EA003514B1 - Замещенные индолиноны, их получение и их применение в качестве лекарственных средств - Google Patents

Замещенные индолиноны, их получение и их применение в качестве лекарственных средств Download PDF

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Publication number
EA003514B1
EA003514B1 EA200100001A EA200100001A EA003514B1 EA 003514 B1 EA003514 B1 EA 003514B1 EA 200100001 A EA200100001 A EA 200100001A EA 200100001 A EA200100001 A EA 200100001A EA 003514 B1 EA003514 B1 EA 003514B1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
alkyl
substituted
groups
phenyl
Prior art date
Application number
EA200100001A
Other languages
English (en)
Russian (ru)
Other versions
EA200100001A1 (ru
Inventor
Армин Хеккель
Райнер Вальтер
Вольфганг Грелль
Якобус С.А. Ван Меель
Норберт Редеманн
Original Assignee
Бёрингер Ингельхайм Фарма Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Фарма Кг filed Critical Бёрингер Ингельхайм Фарма Кг
Publication of EA200100001A1 publication Critical patent/EA200100001A1/ru
Publication of EA003514B1 publication Critical patent/EA003514B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EA200100001A 1998-06-04 1999-05-28 Замещенные индолиноны, их получение и их применение в качестве лекарственных средств EA003514B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19824922A DE19824922A1 (de) 1998-06-04 1998-06-04 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/003692 WO1999062882A1 (de) 1998-06-04 1999-05-28 Substituierte indolinone, ihre herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
EA200100001A1 EA200100001A1 (ru) 2001-08-27
EA003514B1 true EA003514B1 (ru) 2003-06-26

Family

ID=7869856

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100001A EA003514B1 (ru) 1998-06-04 1999-05-28 Замещенные индолиноны, их получение и их применение в качестве лекарственных средств

Country Status (23)

Country Link
EP (1) EP1100779A1 (de)
JP (1) JP2002516906A (de)
KR (1) KR20010043973A (de)
CN (1) CN1303374A (de)
AU (1) AU764782B2 (de)
BG (1) BG104938A (de)
BR (1) BR9910898A (de)
CA (1) CA2328291A1 (de)
CO (1) CO5050294A1 (de)
DE (1) DE19824922A1 (de)
EA (1) EA003514B1 (de)
EE (1) EE200000723A (de)
HR (1) HRP20000831A2 (de)
HU (1) HUP0102210A3 (de)
ID (1) ID27035A (de)
IL (1) IL138702A0 (de)
NO (1) NO20006138L (de)
PL (1) PL344467A1 (de)
SK (1) SK18222000A3 (de)
TR (1) TR200003515T2 (de)
WO (1) WO1999062882A1 (de)
YU (1) YU73900A (de)
ZA (1) ZA200005435B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19816624A1 (de) * 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
GB9904933D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
UA75054C2 (uk) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
US6762180B1 (en) 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
WO2002020513A1 (en) * 2000-09-01 2002-03-14 Glaxo Group Limited Oxindole derivatives
AU2001288374A1 (en) 2000-09-01 2002-03-22 Glaxo Group Limited Substituted oxindole derivatives as tyrosine kinase inhibitors
DE10117204A1 (de) 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
ES2274075T3 (es) 2001-06-29 2007-05-16 Ab Science Utilizacion de inhibidores de c-kit para tratar enfermedades inflamatorias intestinales (eii).
ES2266553T3 (es) 2001-06-29 2007-03-01 Ab Science Utilizacion de derivados de la n-fenil-2-pirimidina-amina para tratar las enfermedades inflamatorias.
EP1401413B1 (de) 2001-06-29 2006-11-22 AB Science Die verwendung von tyrosinkinasehemmer zur behandlung von allergischen erkrankungen
ATE401079T1 (de) * 2001-06-29 2008-08-15 Ab Science Die verwendung von c-kithemmern zur behandlung von autoimmunerkrankungen
DE60223063T2 (de) 2001-06-29 2008-07-17 Ab Science C-kit inhibitoren
CA2461812C (en) 2001-09-27 2011-09-20 Allergan, Inc. 3-(arylamino)methylene-1,3-dihydro-2h-indol-2-ones as kinase inhibitors
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
DE102004012070A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
PE20060777A1 (es) * 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
SG177128A1 (en) * 2006-12-05 2012-01-30 Arena Pharm Inc Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
CN101735071A (zh) * 2009-12-04 2010-06-16 大连凯飞精细化工有限公司 一种生产4-n,n-二甲胺基甲基苯胺的方法
CN103102352B (zh) * 2011-11-15 2015-08-12 山东亨利医药科技有限责任公司 酪氨酸激酶抑制剂吲哚满酮衍生物
CN103130775B (zh) * 2011-11-22 2015-09-30 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的吲哚满酮衍生物
GB201208775D0 (en) * 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
CN103848814B (zh) * 2012-12-06 2016-08-17 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的取代吲哚满酮衍生物
US20240150368A1 (en) * 2022-09-02 2024-05-09 Deciphera Pharmaceuticals, Llc Ulk inhibitors and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE838623A (fr) * 1976-02-16 1976-06-16 Derives de 3-hydroxymethylene-2-indolinone et procede pour leur production
US4145422A (en) * 1977-09-06 1979-03-20 Abbott Laboratories Aminomethylene oxindoles
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
CA2264220A1 (en) * 1996-08-23 1998-02-26 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
JP2002516906A (ja) 2002-06-11
DE19824922A1 (de) 1999-12-09
CA2328291A1 (en) 1999-12-09
HUP0102210A2 (hu) 2001-11-28
CO5050294A1 (es) 2001-06-27
AU4370799A (en) 1999-12-20
IL138702A0 (en) 2001-10-31
EE200000723A (et) 2002-04-15
BG104938A (en) 2001-06-29
PL344467A1 (en) 2001-11-05
WO1999062882A1 (de) 1999-12-09
AU764782B2 (en) 2003-08-28
HRP20000831A2 (en) 2001-12-31
HUP0102210A3 (en) 2002-12-28
CN1303374A (zh) 2001-07-11
NO20006138L (no) 2001-02-01
EP1100779A1 (de) 2001-05-23
ID27035A (id) 2001-02-22
ZA200005435B (en) 2002-01-07
NO20006138D0 (no) 2000-12-01
YU73900A (sh) 2003-04-30
KR20010043973A (ko) 2001-05-25
TR200003515T2 (tr) 2001-06-21
SK18222000A3 (sk) 2001-08-06
BR9910898A (pt) 2001-02-13
EA200100001A1 (ru) 2001-08-27

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Legal Events

Date Code Title Description
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU