AR069691A1 - Derivados ciclopropilamina - Google Patents

Derivados ciclopropilamina

Info

Publication number
AR069691A1
AR069691A1 ARP080105430A ARP080105430A AR069691A1 AR 069691 A1 AR069691 A1 AR 069691A1 AR P080105430 A ARP080105430 A AR P080105430A AR P080105430 A ARP080105430 A AR P080105430A AR 069691 A1 AR069691 A1 AR 069691A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
hydrogen
independently selected
hydroxyalkyl
Prior art date
Application number
ARP080105430A
Other languages
English (en)
Inventor
Huaquing Liu
Lawrence A Black
Zhenping Tian
Paul J Brackmeyer
Marlon D Cowart
Youssef L Bennani
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of AR069691A1 publication Critical patent/AR069691A1/es

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

Estos compuestos son utiles para tratar condiciones o trastornos que se pueden prevenir o mejorar mediante los ligandos del receptor de histamina-3. También se divulgan composiciones farmacéuticas que comprenden los ligandos del receptor de histamina-3 y métodos de tratamiento terapéutico: trastornos de la atencion, déficit de memoria y aprendizaje, esquizofrenia, Alzheimer, epilepsia, discapacidad cognitiva leve. Reivindicacion 1: Un compuesto caracterizado porque responde a la formula (1) o una sal aceptable para uso farmacéutico, éster, amida o prodroga del mismo, en donde: uno de R1 y R2 es un grupo de la formula -L2-R6a-L3-R6b; el otro de R1 y R2 se selecciona entre el grupo que consiste de hidrogeno, alquilo, alcoxi, halogeno, ciano, y tioalcoxi; R3, R3a, y R3b cada uno se selecciona en forma independiente entre el grupo que consiste de hidrogeno, alquilo, trifluoroalquilo, trifluoroalcoxi, alcoxi, halogeno, ciano, y tioalcoxi; R4 y R5 cada uno se selecciona en forma independiente entre el grupo que consiste de alquilo, fluoroalquilo, hidroxialquilo, alcoxialquilo, y cicloalquilo, o R4 y R5 tomados junto con el átomo de nitrogeno al cual cada uno se encuentra unido forman un anillo no aromático de la formula (2) o (3); R7, R8, R9, y R10 en cada oportunidad cada uno se selecciona en forma independiente entre el grupo que consiste de hidrogeno, hidroxialquilo, fluoroalquilo, cicloalquilo, y alquilo; R11, R12, R13, y R14 cada uno se selecciona en forma independiente entre el grupo que consiste de hidrogeno, hidroxialquilo, alquilo, y fluoroalquilo; R6a se selecciona entre el grupo que consiste de un anillo heteroarilo de 5 o 6 miembros, cianofenilo, un anillo heteroarilo bicíclico de 8 a 12 miembros, y un anillo heterocíclico de 4 a 12 miembros; R6b se selecciona entre el grupo que consiste de hidrogeno, un anillo heteroarilo de 5 o 6 miembros, un anillo arilo, un anillo heteroarilo bicíclico de 8 a 12 miembros, y un anillo heterocíclico de 4 a 12 miembros; Q es O o S; L es -[C(R16)(R17)]k; L2 se selecciona entre el grupo que consiste de una union, alquileno, -O-, -C(=O)-, -S-, -NH-, -N(R16)C(=O)-, -C(=O)N(R16), y -N(alquilo)-; L3 se selecciona entre el grupo que consiste de una union, alquileno, -O-, -C(=O)-, -S-, -N(R16)C(=O)-, -C(=O)N(R16), y -N(R15)-; R15 se selecciona entre el grupo que consiste de hidrogeno, alquilo, acilo, alcoxicarbonilo, amido, y formilo; R16 y R17 en cada oportunidad se seleccionan en forma independiente entre el grupo que consiste de hidrogeno y alquilo; Rx y Ry en cada oportunidad se seleccionan en forma independiente entre el grupo que consiste de hidrogeno, hidroxi, hidroxialquilo, alquilo, alcoxi, alquilamino, fluoro, y dialquilamino; k es 1, 2 o 3; y m es un entero de 1 a 5.
ARP080105430A 2007-12-14 2008-12-12 Derivados ciclopropilamina AR069691A1 (es)

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PA8807301A1 (es) 2009-07-23
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AU2008338748A1 (en) 2009-06-25
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