EA200201164A1 - Система трансфекции днк для получения инфекционного вируса гриппа - Google Patents
Система трансфекции днк для получения инфекционного вируса гриппаInfo
- Publication number
- EA200201164A1 EA200201164A1 EA200201164A EA200201164A EA200201164A1 EA 200201164 A1 EA200201164 A1 EA 200201164A1 EA 200201164 A EA200201164 A EA 200201164A EA 200201164 A EA200201164 A EA 200201164A EA 200201164 A1 EA200201164 A1 EA 200201164A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- rna
- viruses
- plasmids
- weakened
- virus
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 5
- 208000015181 infectious disease Diseases 0.000 title 1
- 230000002458 infectious effect Effects 0.000 title 1
- 230000009466 transformation Effects 0.000 title 1
- 239000013612 plasmid Substances 0.000 abstract 3
- 241000712461 unidentified influenza virus Species 0.000 abstract 3
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 101710154606 Hemagglutinin Proteins 0.000 abstract 1
- 102000012750 Membrane Glycoproteins Human genes 0.000 abstract 1
- 108010090054 Membrane Glycoproteins Proteins 0.000 abstract 1
- 102000005348 Neuraminidase Human genes 0.000 abstract 1
- 108010006232 Neuraminidase Proteins 0.000 abstract 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 abstract 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 abstract 1
- 101710176177 Protein A56 Proteins 0.000 abstract 1
- 108020000999 Viral RNA Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 230000002238 attenuated effect Effects 0.000 abstract 1
- 241001493065 dsRNA viruses Species 0.000 abstract 1
- 239000000185 hemagglutinin Substances 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
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- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
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Abstract
Настоящее изобретение основано на создании системы с двойным промотором (предпочтительно РНК pol I-pol II системы) для эффективного внутриклеточного синтеза вирусной РНК. Полученная система, основанная на минимальном количестве плазмид, может быть использована для синтеза РНК вируса, предпочтительно вирусов с геномом, представленным отрицательной одноцепочечной РНК. Вирусный продукт системы образуется, когда плазмиды системы вводят в соответствующую клетку-хозяина. Одним из вариантов реализации изобретения является получение ослабленных реассортированных вирусов гриппа для использования их в качестве антигенов в вакцинах. Реассортированные вирусы, полученные путем котрансфекции плазмид, могут содержать гены, кодирующие поверхностные гликопротеины - гемагглютинин и невраминидазу из вируса гриппа, который в настоящее время инфицирует население, и внутренние гены из ослабленного вируса гриппа. Одним из достоинств настоящего изобретения является его универсальность; систему можно быстро и легко адаптировать для синтеза ослабленного варианта любого РНК вируса. Ослабленные или инактивированные РНК-вирусы, полученные согласно настоящему изобретению, при необходимости вакцинации можно вводить пациенту любым из нескольких способов, в том числе интраназально или внутримышечно.Отчет о международном поиске был опубликован 2003.03.27.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20067900P | 2000-04-28 | 2000-04-28 | |
PCT/US2001/013656 WO2001083794A2 (en) | 2000-04-28 | 2001-04-27 | Dna transfection system for the generation of infectious influenza virus |
Publications (2)
Publication Number | Publication Date |
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EA200201164A1 true EA200201164A1 (ru) | 2003-10-30 |
EA006311B1 EA006311B1 (ru) | 2005-10-27 |
Family
ID=22742710
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EA200201164A EA006311B1 (ru) | 2000-04-28 | 2001-04-27 | Система трансфекции днк для получения инфекционного вируса гриппа |
Country Status (26)
Country | Link |
---|---|
US (6) | US6951754B2 (ru) |
EP (2) | EP2085468A1 (ru) |
JP (3) | JP2004500842A (ru) |
KR (2) | KR100862758B1 (ru) |
CN (2) | CN100489107C (ru) |
AT (1) | ATE420189T1 (ru) |
AU (3) | AU2001259211B2 (ru) |
BR (1) | BRPI0110607B8 (ru) |
CA (1) | CA2406100C (ru) |
CY (1) | CY1108735T1 (ru) |
DE (2) | DE122011100039I1 (ru) |
DK (1) | DK1317559T3 (ru) |
EA (1) | EA006311B1 (ru) |
ES (1) | ES2319864T3 (ru) |
HK (1) | HK1055992A1 (ru) |
HU (1) | HU229101B1 (ru) |
IL (1) | IL152426A (ru) |
MX (1) | MXPA02010642A (ru) |
NO (1) | NO332080B1 (ru) |
NZ (1) | NZ521840A (ru) |
PL (1) | PL205955B1 (ru) |
PT (1) | PT1317559E (ru) |
SI (1) | SI1317559T1 (ru) |
UA (1) | UA84254C2 (ru) |
WO (1) | WO2001083794A2 (ru) |
ZA (1) | ZA200208065B (ru) |
Families Citing this family (132)
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US8715940B2 (en) | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
US6951754B2 (en) * | 2000-04-28 | 2005-10-04 | St. Jude Children's Research Hospital | DNA transfection system for the generation of infectious influenza virus |
WO2003091401A2 (en) | 2002-04-26 | 2003-11-06 | Medimmune Vaccines, Inc. | Multi plasmid system for the production of influenza virus |
US7465456B2 (en) * | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
ES2427139T3 (es) | 2002-06-20 | 2013-10-29 | Institut Pasteur | Virus recombinantes del sarampión que expresan epítopos de antígenos de virus de ARN y uso de los virus recombinantes para la preparación de composiciones de vacuna |
EP1375512B1 (en) | 2002-06-20 | 2009-07-22 | Institut Pasteur | Infectious cDNA of an approved vaccine strain of measles virus. Use for immunogenic compositions |
DE10248301A1 (de) * | 2002-10-16 | 2004-04-29 | Philipps-Universität Marburg | Herstellung eines Lebend-Impfstoffes gegen Influenza-Viren |
JP4617300B2 (ja) | 2003-02-25 | 2011-01-19 | メディミューン,エルエルシー | インフルエンザワクチン組成物を生成する方法 |
US20060110406A1 (en) * | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
CA2432738A1 (en) | 2003-02-26 | 2004-08-26 | Philippe Despres | New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications |
CA2526834A1 (en) * | 2003-05-28 | 2005-03-31 | Wisconsin Alumni Research Foundation | Recombinant influenza vectors with a polii promoter and ribozymes |
WO2004112831A2 (en) * | 2003-05-28 | 2004-12-29 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines and gene therapy |
WO2005018539A2 (en) * | 2003-06-16 | 2005-03-03 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
US7037707B2 (en) * | 2003-09-04 | 2006-05-02 | St. Jude Children's Research Hospital | Method for generating influenza viruses and vaccines |
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