EA027971B1 - Пирролбензодиазепины - Google Patents

Пирролбензодиазепины Download PDF

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Publication number
EA027971B1
EA027971B1 EA201490518A EA201490518A EA027971B1 EA 027971 B1 EA027971 B1 EA 027971B1 EA 201490518 A EA201490518 A EA 201490518A EA 201490518 A EA201490518 A EA 201490518A EA 027971 B1 EA027971 B1 EA 027971B1
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EA
Eurasian Patent Office
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group
attachment
point
groups
compound
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Application number
EA201490518A
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English (en)
Russian (ru)
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EA201490518A1 (ru
Inventor
Филип Уилсон Ховард
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Медимьюн Лимитед
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Publication of EA201490518A1 publication Critical patent/EA201490518A1/ru
Publication of EA027971B1 publication Critical patent/EA027971B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • C07K5/06008—Dipeptides with the first amino acid being neutral
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    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • C07K5/06043—Leu-amino acid
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    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
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    • C07K—PEPTIDES
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    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biophysics (AREA)
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  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
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EA201490518A 2011-09-20 2012-09-20 Пирролбензодиазепины EA027971B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161536669P 2011-09-20 2011-09-20
PCT/EP2012/068506 WO2013041606A1 (en) 2011-09-20 2012-09-20 Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates

Publications (2)

Publication Number Publication Date
EA201490518A1 EA201490518A1 (ru) 2014-08-29
EA027971B1 true EA027971B1 (ru) 2017-09-29

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EA201490518A EA027971B1 (ru) 2011-09-20 2012-09-20 Пирролбензодиазепины

Country Status (12)

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US (1) US9399641B2 (https=)
EP (1) EP2751120B1 (https=)
JP (1) JP6170494B2 (https=)
KR (1) KR101860174B1 (https=)
CN (1) CN103987718A (https=)
AU (1) AU2012311505B2 (https=)
BR (1) BR112014006703A8 (https=)
CA (1) CA2849039C (https=)
EA (1) EA027971B1 (https=)
MX (1) MX341524B (https=)
SG (1) SG11201400770SA (https=)
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EA201490518A1 (ru) 2014-08-29
JP6170494B2 (ja) 2017-07-26
AU2012311505B2 (en) 2016-09-29
CN103987718A (zh) 2014-08-13
BR112014006703A2 (pt) 2017-04-11
KR20140064961A (ko) 2014-05-28
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JP2014527974A (ja) 2014-10-23
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