EE05273B1 - Epotilooni analoogi polmorfid, meetod nende saamiseks ning kasutamine - Google Patents
Epotilooni analoogi polmorfid, meetod nende saamiseks ning kasutamineInfo
- Publication number
- EE05273B1 EE05273B1 EEP200300063A EEP200300063A EE05273B1 EE 05273 B1 EE05273 B1 EE 05273B1 EE P200300063 A EEP200300063 A EE P200300063A EE P200300063 A EEP200300063 A EE P200300063A EE 05273 B1 EE05273 B1 EE 05273B1
- Authority
- EE
- Estonia
- Prior art keywords
- polymorphs
- epothilone analog
- epothilone
- analog
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22559000P | 2000-08-16 | 2000-08-16 | |
PCT/US2001/024540 WO2002014323A2 (en) | 2000-08-16 | 2001-08-01 | Polymorphs of an epothilone analog |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200300063A EE200300063A (et) | 2004-12-15 |
EE05273B1 true EE05273B1 (et) | 2010-02-15 |
Family
ID=22845469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200300063A EE05273B1 (et) | 2000-08-16 | 2001-08-01 | Epotilooni analoogi polmorfid, meetod nende saamiseks ning kasutamine |
Country Status (42)
Country | Link |
---|---|
US (4) | US6689802B2 (el) |
EP (1) | EP1309597B1 (el) |
JP (1) | JP5046467B2 (el) |
KR (1) | KR100810342B1 (el) |
CN (1) | CN1269821C (el) |
AR (1) | AR034259A1 (el) |
AT (1) | ATE366735T1 (el) |
AU (2) | AU8108201A (el) |
BG (1) | BG66132B1 (el) |
BR (1) | BR0113234A (el) |
CA (1) | CA2418109C (el) |
CY (1) | CY1107758T1 (el) |
CZ (1) | CZ305523B6 (el) |
DE (1) | DE60129334T2 (el) |
DK (1) | DK1309597T3 (el) |
EE (1) | EE05273B1 (el) |
ES (1) | ES2288518T3 (el) |
GE (1) | GEP20053495B (el) |
HK (1) | HK1052010A1 (el) |
HR (1) | HRP20030190B1 (el) |
HU (1) | HU229314B1 (el) |
IL (2) | IL153993A0 (el) |
IS (1) | IS2845B (el) |
LT (1) | LT5138B (el) |
LV (1) | LV13032B (el) |
MX (1) | MXPA03001431A (el) |
MY (1) | MY134129A (el) |
NO (1) | NO328500B1 (el) |
NZ (1) | NZ523722A (el) |
PE (1) | PE20020290A1 (el) |
PL (1) | PL205628B1 (el) |
PT (1) | PT1309597E (el) |
RO (1) | RO123296B1 (el) |
RU (1) | RU2272039C2 (el) |
SI (1) | SI21100B (el) |
SK (1) | SK287876B6 (el) |
TW (1) | TWI320040B (el) |
UA (1) | UA75365C2 (el) |
UY (1) | UY26886A1 (el) |
WO (1) | WO2002014323A2 (el) |
YU (1) | YU12103A (el) |
ZA (1) | ZA200300522B (el) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
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US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
CA2273083C (en) * | 1996-12-03 | 2012-09-18 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6518421B1 (en) * | 2000-03-20 | 2003-02-11 | Bristol-Myers Squibb Company | Process for the preparation of epothilone analogs |
MXPA03006412A (es) * | 2001-01-25 | 2003-10-15 | Bristol Myers Squibb Co | Metodos para administrar analogos de epotilona para tratamiento de cancer. |
SK8552003A3 (en) * | 2001-01-25 | 2004-06-08 | Bristol Myers Squibb Co | Parenteral formulation containing epothilone analogs |
CA2438610A1 (en) | 2001-02-20 | 2002-08-29 | Francis Y. F. Lee | Treatment of refractory tumors using epothilone derivatives |
JP2004529904A (ja) * | 2001-03-14 | 2004-09-30 | ブリストル−マイヤーズ スクイブ カンパニー | 増殖性疾患の治療のためのエポシロン類似体および化学療法剤の組み合わせ |
PL371098A1 (en) * | 2002-03-08 | 2005-06-13 | Novartis Ag | Combinations comprising epothilone derivatives and alkylating agents |
US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
