DOP2010000181A - Derivados ciclopropilamina - Google Patents

Derivados ciclopropilamina

Info

Publication number
DOP2010000181A
DOP2010000181A DO2010000181A DO2010000181A DOP2010000181A DO P2010000181 A DOP2010000181 A DO P2010000181A DO 2010000181 A DO2010000181 A DO 2010000181A DO 2010000181 A DO2010000181 A DO 2010000181A DO P2010000181 A DOP2010000181 A DO P2010000181A
Authority
DO
Dominican Republic
Prior art keywords
compounds
histamine
formula
cyclopropylamine derivatives
ligands
Prior art date
Application number
DO2010000181A
Other languages
English (en)
Inventor
Marlon D Cowart
Paul J Brackemeyer
Huaqing Liu
Lawrence A Black
Youssef L Bennani
Zhenping Tian
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of DOP2010000181A publication Critical patent/DOP2010000181A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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Abstract

Compuestos con la fórmula (I) donde R1, R2, R3, R3a, R3b, R4, and R5 tienen los valores que se definen en la memoria descriptiva, que son útiles para tratar condiciones o trastornos que se pueden prevenir o mejorar mediante los ligandos del receptor de histamina-3. También se divulgan composiciones farmacéuticas que comprenden los ligandos del receptor de histamina-3, métodos para usar dichos compuestos y composiciones, y un proceso para preparar compuestos dentro del alcance de la fórmula (I).
DO2010000181A 2007-12-14 2010-06-14 Derivados ciclopropilamina DOP2010000181A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/956,816 US9108948B2 (en) 2006-06-23 2007-12-14 Cyclopropyl amine derivatives

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DOP2010000181A true DOP2010000181A (es) 2010-06-30

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JP (1) JP5649975B2 (es)
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JP5649975B2 (ja) 2015-01-07
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CA2709081A1 (en) 2009-06-25
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ZA201004655B (en) 2011-03-30
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ECSP10010253A (es) 2010-07-30
MX2010006535A (es) 2010-08-31
US9108948B2 (en) 2015-08-18
JP2011506456A (ja) 2011-03-03
NZ617334A (en) 2015-10-30
CR11500A (es) 2010-10-11

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