KR870003985A - 디하이드로피리딘 유도체의 제조방법 - Google Patents

디하이드로피리딘 유도체의 제조방법 Download PDF

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Publication number
KR870003985A
KR870003985A KR860008877A KR860008877A KR870003985A KR 870003985 A KR870003985 A KR 870003985A KR 860008877 A KR860008877 A KR 860008877A KR 860008877 A KR860008877 A KR 860008877A KR 870003985 A KR870003985 A KR 870003985A
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South Korea
Prior art keywords
formula
compound
group
oxidant
dihydropyridine derivative
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KR860008877A
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English (en)
Inventor
알커 데이비드
에드워드 크로스 피터
프래저 캠벨 시몬
Original Assignee
알렌. 제이. 스피겔.
화이자 인코포레이티드
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Application filed by 알렌. 제이. 스피겔., 화이자 인코포레이티드 filed Critical 알렌. 제이. 스피겔.
Publication of KR870003985A publication Critical patent/KR870003985A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)

Abstract

내용 없음

Description

디하이드로피리딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 티올과 반응시켜 m이 0인 일반식(Ⅰ)의 화합물을 수득한 다음 임의로 산화시켜 m이 1 또는 2인 일반식(Ⅰ)의 화합물을 수득함을 특징으로 하여 일반식(Ⅰ)의 1, 4-디하이드로피리딘 유도체를 제조하는 방법.
    상기식에서, R은 임의로 치환된 아릴그룹 또는 헤테로아릴그룹이고, R1및 R2는 각각 독립적으로 C1내지 C4알킬 또는 2-메톡시에틸이며, Y는 -(CH2)n- (여기서, n은 2, 3 또는 4이다), -CH2CH(CH3)- 또는 -CH2C(CH3)2-이고, m은 0, 1 또는 2이며, Q는 우수한 이탈그룹이다.
  2. 제1항에 있어서, Q가 할로, p-톨루엔설포닐옥시, 메탄설포닐옥시, 트리플루오로메탄설포닐옥시 또는 1-이미다졸릴설포닐옥시 그룹인 방법.
  3. 제1항 또는 제2항에 있어서, R이 2-클로로페닐 또는 2, 3-디클로로페닐인 방법.
  4. 제1항에 있어서, R1이 CH3이고 R2가 C2H5이거나, R1이 C2H5이고 R2가 CH3인 방법.
  5. 제1항에 있어서, Y가-(CH2)2-이고, m이 0인 방법.
  6. 제1항에 있어서, 염기의 존재하에 반응을 행하는 방법.
  7. 제6항에 있어서, 염기가 탄산칼륨인 방법.
  8. 제1항에 있어서, 산화제가 1당량의 양으로 존재하여 설피닐 화합물을 수득하거나, 2당량 이상의 양으로 존재하여 설포닐 유도체를 수득하는 방법.
  9. 제1항에 있어서, 산화제가 m-클로로퍼벤조산 또는 나트륨 m-퍼요오데이트인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR860008877A 1985-10-25 1986-10-23 디하이드로피리딘 유도체의 제조방법 KR870003985A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8526411 1985-10-25
GB858526411A GB8526411D0 (en) 1985-10-25 1985-10-25 Dihydropyridines

Publications (1)

Publication Number Publication Date
KR870003985A true KR870003985A (ko) 1987-05-06

Family

ID=10587282

Family Applications (1)

Application Number Title Priority Date Filing Date
KR860008877A KR870003985A (ko) 1985-10-25 1986-10-23 디하이드로피리딘 유도체의 제조방법

Country Status (13)

Country Link
EP (1) EP0221720B1 (ko)
JP (1) JPS62106077A (ko)
KR (1) KR870003985A (ko)
AT (1) ATE54139T1 (ko)
AU (1) AU6436386A (ko)
DE (1) DE3672252D1 (ko)
DK (1) DK509186A (ko)
FI (1) FI864328A (ko)
GB (1) GB8526411D0 (ko)
HU (1) HUT42443A (ko)
IL (1) IL80402A0 (ko)
PT (1) PT83599B (ko)
ZA (1) ZA868104B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601382D0 (en) * 1986-01-21 1986-02-26 Pfizer Ltd Dihydropyridine antiischaemic & antihypertensive agents
IT1213555B (it) * 1986-12-11 1989-12-20 Boehringer Biochemia Srl 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono.
JP4465536B2 (ja) 2007-06-13 2010-05-19 Ｓｍｃ株式会社 電磁弁

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658183A1 (de) * 1976-12-22 1978-07-06 Bayer Ag In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
SE7910521L (sv) * 1979-12-20 1981-06-21 Haessle Ab Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
CA1267416A (en) * 1985-06-17 1990-04-03 Ila Sircar 1,4-dihydropyridine derivatives useful for the treatment of cardiovascular disorders

Also Published As

Publication number Publication date
EP0221720B1 (en) 1990-06-27
AU6436386A (en) 1987-05-14
PT83599B (en) 1988-11-10
IL80402A0 (en) 1987-01-30
EP0221720A2 (en) 1987-05-13
HUT42443A (en) 1987-07-28
ATE54139T1 (de) 1990-07-15
DE3672252D1 (en) 1990-08-02
EP0221720A3 (en) 1988-09-21
ZA868104B (en) 1988-06-29
DK509186D0 (da) 1986-10-24
FI864328A (fi) 1987-04-26
JPS62106077A (ja) 1987-05-16
DK509186A (da) 1987-04-26
FI864328A0 (fi) 1986-10-24
GB8526411D0 (en) 1985-11-27
PT83599A (en) 1986-11-01

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