YU73900A - Supstituisani indolinoni, njihovo pripremanje i njihova primena kao lekova - Google Patents

Supstituisani indolinoni, njihovo pripremanje i njihova primena kao lekova

Info

Publication number
YU73900A
YU73900A YU73900A YU73900A YU73900A YU 73900 A YU73900 A YU 73900A YU 73900 A YU73900 A YU 73900A YU 73900 A YU73900 A YU 73900A YU 73900 A YU73900 A YU 73900A
Authority
YU
Yugoslavia
Prior art keywords
production
medicaments
substituted indolinones
relates
salts
Prior art date
Application number
YU73900A
Other languages
English (en)
Inventor
Armin Heckel
Rainer Walter
Wolfgang Grell
Jacobus Meel
Norbert Redemann
Original Assignee
Boehringer Ingelheim Pharma Gmbh. & Co. Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh. & Co. Kg. filed Critical Boehringer Ingelheim Pharma Gmbh. & Co. Kg.
Publication of YU73900A publication Critical patent/YU73900A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Pronalazak se odnosi na supstituisane indolinone, opšte formule (I), u kojoj R1 do R5 i X jesu definisani kao u zahtevu (1), na njihove izomere i njihove soli, naročito njihove fiziološki podnošljive soli, koje imaju dragocena farmakološka svojstva, naročito inhibirajuće dejstvo na različite kinaze i komplekse ciklin/CDK, kao i na proliferaciju različitih ćelija tumora, na lekove koji sadrže ova jedinjenja, na njihovu primenu i postupke za njihovo pripremanje.[The invention relates to substituted indolinones of general formula (I) in which R1 to R5 and X are defined as in Claim No. 1, to the isomers thereof, and to their salts, especially to the physiologically compatible salts thereof, which exhibit valuable pharmacological characteristics, especially an inhibiting effect on different kinases and cyclin/CDK complexes, and on the proliferation of different tumor cells. The invention also relates to medicaments containing these compounds, to their use, and to a method for the production thereof.
YU73900A 1998-06-04 1999-05-28 Supstituisani indolinoni, njihovo pripremanje i njihova primena kao lekova YU73900A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19824922A DE19824922A1 (de) 1998-06-04 1998-06-04 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
YU73900A true YU73900A (sh) 2003-04-30

Family

ID=7869856

Family Applications (1)

Application Number Title Priority Date Filing Date
YU73900A YU73900A (sh) 1998-06-04 1999-05-28 Supstituisani indolinoni, njihovo pripremanje i njihova primena kao lekova

Country Status (23)

Country Link
EP (1) EP1100779A1 (sh)
JP (1) JP2002516906A (sh)
KR (1) KR20010043973A (sh)
CN (1) CN1303374A (sh)
AU (1) AU764782B2 (sh)
BG (1) BG104938A (sh)
BR (1) BR9910898A (sh)
CA (1) CA2328291A1 (sh)
CO (1) CO5050294A1 (sh)
DE (1) DE19824922A1 (sh)
EA (1) EA003514B1 (sh)
EE (1) EE200000723A (sh)
HR (1) HRP20000831A2 (sh)
HU (1) HUP0102210A3 (sh)
ID (1) ID27035A (sh)
IL (1) IL138702A0 (sh)
NO (1) NO20006138L (sh)
PL (1) PL344467A1 (sh)
SK (1) SK18222000A3 (sh)
TR (1) TR200003515T2 (sh)
WO (1) WO1999062882A1 (sh)
YU (1) YU73900A (sh)
ZA (1) ZA200005435B (sh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19816624A1 (de) * 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
UA75054C2 (uk) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
US6762180B1 (en) 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
EP1317446A1 (en) * 2000-09-01 2003-06-11 Glaxo Group Limited Oxindole derivatives
WO2002020479A1 (en) 2000-09-01 2002-03-14 Glaxo Group Limited Substituted oxindole derivatives as tyrosine kinase inhibitors
DE10117204A1 (de) 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US20050176687A1 (en) * 2001-06-29 2005-08-11 Alain Moussy Use of tyrosine kinase inhibitors for treating autoimmune diseases
JP2005500041A (ja) 2001-06-29 2005-01-06 アブ サイエンス 強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤
US7678805B2 (en) 2001-06-29 2010-03-16 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (IBD)
US7700610B2 (en) 2001-06-29 2010-04-20 Ab Science Use of tyrosine kinase inhibitors for treating allergic diseases
ATE330608T1 (de) * 2001-06-29 2006-07-15 Ab Science Die verwendung von n-phenyl-2-pyrimidine-amine derivaten zur behandlung von entzündlichen erkrankungen
US6765012B2 (en) 2001-09-27 2004-07-20 Allergan, Inc. 3-(Arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
DE102004012070A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
WO2008070111A2 (en) * 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
CN101735071A (zh) * 2009-12-04 2010-06-16 大连凯飞精细化工有限公司 一种生产4-n,n-二甲胺基甲基苯胺的方法
CN103102352B (zh) * 2011-11-15 2015-08-12 山东亨利医药科技有限责任公司 酪氨酸激酶抑制剂吲哚满酮衍生物
CN103130775B (zh) * 2011-11-22 2015-09-30 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的吲哚满酮衍生物
GB201208775D0 (en) 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
CN103848814B (zh) * 2012-12-06 2016-08-17 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的取代吲哚满酮衍生物
WO2024050297A1 (en) * 2022-09-02 2024-03-07 Deciphera Pharmaceuticals, Llc Ulk inhibitors and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE838623A (fr) * 1976-02-16 1976-06-16 Derives de 3-hydroxymethylene-2-indolinone et procede pour leur production
US4145422A (en) * 1977-09-06 1979-03-20 Abbott Laboratories Aminomethylene oxindoles
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
AU4155697A (en) * 1996-08-23 1998-03-06 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
ZA200005435B (en) 2002-01-07
HUP0102210A2 (hu) 2001-11-28
HRP20000831A2 (en) 2001-12-31
AU4370799A (en) 1999-12-20
EE200000723A (et) 2002-04-15
ID27035A (id) 2001-02-22
CN1303374A (zh) 2001-07-11
WO1999062882A1 (de) 1999-12-09
JP2002516906A (ja) 2002-06-11
DE19824922A1 (de) 1999-12-09
BR9910898A (pt) 2001-02-13
HUP0102210A3 (en) 2002-12-28
EA003514B1 (ru) 2003-06-26
PL344467A1 (en) 2001-11-05
SK18222000A3 (sk) 2001-08-06
TR200003515T2 (tr) 2001-06-21
EA200100001A1 (ru) 2001-08-27
BG104938A (en) 2001-06-29
CO5050294A1 (es) 2001-06-27
AU764782B2 (en) 2003-08-28
KR20010043973A (ko) 2001-05-25
NO20006138D0 (no) 2000-12-01
NO20006138L (no) 2001-02-01
EP1100779A1 (de) 2001-05-23
IL138702A0 (en) 2001-10-31
CA2328291A1 (en) 1999-12-09

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