EA024792B1 - Производные полимиксина - Google Patents

Производные полимиксина Download PDF

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Publication number
EA024792B1
EA024792B1 EA201490634A EA201490634A EA024792B1 EA 024792 B1 EA024792 B1 EA 024792B1 EA 201490634 A EA201490634 A EA 201490634A EA 201490634 A EA201490634 A EA 201490634A EA 024792 B1 EA024792 B1 EA 024792B1
Authority
EA
Eurasian Patent Office
Prior art keywords
nanopeptide
alkyl
group
compound
formula
Prior art date
Application number
EA201490634A
Other languages
English (en)
Russian (ru)
Other versions
EA201490634A1 (ru
Inventor
Мона Саади
Эстер Дюперчи
Памела Браун
Майкл Джон Доусон
Сьёрд Николаас Вадман
Original Assignee
Новакта Биосистемс Лимитед
Кентаб Анти-Инфективис Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новакта Биосистемс Лимитед, Кентаб Анти-Инфективис Лимитед filed Critical Новакта Биосистемс Лимитед
Publication of EA201490634A1 publication Critical patent/EA201490634A1/ru
Publication of EA024792B1 publication Critical patent/EA024792B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EA201490634A 2011-11-18 2012-11-16 Производные полимиксина EA024792B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161561361P 2011-11-18 2011-11-18
PCT/GB2012/052844 WO2013072695A1 (en) 2011-11-18 2012-11-16 Polymyxin derivatives

Publications (2)

Publication Number Publication Date
EA201490634A1 EA201490634A1 (ru) 2014-12-30
EA024792B1 true EA024792B1 (ru) 2016-10-31

Family

ID=47297320

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490634A EA024792B1 (ru) 2011-11-18 2012-11-16 Производные полимиксина

Country Status (15)

Country Link
US (1) US9234006B2 (OSRAM)
EP (1) EP2780357A1 (OSRAM)
JP (1) JP6185920B2 (OSRAM)
KR (1) KR20140091724A (OSRAM)
CN (1) CN103946233A (OSRAM)
AU (1) AU2012338571B2 (OSRAM)
BR (1) BR112014012016A2 (OSRAM)
CA (1) CA2855916A1 (OSRAM)
CO (1) CO7061068A2 (OSRAM)
EA (1) EA024792B1 (OSRAM)
IL (1) IL232278A0 (OSRAM)
MX (1) MX355217B (OSRAM)
SG (1) SG11201402390PA (OSRAM)
TW (1) TWI608019B (OSRAM)
WO (1) WO2013072695A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2730012C2 (ru) * 2013-05-22 2020-08-14 Сперо Терапьютикс, Инк. Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками
RU2740190C2 (ru) * 2014-03-11 2021-01-12 Сперо Терапьютикс, Инк. Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками

Families Citing this family (19)

