EE05110B1 - 3-(3-isopropl-5-metl-4H-1,2,4-triasool-4-l)ekso-8-asabitsklo[3.2.1]oktaani derivaadid, selliste derivaatide valmistamismeetodid, nende valmistamisel kasutatavad vahehendid, selliseid derivaatesisaldavad kompositsioonid ja kombinatsioonid ning - Google Patents
3-(3-isopropl-5-metl-4H-1,2,4-triasool-4-l)ekso-8-asabitsklo[3.2.1]oktaani derivaadid, selliste derivaatide valmistamismeetodid, nende valmistamisel kasutatavad vahehendid, selliseid derivaatesisaldavad kompositsioonid ja kombinatsioonid ningInfo
- Publication number
- EE05110B1 EE05110B1 EEP200200656A EEP200200656A EE05110B1 EE 05110 B1 EE05110 B1 EE 05110B1 EE P200200656 A EEP200200656 A EE P200200656A EE P200200656 A EEP200200656 A EE P200200656A EE 05110 B1 EE05110 B1 EE 05110B1
- Authority
- EE
- Estonia
- Prior art keywords
- derivatives
- preparation
- azabicyclo
- exo
- triazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0014046A GB0014046D0 (en) | 2000-05-26 | 2000-05-26 | Compounds useful in therapy |
GB0015835A GB0015835D0 (en) | 2000-06-27 | 2000-06-27 | Compounds useful in therapy |
PCT/IB2001/000806 WO2001090106A2 (en) | 2000-05-26 | 2001-05-09 | Tryasolyl tropane derivatives as ccr5 modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200200656A EE200200656A (et) | 2004-06-15 |
EE05110B1 true EE05110B1 (et) | 2008-12-15 |
Family
ID=26244452
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200200656A EE05110B1 (et) | 2000-05-26 | 2001-05-09 | 3-(3-isopropl-5-metl-4H-1,2,4-triasool-4-l)ekso-8-asabitsklo[3.2.1]oktaani derivaadid, selliste derivaatide valmistamismeetodid, nende valmistamisel kasutatavad vahehendid, selliseid derivaatesisaldavad kompositsioonid ja kombinatsioonid ning |
Country Status (51)
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR200400541T4 (tr) * | 2000-05-26 | 2004-04-21 | Pfizer Inc. | Terapide faydalı tropan türevleri. |
KR20040007672A (ko) * | 2001-06-12 | 2004-01-24 | 에스케이 주식회사 | 신규한 페닐알킬디아민 및 아미드 유사체 |
SE0200919D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Chemical compounds |
WO2003084954A1 (en) * | 2002-04-08 | 2003-10-16 | Pfizer Limited | Tropane derivatives as ccr5 modulators |
GB0208071D0 (en) * | 2002-04-08 | 2002-05-22 | Pfizer Ltd | Tropane derivatives useful in therapy |
US6855724B2 (en) | 2002-04-08 | 2005-02-15 | Agouron Pharmaceuticals, Inc. | Tropane derivatives useful in therapy |
JP2005533999A (ja) * | 2002-05-23 | 2005-11-10 | ファイザー・インク | 受容体滞留時間を測定するリガンドの同定方法 |
ATE405269T1 (de) * | 2002-12-13 | 2008-09-15 | Smithkline Beecham Corp | Cyclohexylverbindungen als ccr5-antagonisten |
DE10336274A1 (de) * | 2003-08-07 | 2005-03-10 | Honeywell Specialty Chemicals | Verfahren zur Herstellung von geminalen Difluoralkanen |
JP2007504123A (ja) | 2003-08-29 | 2007-03-01 | ランバクシー ラボラトリーズ リミテッド | Iv型ホスホジエステラーゼの阻害剤 |
WO2005023810A1 (en) | 2003-09-10 | 2005-03-17 | Virochem Pharma Inc. | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity |
ES2295924T3 (es) * | 2003-10-03 | 2008-04-16 | Pfizer, Inc. | Derivados de tropano imidazopirina sustituidos con actividad antagonista de los receptores ccr5 para el tratamiento de vih y de la inflamacion. |
TW200610761A (en) * | 2004-04-23 | 2006-04-01 | Astrazeneca Ab | Chemical compounds |
DE602005004144T2 (de) | 2004-06-09 | 2009-01-29 | F. Hoffmann-La Roche Ag | Octahydropyrroloä3,4-cüpyrrolderivate und deren verwendung als antivirale mittel |
CA2586231A1 (en) * | 2004-11-19 | 2006-05-26 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and uk-427, 857 |
WO2006064340A2 (en) * | 2004-12-13 | 2006-06-22 | Pfizer Limited | Process for the preparation of n-acyl beta-aminoaldehydes |
US7665658B2 (en) | 2005-06-07 | 2010-02-23 | First Data Corporation | Dynamic aggregation of payment transactions |
US20070026441A1 (en) | 2005-07-22 | 2007-02-01 | Olson William C | Methods for reducing viral load in HIV-1-infected patients |
CA2625047A1 (en) | 2005-10-19 | 2007-04-26 | F. Hoffmann-La Roche Ag | Phenyl-acetamide nnrt inhibitors |
DK2057125T3 (da) | 2006-08-16 | 2011-05-16 | Hoffmann La Roche | Ikke-nucleosid revers transkriptase-inhibitorer |
US7932235B2 (en) | 2006-11-17 | 2011-04-26 | Concert Pharmaceuticals, Inc. | Triazolyl tropane derivatives |
KR101475091B1 (ko) | 2006-12-13 | 2014-12-22 | 에프. 호프만-라 로슈 아게 | 비뉴클레오시드 역전사 효소 억제제로서 2-(피페리딘-4-일)-4-페녹시- 또는 페닐아미노-피리미딘 유도체 |
US20080146605A1 (en) * | 2006-12-19 | 2008-06-19 | Auspex Pharmaceuticals, Inc. | Preparation and utility of ccr5 inhibitors |
EP1958947A1 (en) | 2007-02-15 | 2008-08-20 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type 4 |
WO2008132128A2 (en) * | 2007-04-27 | 2008-11-06 | Solvay (Société Anonyme) | Synthesis of a pharmaceutically active compound |
EP2259772A2 (en) * | 2008-02-29 | 2010-12-15 | Schering Corporation | Ccr5 antagonists as prophylactics for preventing hiv infection and methods of inhibiting transmission of same |
CN101712679B (zh) * | 2008-10-08 | 2013-04-10 | 中国科学院上海药物研究所 | 一种酰胺类化合物、其药物组合物及其制备方法和用途 |
WO2011011652A1 (en) * | 2009-07-24 | 2011-01-27 | Glaxosmithkline Llc | Therapeutic compounds |
CN102140104B (zh) * | 2010-02-03 | 2014-11-12 | 中国科学院上海药物研究所 | 1-(3-(s)-氨基丙基)-哌啶-4-氨基酰胺类化合物、其药物组合物及其制备方法和用途 |
KR20130025899A (ko) | 2010-04-02 | 2013-03-12 | 피비코-1 엘엘씨 | Ccr5 길항제,hiv―1 프로테아제 억제제 및 약동학적 인핸서를 포함하는 병용 요법 |
CN106977511B (zh) * | 2011-12-19 | 2019-04-12 | 中国科学院上海药物研究所 | 一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途 |
EP2912047B1 (en) | 2012-10-29 | 2016-08-24 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
CZ306455B6 (cs) | 2013-04-26 | 2017-02-01 | Zentiva, K.S. | Nový způsob syntézy Maravirocu |
CN103497164B (zh) * | 2013-09-23 | 2015-12-23 | 西安近代化学研究所 | 一种蒽衍生物及其制备方法 |
CN104304248B (zh) * | 2014-10-23 | 2016-08-10 | 西北农林科技大学 | 3-芳基丙酸酯类化合物作为制备杀螨药物的应用 |
CN104402883B (zh) * | 2014-10-24 | 2016-04-27 | 艾琪康医药科技(上海)有限公司 | 4,4-二氟金刚烷甲酰胺衍生物、药物组合物及其制备方法和用途 |
CN104387379B (zh) * | 2014-11-26 | 2017-01-11 | 扬州氟药科技有限公司 | 一种二氟亚甲基哌啶甲酰胺衍生物及其制备方法和用途 |
CN104860946A (zh) * | 2015-05-14 | 2015-08-26 | 湖北生物医药产业技术研究院有限公司 | Ccr5拮抗剂的制备方法 |
CN107879963A (zh) | 2016-09-29 | 2018-04-06 | 中国科学院上海药物研究所 | 新型手性配体、金属螯合物、多种非天然氨基酸、马拉维诺及其关键中间体的合成方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
US5648511A (en) * | 1990-11-19 | 1997-07-15 | G.D. Searle & Co. | Method for making intermediates useful in the synthesis of retroviral protease inhibitors |
FR2676444B1 (fr) * | 1991-05-16 | 1995-03-10 | Sanofi Elf | Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant. |
GB9310713D0 (en) * | 1993-05-24 | 1993-07-07 | Zeneca Ltd | Aryl substituted heterocycles |
US5736556A (en) * | 1994-04-19 | 1998-04-07 | Neurosearch A/S | Tropane-2-aldoxime derivatives as nevro transmitter reuptake inhibitors |
GB9523526D0 (en) * | 1995-11-17 | 1996-01-17 | Zeneca Ltd | Therapeutic compounds |
DE19546462A1 (de) * | 1995-12-13 | 1997-06-19 | Bayer Ag | Diarylacetylenketone |
WO1997024325A1 (en) * | 1995-12-28 | 1997-07-10 | Takeda Chemical Industries, Ltd. | DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS |
US6323206B1 (en) * | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6281212B1 (en) * | 1996-07-12 | 2001-08-28 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
WO1998025617A1 (en) * | 1996-12-13 | 1998-06-18 | Merck & Co., Inc. | Substituted aryl piperazines as modulators of chemokine receptor activity |
AU5604998A (en) * | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
WO1999004794A1 (en) * | 1997-07-25 | 1999-02-04 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
IL125658A0 (en) * | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
AR013669A1 (es) * | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
AU2335699A (en) * | 1998-01-21 | 1999-08-09 | Kyowa Hakko Kogyo Co. Ltd. | Chemokine receptor antagonists and methods of use therefor |
EP1013276A1 (en) | 1998-12-23 | 2000-06-28 | Pfizer Inc. | Aminoazacycloalkanes as CCR5 modulators |
PE20001420A1 (es) * | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
US7217714B1 (en) * | 1998-12-23 | 2007-05-15 | Agouron Pharmaceuticals, Inc. | CCR5 modulators |
TR200400541T4 (tr) * | 2000-05-26 | 2004-04-21 | Pfizer Inc. | Terapide faydalı tropan türevleri. |
-
2001
- 2001-05-09 TR TR200400541T patent/TR200400541T4/xx unknown
- 2001-05-09 RS YUP82202 patent/RS50904B/sr unknown
- 2001-05-09 DZ DZ013464A patent/DZ3464A1/fr active
- 2001-05-09 EA EA200201141A patent/EA005382B1/ru not_active IP Right Cessation
- 2001-05-09 PT PT01925808T patent/PT1284974E/pt unknown
- 2001-05-09 PL PL359267A patent/PL200551B1/pl unknown
- 2001-05-09 AU AU2001252482A patent/AU2001252482B2/en not_active Expired
- 2001-05-09 CA CA 2408909 patent/CA2408909C/en not_active Expired - Lifetime
- 2001-05-09 CN CNB2005100068151A patent/CN100355753C/zh not_active Expired - Lifetime
- 2001-05-09 NZ NZ521477A patent/NZ521477A/en not_active IP Right Cessation
- 2001-05-09 DE DE2001602233 patent/DE60102233T2/de not_active Expired - Lifetime
- 2001-05-09 MX MXPA02011631A patent/MXPA02011631A/es active IP Right Grant
- 2001-05-09 IL IL15253101A patent/IL152531A0/xx unknown
- 2001-05-09 CZ CZ20023806A patent/CZ299102B6/cs not_active IP Right Cessation
- 2001-05-09 KR KR1020057003492A patent/KR100548854B1/ko active IP Right Grant
- 2001-05-09 AP APAP/P/2002/002663A patent/AP1965A/en active
- 2001-05-09 JP JP2001586293A patent/JP3693957B2/ja not_active Expired - Lifetime
- 2001-05-09 EP EP20010925808 patent/EP1284974B1/en not_active Expired - Lifetime
- 2001-05-09 GE GEAP2001004960 patent/GEP20063799B/en unknown
- 2001-05-09 EP EP20080163025 patent/EP1990341B1/en not_active Expired - Lifetime
- 2001-05-09 BR BRPI0110955A patent/BRPI0110955B8/pt not_active IP Right Cessation
- 2001-05-09 CN CNB018088287A patent/CN1279040C/zh not_active Expired - Lifetime
- 2001-05-09 EE EEP200200656A patent/EE05110B1/et active Protection Beyond IP Right Term
- 2001-05-09 KR KR10-2002-7015934A patent/KR100523501B1/ko active IP Right Grant
- 2001-05-09 DE DE200812000011 patent/DE122008000011I1/de active Pending
- 2001-05-09 AU AU5248201A patent/AU5248201A/xx active Pending
- 2001-05-09 ES ES08163025T patent/ES2401812T3/es not_active Expired - Lifetime
- 2001-05-09 AT AT04004193T patent/ATE407134T1/de active
- 2001-05-09 SI SI200130862T patent/SI1526134T1/sl unknown
- 2001-05-09 DK DK01925808T patent/DK1284974T3/da active
- 2001-05-09 PT PT04004193T patent/PT1526134E/pt unknown
- 2001-05-09 WO PCT/IB2001/000806 patent/WO2001090106A2/en active IP Right Grant
- 2001-05-09 ME MEP-693/08A patent/ME00555A/xx unknown
- 2001-05-09 DE DE60135685T patent/DE60135685D1/de not_active Expired - Lifetime
- 2001-05-09 EP EP20040004193 patent/EP1526134B1/en not_active Expired - Lifetime
- 2001-05-09 AT AT01925808T patent/ATE260914T1/de active
- 2001-05-09 OA OA1200200343A patent/OA12264A/en unknown
- 2001-05-09 ES ES01925808T patent/ES2215129T3/es not_active Expired - Lifetime
- 2001-05-09 EA EA200401056A patent/EA007580B1/ru not_active IP Right Cessation
- 2001-05-09 DK DK04004193T patent/DK1526134T3/da active
- 2001-05-09 SI SI200130090T patent/SI1284974T1/xx unknown
- 2001-05-09 RS RSP-2009/0438A patent/RS51436B/en unknown
- 2001-05-09 SK SK1643-2002A patent/SK286129B6/sk active Protection Beyond IP Right Term
- 2001-05-09 ES ES04004193T patent/ES2311126T3/es not_active Expired - Lifetime
- 2001-05-09 HU HU0302474A patent/HU225810B1/hu active Protection Beyond IP Right Term
- 2001-05-21 TW TW90112055A patent/TWI230160B/zh active
- 2001-05-22 PA PA8517101A patent/PA8517101A1/es unknown
- 2001-05-22 EG EG20010535A patent/EG24137A/xx active
- 2001-05-23 MY MYPI20041980 patent/MY153023A/en unknown
- 2001-05-23 MY MYPI20012461 patent/MY131019A/en unknown
- 2001-05-23 MY MYPI20094132A patent/MY156920A/en unknown
- 2001-05-24 UY UY26727A patent/UY26727A1/es not_active IP Right Cessation
- 2001-05-24 AR ARP010102486 patent/AR028622A1/es active IP Right Grant
- 2001-05-24 PE PE2001000476A patent/PE20011371A1/es active IP Right Grant
- 2001-05-25 TN TNSN01077 patent/TNSN01077A1/fr unknown
-
2002
- 2002-09-23 BG BG107140A patent/BG65966B1/bg unknown
- 2002-09-24 IS IS6565A patent/IS2511B/is unknown
- 2002-10-28 IL IL152531A patent/IL152531A/en active Protection Beyond IP Right Term
- 2002-10-28 CU CU20020243A patent/CU23288B7/es unknown
- 2002-10-31 NO NO20025227A patent/NO327892B1/no not_active IP Right Cessation
- 2002-11-14 MA MA26910A patent/MA26902A1/fr unknown
- 2002-11-26 HR HR20020938A patent/HRP20020938B1/xx not_active IP Right Cessation
-
2003
- 2003-09-30 HK HK03107045A patent/HK1054927A1/xx not_active IP Right Cessation
-
2005
- 2005-02-15 JP JP2005038062A patent/JP4854970B2/ja not_active Expired - Lifetime
- 2005-11-18 HK HK05110416A patent/HK1078573A1/xx not_active IP Right Cessation
-
2006
- 2006-10-18 HK HK06111446A patent/HK1090836A1/xx not_active IP Right Cessation
-
2007
- 2007-03-27 AR ARP070101273 patent/AR060159A2/es unknown
-
2008
- 2008-02-22 NL NL300338C patent/NL300338I2/nl unknown
- 2008-02-22 LU LU91417C patent/LU91417I2/fr unknown
- 2008-02-25 LT LTPA2008004C patent/LTC1284974I2/lt unknown
- 2008-03-04 FR FR08C0007C patent/FR08C0007I2/fr active Active
- 2008-03-17 CY CY200800006C patent/CY2008006I1/el unknown
- 2008-07-16 CR CR10145A patent/CR10145A/es unknown
- 2008-10-24 CY CY081101203T patent/CY1108451T1/el unknown
-
2010
- 2010-04-08 NO NO2010007C patent/NO2010007I2/no unknown
-
2020
- 2020-06-30 NO NO2020019C patent/NO2020019I1/no not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EE05110B1 (et) | 3-(3-isopropl-5-metl-4H-1,2,4-triasool-4-l)ekso-8-asabitsklo[3.2.1]oktaani derivaadid, selliste derivaatide valmistamismeetodid, nende valmistamisel kasutatavad vahehendid, selliseid derivaatesisaldavad kompositsioonid ja kombinatsioonid ning | |
HUS1300057I1 (hu) | Új fenil-propargil-éter-származékok | |
AU2001276048A1 (en) | Rapid-melt semi-solid compositions, methods of making same and methods of using same | |
AU2001279284A1 (en) | Rapid-melt semi-solid compositions, methods of making same and methods of using same | |
BE2015C026I2 (en) | 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens | |
FR2810033B1 (fr) | Nouveaux composes de la famille des n-acylamino-amides, compositions les comprenant, et utilisations | |
EE200000596A (et) | Tienüülasolüülalkoksüetaanamiinderivaadid, nende ja nende soolade valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja kasutamine ning vaheühend ja selle valmistamismeetod | |
EE200300151A (et) | Ravimitena kasutatavad antikolinergikumid ning meetodid nende valmistamiseks | |
EE05104B1 (et) | Asetidiini derivaadid, nende valmistamise meetodid ja farmatseutiline kompositsioon | |
EE200200470A (et) | Uued ühendid, meetod nende valmistamiseks ning nende kasutamine | |
ZA200303794B (en) | Heterocyclylalkyl piperidine derivatives, their preparation and compositions containing same. | |
EE05157B1 (et) | N-[(asendatud bensüül)-4-piperidinüüli v?i pürrolidinüül]aminohüdroksüalkoksüfenüülide derivaadid, meetod nende valmistamiseks ning nende kasutamine meditsiinis | |
AU2001241474A1 (en) | Biosensor compositions and methods of use | |
GB9903216D0 (en) | Preservative compounds,compositions and methods of making and using the same | |
EE200300080A (et) | Polüarüülkarboksamiidühendid, nende valmistamine ja kasutamine lipiiditaset alandavate toimeainetena ning neid sisaldav farmatseutiline kompositsioon | |
NO990685L (no) | FremgangsmÕte ved inkubering av u°nsket smak i orale sammensetninger | |
AU2268401A (en) | Novel succinate compounds, compositions and methods of use and preparation | |
FR2811552B1 (fr) | Composition notamment cosmetique ou pharmaceutique se presentant sous forme solide | |
AU2001235737A1 (en) | Novel 1,3-dihydro-2h-indol-2-one, preparation method and pharmaceutical compositions containing same | |
EE200100653A (et) | Indolüülpiperidiinühendid, nende valmistamismeetod, kompositsioon ja nende kasutamine | |
WO2002041881A3 (de) | Repinotan-kit | |
EE04917B1 (et) | Antihistamiinsed spirohendid, vahehendid ja farmatseutiline kompositsioon ning nende valmistamismeetodid ja kasutamine | |
HUP0204563A3 (en) | Process for preparation of 3,3-diarylpropylamine derivatives and their intermediates and their use for preparation of pharmaceutical compositions | |
AU2002218075A1 (en) | Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them | |
HUP0204354A3 (en) | Novel heterocyclic derivatives, preparation method and pharmaceutical compositions containing same and their use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
AA1Y | Spc filed |
Free format text: PRODUCT NAME: CELSENTRI-MARAVIROC Spc suppl protection certif: C20090002 Filing date: 20090529 |
|
FG1Y | Spc granted |
Free format text: PRODUCT NAME: CELSENTRI-MARAVIROC Spc suppl protection certif: C20090002 00023 Filing date: 20090529 Extension date: 20220918 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20101231 |
|
HC1A | Change of owner name | ||
SPCM | Correction and amendment to the data concerning application for a supplementary protection certificate |
Spc suppl protection certif: C20090002 00023 Extension date: 20220920 |
|
GB1A | Change in the ownership or in the address of the owner | ||
SPCZ | Extension of supplementary protection certificate: granted [paediatric extension] |
Free format text: PRODUCT NAME: MARAVIROC; NATIONAL AUTHORISATION NUMBER: EMA/253407/2017; DATE OF AUTHORISATION: 20170421 Spc suppl protection certif: C20090002 Extension date: 20230318 |