CN1303374A - 取代的吲哚满酮,其制法及其作为药物组合物的用途 - Google Patents
取代的吲哚满酮,其制法及其作为药物组合物的用途 Download PDFInfo
- Publication number
- CN1303374A CN1303374A CN99806884A CN99806884A CN1303374A CN 1303374 A CN1303374 A CN 1303374A CN 99806884 A CN99806884 A CN 99806884A CN 99806884 A CN99806884 A CN 99806884A CN 1303374 A CN1303374 A CN 1303374A
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- China
- Prior art keywords
- methyl
- amino
- phenyl
- alkyl
- methylene radical
- Prior art date
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- 239000003814 drug Substances 0.000 title claims abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract description 67
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 55
- 150000003839 salts Chemical class 0.000 claims abstract description 31
- 238000000034 method Methods 0.000 claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims description 139
- -1 dihydroindole ketone Chemical class 0.000 claims description 118
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 69
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 67
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 45
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 41
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 23
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 22
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- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical compound C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 claims description 9
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19824922A DE19824922A1 (de) | 1998-06-04 | 1998-06-04 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE19824922.5 | 1998-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1303374A true CN1303374A (zh) | 2001-07-11 |
Family
ID=7869856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99806884A Pending CN1303374A (zh) | 1998-06-04 | 1999-05-28 | 取代的吲哚满酮,其制法及其作为药物组合物的用途 |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1100779A1 (de) |
| JP (1) | JP2002516906A (de) |
| KR (1) | KR20010043973A (de) |
| CN (1) | CN1303374A (de) |
| AU (1) | AU764782B2 (de) |
| BG (1) | BG104938A (de) |
| BR (1) | BR9910898A (de) |
| CA (1) | CA2328291A1 (de) |
| CO (1) | CO5050294A1 (de) |
| DE (1) | DE19824922A1 (de) |
| EA (1) | EA003514B1 (de) |
| EE (1) | EE200000723A (de) |
| HR (1) | HRP20000831A2 (de) |
| HU (1) | HUP0102210A3 (de) |
| ID (1) | ID27035A (de) |
| IL (1) | IL138702A0 (de) |
| NO (1) | NO20006138L (de) |
| PL (1) | PL344467A1 (de) |
| SK (1) | SK18222000A3 (de) |
| TR (1) | TR200003515T2 (de) |
| WO (1) | WO1999062882A1 (de) |
| YU (1) | YU73900A (de) |
| ZA (1) | ZA200005435B (de) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100338036C (zh) * | 1998-04-15 | 2007-09-19 | 贝林格尔英格海姆法玛两合公司 | 对激酶及细胞周期蛋白复合物具有抑制作用的取代的吲哚满酮 |
| CN100455568C (zh) * | 1999-10-13 | 2009-01-28 | 贝林格尔英格海姆法玛两合公司 | 6-位取代的吲哚满酮,其制备及其作为药物组合物的用途 |
| CN101735071A (zh) * | 2009-12-04 | 2010-06-16 | 大连凯飞精细化工有限公司 | 一种生产4-n,n-二甲胺基甲基苯胺的方法 |
| CN103102352A (zh) * | 2011-11-15 | 2013-05-15 | 山东亨利医药科技有限责任公司 | 酪氨酸激酶抑制剂吲哚满酮衍生物 |
| CN103130775A (zh) * | 2011-11-22 | 2013-06-05 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的吲哚满酮衍生物 |
| CN103848814A (zh) * | 2012-12-06 | 2014-06-11 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的取代吲哚满酮衍生物 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9904933D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
| US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
| WO2002020513A1 (en) * | 2000-09-01 | 2002-03-14 | Glaxo Group Limited | Oxindole derivatives |
| AU2001288374A1 (en) | 2000-09-01 | 2002-03-22 | Glaxo Group Limited | Substituted oxindole derivatives as tyrosine kinase inhibitors |
| DE10117204A1 (de) | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| ES2274075T3 (es) | 2001-06-29 | 2007-05-16 | Ab Science | Utilizacion de inhibidores de c-kit para tratar enfermedades inflamatorias intestinales (eii). |
| ES2266553T3 (es) | 2001-06-29 | 2007-03-01 | Ab Science | Utilizacion de derivados de la n-fenil-2-pirimidina-amina para tratar las enfermedades inflamatorias. |
| EP1401413B1 (de) | 2001-06-29 | 2006-11-22 | AB Science | Die verwendung von tyrosinkinasehemmer zur behandlung von allergischen erkrankungen |
| ATE401079T1 (de) * | 2001-06-29 | 2008-08-15 | Ab Science | Die verwendung von c-kithemmern zur behandlung von autoimmunerkrankungen |
| DE60223063T2 (de) | 2001-06-29 | 2008-07-17 | Ab Science | C-kit inhibitoren |
| CA2461812C (en) | 2001-09-27 | 2011-09-20 | Allergan, Inc. | 3-(arylamino)methylene-1,3-dihydro-2h-indol-2-ones as kinase inhibitors |
| US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
| JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
| DE102004012070A1 (de) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
| PE20060777A1 (es) * | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| SG177128A1 (en) * | 2006-12-05 | 2012-01-30 | Arena Pharm Inc | Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof |
| GB0706072D0 (en) | 2007-03-28 | 2007-05-09 | Sterix Ltd | Compound |
| US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
| GB201208775D0 (en) * | 2012-05-18 | 2012-07-04 | Uni I Oslo | Chemical compounds |
| US20240150368A1 (en) * | 2022-09-02 | 2024-05-09 | Deciphera Pharmaceuticals, Llc | Ulk inhibitors and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE838623A (fr) * | 1976-02-16 | 1976-06-16 | Derives de 3-hydroxymethylene-2-indolinone et procede pour leur production | |
| US4145422A (en) * | 1977-09-06 | 1979-03-20 | Abbott Laboratories | Aminomethylene oxindoles |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| CA2264220A1 (en) * | 1996-08-23 | 1998-02-26 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
-
1998
- 1998-06-04 DE DE19824922A patent/DE19824922A1/de not_active Withdrawn
-
1999
- 1999-05-28 HU HU0102210A patent/HUP0102210A3/hu unknown
- 1999-05-28 KR KR1020007013597A patent/KR20010043973A/ko not_active Application Discontinuation
- 1999-05-28 CA CA002328291A patent/CA2328291A1/en not_active Abandoned
- 1999-05-28 WO PCT/EP1999/003692 patent/WO1999062882A1/de not_active Application Discontinuation
- 1999-05-28 EP EP99926454A patent/EP1100779A1/de not_active Withdrawn
- 1999-05-28 TR TR2000/03515T patent/TR200003515T2/xx unknown
- 1999-05-28 BR BR9910898-4A patent/BR9910898A/pt not_active IP Right Cessation
- 1999-05-28 ID IDW20002523A patent/ID27035A/id unknown
- 1999-05-28 IL IL13870299A patent/IL138702A0/xx unknown
- 1999-05-28 CN CN99806884A patent/CN1303374A/zh active Pending
- 1999-05-28 SK SK1822-2000A patent/SK18222000A3/sk unknown
- 1999-05-28 EA EA200100001A patent/EA003514B1/ru not_active IP Right Cessation
- 1999-05-28 YU YU73900A patent/YU73900A/sh unknown
- 1999-05-28 EE EEP200000723A patent/EE200000723A/xx unknown
- 1999-05-28 PL PL99344467A patent/PL344467A1/xx unknown
- 1999-05-28 AU AU43707/99A patent/AU764782B2/en not_active Ceased
- 1999-05-28 JP JP2000552094A patent/JP2002516906A/ja active Pending
- 1999-06-04 CO CO99035396A patent/CO5050294A1/es unknown
-
2000
- 2000-10-05 ZA ZA200005435A patent/ZA200005435B/en unknown
- 2000-11-13 BG BG104938A patent/BG104938A/xx active Pending
- 2000-12-01 HR HR20000831A patent/HRP20000831A2/hr not_active Application Discontinuation
- 2000-12-01 NO NO20006138A patent/NO20006138L/no not_active Application Discontinuation
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100338036C (zh) * | 1998-04-15 | 2007-09-19 | 贝林格尔英格海姆法玛两合公司 | 对激酶及细胞周期蛋白复合物具有抑制作用的取代的吲哚满酮 |
| CN100455568C (zh) * | 1999-10-13 | 2009-01-28 | 贝林格尔英格海姆法玛两合公司 | 6-位取代的吲哚满酮,其制备及其作为药物组合物的用途 |
| CN101735071A (zh) * | 2009-12-04 | 2010-06-16 | 大连凯飞精细化工有限公司 | 一种生产4-n,n-二甲胺基甲基苯胺的方法 |
| CN103102352A (zh) * | 2011-11-15 | 2013-05-15 | 山东亨利医药科技有限责任公司 | 酪氨酸激酶抑制剂吲哚满酮衍生物 |
| CN103102352B (zh) * | 2011-11-15 | 2015-08-12 | 山东亨利医药科技有限责任公司 | 酪氨酸激酶抑制剂吲哚满酮衍生物 |
| CN103130775A (zh) * | 2011-11-22 | 2013-06-05 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的吲哚满酮衍生物 |
| CN103130775B (zh) * | 2011-11-22 | 2015-09-30 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的吲哚满酮衍生物 |
| CN103848814A (zh) * | 2012-12-06 | 2014-06-11 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的取代吲哚满酮衍生物 |
| CN103848814B (zh) * | 2012-12-06 | 2016-08-17 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的取代吲哚满酮衍生物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002516906A (ja) | 2002-06-11 |
| DE19824922A1 (de) | 1999-12-09 |
| CA2328291A1 (en) | 1999-12-09 |
| HUP0102210A2 (hu) | 2001-11-28 |
| CO5050294A1 (es) | 2001-06-27 |
| AU4370799A (en) | 1999-12-20 |
| IL138702A0 (en) | 2001-10-31 |
| EE200000723A (et) | 2002-04-15 |
| BG104938A (en) | 2001-06-29 |
| PL344467A1 (en) | 2001-11-05 |
| WO1999062882A1 (de) | 1999-12-09 |
| AU764782B2 (en) | 2003-08-28 |
| HRP20000831A2 (en) | 2001-12-31 |
| HUP0102210A3 (en) | 2002-12-28 |
| EA003514B1 (ru) | 2003-06-26 |
| NO20006138L (no) | 2001-02-01 |
| EP1100779A1 (de) | 2001-05-23 |
| ID27035A (id) | 2001-02-22 |
| ZA200005435B (en) | 2002-01-07 |
| NO20006138D0 (no) | 2000-12-01 |
| YU73900A (sh) | 2003-04-30 |
| KR20010043973A (ko) | 2001-05-25 |
| TR200003515T2 (tr) | 2001-06-21 |
| SK18222000A3 (sk) | 2001-08-06 |
| BR9910898A (pt) | 2001-02-13 |
| EA200100001A1 (ru) | 2001-08-27 |
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