WO2001027080A3 - In 5-stellung substituierte indolinone und ihre verwendung als kinase und cyclin-cdk-komplexe inhibitoren - Google Patents
In 5-stellung substituierte indolinone und ihre verwendung als kinase und cyclin-cdk-komplexe inhibitoren Download PDFInfo
- Publication number
- WO2001027080A3 WO2001027080A3 PCT/EP2000/009847 EP0009847W WO0127080A3 WO 2001027080 A3 WO2001027080 A3 WO 2001027080A3 EP 0009847 W EP0009847 W EP 0009847W WO 0127080 A3 WO0127080 A3 WO 0127080A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cyclin
- kinase
- substituted indolinones
- cdk complex
- complex inhibitors
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title abstract 3
- 102000020233 phosphotransferase Human genes 0.000 title abstract 3
- -1 5-substituted indolinones Chemical class 0.000 title abstract 2
- 102000016736 Cyclin Human genes 0.000 title abstract 2
- 108050006400 Cyclin Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU76631/00A AU7663100A (en) | 1999-10-13 | 2000-10-07 | Production of 5-substituted indolinones and use thereof as medicaments |
EP00966136A EP1224169A2 (de) | 1999-10-13 | 2000-10-07 | In 5-stellung substituierte indolinone und ihre verwendung als kinase und cyclin/cdk-komplexe inhibitoren |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19949209A DE19949209A1 (de) | 1999-10-13 | 1999-10-13 | In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE19949209.3 | 1999-10-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001027080A2 WO2001027080A2 (de) | 2001-04-19 |
WO2001027080A3 true WO2001027080A3 (de) | 2001-11-22 |
Family
ID=7925398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2000/009847 WO2001027080A2 (de) | 1999-10-13 | 2000-10-07 | In 5-stellung substituierte indolinone und ihre verwendung als kinase und cyclin-cdk-komplexe inhibitoren |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1224169A2 (de) |
AR (1) | AR026037A1 (de) |
AU (1) | AU7663100A (de) |
CO (1) | CO5261507A1 (de) |
DE (1) | DE19949209A1 (de) |
WO (1) | WO2001027080A2 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
IL162203A0 (en) | 2001-12-27 | 2005-11-20 | Theravance Inc | Indolinone derivatives useful as protein inase inhibitors |
US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
US7514468B2 (en) | 2002-07-23 | 2009-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions |
DE10233500A1 (de) * | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
DE10237423A1 (de) * | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
US20040204458A1 (en) | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
US7148249B2 (en) | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
DE102004012068A1 (de) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue alkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
DE102004012070A1 (de) | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
CA2646638A1 (en) | 2006-04-24 | 2007-11-01 | Boehringer Ingelheim International Gmbh | 3- (aminomethyliden) 2-indolinone derivatives and their use as cell proliferation inhibitors |
US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
PE20211054A1 (es) * | 2018-10-05 | 2021-06-07 | Ichnos Sciences S A | Compuestos de indolinona para uso como inhibidores de map4k1 |
CN111285872B (zh) * | 2018-12-06 | 2022-05-17 | 北京志健金瑞生物医药科技有限公司 | 吲哚-2-酮衍生物及其制备方法与用途 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0104860A1 (de) * | 1982-09-20 | 1984-04-04 | Pfizer Inc. | Psychotherapeutische Wirkstoffe auf Basis von 1-Phenyl-2(1H,3H)-indolonen |
US5886020A (en) * | 1995-06-07 | 1999-03-23 | Sugen, Inc. | 3-(4'-dimethylaminobenzylidenyl)-2-indolinone and analogues thereof for the treatment of disease |
WO1999015500A1 (en) * | 1997-09-05 | 1999-04-01 | Glaxo Group Limited | Substituted oxindole derivatives as protein tyrosine kinase and as protein serine/threonine kinase inhibitors |
DE19815020A1 (de) * | 1998-04-03 | 1999-10-07 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
-
1999
- 1999-10-13 DE DE19949209A patent/DE19949209A1/de not_active Withdrawn
-
2000
- 2000-10-07 WO PCT/EP2000/009847 patent/WO2001027080A2/de active Search and Examination
- 2000-10-07 EP EP00966136A patent/EP1224169A2/de not_active Withdrawn
- 2000-10-07 AU AU76631/00A patent/AU7663100A/en not_active Abandoned
- 2000-10-12 CO CO00077919A patent/CO5261507A1/es not_active Application Discontinuation
- 2000-10-13 AR ARP000105395A patent/AR026037A1/es active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0104860A1 (de) * | 1982-09-20 | 1984-04-04 | Pfizer Inc. | Psychotherapeutische Wirkstoffe auf Basis von 1-Phenyl-2(1H,3H)-indolonen |
US5886020A (en) * | 1995-06-07 | 1999-03-23 | Sugen, Inc. | 3-(4'-dimethylaminobenzylidenyl)-2-indolinone and analogues thereof for the treatment of disease |
WO1999015500A1 (en) * | 1997-09-05 | 1999-04-01 | Glaxo Group Limited | Substituted oxindole derivatives as protein tyrosine kinase and as protein serine/threonine kinase inhibitors |
DE19815020A1 (de) * | 1998-04-03 | 1999-10-07 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
Non-Patent Citations (4)
Title |
---|
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GOLOVKO, T. V. ET AL: "Synthesis and pharmacological activity of 3-(aminomethylene)-2- indolinone derivatives", XP002170073, retrieved from STN Database accession no. 121:300712 * |
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SESHADRI, S. ET AL: "Application of the Vilsmeier-Haack reaction to lactams. II. Reaction of substituted formanilide/phosphorus oxychloride complex on oxindole and other lactams", XP002170074, retrieved from STN Database accession no. 71:112732 * |
INDIAN J. CHEM. (1969), 7(7), 667-71 * |
KHIM.-FARM. ZH. (1994), 28(4), 22-6 * |
Also Published As
Publication number | Publication date |
---|---|
EP1224169A2 (de) | 2002-07-24 |
AU7663100A (en) | 2001-04-23 |
DE19949209A1 (de) | 2001-04-19 |
CO5261507A1 (es) | 2003-03-31 |
AR026037A1 (es) | 2002-12-26 |
WO2001027080A2 (de) | 2001-04-19 |
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