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CA2855916A1 (en) 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives
PL3126376T3 (pl) 2014-04-01 2024-10-28 Monash University Pochodne polimyksyn jako związki przeciwdrobnoustrojowe
JP7349773B2 (ja) * 2014-11-26 2023-09-25 スペロ・セラピューティクス・インコーポレーテッド 化合物
WO2016100578A2 (en) 2014-12-16 2016-06-23 Micurx Pharmaceuticals, Inc. Antimicrobial polymyxins for treatment of bacterial infections
FI126143B (en) 2015-01-15 2016-07-15 Northern Antibiotics Oy Polymyxine derivative and its uses
US9763996B2 (en) 2015-01-16 2017-09-19 Northern Antibiotics, Ltd. Polymyxin derivative and uses thereof
US10322187B2 (en) 2015-08-10 2019-06-18 Lehigh University Reduced toxicity molecular conjugates of anti-fungal agents
AU2016331658B2 (en) * 2015-09-29 2021-04-01 Monash University Antimicrobial polymyxin derivative compounds
EP3512544B1 (en) * 2016-09-13 2020-10-28 Centauri Therapeutics Limited Peptide compounds and therapeutic uses thereof
CN108226315B (zh) * 2016-12-15 2022-04-12 上海医药工业研究院 一种检测多黏菌素e残留量的分析方法
WO2019084628A1 (en) * 2017-11-02 2019-05-09 The University Of Queensland Peptide antibiotics
UA128162C2 (uk) 2018-06-25 2024-04-24 Сперо Терапьютікс, Інк. Поліміксинові сполуки
CN111690040A (zh) * 2019-03-12 2020-09-22 上海来益生物药物研究开发中心有限责任公司 多粘菌素衍生物、其制备方法和应用
JP7045520B2 (ja) * 2020-01-02 2022-03-31 上海上薬第一生化薬業有限公司 ポリミキシンｂ成分又はその塩、その製造方法及び使用
CN115298198A (zh) 2020-01-21 2022-11-04 上海盟科药业股份有限公司 用于肾相关癌症靶向治疗的新型化合物和组合物
TW202233649A (zh) 2020-11-06 2022-09-01 美商斯佩羅治療學股份有限公司 化合物
CN112755174B (zh) * 2021-02-26 2022-11-18 沈阳药科大学 多粘菌素衍生物及其制备方法和应用
CN115490757B (zh) * 2021-06-18 2025-10-14 华南理工大学 活性氧自由基响应的多粘菌素前药化合物及其应用
NL2030897B1 (en) * 2022-02-11 2023-08-18 Univ Leiden Antibiotic compounds, formulations and methods of use

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WO2008017734A1 (en) * 2006-08-11 2008-02-14 Northern Antibiotics Oy Polymyxin derivatives and uses thereof
WO2009098357A1 (en) * 2008-02-08 2009-08-13 Northern Antibiotics Oy Short fatty acid tail polymyxin derivatives and uses thereof
US20090215677A1 (en) * 2008-02-08 2009-08-27 Martti Sakari Vaara Polymyxin derivatives and uses thereof
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents

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GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
WO1988000950A2 (fr) 1986-08-06 1988-02-11 Fauchere Jean Luc Fabrication de conjugues a liaisons de covalence a partir d'un antibiotique et d'un derive non toxique de la polymyxine b
US20010021697A1 (en) 1987-09-14 2001-09-13 Henning Lowenstein Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom, proteinageous or polypeptide components thereof, or analogues of such proteinaceous or polypeptide components
TW274552B (OSRAM) 1992-05-26 1996-04-21 Hoechst Ag
US5767068A (en) 1997-02-13 1998-06-16 Pathogenesis Corporation Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections
CN1886128A (zh) 2003-09-30 2006-12-27 柯西有限公司 用于治疗灼伤的组合物及方法
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
US8193148B2 (en) 2008-02-08 2012-06-05 Northern Antibiotics Ltd. Short fatty acid tail polymyxin derivatives and uses thereof
ES2334547B1 (es) 2008-09-10 2010-12-03 Universidad De Barcelona Compuestos peptidicos antibacterianos.
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CN101851270A (zh) 2009-04-03 2010-10-06 梁浩 一种多粘菌素衍生物及其制备方法
WO2010130007A1 (en) 2009-05-14 2010-11-18 Monash University Antimicrobial compounds
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2012051663A1 (en) 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
CA2855916A1 (en) 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives
HRP20220898T1 (hr) 2013-05-22 2022-10-14 Spero Therapeutics, Inc. Derivati polimiksina i njihova upotreba u kombinacijskoj terapiji zajedno s različitim antibioticima
TWI709575B (zh) * 2014-03-11 2020-11-11 美商斯佩羅治療學股份有限公司 多黏菌素衍生物以及其與不同抗生素一起之組合療法的用途

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
WO2008017734A1 (en) * 2006-08-11 2008-02-14 Northern Antibiotics Oy Polymyxin derivatives and uses thereof
WO2009098357A1 (en) * 2008-02-08 2009-08-13 Northern Antibiotics Oy Short fatty acid tail polymyxin derivatives and uses thereof
US20090215677A1 (en) * 2008-02-08 2009-08-27 Martti Sakari Vaara Polymyxin derivatives and uses thereof
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents

Non-Patent Citations (6)

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KATSUMA NAOKO , SATO YUKI , OHKI KAZUHIRO , OKIMURA KEIKO, UCHIDA YOSHIKI , SHINDO MITSUNO , SAKURA NAOKI: "Antimicrobial activity of Des-fatty acyl-polymyxin B decapeptide N-terminal analogs", PEPTIDE SCIENCE, PROTEIN RESEARCH FOUNDATION, MINOO,, JP, vol. 2004, 1 January 2005 (2005-01-01), JP, pages 549 - 550, XP002690946, ISSN: 1344-7661 *
KATSUMA NAOKO, ET AL: "Development of Des-Fatty Acyl-Polymyxin B Decapeptide Analogs with Pseudomonas aeruginosa-Specific Antimicrobial Activity", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 57, no. 4, 1 April 2009 (2009-04-01), JP, pages 332 - 336, XP002683206, ISSN: 0009-2363 *
OKIMURA KEIKO, SATO YUKI, OHKI KAZUHIRO, OHNISHI KUNIHARU, SAKURA NAOKI: "Antimicrobial activity of various aminocyclohexylcarbonyl-polymyxin B (2-10) derivatives", PEPTIDE SCIENCE, PROTEIN RESEARCH FOUNDATION, MINOO,, JP, no. NUMB 45, 1 January 2009 (2009-01-01), JP, pages 243 - 244, XP002690948, ISSN: 1344-7661 *
SATO Y., KATSUMA N., OHKI K., OKIMURA K., UCHIDA Y., OHNISHI K., SAKURA N.: "Des-fatty acyl-polymyxin B decapeptide analogs with antimicrobial activity specifically against Pseudomonas aeruginosa", PEPTIDE SCIENCE, PROTEIN RESEARCH FOUNDATION, MINOO,, JP, no. NUMB 44, 1 January 2007 (2007-01-01), JP, pages 307 - 308, XP002690947, ISSN: 1344-7661 *
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YUKIO KIMURA, HISAMI MATSUNAGA, MARTTI VAARA: "Polymyxin B octapeptide and polymyxin B heptapeptide are potent outer membrane permeability-increasing agents.", THE JOURNAL OF ANTIBIOTICS, vol. 45, no. 5, 1 January 1992 (1992-01-01), pages 742 - 749, XP055050711, ISSN: 00218820, DOI: 10.7164/antibiotics.45.742 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2730012C2 (ru) * 2013-05-22 2020-08-14 Сперо Терапьютикс, Инк. Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками
RU2740190C2 (ru) * 2014-03-11 2021-01-12 Сперо Терапьютикс, Инк. Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками

Also Published As

Publication number Publication date
US20150031602A1 (en) 2015-01-29
WO2013072695A1 (en) 2013-05-23
CO7061068A2 (es) 2014-09-19
CA2855916A1 (en) 2013-05-23
CN103946233A (zh) 2014-07-23
EA201490634A1 (ru) 2014-12-30
SG11201402390PA (en) 2014-06-27
JP6185920B2 (ja) 2017-08-23
TWI608019B (zh) 2017-12-11
BR112014012016A2 (pt) 2017-05-16
US9234006B2 (en) 2016-01-12
JP2014533678A (ja) 2014-12-15
IL232278A0 (en) 2014-06-30
KR20140091724A (ko) 2014-07-22
TW201326215A (zh) 2013-07-01
AU2012338571A1 (en) 2014-05-22
MX355217B (es) 2018-04-10
EP2780357A1 (en) 2014-09-24
AU2012338571B2 (en) 2016-06-16
MX2014005542A (es) 2014-10-24

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Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU