EE05273B1 - Epotilooni analoogi polmorfid, meetod nende saamiseks ning kasutamine - Google Patents
Epotilooni analoogi polmorfid, meetod nende saamiseks ning kasutamineInfo
- Publication number
- EE05273B1 EE05273B1 EEP200300063A EEP200300063A EE05273B1 EE 05273 B1 EE05273 B1 EE 05273B1 EE P200300063 A EEP200300063 A EE P200300063A EE P200300063 A EEP200300063 A EE P200300063A EE 05273 B1 EE05273 B1 EE 05273B1
- Authority
- EE
- Estonia
- Prior art keywords
- polymorphs
- epothilone analog
- epothilone
- analog
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22559000P | 2000-08-16 | 2000-08-16 | |
| PCT/US2001/024540 WO2002014323A2 (en) | 2000-08-16 | 2001-08-01 | Polymorphs of an epothilone analog |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200300063A EE200300063A (et) | 2004-12-15 |
| EE05273B1 true EE05273B1 (et) | 2010-02-15 |
Family
ID=22845469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200300063A EE05273B1 (et) | 2000-08-16 | 2001-08-01 | Epotilooni analoogi polmorfid, meetod nende saamiseks ning kasutamine |
Country Status (41)
| Country | Link |
|---|---|
| US (4) | US6689802B2 (de) |
| EP (1) | EP1309597B1 (de) |
| JP (1) | JP5046467B2 (de) |
| KR (1) | KR100810342B1 (de) |
| CN (1) | CN1269821C (de) |
| AR (1) | AR034259A1 (de) |
| AT (1) | ATE366735T1 (de) |
| AU (2) | AU2001281082B2 (de) |
| BG (1) | BG66132B1 (de) |
| BR (1) | BR0113234A (de) |
| CA (1) | CA2418109C (de) |
| CY (1) | CY1107758T1 (de) |
| CZ (1) | CZ305523B6 (de) |
| DE (1) | DE60129334T2 (de) |
| DK (1) | DK1309597T3 (de) |
| EE (1) | EE05273B1 (de) |
| ES (1) | ES2288518T3 (de) |
| GE (1) | GEP20053495B (de) |
| HR (1) | HRP20030190B1 (de) |
| HU (1) | HU229314B1 (de) |
| IL (2) | IL153993A0 (de) |
| IS (1) | IS2845B (de) |
| LT (1) | LT5138B (de) |
| LV (1) | LV13032B (de) |
| MX (1) | MXPA03001431A (de) |
| MY (1) | MY134129A (de) |
| NO (1) | NO328500B1 (de) |
| NZ (1) | NZ523722A (de) |
| PE (1) | PE20020290A1 (de) |
| PL (1) | PL205628B1 (de) |
| PT (1) | PT1309597E (de) |
| RO (1) | RO123296B1 (de) |
| RU (1) | RU2272039C2 (de) |
| SI (1) | SI21100B (de) |
| SK (1) | SK287876B6 (de) |
| TW (1) | TWI320040B (de) |
| UA (1) | UA75365C2 (de) |
| UY (1) | UY26886A1 (de) |
| WO (1) | WO2002014323A2 (de) |
| YU (1) | YU12103A (de) |
| ZA (1) | ZA200300522B (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999001124A1 (en) * | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6518421B1 (en) * | 2000-03-20 | 2003-02-11 | Bristol-Myers Squibb Company | Process for the preparation of epothilone analogs |
| IL156580A0 (en) * | 2001-01-25 | 2004-01-04 | Bristol Myers Squibb Co | A method for formulating an epothilone analog for parenteral use and pharmaceutical preparations including an epothilone analog |
| AU2002245296B2 (en) * | 2001-01-25 | 2006-12-21 | Bristol-Myers Squibb Company | Methods of administering epothilone analogs for the treatment of cancer |
| BR0207487A (pt) | 2001-02-20 | 2004-08-10 | Brystol Myers Squibb Company | Método de tratamento de tumores em mamìferos e uso de compostos de epotilona |
| WO2002072085A1 (en) * | 2001-03-14 | 2002-09-19 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| EP1485090B1 (de) * | 2002-03-08 | 2007-10-10 | Novartis AG | Kombinationspräparat aus epothilone derivate und imidazotetrazinone |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| DE60330407D1 (de) * | 2002-08-23 | 2010-01-14 | Sloan Kettering Inst Cancer | Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| ITMI20032144A1 (it) * | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
