어서, 과산화수소, 또는 퍼아세트산, 퍼포름산 및 m-클로로퍼벤조산으로 부터 선택된 유기 과산을 사용하는 방법.
  3. 제1항에 있어서, 과산화수소를 사용하는 방법.
  4. 제2항에 있어서, R1및 R4가 수소이고 : R5가 C1-C4알킬티오이며 : R2가 수소, C1-C4알킬, C1-C4알콕시 또는 할로겐인(N-3-아미노-4-피리디닐)알킬티오 벤즈아미드를 사용하는 방법.
  5. 제2항에 있어서, R1및 R4가 수소이고 : R5가 메틸티오이며 : R2가 수소, 메틸, 메톡시 또는 할로겐인(N-3-아미노-4-피리디닐)알킬티오벤즈아미드를 사용하는 방법.
  6. 제2항에 있어서, N-(3-아미노-4-피리디닐)-2-메톡시-4-메틸티오벤즈아미드를 2-[2-메톡시-4-(메틸설피닐)페닐]-이미다조[4,5-c]피리딘으로 전환시키는 방법.
  7. 제1항 내지 제6항에 따른 방법에 의해 제조된 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870011039A 1986-10-03 1987-10-02 알킬설피닐 치환된 2- 페닐이미다조[4,5-c] 피리딘의 제조방법 KR880005126A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US915287 1986-10-03
US06/915,287 US4740599A (en) 1986-10-03 1986-10-03 Synthesis of alkylsulfinyl substituted 2-phenylimidazo(4,5-c)pyridines

Publications (1)

Publication Number Publication Date
KR880005126A true KR880005126A (ko) 1988-06-28

Family

ID=25435510

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870011039A KR880005126A (ko) 1986-10-03 1987-10-02 알킬설피닐 치환된 2- 페닐이미다조[4,5-c] 피리딘의 제조방법

Country Status (7)

Country Link
US (1) US4740599A (ko)
EP (1) EP0266897A1 (ko)
JP (1) JPS6396185A (ko)
KR (1) KR880005126A (ko)
HU (1) HU198715B (ko)
IE (1) IE872638L (ko)
IL (1) IL84008A0 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002223869A (ja) * 2001-02-01 2002-08-13 Sun Wave Ind Co Ltd 流し台後部上方に設けた吊下げ装置

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813407A (en) * 1970-03-19 1974-05-28 Lilly Co Eli Process for the preparation of 1-hydroxy-2-(1,1-difluoroalkyl)benzimidazoles and 1-hydroxy-2-(1,1-difluoroalkyl)-1h-imidazo(4,5-b)pyridines
US3985891A (en) * 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
JPS5521375A (en) * 1978-08-03 1980-02-15 Kuruuzu Robaato Bottle orientation apparatus
DE2927988A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel
DE3273461D1 (en) * 1981-08-19 1986-10-30 Merck Patent Gmbh 2-arylimidazopyridines
ES517193A0 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
IL68495A0 (en) * 1982-05-03 1983-07-31 Lilly Co Eli 2-phenylimidazo(4,5-c)pyridines
DE3217583A1 (de) * 1982-05-11 1983-11-17 Merck Patent Gmbh, 6100 Darmstadt 2-aryl-tetraazaindene
DE3346602A1 (de) * 1983-12-23 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazo(4,5-c)pyridin-one, deren herstellung und diese verbindungen enthaltende arzneimittel
NZ217755A (en) * 1985-10-09 1989-08-29 Chemie Linz Ag 2-(2-thienyl)-imidazo(4,5-c)pyridine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
JPS6396185A (ja) 1988-04-27
HUT45251A (en) 1988-06-28
IE872638L (en) 1988-04-03
US4740599A (en) 1988-04-26
HU198715B (en) 1989-11-28
IL84008A0 (en) 1988-02-29
EP0266897A1 (en) 1988-05-11

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