EA201692046A1 - СПОСОБ ПОЛУЧЕНИЯ α-ТОКОТРИЕНОЛА И ЕГО ПРОИЗВОДНЫХ - Google Patents
СПОСОБ ПОЛУЧЕНИЯ α-ТОКОТРИЕНОЛА И ЕГО ПРОИЗВОДНЫХInfo
- Publication number
- EA201692046A1 EA201692046A1 EA201692046A EA201692046A EA201692046A1 EA 201692046 A1 EA201692046 A1 EA 201692046A1 EA 201692046 A EA201692046 A EA 201692046A EA 201692046 A EA201692046 A EA 201692046A EA 201692046 A1 EA201692046 A1 EA 201692046A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tocotrienol
- derivatives
- obtaining
- enriching
- isolating
- Prior art date
Links
- 229940064063 alpha tocotrienol Drugs 0.000 title abstract 3
- RZFHLOLGZPDCHJ-DLQZEEBKSA-N alpha-Tocotrienol Natural products Oc1c(C)c(C)c2O[C@@](CC/C=C(/CC/C=C(\CC/C=C(\C)/C)/C)\C)(C)CCc2c1C RZFHLOLGZPDCHJ-DLQZEEBKSA-N 0.000 title abstract 3
- RZFHLOLGZPDCHJ-XZXLULOTSA-N α-Tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C RZFHLOLGZPDCHJ-XZXLULOTSA-N 0.000 title abstract 3
- 235000019145 α-tocotrienol Nutrition 0.000 title abstract 3
- 239000011730 α-tocotrienol Substances 0.000 title abstract 3
- 229930003802 tocotrienol Natural products 0.000 abstract 2
- 239000011731 tocotrienol Substances 0.000 abstract 2
- 235000019148 tocotrienols Nutrition 0.000 abstract 2
- GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 abstract 1
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- -1 natural extracts Natural products 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 229940068778 tocotrienols Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
- C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19758508P | 2008-10-28 | 2008-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201692046A1 true EA201692046A1 (ru) | 2017-06-30 |
Family
ID=42118126
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201692046A EA201692046A1 (ru) | 2008-10-28 | 2009-10-27 | СПОСОБ ПОЛУЧЕНИЯ α-ТОКОТРИЕНОЛА И ЕГО ПРОИЗВОДНЫХ |
| EA201100699A EA026417B1 (ru) | 2008-10-28 | 2009-10-27 | СПОСОБ ПОЛУЧЕНИЯ α-ТОКОТРИЕНОЛА И ЕГО ПРОИЗВОДНЫХ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201100699A EA026417B1 (ru) | 2008-10-28 | 2009-10-27 | СПОСОБ ПОЛУЧЕНИЯ α-ТОКОТРИЕНОЛА И ЕГО ПРОИЗВОДНЫХ |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US8106223B2 (enExample) |
| EP (3) | EP2362875B1 (enExample) |
| JP (7) | JP5775459B2 (enExample) |
| CN (2) | CN102264730B (enExample) |
| BR (1) | BRPI0920414B1 (enExample) |
| CA (2) | CA2974482C (enExample) |
| DK (2) | DK2963006T3 (enExample) |
| EA (2) | EA201692046A1 (enExample) |
| ES (2) | ES2701260T3 (enExample) |
| HU (1) | HUE041714T2 (enExample) |
| MX (1) | MX2011004440A (enExample) |
| MY (2) | MY157119A (enExample) |
| PL (2) | PL2362875T3 (enExample) |
| PT (2) | PT2963006T (enExample) |
| SI (1) | SI2963006T1 (enExample) |
| TR (1) | TR201819154T4 (enExample) |
| WO (1) | WO2010051277A1 (enExample) |
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| WO2005032544A1 (en) | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | Treatment of mitochondrial diseases |
| EP2564842A1 (en) | 2005-06-01 | 2013-03-06 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| CA2635280C (en) | 2006-02-22 | 2017-12-12 | Edison Pharmaceuticals, Inc. | Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
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| WO2009111576A2 (en) | 2008-03-05 | 2009-09-11 | Edison Pharmaceuticals, Inc. | 2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES |
| JP5798481B2 (ja) | 2008-06-25 | 2015-10-21 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス疾患を治療するための２−ヘテロシクリルアミノアルキル−（ｐ−キノン）誘導体 |
| LT3827815T (lt) | 2008-09-10 | 2023-10-10 | Ptc Therapeutics, Inc. | Psichologinių raidos sutrikimų gydymas oksidacijos redukcijos atžvilgiu aktyviais vaistais |
| CA2740773A1 (en) | 2008-10-14 | 2010-04-22 | Edison Pharmaceuticals, Inc. | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| EA201692046A1 (ru) | 2008-10-28 | 2017-06-30 | Эдисон Фармасьютикалз, Инк. | СПОСОБ ПОЛУЧЕНИЯ α-ТОКОТРИЕНОЛА И ЕГО ПРОИЗВОДНЫХ |
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| US9512098B1 (en) | 2014-02-03 | 2016-12-06 | Board Of Trustees Of The University Of Arkansas | Process of producing purified gamma- and delta-tocotrienols from tocol-rich oils or distillates |
| CN104262315A (zh) * | 2014-09-05 | 2015-01-07 | 宁波大红鹰生物工程股份有限公司 | 一种生育三烯酚的分离提纯方法 |
| CN107531616B (zh) | 2014-12-16 | 2022-04-26 | Ptc医疗公司 | (r)-2羟基-2-甲基-4-(2，4，5-三甲基-3，6-二氧环己-1，4-二烯基)丁酰胺的多晶型和无定形形式 |
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| JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩 |
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| JP7586815B2 (ja) | 2018-10-17 | 2024-11-19 | ピーティーシー セラピューティクス， インコーポレイテッド | α－シヌクレイノパチー、タウオパチー、および他の障害を抑制および処置するための２，３，５－トリメチル－６－ノニルシクロヘキサ－２，５－ジエン－１，４－ジオン |
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