DK2663402T3 - Fluidindretning og fremgangsmåde til positionering af fluidindretning - Google Patents

Fluidindretning og fremgangsmåde til positionering af fluidindretning Download PDF

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Publication number
DK2663402T3
DK2663402T3 DK11791076.0T DK11791076T DK2663402T3 DK 2663402 T3 DK2663402 T3 DK 2663402T3 DK 11791076 T DK11791076 T DK 11791076T DK 2663402 T3 DK2663402 T3 DK 2663402T3
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Denmark
Prior art keywords
fluid device
procedure
positioning
positioning fluid
fluid
Prior art date
Application number
DK11791076.0T
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English (en)
Inventor
Erik Williamson
Patrick Leung
Mark Pratt
Jason Harris
Jason Bryant
Mark T Reed
Bryan Crane
Alexander P Kindwall
Stanley S Hong
Drew Verkade
Dale Buermann
Frederick Erie
Andrew James Carson
Mark Wang
Original Assignee
Illumina Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45094202&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2663402(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Illumina Inc filed Critical Illumina Inc
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Publication of DK2663402T3 publication Critical patent/DK2663402T3/da

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/05Flow-through cuvettes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002Reagent dispensers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011Control of the position or alignment of the transfer device
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065Multiple transfer devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/025Align devices or objects to ensure defined positions relative to each other
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04Exchange or ejection of cartridges, containers or reservoirs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0689Sealing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • B01L2300/021Identification, e.g. bar codes
    • B01L2300/022Transponder chips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/041Connecting closures to device or container
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/041Connecting closures to device or container
    • B01L2300/043Hinged closures
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877Flow chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/05Flow-through cuvettes
    • G01N2021/058Flat flow cell
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00435Refrigerated reagent storage
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
DK11791076.0T 2011-01-10 2011-10-21 Fluidindretning og fremgangsmåde til positionering af fluidindretning DK2663402T3 (da)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161431429P 2011-01-10 2011-01-10
US201161431425P 2011-01-10 2011-01-10
US201161431440P 2011-01-11 2011-01-11
US201161431439P 2011-01-11 2011-01-11
US201161438567P 2011-02-01 2011-02-01
US201161438530P 2011-02-01 2011-02-01
US201161438486P 2011-02-01 2011-02-01
US13/273,666 US8951781B2 (en) 2011-01-10 2011-10-14 Systems, methods, and apparatuses to image a sample for biological or chemical analysis
PCT/US2011/057221 WO2012096703A1 (en) 2011-01-10 2011-10-21 Systems, methods, and apparatuses to image a sample for biological or chemical analysis

Publications (1)

Publication Number Publication Date
DK2663402T3 true DK2663402T3 (da) 2021-06-21

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ID=45094202

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DK11791076.0T DK2663402T3 (da) 2011-01-10 2011-10-21 Fluidindretning og fremgangsmåde til positionering af fluidindretning

Country Status (11)

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US (6) US8951781B2 (da)
EP (3) EP3378564B1 (da)
JP (4) JP3192220U (da)
CN (1) CN103501907B (da)
AU (1) AU2011354719B2 (da)
CA (4) CA3112069C (da)
DK (1) DK2663402T3 (da)
ES (2) ES2793230T3 (da)
PL (1) PL2663402T3 (da)
PT (1) PT2663402T (da)
WO (1) WO2012096703A1 (da)

Families Citing this family (323)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
AU2011221244B2 (en) * 2010-02-23 2014-02-13 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
US9102979B2 (en) * 2010-02-23 2015-08-11 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
ES2555106T3 (es) 2010-04-05 2015-12-29 Prognosys Biosciences, Inc. Ensayos biológicos codificados espacialmente
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
CN202401049U (zh) * 2011-01-10 2012-08-29 伊鲁米那股份有限公司 用于试剂存储和传递的卡盘和系统
EP2670894B1 (en) 2011-02-02 2017-11-29 University Of Washington Through Its Center For Commercialization Massively parallel continguity mapping
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
WO2013063382A2 (en) 2011-10-28 2013-05-02 Illumina, Inc. Microarray fabrication system and method
WO2013096692A1 (en) 2011-12-21 2013-06-27 Illumina, Inc. Apparatus and methods for kinetic analysis and determination of nucleic acid sequences
EP4219012A1 (en) 2012-04-03 2023-08-02 Illumina, Inc. Method of imaging a substrate comprising fluorescent features and use of the method in nucleic acid sequencing
US20130274148A1 (en) 2012-04-11 2013-10-17 Illumina, Inc. Portable genetic detection and analysis system and method
US9444880B2 (en) 2012-04-11 2016-09-13 Illumina, Inc. Cloud computing environment for biological data
CN103424304B (zh) 2012-05-18 2015-08-26 光宝科技股份有限公司 分析卡匣
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
JP1628115S (da) 2012-10-24 2019-04-01
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
EP2970951B1 (en) 2013-03-13 2019-02-20 Illumina, Inc. Methods for nucleic acid sequencing
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US20140274747A1 (en) 2013-03-15 2014-09-18 Illumina, Inc. Super resolution imaging
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
AU2014235532B2 (en) 2013-03-15 2018-08-09 Genmark Diagnostics, Inc. Systems, methods, and apparatus for manipulating deformable fluid vessels
US9193998B2 (en) 2013-03-15 2015-11-24 Illumina, Inc. Super resolution imaging
KR20140141879A (ko) * 2013-05-31 2014-12-11 삼성전자주식회사 자동화된 핵산 분석 시스템
WO2014210225A1 (en) 2013-06-25 2014-12-31 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
KR102070483B1 (ko) 2013-07-01 2020-01-29 일루미나, 인코포레이티드 촉매-무함유 표면 작용화 및 중합체 그라프팅
ES2628485T3 (es) 2013-07-03 2017-08-03 Illumina, Inc. Secuenciación mediante síntesis ortogonal
DK3030645T3 (da) * 2013-08-08 2023-01-30 Illumina Inc Fluidsystem til levering af reagenser til en flowcelle
DK3039409T3 (da) 2013-08-28 2018-01-29 Illumina Inc Optisk opretningsværktøj
KR20160081896A (ko) 2013-08-30 2016-07-08 일루미나, 인코포레이티드 친수성 또는 다양한-친수성 표면 상에서의 액적의 조작
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US10540783B2 (en) 2013-11-01 2020-01-21 Illumina, Inc. Image analysis useful for patterned objects
ES2808824T3 (es) 2013-12-03 2021-03-02 Illumina Inc Métodos y sistemas para analizar datos de imagen
WO2015095291A1 (en) 2013-12-19 2015-06-25 Illumina, Inc. Substrates comprising nano-patterning surfaces and methods of preparing thereof
JP6366719B2 (ja) 2013-12-20 2018-08-01 イルミナ インコーポレイテッド 断片化したゲノムdna試料におけるゲノム連結性情報の保存
KR102475314B1 (ko) 2013-12-23 2022-12-06 일루미나, 인코포레이티드 광 방출의 검출을 개선시키기 위한 구조화 기판 및 이와 관련한 방법
LT3108009T (lt) 2014-02-18 2021-07-12 Illumina, Inc. Būdai ir kompozicijos, skirti dnr profiliavimui
WO2015138648A1 (en) 2014-03-11 2015-09-17 Illumina, Inc. Disposable, integrated microfluidic cartridge and methods of making and using same
US20170089836A1 (en) * 2014-04-03 2017-03-30 Hitachi High-Technologies Corporation Analysis Device
WO2015161219A1 (en) * 2014-04-17 2015-10-22 SFC Fluidics, Inc. Microdialysis platform
SG11201610168YA (en) 2014-05-16 2017-01-27 Illumina Inc Nucleic acid synthesis techniques
KR102231650B1 (ko) 2014-05-27 2021-03-23 일루미나, 인코포레이티드 베이스 기구 및 제거 가능한 카트리지를 포함하는 생화학적 분석을 위한 시스템들 및 방법들
CN106661548B (zh) 2014-05-28 2020-12-11 儿童医院医疗中心 用于经由定向分化将前体细胞转化为胃组织的方法和系统
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
CA2952058A1 (en) 2014-06-13 2015-12-17 Illumina Cambridge Limited Methods and compositions for preparing sequencing libraries
EP3161152B1 (en) 2014-06-30 2018-12-26 Illumina, Inc. Methods and compositions using one-sided transposition
CN107076739B (zh) 2014-08-21 2018-12-25 伊卢米纳剑桥有限公司 可逆表面官能化
WO2016040602A1 (en) 2014-09-11 2016-03-17 Epicentre Technologies Corporation Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
JP6668336B2 (ja) 2014-10-09 2020-03-18 イラミーナ インコーポレーテッド 非混和性液体を分離して少なくとも1つの液体を効果的に単離する方法及び装置
US9897791B2 (en) * 2014-10-16 2018-02-20 Illumina, Inc. Optical scanning systems for in situ genetic analysis
SG10201903408VA (en) 2014-10-17 2019-05-30 Illumina Cambridge Ltd Contiguity preserving transposition
EP3207123A1 (en) 2014-10-17 2017-08-23 Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
ES2772127T3 (es) 2014-10-31 2020-07-07 Illumina Cambridge Ltd Polímeros y recubrimientos de copolímeros de ADN
WO2016073237A1 (en) 2014-11-05 2016-05-12 Illumina Cambridge Limited Reducing dna damage during sample preparation and sequencing using siderophore chelators
GB201419731D0 (en) 2014-11-05 2014-12-17 Illumina Cambridge Ltd Sequencing from multiple primers to increase data rate and density
SG10202004350TA (en) 2014-11-11 2020-06-29 Illumina Cambridge Ltd Methods and arrays for producing and sequencing monoclonal clusters of nucleic acid
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
CN114438172A (zh) 2014-12-15 2022-05-06 亿明达股份有限公司 用于基底上的单分子放置的组合物和方法
WO2016149122A2 (en) * 2015-03-13 2016-09-22 Illumina, Inc. Reading and writing codes using optical devices
US10576471B2 (en) 2015-03-20 2020-03-03 Illumina, Inc. Fluidics cartridge for use in the vertical or substantially vertical position
AU2016235288B2 (en) * 2015-03-24 2019-02-28 Illumina Cambridge Limited Methods, carrier assemblies, and systems for imaging samples for biological or chemical analysis
EP3277839B1 (en) 2015-03-31 2020-12-02 Illumina Cambridge Limited Surface concatamerization of templates
EP3901281B1 (en) 2015-04-10 2022-11-23 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
EP3283870B1 (en) 2015-04-14 2020-05-06 Illumina, Inc. Structured substrates for improving detection of light emissions and methods relating to the same
EP4190912A1 (en) 2015-05-11 2023-06-07 Illumina, Inc. Platform for discovery and analysis of therapeutic agents
DK3303614T3 (da) 2015-05-29 2020-05-18 Illumina Cambridge Ltd Forbedret anvendelse af overfladeprimere i klynger
US10640809B2 (en) 2015-05-29 2020-05-05 Epicentre Technologies Corporation Methods of analyzing nucleic acids
CA2985850C (en) * 2015-06-09 2023-07-11 Gen-Probe Incorporated Methods and devices for calibrating and/or monitoring optical measurement devices
CN115261468A (zh) 2015-07-06 2022-11-01 伊卢米纳剑桥有限公司 用于核酸扩增的样品制备
WO2017007757A1 (en) 2015-07-06 2017-01-12 Illumina, Inc. Balanced ac modulation for driving droplet operations electrodes
CN107924121B (zh) 2015-07-07 2021-06-08 亿明达股份有限公司 经由纳米压印的选择性表面图案化
US20180207920A1 (en) 2015-07-17 2018-07-26 Illumina, Inc. Polymer sheets for sequencing applications
EP3957747A1 (en) 2015-07-27 2022-02-23 Illumina, Inc. Spatial mapping of nucleic acid sequence information
BR112017023418A2 (pt) 2015-07-30 2018-07-24 Illumina, Inc. desbloqueio ortogonal de nucleotídeos
PL3334839T3 (pl) 2015-08-14 2021-08-02 Illumina, Inc. Systemy i sposoby wykorzystujące czujniki reagujące na pole magnetyczne do określania informacji genetycznej
CN108474805A (zh) 2015-08-24 2018-08-31 亿明达股份有限公司 用于生物和化学测定的线路内蓄压器和流量控制系统
CN108473927B (zh) 2015-12-01 2021-10-22 亿明达股份有限公司 用于单细胞分离和分析物表征的数字微流体系统
WO2017095845A1 (en) 2015-12-01 2017-06-08 Illumina, Inc. Liquid storage and delivery mechanisms and methods
CA3008031A1 (en) * 2016-01-11 2017-07-20 Illumina Singapore Pte Ltd Detection apparatus having a microfluorometer, a fluidic system, and a flow cell latch clamp module
US20170274374A1 (en) 2016-03-28 2017-09-28 Ilumina, Inc. Multi-plane microarrays
US11326206B2 (en) 2016-04-07 2022-05-10 Pacific Biosciences Of California, Inc. Methods of quantifying target nucleic acids and identifying sequence variants
WO2017176896A1 (en) 2016-04-07 2017-10-12 Illumina, Inc. Methods and systems for construction of normalized nucleic acid libraries
JP6963882B2 (ja) 2016-05-05 2021-11-10 チルドレンズ ホスピタル メディカル センター 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物
KR102171865B1 (ko) 2016-05-18 2020-10-29 일루미나, 인코포레이티드 패턴화된 소수성 표면을 사용한 자가 조립된 패터닝
CN109791161A (zh) 2016-07-21 2019-05-21 西门子医疗保健诊断公司 自动临床分析器系统和方法
CA3026773C (en) 2016-07-22 2022-10-18 Oregon Health & Science University Single cell whole genome libraries and combinatorial indexing methods of making thereof
EP4039824A1 (en) 2016-08-15 2022-08-10 Pacific Biosciences of California, Inc. Method and system for sequencing nucleic acids
WO2018064116A1 (en) 2016-09-28 2018-04-05 Illumina, Inc. Methods and systems for data compression
CN109688817B (zh) 2016-10-03 2022-02-22 Illumina公司 胺和肼的荧光检测及其分析方法
JP2019537706A (ja) 2016-10-07 2019-12-26 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーBoehringer Ingelheim Vetmedica GmbH サンプルを検査するための方法及び分析システム
CA3035143A1 (en) * 2016-10-07 2018-04-12 Boehringer Ingelheim Vetmedica Gmbh Analysis system and method for testing a sample
CN111781139B (zh) 2016-10-14 2023-09-12 亿明达股份有限公司 夹盒组件
GB201619458D0 (en) 2016-11-17 2017-01-04 Spatial Transcriptomics Ab Method for spatial tagging and analysing nucleic acids in a biological specimen
US10718786B2 (en) 2016-11-23 2020-07-21 Illumina, Inc. Flow cell assembly securement system and method
NL2017853B1 (en) * 2016-11-23 2018-05-28 Illumina Inc Flow cell assembly securement system and method
SG11201811614YA (en) * 2016-11-23 2019-01-30 Illumina Inc Flow cell assembly securement system and method
KR20230110839A (ko) 2016-12-05 2023-07-25 칠드런즈 호스피탈 메디칼 센터 결장 유사장기 및 이를 제조 및 사용하는 방법
CN108265112B (zh) 2016-12-30 2023-04-25 深圳市真迈生物科技有限公司 对序列测定反应进行控制的方法、序列测定系统和控制装置
CA3048415C (en) 2016-12-30 2023-02-28 Omniome, Inc. Method and system employing distinguishable polymerases for detecting ternary complexes and identifying cognate nucleotides
GB201704769D0 (en) * 2017-01-03 2017-05-10 Illumina Inc Flowcell cartridge with floating seal bracket
GB201704758D0 (en) * 2017-01-05 2017-05-10 Illumina Inc Reagent channel mixing systema and method
GB201704771D0 (en) 2017-01-05 2017-05-10 Illumina Inc Modular optical analytic systems and methods
GB201704772D0 (en) 2017-01-05 2017-05-10 Illumina Inc Automated volumetric reagent delivery testing
GB201704754D0 (en) 2017-01-05 2017-05-10 Illumina Inc Kinetic exclusion amplification of nucleic acid libraries
WO2018129314A1 (en) 2017-01-06 2018-07-12 Illumina, Inc. Phasing correction
EP3568490B1 (en) 2017-01-10 2021-03-10 Omniome, Inc. Polymerases engineered to reduce nucleotide-independent dna binding
CA3045498C (en) 2017-01-17 2021-07-13 Illumina, Inc. Oncogenic splice variant determination
CA3050695C (en) 2017-01-20 2024-02-20 Omniome, Inc. Process for cognate nucleotide detection in a nucleic acid sequencing workflow
AU2017394644B2 (en) 2017-01-20 2020-02-06 Pacific Biosciences Of California, Inc. Allele-specific capture of nucleic acids
EP3565900B1 (en) 2017-01-20 2021-04-07 Omniome, Inc. Genotyping by polymerase binding
GB201701691D0 (en) 2017-02-01 2017-03-15 Illumina Inc System and method with reflective fiducials
GB201701689D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials of non-closed shapes
GB201701688D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials in non-recliner layouts
SG11201906442TA (en) 2017-02-01 2019-08-27 Illumina Inc System and method with fiducials responding to multiple excitation frequencies
GB201701686D0 (en) 2017-02-01 2017-03-15 Illunina Inc System & method with fiducials having offset layouts
WO2018152162A1 (en) 2017-02-15 2018-08-23 Omniome, Inc. Distinguishing sequences by detecting polymerase dissociation
CN117116360A (zh) 2017-03-30 2023-11-24 Illumina公司 基因组数据分析系统和方法
WO2018187013A1 (en) 2017-04-04 2018-10-11 Omniome, Inc. Fluidic apparatus and methods useful for chemical and biological reactions
DK3615671T3 (da) 2017-04-23 2021-10-18 Illumina Cambridge Ltd Sammensætninger og fremgangsmåder til forbedring af prøveidentificering i indekserede nukleinsyrebiblioteker
US9951385B1 (en) 2017-04-25 2018-04-24 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
SG11201911730XA (en) 2017-06-07 2020-01-30 Univ Oregon Health & Science Single cell whole genome libraries for methylation sequencing
WO2018236631A1 (en) 2017-06-20 2018-12-27 Illumina, Inc. METHODS AND COMPOSITIONS FOR RESOLVING INEFFICIENCY IN AMPLIFICATION REACTIONS
EP3655153B1 (en) 2017-07-18 2020-09-16 Omniome, Inc. Method of chemically modifying plastic surfaces
US20200202977A1 (en) 2017-07-31 2020-06-25 Illumina, Inc. Sequencing system with multiplexed biological sample aggregation
EP4289967A3 (en) 2017-08-01 2024-03-20 Illumina, Inc. Spatial indexing of genetic material and library preparation using hydrogel beads and flow cells
CN107369485B (zh) * 2017-08-04 2023-07-04 成都天翔环境股份有限公司 废树脂转运槽车卸料系统、废料输送系统以及转运槽车
CN107287106A (zh) * 2017-08-10 2017-10-24 卡尤迪生物科技宜兴有限公司 使用定量pcr和数字pcr进行核酸检测的新颖方法和系统
US10858701B2 (en) 2017-08-15 2020-12-08 Omniome, Inc. Scanning apparatus and method useful for detection of chemical and biological analytes
GB2565564B (en) * 2017-08-16 2020-04-08 Peratech Holdco Ltd Detecting force
