ATE516305T1 - Il-15-bindungsstelle für il-15-ralpha und spezifische il-15-mutanten mit wirkung als agonisten/antagonisten - Google Patents
Il-15-bindungsstelle für il-15-ralpha und spezifische il-15-mutanten mit wirkung als agonisten/antagonistenInfo
- Publication number
- ATE516305T1 ATE516305T1 AT05707720T AT05707720T ATE516305T1 AT E516305 T1 ATE516305 T1 AT E516305T1 AT 05707720 T AT05707720 T AT 05707720T AT 05707720 T AT05707720 T AT 05707720T AT E516305 T1 ATE516305 T1 AT E516305T1
- Authority
- AT
- Austria
- Prior art keywords
- ralpha
- agonists
- antagonists
- specific
- binding site
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04290542 | 2004-02-27 | ||
PCT/EP2005/002367 WO2005085282A1 (en) | 2004-02-27 | 2005-02-10 | Il-15 binding site for il15-ralpha and specific il-15 mutants having agonists/antagonists activity |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE516305T1 true ATE516305T1 (de) | 2011-07-15 |
Family
ID=34917212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05707720T ATE516305T1 (de) | 2004-02-27 | 2005-02-10 | Il-15-bindungsstelle für il-15-ralpha und spezifische il-15-mutanten mit wirkung als agonisten/antagonisten |
Country Status (6)
Country | Link |
---|---|
US (2) | US7858081B2 (de) |
EP (1) | EP1718670B1 (de) |
JP (3) | JP5744369B2 (de) |
AT (1) | ATE516305T1 (de) |
ES (1) | ES2367027T3 (de) |
WO (1) | WO2005085282A1 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5744369B2 (ja) * | 2004-02-27 | 2015-07-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | IL15−Rα用IL−15結合部位およびアゴニスト/アンタゴニスト活性を有する特異的IL−15突然変異体 |
EP2314621B1 (de) | 2004-05-27 | 2014-03-05 | Crucell Holland B.V. | Bindungsmoleküle, die zur Neutralisierung des Tollwutvirus fähig sind, sowie deren Verwendungen |
CU23472A1 (es) | 2004-09-17 | 2009-12-17 | Ct Ingenieria Genetica Biotech | Péptido antagonista de la interleucina-15 |
US8124084B2 (en) | 2005-05-17 | 2012-02-28 | University Of Connecticut | Compositions and methods for immunomodulation in an organism using IL-15 and soluble IL-15Ra |
EP1777294A1 (de) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi Domäin als selektieve und potente Enhancer von IL-15 Aktion durch IL-15Rbeta/gamma, und Hyperagonist (IL15Ralpha sushi -IL15) Fusionsproteine |
EP2251034B1 (de) | 2005-12-02 | 2018-02-14 | Icahn School of Medicine at Mount Sinai | Chimäre newcastle disease viren zur präsentation von nicht -nativen oberflächenproteinen und deren verwendung |
AU2007207785B2 (en) | 2006-01-13 | 2013-11-14 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Codon optimized IL- 15 and IL- 15R-alpha genes for expression in mammalian cells |
AU2013273643C1 (en) * | 2007-05-11 | 2016-08-11 | Altor Bioscience Corporation | Fusion molecules and il-15 variants |
CN104109200B (zh) | 2007-05-11 | 2018-03-20 | 阿尔托生物科学有限公司 | 融合分子与il‑15变异体 |
EP2173378B1 (de) | 2007-06-27 | 2014-03-19 | Admune Therapeutics LLC | Komplexe von il-15 und il-15ralpha und ihre verwendungen |
CU23716A1 (es) * | 2008-09-30 | 2011-10-05 | Ct Ingenieria Genetica Biotech | Péptido antagonista de la actividad de la interleucina-15 |
EP2464377B1 (de) | 2009-08-14 | 2016-07-27 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Verwendung von il-15 zur erhöhung der thymusleistung und zur behandlung von lymphopenie |
WO2011031986A1 (en) | 2009-09-10 | 2011-03-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health | Assays for soluble il-15 receptor alpha |
AU2010291900A1 (en) * | 2009-09-14 | 2012-03-22 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics comprising IL-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same |
CN107880136B (zh) | 2010-09-21 | 2021-11-12 | 阿尔托生物科学有限公司 | 多聚体il-15可溶性融合分子与其制造与使用方法 |
US11053299B2 (en) | 2010-09-21 | 2021-07-06 | Immunity Bio, Inc. | Superkine |
