KR850006407A - 2-아릴이미다조[4,5,-c] 피리딘의 제조방법 - Google Patents

2-아릴이미다조[4,5,-c] 피리딘의 제조방법 Download PDF

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Publication number
KR850006407A
KR850006407A KR1019850001060A KR850001060A KR850006407A KR 850006407 A KR850006407 A KR 850006407A KR 1019850001060 A KR1019850001060 A KR 1019850001060A KR 850001060 A KR850001060 A KR 850001060A KR 850006407 A KR850006407 A KR 850006407A
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South Korea
Prior art keywords
alkyl
halo
sulfinyl
trifluoromethyl
alkoxy
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KR1019850001060A
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English (en)
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웨인 로버트슨 데이비드
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마리 앤 터커
일라이 릴리 앤드 캄파니
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Publication of KR850006407A publication Critical patent/KR850006407A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

2-아릴아미다조[4,5-c] 피리딘의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식(Ⅳ)의 화합물 또는 이의 토오토머를 하기 일반식(Ⅴ)의 할로화합물과 반응시킴을 특징으로 하여, 하기 일반식(Ⅰ) 및 (Ⅰa)의 화합물 또는 이의 제약학상 허용되는 염을 제조하는 방법.
    상기 일반식에서, R1은 수소, C1-C4알킬, C1-C4알콕시, 알릴옥시, 프로파길옥시, 벤질옥시, (C1-C4알킬)티오, (C1-C4알킬)설피닐, (C1-C4알킬)설포닐, 하이드록시, 할로, 시아노, 니트로, 아미노, 모노-또는 디-(C1-C4알킬)아미노, 트리플루오로메틸 또는 Z-Q치환된 C1-C4알콕시 [여기서, Q는 산소, 황, 설피닐, 설포닐 또는 하나의 결합을 나타내고, Z는 C1-C4알킬, 페닐 또는 치환된 페닐(여기서, 치환체는 할로, C1-C4알킬, C1-C4알콕시, 하이드록시, 니트로, 아미노, (C1-C4알킬)티오, (C1-C4알킬)설피닐, 또는 (C1-C4알킬)설포닐이다)이다]이고; Y는 -O- 또는 -NH-이고; G는 C=O 또는 -S(O)r--(여기서 r은 0,1 또는 2이다)이고; R2는 C1-C4알킬, 페닐, 트리플루오로메틸 또는 -NR3R4(여기서 R3및 R4는 각각 수소 또는 C1-C3알킬이다)이며; X는 할로이고; 단, R2가 트리플루오로메틸 또는 -NR3R4이고 G가 -S(O)r-이면, r은 0 또는 1일 수 없고, Y가 -O-이고 G가 -S(O)r-이면, r은 0 또는 1일 수 없다.
  2. 제1항에 있어서, R1이 메톡시인 방법.
  3. 제2항에 있어서, -GR2가 메탄설포닐인 방법.
  4. 제3항에 있어서, Y가 -O-인 방법.
  5. 제3항에 있어서, Y가 -NH-인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850001060A 1984-02-24 1985-02-21 2-아릴이미다조[4,5,-c] 피리딘의 제조방법 KR850006407A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58351884A 1984-02-24 1984-02-24
US583518 1984-02-24

Publications (1)

Publication Number Publication Date
KR850006407A true KR850006407A (ko) 1985-10-05

Family

ID=24333426

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850001060A KR850006407A (ko) 1984-02-24 1985-02-21 2-아릴이미다조[4,5,-c] 피리딘의 제조방법

Country Status (11)

Country Link
EP (1) EP0155094A1 (ko)
JP (1) JPS60202884A (ko)
KR (1) KR850006407A (ko)
AU (1) AU3901385A (ko)
DK (1) DK79485A (ko)
ES (1) ES8601990A1 (ko)
GR (1) GR850426B (ko)
HU (1) HUT37793A (ko)
IL (1) IL74372A0 (ko)
PT (1) PT79987B (ko)
ZA (1) ZA851236B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4720501A (en) * 1985-10-09 1988-01-19 Chemi Linz Aktiengesellschaft 2-(2-thienyl)-imidazo(4,5-c)pyridine derivatives and salts thereof useful in the treatment of myocardial insufficiency
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
AU3820989A (en) * 1988-08-02 1990-02-08 Ciba-Geigy Ag 7-amino-3-beta-d-ribofuranosyl-3h-imidazo(4,5-b) pyridin-5-amine derivatives
US4977144A (en) * 1988-08-02 1990-12-11 Ciba-Geigy Corporation Imidazo[4,5-b]pyridine derivatives as cardiovascular agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3273461D1 (en) * 1981-08-19 1986-10-30 Merck Patent Gmbh 2-arylimidazopyridines
ES8401486A1 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
ZA832938B (en) * 1982-05-03 1984-12-24 Lilly Co Eli 2-phenylimidazo(4,5-c)pyridines
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
GR850426B (ko) 1985-06-18
EP0155094A1 (en) 1985-09-18
ES540589A0 (es) 1985-11-16
PT79987B (en) 1987-02-02
AU3901385A (en) 1985-09-05
DK79485A (da) 1985-09-24
JPS60202884A (ja) 1985-10-14
IL74372A0 (en) 1985-05-31
PT79987A (en) 1985-03-01
ES8601990A1 (es) 1985-11-16
HUT37793A (en) 1986-02-28
DK79485D0 (da) 1985-02-21
ZA851236B (en) 1986-09-24

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