DE60310916T2 (de) * | 2002-08-23 | 2007-11-15 | Sloan-Kettering Institute For Cancer Research | Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen |
US7649006B2 (en) * | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
ITMI20032144A1 (it) * | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
US20090004277A1 (en) * | 2004-05-18 | 2009-01-01 | Franchini Miriam K | Nanoparticle dispersion containing lactam compound |
EP1640004A1 (en) * | 2004-09-24 | 2006-03-29 | Schering Aktiengesellschaft | Use of epothilones in the treatment of bone metastases and bone tumors or cancers |
JP2008520696A (ja) | 2004-11-18 | 2008-06-19 | ブリストル−マイヤーズ スクイブ カンパニー | イキサベピロンを含む腸溶性被覆ビーズおよびその製造 |
EP1824458A1 (en) * | 2004-11-18 | 2007-08-29 | Bristol-Myers Squibb Company | Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof |
US20060121511A1 (en) | 2004-11-30 | 2006-06-08 | Hyerim Lee | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
EP1674098A1 (en) | 2004-12-23 | 2006-06-28 | Schering Aktiengesellschaft | Stable and tolerable parental formulations of highly reactive organic drug substances with low or no solubility in water |
EP1856255A4 (en) | 2005-02-11 | 2010-01-27 | Univ Southern California | METHODS OF EXPRESSING PROTEINS WITH DISULFIDE BRIDGES |
SI1698630T1 (sl) * | 2005-03-03 | 2015-01-30 | Alfa Wassermann S.P.A. | Nove polimorfne oblike rifaksimina, postopki za njihovo pripravo in njihova uporaba v medicinskih pripravkih |
CA2607940C (en) | 2005-05-18 | 2009-12-15 | Aegera Therapeutics Inc. | Bir domain binding compounds |
US7693596B2 (en) | 2005-12-14 | 2010-04-06 | Dell Products L.P. | System and method for configuring information handling system integrated circuits |
US20080286325A1 (en) * | 2006-01-05 | 2008-11-20 | Med Institute, Inc. | Cyclodextrin elution media for medical device coatings comprising a taxane therapeutic agent |
US7919108B2 (en) * | 2006-03-10 | 2011-04-05 | Cook Incorporated | Taxane coatings for implantable medical devices |
US7875284B2 (en) * | 2006-03-10 | 2011-01-25 | Cook Incorporated | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
JP2009532035A (ja) | 2006-03-31 | 2009-09-10 | ブリストル−マイヤーズ スクイブ カンパニー | 微小管安定化剤に対する感受性を決定するためのバイオマーカーおよび方法 |
US8008256B2 (en) * | 2006-05-01 | 2011-08-30 | University Of Southern California | Combination therapy for treatment of cancer |
CN101535300B (zh) | 2006-05-16 | 2014-05-28 | 埃格拉医疗公司 | Iap bir域结合化合物 |
PE20081317A1 (es) * | 2006-08-16 | 2008-10-28 | Novartis Ag | Formas de cristal de la epotilona b |
US8463852B2 (en) * | 2006-10-06 | 2013-06-11 | Oracle International Corporation | Groupware portlets for integrating a portal with groupware systems |
US20110124690A1 (en) * | 2007-02-23 | 2011-05-26 | Danishefsky Samuel J | Compositions and methods for treating cancer or a neurotrophic disorder |
EP2065054A1 (en) | 2007-11-29 | 2009-06-03 | Bayer Schering Pharma Aktiengesellschaft | Combinations comprising a prostaglandin and uses thereof |
EP2070521A1 (en) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Surface-modified nanoparticles |
DE102007059752A1 (de) | 2007-12-10 | 2009-06-18 | Bayer Schering Pharma Aktiengesellschaft | Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone |
WO2010056901A2 (en) | 2008-11-13 | 2010-05-20 | University Of Southern California | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
EP2210584A1 (en) | 2009-01-27 | 2010-07-28 | Bayer Schering Pharma Aktiengesellschaft | Stable polymeric composition comprising an epothilone and an amphiphilic block copolymer |
SG10201501095WA (en) | 2010-02-12 | 2015-04-29 | Pharmascience Inc | Iap bir domain binding compounds |
IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
JP2013527239A (ja) * | 2010-06-01 | 2013-06-27 | プラス・ケミカルス・エスアー | イクサベピロンの固体形 |
WO2013092998A1 (en) | 2011-12-23 | 2013-06-27 | Innate Pharma | Enzymatic conjugation of antibodies |
ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
US10132799B2 (en) | 2012-07-13 | 2018-11-20 | Innate Pharma | Screening of conjugated antibodies |
US10036010B2 (en) | 2012-11-09 | 2018-07-31 | Innate Pharma | Recognition tags for TGase-mediated conjugation |
CN103183681B (zh) * | 2013-03-06 | 2016-01-13 | 浙江海正药业股份有限公司 | 伊沙匹隆的新晶型及其制备方法 |
EP2968582B1 (en) | 2013-03-15 | 2020-07-01 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
EP3010547B1 (en) | 2013-06-20 | 2021-04-21 | Innate Pharma | Enzymatic conjugation of polypeptides |
EP3010548A1 (en) | 2013-06-21 | 2016-04-27 | Innate Pharma | Enzymatic conjugation of polypeptides |
WO2019092148A1 (en) | 2017-11-10 | 2019-05-16 | Innate Pharma | Antibodies with functionalized glutamine residues |
US20230062248A1 (en) | 2020-01-31 | 2023-03-02 | Allarity Therapeutics Europe ApS | Methods for predicting ixabepilone responsiveness in cancer patients |
CN112457320A (zh) * | 2020-11-30 | 2021-03-09 | 湖北宏中药业股份有限公司 | 一种提高伊沙匹隆合成反应速率的方法 |
CN112375085A (zh) * | 2020-11-30 | 2021-02-19 | 湖北宏中药业股份有限公司 | 一种伊沙匹隆反应液的高收率高纯度处理方法 |
CN112409366A (zh) * | 2020-11-30 | 2021-02-26 | 湖北宏中药业股份有限公司 | 一种伊沙匹隆二聚体的高收率制备方法 |
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-
2001
- 2001-01-08 UA UA2003032259A patent/UA75365C2/uk unknown
- 2001-07-26 MY MYPI20013545 patent/MY134129A/en unknown
- 2001-08-01 RO ROA200300114A patent/RO123296B1/ro unknown
- 2001-08-01 DE DE60129334T patent/DE60129334T2/de not_active Expired - Lifetime
- 2001-08-01 YU YU12103A patent/YU12103A/sh unknown
- 2001-08-01 AT AT01959536T patent/ATE366735T1/de active
- 2001-08-01 RU RU2003106431/04A patent/RU2272039C2/ru active
- 2001-08-01 CZ CZ2003-418A patent/CZ305523B6/cs not_active IP Right Cessation
- 2001-08-01 WO PCT/US2001/024540 patent/WO2002014323A2/en active IP Right Grant
- 2001-08-01 PT PT01959536T patent/PT1309597E/pt unknown
- 2001-08-01 AU AU8108201A patent/AU8108201A/xx active Pending
- 2001-08-01 CN CNB018170641A patent/CN1269821C/zh not_active Expired - Lifetime
- 2001-08-01 MX MXPA03001431A patent/MXPA03001431A/es active IP Right Grant
- 2001-08-01 GE GE5091A patent/GEP20053495B/en unknown
- 2001-08-01 DK DK01959536T patent/DK1309597T3/da active
- 2001-08-01 KR KR1020037002256A patent/KR100810342B1/ko not_active IP Right Cessation
- 2001-08-01 ES ES01959536T patent/ES2288518T3/es not_active Expired - Lifetime
- 2001-08-01 NZ NZ523722A patent/NZ523722A/en not_active IP Right Cessation
- 2001-08-01 EP EP01959536A patent/EP1309597B1/en not_active Expired - Lifetime
- 2001-08-01 SK SK134-2003A patent/SK287876B6/sk not_active IP Right Cessation
- 2001-08-01 SI SI200120055A patent/SI21100B/sl not_active IP Right Cessation
- 2001-08-01 BR BR0113234-2A patent/BR0113234A/pt active Search and Examination
- 2001-08-01 IL IL15399301A patent/IL153993A0/xx unknown
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