EE05110B1 - 3-(3-isopropl-5-metl-4H-1,2,4-triasool-4-l)ekso-8-asabitsklo[3.2.1]oktaani derivaadid, selliste derivaatide valmistamismeetodid, nende valmistamisel kasutatavad vahehendid, selliseid derivaatesisaldavad kompositsioonid ja kombinatsioonid ning - Google Patents
3-(3-isopropl-5-metl-4H-1,2,4-triasool-4-l)ekso-8-asabitsklo[3.2.1]oktaani derivaadid, selliste derivaatide valmistamismeetodid, nende valmistamisel kasutatavad vahehendid, selliseid derivaatesisaldavad kompositsioonid ja kombinatsioonid ningInfo
- Publication number
- EE05110B1 EE05110B1 EEP200200656A EEP200200656A EE05110B1 EE 05110 B1 EE05110 B1 EE 05110B1 EE P200200656 A EEP200200656 A EE P200200656A EE P200200656 A EEP200200656 A EE P200200656A EE 05110 B1 EE05110 B1 EE 05110B1
- Authority
- EE
- Estonia
- Prior art keywords
- derivatives
- preparation
- azabicyclo
- exo
- triazol
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
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- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
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- Diabetes (AREA)
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- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
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- Endocrinology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Reproductive Health (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0014046A GB0014046D0 (en) | 2000-05-26 | 2000-05-26 | Compounds useful in therapy |
| GB0015835A GB0015835D0 (en) | 2000-06-27 | 2000-06-27 | Compounds useful in therapy |
| PCT/IB2001/000806 WO2001090106A2 (en) | 2000-05-26 | 2001-05-09 | Tryasolyl tropane derivatives as ccr5 modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200200656A EE200200656A (et) | 2004-06-15 |
| EE05110B1 true EE05110B1 (et) | 2008-12-15 |
Family
ID=26244452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200200656A EE05110B1 (et) | 2000-05-26 | 2001-05-09 | 3-(3-isopropl-5-metl-4H-1,2,4-triasool-4-l)ekso-8-asabitsklo[3.2.1]oktaani derivaadid, selliste derivaatide valmistamismeetodid, nende valmistamisel kasutatavad vahehendid, selliseid derivaatesisaldavad kompositsioonid ja kombinatsioonid ning |
Country Status (50)
Families Citing this family (44)
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| HRP20020938B1 (en) * | 2000-05-26 | 2011-05-31 | Pfizer Inc. | Tropane derivatives useful in therapy |
| CA2450271A1 (en) * | 2001-06-12 | 2002-12-19 | Sk Corporation | Novel phenylalkyl diamine and amide analogs |
| SE0103818D0 (sv) | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
| SE0200919D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Chemical compounds |
| GB0208071D0 (en) * | 2002-04-08 | 2002-05-22 | Pfizer Ltd | Tropane derivatives useful in therapy |
| RS51550B (sr) * | 2002-04-08 | 2011-06-30 | Pfizer Inc. | Derivati tropana kao modulatori ccr5 |
| US6855724B2 (en) | 2002-04-08 | 2005-02-15 | Agouron Pharmaceuticals, Inc. | Tropane derivatives useful in therapy |
| BR0309982A (pt) * | 2002-05-23 | 2005-03-22 | Pfizer | Método para identificação de um ligando, pelo qual o tempo de residência no receptor é medido |
| ES2311755T3 (es) * | 2002-12-13 | 2009-02-16 | Smithkline Beecham Corporation | Compuestos de ciclohexilo como antagonistas de ccrs. |
| SE0301369D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
| DE10336274A1 (de) * | 2003-08-07 | 2005-03-10 | Honeywell Specialty Chemicals | Verfahren zur Herstellung von geminalen Difluoralkanen |
| US7825147B2 (en) | 2003-08-29 | 2010-11-02 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type-IV |
| EP1786816A4 (en) | 2003-09-10 | 2009-11-04 | Virochem Pharma Inc | SPIROHYDANTOIN COMPOUNDS AND METHODS FOR MODULATING CHEMOKINE RECEPTOR ACTIVITY |
| MXPA06003749A (es) * | 2003-10-03 | 2006-06-14 | Pfizer | Derivados de tropano. |
| TW200610761A (en) * | 2004-04-23 | 2006-04-01 | Astrazeneca Ab | Chemical compounds |
| DK1761542T3 (da) | 2004-06-09 | 2008-04-28 | Hoffmann La Roche | Octahydropyrrolo[3,4-C] pyrrolderivater og anvendelsen deraf som antivirusmidler |
| CA2586231A1 (en) * | 2004-11-19 | 2006-05-26 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and uk-427, 857 |
| WO2006064340A2 (en) * | 2004-12-13 | 2006-06-22 | Pfizer Limited | Process for the preparation of n-acyl beta-aminoaldehydes |
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| KR20080035653A (ko) | 2005-07-22 | 2008-04-23 | 프로제닉스 파머슈티컬스, 인코포레이티드 | Ｈｉｖ―１ 감염 환자에서 바이러스 부하를 감소시키는방법 |
| EP1940781A1 (en) | 2005-10-19 | 2008-07-09 | F.Hoffmann-La Roche Ag | Phenyl-acetamide nnrt inhibitors |
| WO2007144720A2 (en) * | 2006-06-12 | 2007-12-21 | Pfizer Products Inc. | Ccr5 antagonist for enhancing immune reconstitution and treating opportunistic infection in hiv patients |
| EP2057125B1 (en) | 2006-08-16 | 2011-03-30 | F. Hoffmann-La Roche AG | Non-nucleoside reverse transcriptase inhibitors |
| WO2008063600A2 (en) * | 2006-11-17 | 2008-05-29 | Concert Pharmaceuticals Inc. | Triazolyl tropane derivatives |
| MX2009005881A (es) | 2006-12-13 | 2009-06-12 | Hoffmann La Roche | Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida. |
| US20080146605A1 (en) * | 2006-12-19 | 2008-06-19 | Auspex Pharmaceuticals, Inc. | Preparation and utility of ccr5 inhibitors |
| US20080207659A1 (en) | 2007-02-15 | 2008-08-28 | Asit Kumar Chakraborti | Inhibitors of phosphodiesterase type 4 |
| WO2008132128A2 (en) * | 2007-04-27 | 2008-11-06 | Solvay (Société Anonyme) | Synthesis of a pharmaceutically active compound |
| RU2368613C1 (ru) * | 2008-02-19 | 2009-09-27 | Институт молекулярной генетики Российской Академии наук (ИМГ РАН) (Статус Государственного учреждения) | Равномерно меченный тритием 4,4-дифтор-n-{(1s)-3-[3-(3-изопропил-5-метил-4н-1,2,4-триазол-4-ил)-8-азабицикло[3.2.1]окт-8-ил]-1-фенилпропил}циклогексан карбодиимид |
| CA2716838C (en) * | 2008-02-29 | 2014-01-07 | Schering Corporation | Ccr5 antagonists as prophylactics for preventing hiv infection and methods of inhibiting transmission of same |
| CN101712679B (zh) * | 2008-10-08 | 2013-04-10 | 中国科学院上海药物研究所 | 一种酰胺类化合物、其药物组合物及其制备方法和用途 |
| EP2456309B1 (en) * | 2009-07-24 | 2015-12-23 | GlaxoSmithKline LLC | Azabicyclo[3.2.1]octyl derivatives for use in the treatment of HIV. |
| CN102140104B (zh) * | 2010-02-03 | 2014-11-12 | 中国科学院上海药物研究所 | 1-(3-(s)-氨基丙基)-哌啶-4-氨基酰胺类化合物、其药物组合物及其制备方法和用途 |
| MX2012011415A (es) | 2010-04-02 | 2013-02-26 | Phivco 1 Llc | Terapia de combinacion que comprende un antagonista de ccr5, un inhibidor de proteasa de vih-1, y un potenciador farmacocinetico. |
| CN103159754A (zh) * | 2011-12-19 | 2013-06-19 | 中国科学院上海药物研究所 | 一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途 |
| WO2014068265A1 (en) | 2012-10-29 | 2014-05-08 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
| CZ306455B6 (cs) | 2013-04-26 | 2017-02-01 | Zentiva, K.S. | Nový způsob syntézy Maravirocu |
| CN103497164B (zh) * | 2013-09-23 | 2015-12-23 | 西安近代化学研究所 | 一种蒽衍生物及其制备方法 |
| CN104304248B (zh) * | 2014-10-23 | 2016-08-10 | 西北农林科技大学 | 3-芳基丙酸酯类化合物作为制备杀螨药物的应用 |
| CN104402883B (zh) * | 2014-10-24 | 2016-04-27 | 艾琪康医药科技（上海）有限公司 | 4，4-二氟金刚烷甲酰胺衍生物、药物组合物及其制备方法和用途 |
| CN104387379B (zh) * | 2014-11-26 | 2017-01-11 | 扬州氟药科技有限公司 | 一种二氟亚甲基哌啶甲酰胺衍生物及其制备方法和用途 |
| CN104860946A (zh) * | 2015-05-14 | 2015-08-26 | 湖北生物医药产业技术研究院有限公司 | Ccr5拮抗剂的制备方法 |
| CN107879963A (zh) | 2016-09-29 | 2018-04-06 | 中国科学院上海药物研究所 | 新型手性配体、金属螯合物、多种非天然氨基酸、马拉维诺及其关键中间体的合成方法 |
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