EA200801501A1 - Химерные вирусы, представляющие неприродные поверхностные белки, и их применение - Google Patents

Химерные вирусы, представляющие неприродные поверхностные белки, и их применение

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EA200801501A1
EA200801501A1 EA200801501A EA200801501A EA200801501A1 EA 200801501 A1 EA200801501 A1 EA 200801501A1 EA 200801501 A EA200801501 A EA 200801501A EA 200801501 A EA200801501 A EA 200801501A EA 200801501 A1 EA200801501 A1 EA 200801501A1
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chimeric
viruses
protein
present
infectious agent
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EA200801501A
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EA016217B1 (ru
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Питер Пейлиз
Адольфо Гастрия-Састре
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Маунт Синай Скул Оф Медсин Оф Нью-Йорк Юниверсити
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Publication of EA200801501A1 publication Critical patent/EA200801501A1/ru
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Abstract

Настоящее изобретение относится к химерным вирусам, содержащим негативную нить РНК, которые делают возможной иммунизацию индивида, например птицы, против двух инфекционных агентов, используя один химерный вирус по настоящему изобретению. В частности, настоящее изобретение относится к химерным вирусам гриппа, разработанным таким образом, что они экспрессируют и встраивают в свои вирионы слитый белок, содержащий эктодомен белка инфекционного агента и трансмембранный и цитоплазматический домены белка вируса гриппа. Такие химерные вирусы индуцируют иммунный ответ против вируса гриппа и инфекционного агента. Настоящее изобретение также относится к химерным вирусам псевдочумы птиц (NDV), разработанным таким образом, что они экспрессируют и встраивают в свои вирионы слитый белок, содержащий эктодомен белка инфекционного агента и трансмембранный и цитоплазматический домены белка NDV. Такие химерные вирусы индуцируют иммунный ответ против NDV и инфекционного агента.
EA200801501A 2005-12-02 2006-12-01 Химерные вирусы, представляющие неприродные поверхностные белки, и их применение EA016217B1 (ru)

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