ATE353370T1 - In vitro-rekonstitution von segmentierten, negativstrang-rna-viren - Google Patents
In vitro-rekonstitution von segmentierten, negativstrang-rna-virenInfo
- Publication number
- ATE353370T1 ATE353370T1 AT00946097T AT00946097T ATE353370T1 AT E353370 T1 ATE353370 T1 AT E353370T1 AT 00946097 T AT00946097 T AT 00946097T AT 00946097 T AT00946097 T AT 00946097T AT E353370 T1 ATE353370 T1 AT E353370T1
- Authority
- AT
- Austria
- Prior art keywords
- segmented negative
- rna viruses
- strand rna
- negative strand
- vitro reconstitution
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 238000000338 in vitro Methods 0.000 title 1
- 210000004748 cultured cell Anatomy 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16161—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14364599P | 1999-07-14 | 1999-07-14 | |
| GBGB9916794.2A GB9916794D0 (en) | 1999-07-16 | 1999-07-16 | In vitro virus reconstitution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353370T1 true ATE353370T1 (de) | 2007-02-15 |
Family
ID=26315773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00946097T ATE353370T1 (de) | 1999-07-14 | 2000-07-14 | In vitro-rekonstitution von segmentierten, negativstrang-rna-viren |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1194580B2 (de) |
| AT (1) | ATE353370T1 (de) |
| AU (1) | AU5998400A (de) |
| CA (1) | CA2379012C (de) |
| CY (2) | CY1106404T1 (de) |
| DE (5) | DE122007000061I2 (de) |
| DK (1) | DK1194580T4 (de) |
| ES (1) | ES2278621T5 (de) |
| FR (1) | FR08C0046I2 (de) |
| LU (1) | LU91367I2 (de) |
| NL (4) | NL300301I2 (de) |
| WO (1) | WO2001004333A1 (de) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2316923T3 (en) | 1998-06-12 | 2018-01-08 | Icahn School Med Mount Sinai | Attenuated influenza viruses with altered interferon antagonist activity for use as vaccines and drugs |
| AU2002309133A1 (en) * | 2001-04-17 | 2002-10-28 | Institut Pasteur | Recombinant segmented negative strand virus with a duplicated 3' noncoding flanking sequence, and therapeutic compositions containing the same |
| EP3009507B1 (de) | 2002-02-13 | 2020-06-24 | Wisconsin Alumini Research Foundation | Signal zur verpackung von influenzavirusvektoren |
| FR2866031B1 (fr) * | 2004-02-11 | 2012-10-19 | David Francois Joseph Millet | Chimere de virus pathogene emergent, medicament la contenant et utilisation en therapie antivirale |
| DE202005022108U1 (de) | 2004-03-09 | 2013-11-12 | Novartis Vaccines And Diagnostics, Inc. | Influenza-Virus-Impfstoffe |
| US8124101B2 (en) | 2004-06-01 | 2012-02-28 | Mount Sinai School Of Medicine | Genetically engineered swine influenza virus and uses thereof |
| DK1831357T3 (da) | 2004-12-24 | 2012-12-10 | Abbott Biologicals Bv | Genvinding af influenzavirus |
| US8137676B2 (en) | 2005-02-15 | 2012-03-20 | Mount Sinai School Of Medicine | Genetically engineered equine influenza virus and uses thereof |
| US11865172B2 (en) | 2005-04-21 | 2024-01-09 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| US7959929B2 (en) | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| CA2613283A1 (en) | 2005-06-21 | 2007-01-04 | Medimmune Vaccines, Inc. | Methods and compositions for expressing a heterologous protease |
| US7790434B2 (en) | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| US20090304742A1 (en) | 2005-11-04 | 2009-12-10 | Novartis Vaccines And Diagnostics Srl | Influenza vaccines with reduced amount of emulsion adjuvant |
| PL1945252T3 (pl) | 2005-11-04 | 2013-11-29 | Seqirus Uk Ltd | Szczepionki zawierające oczyszczone antygeny powierzchniowe otrzymane z wirusów grypy hodowanych w hodowli komórkowej i skwalen jako adiuwant |
| PL1951299T3 (pl) | 2005-11-04 | 2012-07-31 | Novartis Ag | Szczepionki przeciw grypie zawierające kombinacje adiuwantów cząsteczkowych i czynników wzmacniających immunogenność |
| BRPI0618254A2 (pt) | 2005-11-04 | 2011-08-23 | Novartis Vaccines & Diagnostic | emulsões com agente tensoativo de fase aquosa livre para fornecer adjuvante às vacinas contra influenza dividido |
| CN102755645A (zh) | 2005-11-04 | 2012-10-31 | 诺华疫苗和诊断有限公司 | 佐剂配制的包含细胞因子诱导剂的流感疫苗 |
| EP2251034B1 (de) | 2005-12-02 | 2018-02-14 | Icahn School of Medicine at Mount Sinai | Chimäre newcastle disease viren zur präsentation von nicht -nativen oberflächenproteinen und deren verwendung |
| KR20080089663A (ko) | 2006-01-27 | 2008-10-07 | 노바티스 백신즈 앤드 다이아그노스틱스 게엠베하 운트 콤파니 카게 | 적혈구응집소 및 기질 단백질을 함유한 인플루엔자 백신 |
| JP2009534303A (ja) | 2006-03-24 | 2009-09-24 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 冷蔵しないインフルエンザワクチンの保存 |
| JP5491173B2 (ja) * | 2006-04-19 | 2014-05-14 | メディミューン,エルエルシー | イヌ細胞中でマイナス鎖ウイルスrnaを発現させるための方法および組成物 |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| WO2008032219A2 (en) | 2006-09-11 | 2008-03-20 | Novartis Ag | Making influenza virus vaccines without using eggs |
| CN101553252A (zh) | 2006-12-06 | 2009-10-07 | 诺华有限公司 | 包含来自于四株流感病毒的抗原的疫苗 |
| US8597661B2 (en) | 2007-05-04 | 2013-12-03 | Wisconsin Alumni Research Foundation | Neuraminidase-deficient live influenza vaccines |
| WO2008156681A2 (en) * | 2007-06-14 | 2008-12-24 | Yoshihiro Kawaoka | Adenoviral vectors for influenza virus production |
| HRP20120790T1 (hr) | 2007-06-27 | 2013-01-31 | Novartis Ag | Cjepiva protiv influence sa niskom koliäśinom aditiva |
| EP2045323A1 (de) * | 2007-10-05 | 2009-04-08 | Avir Green Hills Biotechnology Research Development Trade Ag | Linearische Expressionskonstrukte zur Herstellung von Partikeln des Influenzavirus |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| ES2535101T3 (es) | 2008-03-18 | 2015-05-05 | Novartis Ag | Mejoras en la preparación de antígenos en vacuna de virus de la gripe |
| EP2233568A1 (de) | 2009-03-19 | 2010-09-29 | Avir Green Hills Biotechnology Research Development Trade AG | Neues Verfahren zur Herstellung eines RNA Virus |
| ES2550179T3 (es) | 2009-02-05 | 2015-11-05 | Icahn School Of Medicine At Mount Sinai | Virus quiméricos de la enfermedad de Newcastle y usos de los mismos |
| WO2010092477A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccines with increased amounts of h3 antigen |
| WO2010092476A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccine regimens for pandemic-associated strains |
| EP2396032B1 (de) | 2009-02-10 | 2016-09-28 | Seqirus UK Limited | Influenza-impfstoffe mit reduzierten squalen-mengen |
| CA2787099A1 (en) | 2009-03-30 | 2010-10-14 | Anice C. Lowen | Influenza virus hemagglutinin polypeptides containing stem domains, vaccines and uses thereof |
| CA2763816A1 (en) | 2009-04-27 | 2010-11-04 | Novartis Ag | Adjuvanted vaccines for protecting against influenza |
| US9217157B2 (en) | 2009-07-27 | 2015-12-22 | Icahn School Of Medicine At Mount Sinai | Recombinant influenza viruses and uses thereof |
| CA2805505C (en) | 2009-07-30 | 2021-08-03 | Mount Sinai School Of Medecine | Chimeric influenza viruses having reduced ability to reassort with other influenza viruses and uses thereof |
