EE05273B1 - Epotilooni analoogi polmorfid, meetod nende saamiseks ning kasutamine - Google Patents

Epotilooni analoogi polmorfid, meetod nende saamiseks ning kasutamine

Info

Publication number
EE05273B1
EE05273B1 EEP200300063A EEP200300063A EE05273B1 EE 05273 B1 EE05273 B1 EE 05273B1 EE P200300063 A EEP200300063 A EE P200300063A EE P200300063 A EEP200300063 A EE P200300063A EE 05273 B1 EE05273 B1 EE 05273B1
Authority
EE
Estonia
Prior art keywords
polymorphs
epothilone analog
epothilone
analog
Prior art date
Application number
EEP200300063A
Other languages
English (en)
Estonian (et)
Inventor
D. Dimarco John
Z. Gougoutas Jack
M. Vitez Imre
Davidovich Martha
Galella Michael
M. Malloy Timothy
Guo Zhenrong
Favreau Denis
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22845469&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE05273(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of EE200300063A publication Critical patent/EE200300063A/xx
Publication of EE05273B1 publication Critical patent/EE05273B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EEP200300063A 2000-08-16 2001-08-01 Epotilooni analoogi polmorfid, meetod nende saamiseks ning kasutamine EE05273B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22559000P 2000-08-16 2000-08-16
PCT/US2001/024540 WO2002014323A2 (en) 2000-08-16 2001-08-01 Polymorphs of an epothilone analog

Publications (2)

Publication Number Publication Date
EE200300063A EE200300063A (et) 2004-12-15
EE05273B1 true EE05273B1 (et) 2010-02-15

Family

ID=22845469

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300063A EE05273B1 (et) 2000-08-16 2001-08-01 Epotilooni analoogi polmorfid, meetod nende saamiseks ning kasutamine

Country Status (42)

Country Link
US (4) US6689802B2 (el)
EP (1) EP1309597B1 (el)
JP (1) JP5046467B2 (el)
KR (1) KR100810342B1 (el)
CN (1) CN1269821C (el)
AR (1) AR034259A1 (el)
AT (1) ATE366735T1 (el)
AU (2) AU8108201A (el)
BG (1) BG66132B1 (el)
BR (1) BR0113234A (el)
CA (1) CA2418109C (el)
CY (1) CY1107758T1 (el)
CZ (1) CZ305523B6 (el)
DE (1) DE60129334T2 (el)
DK (1) DK1309597T3 (el)
EE (1) EE05273B1 (el)
ES (1) ES2288518T3 (el)
GE (1) GEP20053495B (el)
HK (1) HK1052010A1 (el)
HR (1) HRP20030190B1 (el)
HU (1) HU229314B1 (el)
IL (2) IL153993A0 (el)
IS (1) IS2845B (el)
LT (1) LT5138B (el)
LV (1) LV13032B (el)
MX (1) MXPA03001431A (el)
MY (1) MY134129A (el)
NO (1) NO328500B1 (el)
NZ (1) NZ523722A (el)
PE (1) PE20020290A1 (el)
PL (1) PL205628B1 (el)
PT (1) PT1309597E (el)
RO (1) RO123296B1 (el)
RU (1) RU2272039C2 (el)
SI (1) SI21100B (el)
SK (1) SK287876B6 (el)
TW (1) TWI320040B (el)
UA (1) UA75365C2 (el)
UY (1) UY26886A1 (el)
WO (1) WO2002014323A2 (el)
YU (1) YU12103A (el)
ZA (1) ZA200300522B (el)

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US6518421B1 (en) * 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
MXPA03006412A (es) * 2001-01-25 2003-10-15 Bristol Myers Squibb Co Metodos para administrar analogos de epotilona para tratamiento de cancer.
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CN103183681B (zh) * 2013-03-06 2016-01-13 浙江海正药业股份有限公司 伊沙匹隆的新晶型及其制备方法
EP2968582B1 (en) 2013-03-15 2020-07-01 Innate Pharma Solid phase tgase-mediated conjugation of antibodies
EP3010547B1 (en) 2013-06-20 2021-04-21 Innate Pharma Enzymatic conjugation of polypeptides
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WO2019092148A1 (en) 2017-11-10 2019-05-16 Innate Pharma Antibodies with functionalized glutamine residues
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CN112457320A (zh) * 2020-11-30 2021-03-09 湖北宏中药业股份有限公司 一种提高伊沙匹隆合成反应速率的方法
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CN112409366A (zh) * 2020-11-30 2021-02-26 湖北宏中药业股份有限公司 一种伊沙匹隆二聚体的高收率制备方法

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Also Published As

Publication number Publication date
HUP0300826A2 (hu) 2003-09-29
AU8108201A (en) 2002-02-25
CA2418109A1 (en) 2002-02-21
NO20030707D0 (no) 2003-02-14
CZ305523B6 (cs) 2015-11-18
DE60129334D1 (en) 2007-08-23
PE20020290A1 (es) 2002-04-03
UA75365C2 (en) 2006-04-17
UY26886A1 (es) 2002-03-22
AR034259A1 (es) 2004-02-18
WO2002014323A3 (en) 2002-05-02
ES2288518T3 (es) 2008-01-16
SK287876B6 (sk) 2012-02-03
SI21100A (sl) 2003-06-30
HRP20030190B1 (en) 2011-07-31
CY1107758T1 (el) 2013-06-19
US20020188014A1 (en) 2002-12-12
PT1309597E (pt) 2007-08-22
PL365610A1 (en) 2005-01-10
BG107467A (bg) 2003-09-30
RU2272039C2 (ru) 2006-03-20
US6689802B2 (en) 2004-02-10
BG66132B1 (bg) 2011-06-30
YU12103A (sh) 2006-08-17
ZA200300522B (en) 2004-04-20
NO20030707L (no) 2003-04-15
IL153993A0 (en) 2003-07-31
RO123296B1 (ro) 2011-06-30
CA2418109C (en) 2011-09-27
IS6714A (is) 2003-02-11
HU229314B1 (en) 2013-10-28
WO2002014323A2 (en) 2002-02-21
CN1269821C (zh) 2006-08-16
LT2003017A (en) 2004-03-25
USRE39251E1 (en) 2006-08-29
EP1309597A2 (en) 2003-05-14
CZ2003418A3 (cs) 2004-01-14
NO328500B1 (no) 2010-03-01
ATE366735T1 (de) 2007-08-15
KR20030022411A (ko) 2003-03-15
US20060063815A1 (en) 2006-03-23
SK1342003A3 (en) 2003-09-11
IS2845B (is) 2013-08-15
TWI320040B (en) 2010-02-01
HRP20030190A2 (en) 2003-04-30
US20040157897A1 (en) 2004-08-12
JP5046467B2 (ja) 2012-10-10
PL205628B1 (pl) 2010-05-31
GEP20053495B (en) 2005-04-25
IL153993A (en) 2009-07-20
HUP0300826A3 (en) 2005-05-30
KR100810342B1 (ko) 2008-03-07
BR0113234A (pt) 2004-02-25
AU2001281082B2 (en) 2007-01-04
JP2004506638A (ja) 2004-03-04
MXPA03001431A (es) 2004-05-04
DK1309597T3 (da) 2007-10-22
LV13032B (en) 2003-12-20
EE200300063A (et) 2004-12-15
US7153879B2 (en) 2006-12-26
SI21100B (sl) 2009-12-31
MY134129A (en) 2007-11-30
DE60129334T2 (de) 2008-04-03
LT5138B (lt) 2004-06-25
EP1309597B1 (en) 2007-07-11
HK1052010A1 (en) 2003-08-29
NZ523722A (en) 2005-04-29
CN1468243A (zh) 2004-01-14
US6982276B2 (en) 2006-01-03

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