EP2537933A1 (de) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Auf IL-15- und IL-15Ralpha-Sushi-Domäne basierende Immunozytokine |
EP2911684B1 (de) | 2012-10-24 | 2019-06-19 | Novartis Ag | Il-15r-alpha-formen, il-15r-alpha-formen exprimierende zellen und therapeutische verwendung von il-15r-alpha und il-15/il-15r-alpha-komplexen |
CN111218429A (zh) | 2013-03-14 | 2020-06-02 | 西奈山伊坎医学院 | 新城疫病毒及其用途 |
CN109395064A (zh) | 2013-04-19 | 2019-03-01 | 赛腾制药 | 降低的血管渗漏综合征的细胞因子衍生治疗 |
WO2014207173A1 (en) * | 2013-06-27 | 2014-12-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Interleukin 15 (il-15) antagonists and uses thereof for the treatment of autoimmune diseases and inflammatory diseases |
KR102564207B1 (ko) | 2013-08-08 | 2023-08-10 | 싸이튠 파마 | Il―15 및 il―15r 알파 스시 도메인 기반 모듈로카인 |
KR102457731B1 (ko) | 2013-08-08 | 2022-10-21 | 싸이튠 파마 | 병용 약학 조성물 |
WO2015048498A2 (en) | 2013-09-27 | 2015-04-02 | Massachusetts Institute Of Technology | Carrier-free biologically-active protein nanostructures |
CA2935599A1 (en) | 2014-01-08 | 2015-07-16 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Il-15 heterodimeric protein and uses thereof |
KR102407019B1 (ko) | 2014-02-27 | 2022-06-08 | 머크 샤프 앤드 돔 코포레이션 | 암의 치료를 위한 결합 방법 |
EP2915569A1 (de) | 2014-03-03 | 2015-09-09 | Cytune Pharma | Reinigungsverfahren für Il-15/Il-15Ralpha-basierte Konjugate |
CA2953816C (en) | 2014-06-30 | 2022-03-15 | Altor Bioscience Corporation | Il-15-based molecules and methods of use thereof |
WO2016018920A1 (en) | 2014-07-29 | 2016-02-04 | Admune Therapeutics Llc | Il-15 and il-15ralpha heterodimer dose escalation regimens for treating conditions |
MX2017004838A (es) * | 2014-10-14 | 2017-10-16 | Armo Biosciences Inc | Composiciones de interleucina-15 y usos de estas. |
EP3064507A1 (de) * | 2015-03-06 | 2016-09-07 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Fusionsproteine mit einem bindenden Protein und einem Interleukin-15-Polypeptid mit reduzierter Affinität für IL15ra und therapeutische Verwendungen davon |
JP2019503348A (ja) * | 2015-12-21 | 2019-02-07 | アルモ・バイオサイエンシーズ・インコーポレイテッド | インターロイキン−15組成物及びその使用 |
US11472856B2 (en) | 2016-06-13 | 2022-10-18 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
WO2018041989A1 (en) | 2016-09-02 | 2018-03-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating refractory celiac disease type 2 |
EP3526241A1 (de) * | 2016-10-14 | 2019-08-21 | Xencor, Inc. | Il15/il15r-heterodimere fc-fusionsproteine |
SG11201903306SA (en) | 2016-10-21 | 2019-05-30 | Altor Bioscience Corp | Multimeric il-15-based molecules |
CU24546B1 (es) * | 2016-12-30 | 2021-09-07 | Ct Ingenieria Genetica Biotecnologia | Composición vacunal que comprende un mutante de la interleucina-15 humana |
WO2018229706A1 (en) * | 2017-06-16 | 2018-12-20 | Novartis Ag | Combination therapy for the treatment of cancer |
WO2018236890A1 (en) | 2017-06-20 | 2018-12-27 | Nantkwest, Inc. | COMBINED THERAPY WITH NK-92 CELLS AND IL-15 AGONIST |
CN111132733A (zh) | 2017-06-30 | 2020-05-08 | Xencor股份有限公司 | 含有IL-15/IL-15Rα和抗原结合结构域的靶向异源二聚体Fc融合蛋白 |
AU2018328209A1 (en) | 2017-09-05 | 2020-04-23 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
AR114445A1 (es) * | 2018-02-26 | 2020-09-09 | Synthorx Inc | Conjugados de il-15, y sus usos |
WO2019166946A1 (en) | 2018-02-28 | 2019-09-06 | Pfizer Inc. | Il-15 variants and uses thereof |
WO2019204655A1 (en) * | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains |
TW202011984A (zh) * | 2018-04-18 | 2020-04-01 | 美商山可爾股份有限公司 | IL-15/IL-15Rα異二聚體Fc融合蛋白及其用途 |
KR20210010862A (ko) | 2018-04-18 | 2021-01-28 | 젠코어 인코포레이티드 | IL-15/IL-15Rα Fc-융합 단백질 및 PD-1 항원 결합 도메인을 함유하는 PD-1 표적화 이종이량체 융합 단백질 및 이의 용도 |
WO2019246392A1 (en) | 2018-06-22 | 2019-12-26 | Cugene Inc. | Cytokine-based bioactivatable drugs and methods of uses thereof |
