ES2111492A1 - Derivados de 1-(2-(vinilo substituido))-3,4-dihidro-5h-2,3-benzodiazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizacion de dichos derivados y composiciones para el tratamiento de trastornos del sistema nervioso central. - Google Patents

Derivados de 1-(2-(vinilo substituido))-3,4-dihidro-5h-2,3-benzodiazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizacion de dichos derivados y composiciones para el tratamiento de trastornos del sistema nervioso central.

Info

Publication number
ES2111492A1
ES2111492A1 ES09600303A ES9600303A ES2111492A1 ES 2111492 A1 ES2111492 A1 ES 2111492A1 ES 09600303 A ES09600303 A ES 09600303A ES 9600303 A ES9600303 A ES 9600303A ES 2111492 A1 ES2111492 A1 ES 2111492A1
Authority
ES
Spain
Prior art keywords
dihydro
uns
substituted vinyl
benzodiazepine derivatives
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09600303A
Other languages
English (en)
Other versions
ES2111492B1 (es
Inventor
Pal Vago
Jozsef Reiter
Istvan Gyertyan
Gabor Gigler
Ferenc Andrasi
Anna Bakonyi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES2111492A1 publication Critical patent/ES2111492A1/es
Application granted granted Critical
Publication of ES2111492B1 publication Critical patent/ES2111492B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

DERIVADOS DE 1-[2-VINILO SUBSTITUIDO)]-3,4-DIHIDRO-5H-2,3-BENZODIAZEPINA, PROCEDIMIENTO PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y UTILIZACION DE DICHOS DERIVADOS Y COMPOSICIONES PARA EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL. LOS COMPUESTOS DE ACUERDO CON LA INVENCION CORRESPONDEN A LA FORMULA GENERAL (I). FORMULA DONDE R REPRESENTA HIDROGENO O ALCANOILO C1-4; R1 REPRESENTA FENILO QUE OPCIONALMENTE LLEVA 1-3 SUBSTITUYENTES IDENTICOS O DIFERENTES, SELECCIONADOS ENTRE EL GRUPO CONSISTENTE EN HALOGENO, NITRO, AMINO, (ALQUILO C1-4)AMINO, DI(ALQUILO C1-4)AMINO, (ALCANOILO C1-4)AMINO, ALQUILO C1-4, ALCOXI C1-4, METILENDIOXI E HIDROXI; O NAFTILO QUE OPCIONALMENTE LLEVA UN SUBSTITUYENTE SELECCIONADO ENTRE EL GRUPO CONSISTENTE EN HIDROXI, ALQUILO C1-4 Y ALCOXI C1-4; R2 REPRESENTA HIDROGENO O ALQUILO C1-4; R3 Y R4 SON, INDEPENDIENTEMENTE ENTRE SI, ALQUILO C1-4, O R3 Y R4 JUNTOS FORMAN METILENO. LOS NUEVOS COMPUESTOS DE ACUERDO CON LA INVENCION AFECTAN AL SISTEMA NERVIOSO CENTRAL Y SE PUEDEN UTILIZAR CON VENTAJA EN TERAPEUTICA.
ES09600303A 1995-02-09 1996-02-08 Derivados de 1-(2-(vinilo substituido))-3,4-dihidro-5h-2,3-benzodiazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizacion de dichos derivados y composiciones para el tratamiento de trastornos del sistema nervioso central. Expired - Fee Related ES2111492B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9500386A HU224435B1 (hu) 1995-02-09 1995-02-09 Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények

Publications (2)

Publication Number Publication Date
ES2111492A1 true ES2111492A1 (es) 1998-03-01
ES2111492B1 ES2111492B1 (es) 1999-07-01

Family

ID=10986432

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09600303A Expired - Fee Related ES2111492B1 (es) 1995-02-09 1996-02-08 Derivados de 1-(2-(vinilo substituido))-3,4-dihidro-5h-2,3-benzodiazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizacion de dichos derivados y composiciones para el tratamiento de trastornos del sistema nervioso central.

Country Status (18)

Country Link
US (1) US6075018A (es)
JP (1) JP3354375B2 (es)
KR (1) KR960031444A (es)
BE (1) BE1009852A3 (es)
CA (1) CA2169112A1 (es)
CZ (1) CZ291218B6 (es)
ES (1) ES2111492B1 (es)
FI (1) FI960616A (es)
FR (1) FR2730490B1 (es)
GB (1) GB2297749B (es)
HR (1) HRP960065A2 (es)
HU (1) HU224435B1 (es)
IT (1) IT1282591B1 (es)
PL (1) PL312707A1 (es)
RU (1) RU2155757C2 (es)
SK (1) SK281482B6 (es)
UA (1) UA45954C2 (es)
YU (1) YU8396A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
CA2510275A1 (en) * 2002-12-03 2004-08-19 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
JP2006510634A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３，４−ジメトキシフェニル）−４−メチル−５−エチル−７−メトキシ−８−ヒドロキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
US20040152694A1 (en) * 2003-02-04 2004-08-05 Istvan Kurucz Methods and compositions for treating inflammatory disorders of the airways
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
EP1833815B1 (en) * 2004-12-30 2010-09-15 Instytut Farmaceutyczny A process for preparation of imatinib base
EP2338492A1 (en) 2009-12-24 2011-06-29 Universidad del Pais Vasco Methods and compositions for the treatment of alzheimer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081426A1 (en) * 1970-01-12 1971-12-03 Smb Laboratoires Spasmolytic dihydrobenz-1,4-oxazepine deriv
FR2439189A1 (fr) * 1978-10-19 1980-05-16 Egyt Gyogyszervegyeszeti Gyar Nouveaux derives de la 5h-2,3-benzodiazepine et procede pour la preparation de ces derives et compositions pharmaceutiques les contenant
FR2501686A1 (fr) * 1981-03-12 1982-09-17 Egyt Gyogyszervegyeszeti Gyar Nouveaux derives de 3,4-dihydro-5h-2,3-benzodiazepine, procede pour les preparer et medicaments les contenant
ES2005582A6 (es) * 1986-05-21 1989-03-16 Egyt Gyogyszervegyeszeti Gyar Procedimiento de obtencion de nuevos derivados de la 1-(hidroxiestiril)-5h-2,3-benzodiazepina.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081426A1 (en) * 1970-01-12 1971-12-03 Smb Laboratoires Spasmolytic dihydrobenz-1,4-oxazepine deriv
FR2439189A1 (fr) * 1978-10-19 1980-05-16 Egyt Gyogyszervegyeszeti Gyar Nouveaux derives de la 5h-2,3-benzodiazepine et procede pour la preparation de ces derives et compositions pharmaceutiques les contenant
FR2501686A1 (fr) * 1981-03-12 1982-09-17 Egyt Gyogyszervegyeszeti Gyar Nouveaux derives de 3,4-dihydro-5h-2,3-benzodiazepine, procede pour les preparer et medicaments les contenant
ES2005582A6 (es) * 1986-05-21 1989-03-16 Egyt Gyogyszervegyeszeti Gyar Procedimiento de obtencion de nuevos derivados de la 1-(hidroxiestiril)-5h-2,3-benzodiazepina.

Also Published As

Publication number Publication date
FI960616A0 (fi) 1996-02-09
JP3354375B2 (ja) 2002-12-09
SK16896A3 (en) 1996-10-02
GB2297749A (en) 1996-08-14
BE1009852A3 (fr) 1997-10-07
ITMI960245A1 (it) 1997-08-09
FI960616A (fi) 1996-08-10
IT1282591B1 (it) 1998-03-31
JPH08283247A (ja) 1996-10-29
YU8396A (sh) 1998-12-23
GB2297749B (en) 1998-07-01
CZ37796A3 (en) 1996-08-14
CA2169112A1 (en) 1996-08-10
HU224435B1 (hu) 2005-10-28
ES2111492B1 (es) 1999-07-01
UA45954C2 (uk) 2002-05-15
HU9500386D0 (en) 1995-03-28
HRP960065A2 (en) 1997-12-31
KR960031444A (ko) 1996-09-17
FR2730490A1 (fr) 1996-08-14
RU2155757C2 (ru) 2000-09-10
US6075018A (en) 2000-06-13
ITMI960245A0 (es) 1996-02-09
SK281482B6 (sk) 2001-04-09
GB9602690D0 (en) 1996-04-10
CZ291218B6 (cs) 2003-01-15
PL312707A1 (en) 1996-08-19
FR2730490B1 (fr) 1997-04-18

Similar Documents

Publication Publication Date Title
HUP9901304A3 (en) Piperazine and piperidine derivatives with analgesic effect, process for their preparation and pharmaceutical compositions containing them
MY133647A (en) Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates
HU9602489D0 (en) New piperazine derivatives, process for producing them and pharmaceutical compositions containing them
AU5488498A (en) Indolin-2-one derivatives, method for preparing them and pharmaceutical compositions containing them
MX9602683A (es) Compuestos de 6-dimetilaminometil-1-fenil-ciclohexano como substancias farmaceuticamente activas.
UA32543C2 (uk) Арилацетаміди, що мають анальгетичну дію, спосіб їх одержання, фармацевтична композиція та спосіб її одержання
MX9700082A (es) Composicion que consiste de morfina, polipirrolidona y oxido de polialquileno.
HUP9904521A3 (en) Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
AP9701041A0 (en) Pyridylpyrrole compounds.
PL326322A1 (en) Ciral methylphenyloxyazolydinones
MX9503529A (es) Derivados de glicinamida, procedimiento para su preparacion y medicamentos que los contienen.
ZA953701B (en) New atagonist compounds
ES2111492A1 (es) Derivados de 1-(2-(vinilo substituido))-3,4-dihidro-5h-2,3-benzodiazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizacion de dichos derivados y composiciones para el tratamiento de trastornos del sistema nervioso central.
EE04491B1 (et) (+)-nortsisapriidi kasutamine
HUP9901389A3 (en) Piperidine and pyrrolidine derivatives acting for the central nervous system, pharmaceutical compositions containing these compounds, preparation and use thereof
UA35607C2 (uk) Похідні оксазолідинонкарбонової кислоти, спосіб їх одержання, фармацевтична композиція і спосіб її одержання
NZ325235A (en) New phenylamidine derivatives, a process for preparing the same and their use as medicaments
EG19361A (en) A process for the preparation of piperidine compound having local anaesthetica and analgetic
HU9601321D0 (en) Substituted (benzyloxy)-carbonyl-guanidine derivatives, process for producing them, their use as pharmaceutical compositions or diagnostica, and pharmaceutical compositions containing them
HUT37617A (en) Process for preparing indolophenantridine-derivatives and pharmaceutical compositions containing such compounds
NZ332545A (es)
BG105204A (en) Salts of paroxetine
NZ320522A (en) Piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same and a process for the preparation of the compounds
TW334424B (en) L-arginine aldehyde derivatives process for preparing them and pharmaceutical composition
HK1038017A1 (en) Novel 2,3,3a,4,9,9a hexahydro-8-hydroxy-1h-benzÄfÜindoles, a method for the production thereof, and their use as medicaments.

Legal Events

Date Code Title Description
FC2A Grant refused

Effective date: 19971201

EC2A Search report published

Date of ref document: 19980301

Kind code of ref document: A1

Effective date: 19980301

FD2A Announcement of lapse in spain

Effective date: 20180806