| CA2773637A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Combination vaccines against respiratory tract diseases |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| CN102939103A (zh) | 2010-03-30 | 2013-02-20 | 西奈山医学院 | 流感病毒疫苗及其应用 |
| EP2576773A2 (de) | 2010-06-02 | 2013-04-10 | Avir Green Hills Biotechnology Research Development Trade AG | Verfahren und helferviren zur erzeugung von rna-viren |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| KR20140068205A (ko) | 2011-09-20 | 2014-06-05 | 마운트 시나이 스쿨 오브 메디슨 | 인플루엔자 바이러스 백신 및 이의 용도 |
| EP2768528A1 (de) | 2011-10-20 | 2014-08-27 | Novartis AG | Adjuvierte influenza-b-viren-impfstoffe für kinder |
| EP2708552A1 (de) | 2012-09-12 | 2014-03-19 | Medizinische Universität Wien | Influenzavirus |
| GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
| KR20150104117A (ko) | 2012-12-18 | 2015-09-14 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | 인플루엔자 바이러스 백신 및 그의 용도 |
| US20140274806A1 (en) | 2013-03-15 | 2014-09-18 | Synthetic Genomics Vaccines | Influenza virus reassortment |
| MX2015009330A (es) * | 2013-01-23 | 2016-04-15 | Novartis Ag | Reordenamiento del virus de influenza. |
| AU2014241843B2 (en) | 2013-03-14 | 2019-05-02 | Icahn School Of Medicine At Mount Sinai | Newcastle disease viruses and uses thereof |
| WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| CN107073099B (zh) | 2014-02-27 | 2022-09-27 | 默沙东公司 | 用于治疗癌症的联合方法 |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| CL2014003146A1 (es) * | 2014-11-20 | 2015-06-12 | Univ Santiago Chile | Método para producir virus arn monocatenario negativo; plásmido recombinante funcional en células animales, que consta de un esqueleto pss-urg; método de obtención de partículas virales; y uso para expresar arn, proteínas autógenas o exógenas al virus. |
| US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| BR112017015789A2 (pt) | 2015-02-26 | 2018-03-27 | Boehringer Ingelheim Vetmedica Gmbh | vacina de vírus da influenza suína bivalente |
| AU2016281904B2 (en) | 2015-06-26 | 2022-08-11 | Seqirus UK Limited | Antigenically matched influenza vaccines |
| WO2017005880A1 (en) | 2015-07-07 | 2017-01-12 | Seqirus UK Limited | Influenza potency assays |
| EP3341018A1 (de) | 2015-08-28 | 2018-07-04 | Wisconsin Alumni Research Foundation | Erzeugung von infektiösen influenza-viren aus virusähnlichen partikeln |
| AU2017221444B2 (en) | 2016-02-19 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza B virus replication for vaccine development |
| WO2017218624A1 (en) | 2016-06-15 | 2017-12-21 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| WO2018187706A2 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| US11197926B2 (en) | 2017-10-25 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| EP3810634A4 (de) | 2018-06-21 | 2022-07-27 | Icahn School of Medicine at Mount Sinai | Mosaik-influenzavirus-hämagglutinin-polypeptide und deren verwendungen |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| WO2020037215A1 (en) | 2018-08-17 | 2020-02-20 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease |
| US11389523B2 (en) | 2018-08-20 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein |
| CN113874496A (zh) | 2019-02-08 | 2021-12-31 | 威斯康星校友研究基金会(Warf) | 人源化细胞系 |
| EP3959216A4 (de) | 2019-04-24 | 2023-01-11 | Icahn School of Medicine at Mount Sinai | Neuraminidase-antikörper gegen influenza-b-virus und verwendungen davon |
| WO2020223699A1 (en) | 2019-05-01 | 2020-11-05 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| JP7627911B2 (ja) | 2019-08-27 | 2025-02-07 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵内複製のための安定化されたhaを持つ組換えインフルエンザウイルス |
| CN111363727B (zh) * | 2020-01-20 | 2021-09-24 | 武汉大学 | 携带幽门螺杆菌的重组流感病毒、宿主细胞及其制备方法与应用 |
| WO2021150874A1 (en) | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| EP3896077A1 (de) | 2020-04-16 | 2021-10-20 | Österreichische Agentur für Gesundheit und Ernährungssicherheit GmbH | Influenzavirusähnliche partikel (vlps) |
| WO2025019631A1 (en) | 2023-07-19 | 2025-01-23 | Icahn School Of Medicine At Mount Sinai | Immunogenic compositions containing inactivated influenza a virus and cpg oligonucleotide adjuvant and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840520A (en) * | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
| PT1820853E (pt) * | 1999-04-06 | 2012-01-03 | Wisconsin Alumni Res Found | Vírus recombinante da gripe para vacinas e terapia genética |
-
2000
- 2000-07-14 EP EP00946097A patent/EP1194580B2/de not_active Expired - Lifetime
- 2000-07-14 DE DE200712000061 patent/DE122007000061I2/de active Active
- 2000-07-14 ES ES00946097T patent/ES2278621T5/es not_active Expired - Lifetime
- 2000-07-14 DE DE122008000057C patent/DE122008000057I1/de active Pending
- 2000-07-14 AT AT00946097T patent/ATE353370T1/de active
- 2000-07-14 DE DE122008000056C patent/DE122008000056I1/de active Pending
- 2000-07-14 DE DE60033284.5T patent/DE60033284T3/de not_active Expired - Lifetime
- 2000-07-14 DK DK00946097.3T patent/DK1194580T4/da active
- 2000-07-14 WO PCT/GB2000/002710 patent/WO2001004333A1/en not_active Ceased
- 2000-07-14 AU AU59984/00A patent/AU5998400A/en not_active Abandoned
- 2000-07-14 CA CA2379012A patent/CA2379012C/en not_active Expired - Lifetime
- 2000-07-14 DE DE200712000070 patent/DE122007000070I1/de active Pending
-
2007
- 2007-03-20 CY CY20071100397T patent/CY1106404T1/el unknown
- 2007-09-21 LU LU91367C patent/LU91367I2/fr unknown
- 2007-09-21 NL NL300301C patent/NL300301I2/nl unknown
- 2007-09-21 CY CY200700023C patent/CY2007023I1/el unknown
- 2007-09-21 NL NL300294C patent/NL300294I2/nl unknown
-
2008
- 2008-11-13 NL NL300368C patent/NL300368I2/nl unknown
- 2008-11-13 NL NL300369C patent/NL300369I1/nl unknown
- 2008-11-13 FR FR08C0046C patent/FR08C0046I2/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DE122007000061I2 (de) | 2011-07-21 |
| CA2379012A1 (en) | 2001-01-18 |
| DE122007000061I1 (de) | 2007-12-20 |
| AU5998400A (en) | 2001-01-30 |
| NL300368I1 (nl) | 2009-01-05 |
| DE122008000056I1 (de) | 2009-04-09 |
| EP1194580A1 (de) | 2002-04-10 |
| NL300294I1 (nl) | 2007-12-03 |
| DE60033284D1 (de) | 2007-03-22 |
| LU91367I2 (fr) | 2007-11-21 |
| WO2001004333A1 (en) | 2001-01-18 |
| DE60033284T2 (de) | 2007-10-25 |
| CY1106404T1 (el) | 2010-07-28 |
| CY2007023I2 (el) | 2009-11-04 |
| CY2007023I1 (el) | 2009-11-04 |
| NL300301I2 (nl) | 2008-10-01 |
| DK1194580T4 (da) | 2011-01-03 |
| EP1194580B1 (de) | 2007-02-07 |
| DE122007000070I1 (de) | 2008-01-31 |
| ES2278621T5 (es) | 2011-02-02 |
| DE122008000057I1 (de) | 2009-04-09 |
| DE60033284T3 (de) | 2014-10-30 |
| CA2379012C (en) | 2013-07-02 |
| NL300369I1 (nl) | 2009-01-05 |
| NL300368I2 (nl) | 2017-08-03 |
| ES2278621T3 (es) | 2007-08-16 |
| NL300301I1 (nl) | 2008-01-02 |
| EP1194580B2 (de) | 2010-08-25 |
| NL300294I2 (nl) | 2008-10-01 |
| FR08C0046I1 (fr) | 2009-01-02 |
| FR08C0046I2 (fr) | 2011-11-25 |
| DK1194580T3 (da) | 2007-04-10 |
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