DK2958603T3 - IMPROVED CURE FOR HARDWARE BONE COMPENSATION - Google Patents
IMPROVED CURE FOR HARDWARE BONE COMPENSATION Download PDFInfo
- Publication number
- DK2958603T3 DK2958603T3 DK14706531.2T DK14706531T DK2958603T3 DK 2958603 T3 DK2958603 T3 DK 2958603T3 DK 14706531 T DK14706531 T DK 14706531T DK 2958603 T3 DK2958603 T3 DK 2958603T3
- Authority
- DK
- Denmark
- Prior art keywords
- powder
- bone
- bone substitute
- calcium sulfate
- setting
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 27
- 239000000843 powder Substances 0.000 claims abstract description 166
- 239000000316 bone substitute Substances 0.000 claims abstract description 131
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims abstract description 101
- 238000000034 method Methods 0.000 claims abstract description 37
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 34
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 33
- 238000011282 treatment Methods 0.000 claims abstract description 25
- 206010031252 Osteomyelitis Diseases 0.000 claims abstract description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 10
- 210000001519 tissue Anatomy 0.000 claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 claims abstract description 6
- 208000010392 Bone Fractures Diseases 0.000 claims abstract description 5
- 208000014674 injury Diseases 0.000 claims abstract description 5
- 230000008733 trauma Effects 0.000 claims abstract description 5
- 206010065687 Bone loss Diseases 0.000 claims abstract description 4
- ZOMBKNNSYQHRCA-UHFFFAOYSA-J calcium sulfate hemihydrate Chemical group O.[Ca+2].[Ca+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ZOMBKNNSYQHRCA-UHFFFAOYSA-J 0.000 claims description 97
- 239000002245 particle Substances 0.000 claims description 77
- 238000010438 heat treatment Methods 0.000 claims description 43
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical group OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 claims description 35
- 229960001025 iohexol Drugs 0.000 claims description 35
- 238000002156 mixing Methods 0.000 claims description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
- 239000003242 anti bacterial agent Substances 0.000 claims description 27
- -1 chemotherapeutics Substances 0.000 claims description 27
- 230000003115 biocidal effect Effects 0.000 claims description 26
- 229940088710 antibiotic agent Drugs 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 24
- 239000002872 contrast media Substances 0.000 claims description 20
- 108010059993 Vancomycin Proteins 0.000 claims description 19
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
- 239000012867 bioactive agent Substances 0.000 claims description 15
- 238000002347 injection Methods 0.000 claims description 15
- 239000007924 injection Substances 0.000 claims description 15
- 230000008569 process Effects 0.000 claims description 15
- 238000005245 sintering Methods 0.000 claims description 15
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 15
- 229960003165 vancomycin Drugs 0.000 claims description 13
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- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims description 13
- MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 claims description 10
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- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 9
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- ODYPLCHSCOJEIZ-GMYJMXFCSA-N 3-[acetyl(methyl)amino]-n-(2-hydroxyethyl)-2,4,6-triiodo-5-[[(2s,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoyl]amino]benzamide Chemical compound CC(=O)N(C)C1=C(I)C(NC(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=C(I)C(C(=O)NCCO)=C1I ODYPLCHSCOJEIZ-GMYJMXFCSA-N 0.000 claims description 4
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
- 229960002227 clindamycin Drugs 0.000 claims description 4
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 4
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- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 229960001225 rifampicin Drugs 0.000 claims description 4
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims description 4
- 229940122361 Bisphosphonate Drugs 0.000 claims description 3
- AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 claims description 3
- 150000004663 bisphosphonates Chemical class 0.000 claims description 3
- 210000001185 bone marrow Anatomy 0.000 claims description 3
- 239000000824 cytostatic agent Substances 0.000 claims description 3
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- 229940088597 hormone Drugs 0.000 claims description 3
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- 229960004359 iodixanol Drugs 0.000 claims description 3
- NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 claims description 3
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- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 claims description 3
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- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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| EP3821917A1 (en) | 2015-10-05 | 2021-05-19 | Hettwer Holding ApS | Compositions and methods for treatment of bone defects |
| US10850113B2 (en) | 2016-07-27 | 2020-12-01 | Medtronic, Inc. | Cardiac electrical signal morphology and pattern-based T-wave oversensing rejection |
| AU2018246536B2 (en) * | 2017-03-31 | 2020-12-10 | Mitsui Chemicals, Inc. | Composition for repairing hard tissue and kit for repairing hard tissue |
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| CN107899082A (zh) * | 2017-11-27 | 2018-04-13 | 山东明德生物医学工程有限公司 | 一种人工骨及制备方法 |
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2014
- 2014-02-20 DK DK14706531.2T patent/DK2958603T3/en active
- 2014-02-20 PT PT147065312T patent/PT2958603T/pt unknown
- 2014-02-20 JP JP2015557483A patent/JP6352947B2/ja active Active
- 2014-02-20 KR KR1020157025650A patent/KR102024692B1/ko active Active
- 2014-02-20 TR TR2018/07495T patent/TR201807495T4/tr unknown
- 2014-02-20 WO PCT/EP2014/053330 patent/WO2014128217A1/en not_active Ceased
- 2014-02-20 AU AU2014220664A patent/AU2014220664B2/en active Active
- 2014-02-20 US US14/185,668 patent/US20140234435A1/en not_active Abandoned
- 2014-02-20 US US14/768,649 patent/US10294107B2/en active Active
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- 2014-02-20 PL PL14706531T patent/PL2958603T3/pl unknown
- 2014-02-20 BR BR112015019981A patent/BR112015019981B8/pt active IP Right Grant
- 2014-02-20 ES ES14706531.2T patent/ES2671122T3/es active Active
- 2014-02-20 CN CN201480009462.8A patent/CN105120908B/zh active Active
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2018
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Also Published As
| Publication number | Publication date |
|---|---|
| PT2958603T (pt) | 2018-06-06 |
| US10994998B2 (en) | 2021-05-04 |
| US20180257939A1 (en) | 2018-09-13 |
| WO2014128217A1 (en) | 2014-08-28 |
| BR112015019981A2 (pt) | 2017-07-18 |
| JP6352947B2 (ja) | 2018-07-04 |
| BR112015019981B1 (pt) | 2020-04-07 |
| AU2014220664A1 (en) | 2015-08-13 |
| JP2016513064A (ja) | 2016-05-12 |
| CA2901528C (en) | 2022-07-26 |
| CA2901528A1 (en) | 2014-08-28 |
| KR20150126626A (ko) | 2015-11-12 |
| BR112015019981B8 (pt) | 2021-01-12 |
| US10294107B2 (en) | 2019-05-21 |
| KR102024692B1 (ko) | 2019-11-04 |
| EP2958603B1 (en) | 2018-03-28 |
| CN105120908A (zh) | 2015-12-02 |
| CN105120908B (zh) | 2018-04-27 |
| EP2958603A1 (en) | 2015-12-30 |
| PL2958603T3 (pl) | 2018-10-31 |
| AU2014220664B2 (en) | 2017-10-05 |
| US20160015856A1 (en) | 2016-01-21 |
| US20140234435A1 (en) | 2014-08-21 |
| ES2671122T3 (es) | 2018-06-05 |
| TR201807495T4 (tr) | 2018-06-21 |
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