WO2020077276A2 (en) | 2018-10-12 | 2020-04-16 | Xencor, Inc. | Pd-1 targeted il-15/il-15ralpha fc fusion proteins and uses in combination therapies thereof |
WO2020132646A1 (en) | 2018-12-20 | 2020-06-25 | Xencor, Inc. | Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains |
EP3972629A1 (de) | 2019-05-20 | 2022-03-30 | Cytune Pharma | Il-2/il-15rssy-agonist-dosierschema zur behandlung von krebs oder infektionskrankheiten |
JP2022536898A (ja) | 2019-06-12 | 2022-08-22 | アスクジーン・ファーマ・インコーポレイテッド | 新規il-15プロドラッグおよびその使用方法 |
US20220289838A1 (en) | 2019-08-19 | 2022-09-15 | Nantong Yichen Biopharma. Co. Ltd. | Immunocytokine, Preparation for the Same, and Uses Thereof |
TW202128757A (zh) | 2019-10-11 | 2021-08-01 | 美商建南德克公司 | 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白 |
US20210188933A1 (en) * | 2019-12-18 | 2021-06-24 | Nantcell, Inc | Methods of treating pancytopenia |
WO2021142476A1 (en) | 2020-01-12 | 2021-07-15 | Dragonfly Therapeutics, Inc. | Single-chain polypeptides |
CN114380919A (zh) * | 2020-10-18 | 2022-04-22 | 北京志道生物科技有限公司 | 经修饰的il-2分子及其用途 |
WO2022090202A1 (en) | 2020-10-26 | 2022-05-05 | Cytune Pharma | IL-2/IL-15RBβү AGONIST FOR TREATING NON-MELANOMA SKIN CANCER |
AU2021367887A1 (en) | 2020-10-26 | 2023-06-01 | Cytune Pharma | IL-2/IL-15Rβү AGONIST FOR TREATING SQUAMOUS CELL CARCINOMA |
CN113185600A (zh) * | 2021-05-28 | 2021-07-30 | 苏州复融生物技术有限公司 | 一种新型白介素15突变体多肽的开发及其应用 |
AU2022299404A1 (en) | 2021-06-23 | 2023-12-07 | Cytune Pharma | Interleukin 15 variants |
AU2022325498A1 (en) | 2021-08-13 | 2024-02-01 | Cytune Pharma | Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer |
WO2023086772A1 (en) | 2021-11-12 | 2023-05-19 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and nkg2d |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5552303A (en) * | 1993-03-08 | 1996-09-03 | Immunex Corporation | DNA encoding epithelium-derived T-cell factor |
US5795966A (en) * | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
US6451308B1 (en) * | 1996-04-26 | 2002-09-17 | Beth Israel Deaconess Medical Center | Antagonists of interleukin-15 |
ES2243995T3 (es) * | 1996-04-26 | 2005-12-01 | Beth Israel Deaconess Medical Center, Inc. | Antagonistas de interleucina-15. |
DZ2788A1 (fr) * | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
JP5744369B2 (ja) * | 2004-02-27 | 2015-07-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | IL15−Rα用IL−15結合部位およびアゴニスト/アンタゴニスト活性を有する特異的IL−15突然変異体 |
-
2005
- 2005-02-10 JP JP2007500188A patent/JP5744369B2/ja not_active Expired - Fee Related
- 2005-02-10 ES ES05707720T patent/ES2367027T3/es active Active
- 2005-02-10 EP EP05707720A patent/EP1718670B1/de not_active Not-in-force
- 2005-02-10 US US10/590,734 patent/US7858081B2/en not_active Expired - Fee Related
- 2005-02-10 WO PCT/EP2005/002367 patent/WO2005085282A1/en active Application Filing
- 2005-02-10 AT AT05707720T patent/ATE516305T1/de not_active IP Right Cessation
-
2010
- 2010-12-23 US US12/978,115 patent/US9493533B2/en not_active Expired - Fee Related
-
2012
- 2012-12-28 JP JP2012287740A patent/JP5819281B2/ja not_active Expired - Fee Related
-
2015
- 2015-07-02 JP JP2015133396A patent/JP2015214561A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP5819281B2 (ja) | 2015-11-24 |
US7858081B2 (en) | 2010-12-28 |
JP5744369B2 (ja) | 2015-07-08 |
US20110158938A1 (en) | 2011-06-30 |
JP2007528726A (ja) | 2007-10-18 |
US9493533B2 (en) | 2016-11-15 |
ES2367027T3 (es) | 2011-10-27 |
EP1718670A1 (de) | 2006-11-08 |
US20080255039A1 (en) | 2008-10-16 |
JP2013081472A (ja) | 2013-05-09 |
EP1718670B1 (de) | 2011-07-13 |
WO2005085282A1 (en) | 2005-09-15 |
JP2015214561A (ja) | 2015-12-03 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |