CY1116415T1 - Φαρμακευτικες συνθεσεις που περιλαμβανουν l-733060 για χρηση στη θεραπευτικη αγωγη καρκινικων ογκων - Google Patents
Φαρμακευτικες συνθεσεις που περιλαμβανουν l-733060 για χρηση στη θεραπευτικη αγωγη καρκινικων ογκωνInfo
- Publication number
- CY1116415T1 CY1116415T1 CY20151100199T CY151100199T CY1116415T1 CY 1116415 T1 CY1116415 T1 CY 1116415T1 CY 20151100199 T CY20151100199 T CY 20151100199T CY 151100199 T CY151100199 T CY 151100199T CY 1116415 T1 CY1116415 T1 CY 1116415T1
- Authority
- CY
- Cyprus
- Prior art keywords
- human
- treatment
- pharmaceutical compositions
- compositions including
- cancer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000032612 Glial tumor Diseases 0.000 abstract 2
- 206010018338 Glioma Diseases 0.000 abstract 2
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 208000011691 Burkitt lymphomas Diseases 0.000 abstract 1
- 208000006168 Ewing Sarcoma Diseases 0.000 abstract 1
- 208000017604 Hodgkin disease Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 206010029260 Neuroblastoma Diseases 0.000 abstract 1
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 abstract 1
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 abstract 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 201000008275 breast carcinoma Diseases 0.000 abstract 1
- 201000005296 lung carcinoma Diseases 0.000 abstract 1
- 208000003747 lymphoid leukemia Diseases 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 abstract 1
- 201000008968 osteosarcoma Diseases 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/046—Tachykinins, e.g. eledoisins, substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση σχετίζεται με τη χρήση ανταγωνιστών της ουσίας Ρ, και ειδικότερα με τη χρήση μη πεπτιδικών ανταγωνιστών των υποδοχέων ΝΚ1 για τη θεραπευτική αγωγή του καρκίνου, και ειδικότερα του ανθρωπίνου μελανώματος, του νευροβλαστώματος, του γλοιώματος, του ανθρωπίνου λεμφώματος Hodgkin ΚΜ-Η2, της λεμφοβλαστικής λευχαιμίας, του ανθρωπίνου ραβδομυοσαρκώματος, του ανθρωπίνου καρκινώματος του μαστού, του ανθρωπίνου λεμφώματος Burkitt, του ανθρωπίνου καρκινώματος του πνεύμονα, του ανθρωπίνου σαρκώματος Ewing, του ανθρωπίνου γλοιώματος και του ανθρωπίνου οστεοσαρκώματος.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200400424A ES2246687B2 (es) | 2004-02-11 | 2004-02-11 | Utilizacion de antagonistas no peptidicos de receptores nk1 para la produccion de apoptosis en celulas tumorales. |
EP05708080.6A EP1803456B1 (en) | 2004-02-11 | 2005-02-10 | Pharmaceutical compositions comprising L-733060 for use in the treatment of cancer tumours |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1116415T1 true CY1116415T1 (el) | 2017-02-08 |
Family
ID=34854896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100199T CY1116415T1 (el) | 2004-02-11 | 2015-02-26 | Φαρμακευτικες συνθεσεις που περιλαμβανουν l-733060 για χρηση στη θεραπευτικη αγωγη καρκινικων ογκων |
Country Status (12)
Country | Link |
---|---|
US (4) | US9867814B2 (el) |
EP (2) | EP2842605A3 (el) |
AU (1) | AU2005211955B2 (el) |
CA (1) | CA2566315C (el) |
CY (1) | CY1116415T1 (el) |
DK (1) | DK1803456T5 (el) |
ES (2) | ES2246687B2 (el) |
HK (2) | HK1105886A1 (el) |
PL (1) | PL1803456T3 (el) |
PT (1) | PT1803456E (el) |
SI (1) | SI1803456T1 (el) |
WO (1) | WO2005077366A1 (el) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2246687B2 (es) | 2004-02-11 | 2006-11-16 | Miguel Muñoz Saez | Utilizacion de antagonistas no peptidicos de receptores nk1 para la produccion de apoptosis en celulas tumorales. |
WO2009124756A1 (en) * | 2008-04-08 | 2009-10-15 | European Molecular Biology Laboratory (Embl) | Use of aprepitant and derivatives thereof for the treatment of cancer |
ES2376564B1 (es) | 2010-08-12 | 2013-01-24 | Manuel Vicente Salinas Martín | Utilización de anticuerpos contra los receptores nk1, nk2 y/o nk3, para producir apoptosis en las células tumorales y modificar el estroma, la inmunidad y la vascularización intra y peritumorales, como tratamiento del cáncer. |
US20150297613A1 (en) | 2011-12-13 | 2015-10-22 | Servicio Andaluz De Salud | Use of agents that alter the peritumoral environment for the treatment of cancer |
ES2493693B1 (es) | 2013-02-11 | 2015-07-07 | Servicio Andaluz De Salud | Método para predecir o pronosticar la respuesta de un sujeto humano que padece un cáncer al tratamiento con un antagonista del receptor NK1 |
ES2541870B1 (es) | 2013-12-27 | 2016-05-12 | Servicio Andaluz De Salud | Uso de antagonistas no peptídicos de NK1 en una determinada dosis para el tratamiento del cáncer |
JP2017502973A (ja) * | 2013-12-30 | 2017-01-26 | オンコプレフェント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌を予防する方法において使用するためのニューロキニン−1受容体アンタゴニスト |
EP3139169A4 (en) * | 2014-04-29 | 2017-11-15 | Servicio Andaluz De Salud | Method for diagnosing and monitoring the presence of cancer in a human subject |
WO2016012594A1 (en) * | 2014-07-24 | 2016-01-28 | Plus Vitech,S.L | Neurokinin-1 receptor antagonist composition for treatment of diseases and conditions of the respiratory tract |
ES2595442B1 (es) * | 2015-05-27 | 2017-10-04 | Consejo Superior De Investigaciones Cientificas (Csic) | Antagonistas de los receptores nk1 derivados de hidratos de carbono, metodo de obtencion y uso medico |
WO2024069344A1 (en) * | 2022-09-29 | 2024-04-04 | Keyzell Holding S.L. | Compositions for the treatment and prevention of cancer |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4680283A (en) | 1984-09-26 | 1987-07-14 | Merck & Co., Inc. | Analogs of substance P and eledoisin |
JPH06507174A (ja) * | 1991-04-22 | 1994-08-11 | マリンクロッド・メディカル・インコーポレイテッド | ニューロキニン1レセプターを有する組織を検出および局部化する方法 |
IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
ATE278687T1 (de) | 1993-12-29 | 2004-10-15 | Merck Sharp & Dohme | Substituierte morpholinderivate und ihre verwendung als therapeutische mittel |
IL112778A0 (en) | 1994-03-04 | 1995-05-26 | Merck & Co Inc | Substituted heterocycles, their preparation and pharmaceutical compositions containing them |
CA2189501A1 (en) * | 1995-11-06 | 1997-05-07 | Harry R. Howard | Nk-1 receptor antagonists for the treatment of cancer |
US6037340A (en) * | 1997-05-28 | 2000-03-14 | Cadus Pharmaceutical Corporation | Synthesis and use of thiophene- and pyrrole-based heteroaromatic compounds |
US5972938A (en) | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
UA60365C2 (uk) * | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
IT1306165B1 (it) * | 1999-07-05 | 2001-05-30 | Innova Ltd | Impiego di inibitori della sostanza p per il trattamento degliadenocarcinomi. |
US20010034320A1 (en) * | 2000-01-18 | 2001-10-25 | Hans-Michael Brecht | NK1-receptor antagonists for treating restless legs syndrome |
ES2244599T3 (es) | 2000-04-10 | 2005-12-16 | Pfizer Products Inc. | Compuestos de benzamido-piperidina como antagonistas de la sustancia p. |
ATE323531T1 (de) * | 2001-04-23 | 2006-05-15 | Hoffmann La Roche | Verwendung von nk-1-rezeptorantagonisten gegen benigne prostatahyperplasie |
US6713490B2 (en) * | 2002-04-26 | 2004-03-30 | Pfizer, Inc. | 3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists |
US20050227929A1 (en) * | 2003-11-13 | 2005-10-13 | Masferrer Jaime L | Combination therapy comprising a Cox-2 inhibitor and an antineoplastic agent |
ES2246687B2 (es) * | 2004-02-11 | 2006-11-16 | Miguel Muñoz Saez | Utilizacion de antagonistas no peptidicos de receptores nk1 para la produccion de apoptosis en celulas tumorales. |
JP2008536881A (ja) | 2005-04-21 | 2008-09-11 | ガストロテック・ファルマ・アクティーゼルスカブ | Glp−1分子と制吐剤との医薬製剤 |
WO2009124756A1 (en) * | 2008-04-08 | 2009-10-15 | European Molecular Biology Laboratory (Embl) | Use of aprepitant and derivatives thereof for the treatment of cancer |
-
2004
- 2004-02-11 ES ES200400424A patent/ES2246687B2/es not_active Expired - Lifetime
-
2005
- 2005-02-10 SI SI200531939T patent/SI1803456T1/sl unknown
- 2005-02-10 US US11/721,256 patent/US9867814B2/en not_active Expired - Fee Related
- 2005-02-10 EP EP20140189674 patent/EP2842605A3/en not_active Withdrawn
- 2005-02-10 CA CA2566315A patent/CA2566315C/en not_active Expired - Fee Related
- 2005-02-10 WO PCT/ES2005/000068 patent/WO2005077366A1/es active Application Filing
- 2005-02-10 ES ES05708080.6T patent/ES2535184T3/es active Active
- 2005-02-10 PL PL05708080T patent/PL1803456T3/pl unknown
- 2005-02-10 AU AU2005211955A patent/AU2005211955B2/en not_active Ceased
- 2005-02-10 EP EP05708080.6A patent/EP1803456B1/en not_active Not-in-force
- 2005-02-10 PT PT05708080T patent/PT1803456E/pt unknown
- 2005-02-10 DK DK05708080.6T patent/DK1803456T5/da active
-
2008
- 2008-01-03 HK HK08100056.3A patent/HK1105886A1/xx not_active IP Right Cessation
-
2015
- 2015-02-26 CY CY20151100199T patent/CY1116415T1/el unknown
- 2015-03-18 HK HK15102803.6A patent/HK1208192A1/xx unknown
- 2015-04-23 US US14/694,697 patent/US20150224095A1/en not_active Abandoned
-
2017
- 2017-12-21 US US15/850,496 patent/US20180117027A1/en not_active Abandoned
-
2019
- 2019-06-12 US US16/438,695 patent/US20200054620A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2566315C (en) | 2013-08-27 |
US20090012086A1 (en) | 2009-01-08 |
EP1803456B1 (en) | 2014-11-26 |
ES2246687A1 (es) | 2006-02-16 |
PL1803456T3 (pl) | 2015-08-31 |
HK1105886A1 (en) | 2008-02-29 |
US20180117027A1 (en) | 2018-05-03 |
WO2005077366A1 (es) | 2005-08-25 |
US9867814B2 (en) | 2018-01-16 |
DK1803456T5 (da) | 2015-06-22 |
WO2005077366B1 (es) | 2005-09-15 |
EP1803456A1 (en) | 2007-07-04 |
ES2535184T3 (es) | 2015-05-06 |
EP2842605A2 (en) | 2015-03-04 |
SI1803456T1 (sl) | 2015-05-29 |
AU2005211955B2 (en) | 2011-06-23 |
HK1208192A1 (en) | 2016-02-26 |
ES2246687B2 (es) | 2006-11-16 |
US20150224095A1 (en) | 2015-08-13 |
PT1803456E (pt) | 2015-03-04 |
DK1803456T3 (en) | 2015-03-02 |
EP2842605A3 (en) | 2015-03-18 |
CA2566315A1 (en) | 2005-08-25 |
US20200054620A1 (en) | 2020-02-20 |
AU2005211955A1 (en) | 2005-08-25 |
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