| US20090004277A1 (en) * | 2004-05-18 | 2009-01-01 | Franchini Miriam K | Nanoparticle dispersion containing lactam compound |
| EP1640004A1 (de) * | 2004-09-24 | 2006-03-29 | Schering Aktiengesellschaft | Verwendung von Epothilonen zur Behandlung von Knochenmetastasen und Knochentumoren oder Knochenkrebs |
| EP1824458A1 (de) * | 2004-11-18 | 2007-08-29 | Bristol-Myers Squibb Company | Kügelchen mit magensaftresistentem überzug mit epothilon oder einem epothilon-analogon und seine herstellung und verabreichung |
| AR052142A1 (es) | 2004-11-18 | 2007-03-07 | Bristol Myers Squibb Co | Perla recubierta enterica que comprende ixabepilona, y preparacion y administracion de la misma |
| US20060121511A1 (en) | 2004-11-30 | 2006-06-08 | Hyerim Lee | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
| EP1674098A1 (de) | 2004-12-23 | 2006-06-28 | Schering Aktiengesellschaft | Stabile, unbedenkliche parenterale Formulierungen von hochreaktiven organischen Arzneimitteln mit niedriger oder keiner wässrigen Löslichkeit |
| EP2634252B1 (de) | 2005-02-11 | 2018-12-19 | University of Southern California | Verfahren zur Expression von Proteinen mit Disulfidbrücken |
| PT1698630E (pt) * | 2005-03-03 | 2014-09-15 | Alfa Wassermann Spa | Novas formas polimorfas de rifaximina, processos para a sua produção e a sua utilização nas preparações medicinais |
| US7772177B2 (en) | 2005-05-18 | 2010-08-10 | Aegera Therapeutics, Inc. | BIR domain binding compounds |
| US7693596B2 (en) | 2005-12-14 | 2010-04-06 | Dell Products L.P. | System and method for configuring information handling system integrated circuits |
| US20080286325A1 (en) * | 2006-01-05 | 2008-11-20 | Med Institute, Inc. | Cyclodextrin elution media for medical device coatings comprising a taxane therapeutic agent |
| US7919108B2 (en) * | 2006-03-10 | 2011-04-05 | Cook Incorporated | Taxane coatings for implantable medical devices |
| US7875284B2 (en) * | 2006-03-10 | 2011-01-25 | Cook Incorporated | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
| US20110104664A1 (en) | 2006-03-31 | 2011-05-05 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to micortubule-stabilizing agents |
| US8008256B2 (en) * | 2006-05-01 | 2011-08-30 | University Of Southern California | Combination therapy for treatment of cancer |
| AU2007250443B2 (en) | 2006-05-16 | 2013-06-13 | Pharmascience Inc. | IAP BIR domain binding compounds |
| US8178566B2 (en) * | 2006-08-16 | 2012-05-15 | Novartis Ag | Crystal form of epothilone B and use in pharmaceutical compositions |
| US8463852B2 (en) * | 2006-10-06 | 2013-06-11 | Oracle International Corporation | Groupware portlets for integrating a portal with groupware systems |
| WO2008103916A2 (en) * | 2007-02-23 | 2008-08-28 | The Trustees Of Columbia Univeristy In The City Of New York | Compositions and methods for treating cancer or a neurotrophic disorder |
| EP2065054A1 (de) | 2007-11-29 | 2009-06-03 | Bayer Schering Pharma Aktiengesellschaft | Kombinationen mit einem Prostaglandin und Verwendungen davon |
| DE102007059752A1 (de) | 2007-12-10 | 2009-06-18 | Bayer Schering Pharma Aktiengesellschaft | Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone |
| EP2070521A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Nanopartikel mit modifizierter Oberfläche |
| WO2010056901A2 (en) | 2008-11-13 | 2010-05-20 | University Of Southern California | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| EP2210584A1 (de) | 2009-01-27 | 2010-07-28 | Bayer Schering Pharma Aktiengesellschaft | Stabile Polymerzusammensetzung mit einem Epothilon und einem amphiphilischen Blockpolymer |
| WO2011098904A1 (en) | 2010-02-12 | 2011-08-18 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
| IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
| KR20130086534A (ko) * | 2010-06-01 | 2013-08-02 | 플러스 케미칼스, 에스.에이. | 익사베필론의 고체 형태 |
| US9764038B2 (en) | 2011-12-23 | 2017-09-19 | Innate Pharma | Enzymatic conjugation of antibodies |
| ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
| WO2014009426A2 (en) | 2012-07-13 | 2014-01-16 | Innate Pharma | Screening of conjugated antibodies |
| US10036010B2 (en) | 2012-11-09 | 2018-07-31 | Innate Pharma | Recognition tags for TGase-mediated conjugation |
| CN103183681B (zh) * | 2013-03-06 | 2016-01-13 | 浙江海正药业股份有限公司 | 伊沙匹隆的新晶型及其制备方法 |
| EP2968582B1 (de) | 2013-03-15 | 2020-07-01 | Innate Pharma | Festphasen-tgase-vermittelte konjugation von antikörpern |
| EP3010547B1 (de) | 2013-06-20 | 2021-04-21 | Innate Pharma | Enzymatische konjugation von polypeptiden |
| JP6744212B2 (ja) | 2013-06-21 | 2020-08-19 | イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. | ポリペプチドの酵素的結合 |
| WO2019092148A1 (en) | 2017-11-10 | 2019-05-16 | Innate Pharma | Antibodies with functionalized glutamine residues |
| US20230062248A1 (en) | 2020-01-31 | 2023-03-02 | Allarity Therapeutics Europe ApS | Methods for predicting ixabepilone responsiveness in cancer patients |
| CN112409366A (zh) * | 2020-11-30 | 2021-02-26 | 湖北宏中药业股份有限公司 | 一种伊沙匹隆二聚体的高收率制备方法 |
| CN112457320A (zh) * | 2020-11-30 | 2021-03-09 | 湖北宏中药业股份有限公司 | 一种提高伊沙匹隆合成反应速率的方法 |
| CN112375085A (zh) * | 2020-11-30 | 2021-02-19 | 湖北宏中药业股份有限公司 | 一种伊沙匹隆反应液的高收率高纯度处理方法 |
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| GB1000809A (en) * | 1960-11-02 | 1965-08-11 | James Oakes & Company Riddings | Pipe manufacture |
| DE2308418B2 (de) * | 1972-06-21 | 1976-04-08 | Petzetakis, Aristovoulos George, Moschaton, Piräus (Griechenland) | Verfahren und vorrichtung zum herstellen eines insbesondere grosskalibrigen rohres aus thermoplastischem kunststoff |
| JPS5240337B2 (de) * | 1973-01-29 | 1977-10-12 | ||
| SE386365B (sv) * | 1973-07-25 | 1976-08-09 | L Brendling | Behallare av plast, gummi eller annat bojligt material, spec. avsedd for uppsamling av urin och/eller fekalier |
| JPS6398413A (ja) * | 1986-10-15 | 1988-04-28 | Smc Corp | 二重管およびその連続製造法 |
| DE3927569A1 (de) * | 1989-08-21 | 1991-02-28 | Fritz Egger Gmbh | Elektroabscheider zum abscheiden von schwebstoffen aus gasen |
| DE3939714A1 (de) * | 1989-12-01 | 1991-06-06 | Baedje K H Meteor Gummiwerke | Schlauch |
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| DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
| DE4206096A1 (de) * | 1992-02-27 | 1993-09-02 | Wolf Woco & Co Franz J | Koaxialrohr |
| DK1186606T4 (da) | 1995-11-17 | 2011-12-05 | Biotechnolog Forschung Gmbh | Epothilonderivater, deres fremstilling og anvendelse |
| DE19639456A1 (de) | 1996-09-25 | 1998-03-26 | Biotechnolog Forschung Gmbh | Epothilon-Derivate, Herstellung und Mittel |
| DE19542986A1 (de) | 1995-11-17 | 1997-05-22 | Biotechnolog Forschung Gmbh | Epothilon-Derivate und deren Verwendung |
| EP0923583A1 (de) | 1996-08-30 | 1999-06-23 | Novartis AG | Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens |
| DE19645362A1 (de) | 1996-10-28 | 1998-04-30 | Ciba Geigy Ag | Verfahren zur Herstellung von Epothilon A und B und Derivaten |
| DE19636343C1 (de) | 1996-08-30 | 1997-10-23 | Schering Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B |
| DE19645361A1 (de) | 1996-08-30 | 1998-04-30 | Ciba Geigy Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II |
| DK1367057T3 (da) | 1996-11-18 | 2009-01-19 | Biotechnolog Forschung Gmbh | Epothiloner E og F |
| US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| WO1999001124A1 (en) | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| DE19701758A1 (de) | 1997-01-20 | 1998-07-23 | Wessjohann Ludgar A Dr | Epothilone-Synthesebausteine |
| PT975638E (pt) * | 1997-02-25 | 2002-12-31 | Biotechnolog Forschung Mbh Gbf | Epothilons modificados nas cadeias laterais |
| DE19713970B4 (de) | 1997-04-04 | 2006-08-31 | R&D-Biopharmaceuticals Gmbh | Epothilone-Synthesebausteine II - Prenylderivate |
| WO1998047891A1 (de) | 1997-04-18 | 1998-10-29 | Studiengesellschaft Kohle Mbh | Selektive olefinmetathese von bi- oder polyfunktionellen substraten in komprimiertem kohlendioxid als reaktionsmedium |
| DE19821954A1 (de) | 1997-05-15 | 1998-11-19 | Biotechnolog Forschung Gmbh | Verfahren zur Herstellung eines Epothilon-Derivats |
| DE19720312A1 (de) | 1997-05-15 | 1998-11-19 | Hoechst Ag | Zubereitung mit erhöhter in vivo Verträglichkeit |
| DE19726627A1 (de) | 1997-06-17 | 1998-12-24 | Schering Ag | Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Epothilon |
| US6605599B1 (en) * | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| US6384230B1 (en) | 1997-07-16 | 2002-05-07 | Schering Aktiengesellschaft | Thiazole derivatives, method for their production and use |
| ES2290993T3 (es) | 1997-08-09 | 2008-02-16 | Bayer Schering Pharma Aktiengesellschaft | Nuevos derivados de epotilona, proceso para su produccion y su utilizacion farmaceutica. |
| DE19747580A1 (de) | 1997-10-28 | 1999-04-29 | Siemens Ag | Rangierfeld mit Anschlußleiste |
| US6365749B1 (en) * | 1997-12-04 | 2002-04-02 | Bristol-Myers Squibb Company | Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs |
| SK287775B6 (sk) | 1998-02-05 | 2011-09-05 | Novartis Ag | Farmaceutická formulácia obsahujúca epothilon, infúzny roztok a použitie farmaceutickej formulácie |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| DE19807505A1 (de) | 1998-02-21 | 1999-08-26 | Roland Man Druckmasch | Bogenrotationsdruckmaschine mit Druckeinheiten für den Mehrfarbendruck und wenigstens einer Beschichtungseinheit |
| FR2775187B1 (fr) | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
| DE69927790T2 (de) | 1998-02-25 | 2006-07-20 | Sloan-Kettering Institute For Cancer Research | Synthese von epothilonen, ihren zwischenprodukten und analogen verbindungen |
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-
2001
- 2001-01-08 UA UA2003032259A patent/UA75365C2/uk unknown
- 2001-07-26 MY MYPI20013545 patent/MY134129A/en unknown
- 2001-08-01 MX MXPA03001431A patent/MXPA03001431A/es active IP Right Grant
- 2001-08-01 HR HR20030190A patent/HRP20030190B1/xx not_active IP Right Cessation
- 2001-08-01 EP EP01959536A patent/EP1309597B1/de not_active Expired - Lifetime
- 2001-08-01 BR BR0113234-2A patent/BR0113234A/pt active Search and Examination
- 2001-08-01 WO PCT/US2001/024540 patent/WO2002014323A2/en not_active Ceased
- 2001-08-01 CN CNB018170641A patent/CN1269821C/zh not_active Expired - Lifetime
- 2001-08-01 CA CA2418109A patent/CA2418109C/en not_active Expired - Lifetime
- 2001-08-01 AU AU2001281082A patent/AU2001281082B2/en not_active Ceased
- 2001-08-01 GE GE5091A patent/GEP20053495B/en unknown
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Effective date: 20160801 |