EA005183B1 - Производные хинолилпропилпиперидина, их получение и содержащие их композиции - Google Patents

Производные хинолилпропилпиперидина, их получение и содержащие их композиции Download PDF

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Publication number
EA005183B1
EA005183B1 EA200200374A EA200200374A EA005183B1 EA 005183 B1 EA005183 B1 EA 005183B1 EA 200200374 A EA200200374 A EA 200200374A EA 200200374 A EA200200374 A EA 200200374A EA 005183 B1 EA005183 B1 EA 005183B1
Authority
EA
Eurasian Patent Office
Prior art keywords
propyl
methoxyquinolin
piperidine
piperidin
acetic acid
Prior art date
Application number
EA200200374A
Other languages
English (en)
Russian (ru)
Other versions
EA200200374A1 (ru
Inventor
Серж Миньани
Мишель Табар
Жан-Кристоф Карри
Мишель Эвер
Юссеф Эль Ахмад
Original Assignee
Авентис Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фарма С.А. filed Critical Авентис Фарма С.А.
Publication of EA200200374A1 publication Critical patent/EA200200374A1/ru
Publication of EA005183B1 publication Critical patent/EA005183B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
EA200200374A 1999-09-17 2000-09-14 Производные хинолилпропилпиперидина, их получение и содержащие их композиции EA005183B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9911679A FR2798656B1 (fr) 1999-09-17 1999-09-17 Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
PCT/FR2000/002541 WO2001025227A2 (fr) 1999-09-17 2000-09-14 Derives de la quinolyl propyl piperidine et leur utilisation en tant que antibacteriens

Publications (2)

Publication Number Publication Date
EA200200374A1 EA200200374A1 (ru) 2002-10-31
EA005183B1 true EA005183B1 (ru) 2004-12-30

Family

ID=9549990

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200374A EA005183B1 (ru) 1999-09-17 2000-09-14 Производные хинолилпропилпиперидина, их получение и содержащие их композиции

Country Status (30)

Country Link
EP (2) EP1218370B1 (fr)
JP (1) JP2004527448A (fr)
KR (1) KR20020038757A (fr)
CN (1) CN1374959A (fr)
AP (1) AP2002002459A0 (fr)
AT (1) ATE284399T1 (fr)
AU (1) AU7429500A (fr)
BG (1) BG106524A (fr)
BR (1) BR0014060A (fr)
CA (1) CA2383836A1 (fr)
CZ (1) CZ2002940A3 (fr)
DE (2) DE60034713T2 (fr)
DZ (1) DZ3195A1 (fr)
EA (1) EA005183B1 (fr)
EE (1) EE200200138A (fr)
FR (1) FR2798656B1 (fr)
GE (1) GEP20043223B (fr)
HR (1) HRP20020214A2 (fr)
HU (1) HUP0204283A3 (fr)
IL (1) IL148720A0 (fr)
MA (1) MA26820A1 (fr)
MX (1) MXPA02001979A (fr)
NO (1) NO20021253L (fr)
OA (1) OA12022A (fr)
PL (1) PL354809A1 (fr)
SK (1) SK3632002A3 (fr)
TN (1) TNSN00184A1 (fr)
WO (1) WO2001025227A2 (fr)
YU (1) YU19002A (fr)
ZA (1) ZA200202073B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2671496C2 (ru) * 2013-10-14 2018-11-01 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Производные 5-пиперидин-8-цианохинолина

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9822440D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
AU2001289749B9 (en) 2000-07-26 2004-08-19 Smithkline Beecham P.L.C. Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
AU2003239302A1 (en) 2002-01-29 2003-09-02 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
JP4445753B2 (ja) 2002-01-29 2010-04-07 グラクソ グループ リミテッド アミノピペリジン誘導体
TW200409637A (en) 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
AR040335A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto
FR2842807A1 (fr) * 2002-07-23 2004-01-30 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant
FR2844270B1 (fr) 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
FR2844268B1 (fr) * 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
ATE463494T1 (de) * 2002-10-10 2010-04-15 Morphochem Ag Komb Chemie Neue verbindungen mit antibakterieller aktivität
ATE461928T1 (de) 2002-11-05 2010-04-15 Glaxosmithkline Llc Antibakterielle wirkstoffe
WO2004041210A2 (fr) 2002-11-05 2004-05-21 Smithkline Beecham Corporation Agents antibacteriens
US7491714B2 (en) 2002-12-04 2009-02-17 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
CN101039935B (zh) * 2004-10-05 2011-04-20 埃科特莱茵药品有限公司 哌啶抗生素
EP1799674B1 (fr) * 2004-10-05 2010-05-05 Actelion Pharmaceuticals Ltd. Nouveaux antibiotiques de piperidine
US7648980B2 (en) 2005-01-25 2010-01-19 Glaxo Group Limited Antibacterial agents
WO2006081179A1 (fr) 2005-01-25 2006-08-03 Glaxo Group Limited Agents antibacteriens
US7592334B2 (en) 2005-01-25 2009-09-22 Glaxo Group Limited Antibacterial agents
EP1846417A4 (fr) 2005-01-25 2009-12-23 Glaxo Group Ltd Agents antibacteriens
EP1981881B1 (fr) 2006-01-26 2011-12-07 Actelion Pharmaceuticals Ltd. Antibiotiques de type tétrahydropyranne
DE602007009205D1 (de) 2006-04-06 2010-10-28 Glaxo Group Ltd Pyrrolochinoxalinonderivate als antibakterielle mittel
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (fr) 2007-05-18 2008-11-19 Glaxo Group Limited Dérivés et analogues de N-éthylquinolones et N-éthylazaquinolones
MX2009012117A (es) * 2007-05-09 2009-11-23 Pfizer Composiciones y derivados heterociclicos sustituidos y su uso farmaceutico como antibacterianos.
EP2080761A1 (fr) 2008-01-18 2009-07-22 Glaxo Group Limited Composés
WO2010043714A1 (fr) 2008-10-17 2010-04-22 Glaxo Group Limited Composés azotés tricycliques utilisés comme agents antibactériens
US8318940B2 (en) 2009-01-15 2012-11-27 Glaxo Group Limited Naphthyridin-2 (1 H)-one compounds useful as antibacterials
TW201618779A (zh) 2014-08-22 2016-06-01 葛蘭素史克智慧財產發展有限公司 方法
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
NZ742476A (en) 2015-12-17 2022-09-30 Merck Patent Gmbh Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders
ES2944573T3 (es) 2016-08-08 2023-06-22 Merck Patent Gmbh Antagonistas de TLR7/8 y usos de los mismos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002501061A (ja) * 1998-01-26 2002-01-15 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 抗菌剤用キノリン誘導体
AU2437900A (en) * 1999-01-20 2000-08-07 Smithkline Beecham Plc Piperidinylquinolines as protein tyrosine kinase inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2671496C2 (ru) * 2013-10-14 2018-11-01 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Производные 5-пиперидин-8-цианохинолина

Also Published As

Publication number Publication date
DE60016611T2 (de) 2005-12-22
EE200200138A (et) 2003-06-16
AP2002002459A0 (en) 2002-06-30
JP2004527448A (ja) 2004-09-09
EP1484328B1 (fr) 2007-05-02
OA12022A (fr) 2006-04-19
FR2798656A1 (fr) 2001-03-23
NO20021253L (no) 2002-04-24
EP1484328A1 (fr) 2004-12-08
EP1218370A2 (fr) 2002-07-03
YU19002A (sh) 2005-06-10
AU7429500A (en) 2001-05-10
DE60016611D1 (de) 2005-01-13
BG106524A (en) 2003-01-31
FR2798656B1 (fr) 2004-12-17
CZ2002940A3 (cs) 2002-07-17
DZ3195A1 (fr) 2001-04-12
BR0014060A (pt) 2002-05-21
DE60034713D1 (de) 2007-06-14
PL354809A1 (en) 2004-02-23
DE60034713T2 (de) 2008-01-17
WO2001025227A3 (fr) 2001-11-22
ATE284399T1 (de) 2004-12-15
HUP0204283A3 (en) 2004-07-28
CA2383836A1 (fr) 2001-04-12
ZA200202073B (en) 2003-08-27
KR20020038757A (ko) 2002-05-23
SK3632002A3 (en) 2003-04-01
NO20021253D0 (no) 2002-03-13
HUP0204283A2 (hu) 2003-04-28
TNSN00184A1 (fr) 2005-11-10
MXPA02001979A (es) 2002-08-20
EA200200374A1 (ru) 2002-10-31
GEP20043223B (en) 2004-04-26
WO2001025227A2 (fr) 2001-04-12
HRP20020214A2 (en) 2005-04-30
MA26820A1 (fr) 2004-12-20
EP1218370B1 (fr) 2004-12-08
IL148720A0 (en) 2002-09-12
CN1374959A (zh) 2002-10-16

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU