EA201692370A1 - КОМПОЗИЦИИ иРНК АНГИОТЕНЗИНОГЕНА (AGT) И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ - Google Patents

КОМПОЗИЦИИ иРНК АНГИОТЕНЗИНОГЕНА (AGT) И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ

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Publication number
EA201692370A1
EA201692370A1 EA201692370A EA201692370A EA201692370A1 EA 201692370 A1 EA201692370 A1 EA 201692370A1 EA 201692370 A EA201692370 A EA 201692370A EA 201692370 A EA201692370 A EA 201692370A EA 201692370 A1 EA201692370 A1 EA 201692370A1
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Prior art keywords
agt
methods
angiotenzinogena
mrna
compositions
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EA201692370A
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English (en)
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Дональд ФОСТЕР
Брайан БЕТТЕНКОРТ
Клаус Хариссе
Грегори Хинкл
Сатиянараяна Кучиманчи
Мартин Майер
Стюарт Милстейн
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Элнилэм Фармасьютикалз, Инк.
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Application filed by Элнилэм Фармасьютикалз, Инк. filed Critical Элнилэм Фармасьютикалз, Инк.
Publication of EA201692370A1 publication Critical patent/EA201692370A1/ru

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Abstract

Настоящее изобретение относится к РНКи средствам, например к средствам из двухцепочечной РНКи, направленной на ген ангиотензиноген (AGT), и к способам использования таких РНКи средств для того, чтобы ингибировать экспрессию AGT, и к способам лечения субъектов, имеющих AGT-ассоциированное нарушение, например гипертензию.
EA201692370A 2014-05-22 2015-05-22 КОМПОЗИЦИИ иРНК АНГИОТЕНЗИНОГЕНА (AGT) И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ EA201692370A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462001731P 2014-05-22 2014-05-22
US201462047978P 2014-09-09 2014-09-09
PCT/US2015/032099 WO2015179724A1 (en) 2014-05-22 2015-05-22 Angiotensinogen (agt) irna compositions and methods of use thereof

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EA201692370A1 true EA201692370A1 (ru) 2017-03-31

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Country Status (14)

Country Link
US (4) US10238749B2 (ru)
EP (2) EP3739048A1 (ru)
JP (3) JP6811094B2 (ru)
KR (2) KR20220087576A (ru)
CN (3) CN112852809A (ru)
AU (2) AU2015264038B2 (ru)
BR (2) BR122020023687B1 (ru)
CA (2) CA3215908A1 (ru)
EA (1) EA201692370A1 (ru)
IL (2) IL248816B (ru)
MX (2) MX2016015126A (ru)
SG (2) SG11201609376SA (ru)
WO (1) WO2015179724A1 (ru)
ZA (1) ZA201607666B (ru)

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TW202016304A (zh) 2018-05-14 2020-05-01 美商阿尼拉製藥公司 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
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WO2022271786A1 (en) 2021-06-23 2022-12-29 University Of Massachusetts Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
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WO2023155909A1 (zh) * 2022-02-18 2023-08-24 南京明德新药研发有限公司 三氮唑核苷类似物及其作为嵌入基团的应用
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