TWI738328B (zh) 2017-09-28 2021-09-01 美商伊路米納有限公司 流體施配器總成與用於將流體施配至流體匣中的方法
US11193166B2 (en) 2017-10-19 2021-12-07 Omniome, Inc. Simultaneous background reduction and complex stabilization in binding assay workflows
WO2019099306A1 (en) 2017-11-14 2019-05-23 Illumina, Inc. Droplet dispensing
WO2019126626A1 (en) * 2017-12-21 2019-06-27 Children's Hospital Medical Center Digitalized human organoids and methods of using same
CN113801784A (zh) * 2018-01-23 2021-12-17 深圳市真迈生物科技有限公司 核酸加载装置及用途
TWI699494B (zh) * 2018-01-24 2020-07-21 美商伊路米納有限公司 流體緩衝
WO2019195225A1 (en) 2018-04-02 2019-10-10 Illumina, Inc. Compositions and methods for making controls for sequence-based genetic testing
CN110343612B (zh) * 2018-04-08 2021-07-13 上海交通大学 基于多色荧光可逆终止核苷酸的dna单分子测序系统与装置
AU2019255987A1 (en) 2018-04-19 2020-12-10 Pacific Biosciences Of California, Inc. Improving accuracy of base calls in nucleic acid sequencing methods
WO2019209426A1 (en) 2018-04-26 2019-10-31 Omniome, Inc. Methods and compositions for stabilizing nucleic acid-nucleotide-polymerase complexes
NL2021147B1 (en) * 2018-05-15 2019-11-21 Illumina Inc Flow cell with flexible connection
JP7100069B2 (ja) 2018-05-15 2022-07-12 イルミナ インコーポレイテッド 表面結合オリゴヌクレオチドを化学開裂および脱保護するための組成物および方法
US11180794B2 (en) 2018-05-31 2021-11-23 Omniome, Inc. Methods and compositions for capping nucleic acids
US11339428B2 (en) 2018-05-31 2022-05-24 Pacific Biosciences Of California, Inc. Increased signal to noise in nucleic acid sequencing
FI3810774T3 (fi) 2018-06-04 2023-12-11 Illumina Inc Menetelmiä suuritehoisten yksittäissolutranskriptomikirjastojen valmistamiseksi
WO2020023362A1 (en) 2018-07-24 2020-01-30 Omniome, Inc. Serial formation of ternary complex species
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
US20210317524A1 (en) 2018-08-28 2021-10-14 10X Genomics, Inc. Resolving spatial arrays
WO2020047010A2 (en) 2018-08-28 2020-03-05 10X Genomics, Inc. Increasing spatial array resolution
WO2020060811A1 (en) 2018-09-17 2020-03-26 Omniome, Inc. Engineered polymerases for improved sequencing
CN109465047B (zh) * 2018-11-06 2019-07-30 东南大学 纳米孔检测芯片的便携式装夹装置
EP3887499A4 (en) * 2018-11-26 2022-07-20 Illumina, Inc. FLOW CELL SYSTEMS AND RELATED PROCEDURES
US10710076B2 (en) 2018-12-04 2020-07-14 Omniome, Inc. Mixed-phase fluids for nucleic acid sequencing and other analytical assays
AU2019391274A1 (en) 2018-12-05 2021-01-07 Illumina Cambridge Limited Methods and compositions for cluster generation by bridge amplification
WO2020123319A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Methods of using master / copy arrays for spatial detection
GB201820341D0 (en) 2018-12-13 2019-01-30 10X Genomics Inc Method for transposase-mediated spatial tagging and analysing genomic DNA in a biological specimen
CN113167806B (zh) * 2018-12-13 2023-10-17 深圳华大智造科技股份有限公司 便携式加样装置
GB201820300D0 (en) 2018-12-13 2019-01-30 10X Genomics Inc Method for spatial tagging and analysing genomic DNA in a biological specimen
AU2019411272A1 (en) 2018-12-18 2021-01-07 Illumina Cambridge Limited Methods and compositions for paired end sequencing using a single surface primer
US20200208214A1 (en) 2018-12-19 2020-07-02 Illumina, Inc. Methods for improving polynucleotide cluster clonality
CN113227348A (zh) 2018-12-20 2021-08-06 欧姆尼欧美公司 用于分析核酸和其他分析物的温度控制
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11493441B2 (en) * 2019-01-15 2022-11-08 Wyatt Technology Corporation Flow cell, read head, and skid attachment
US11499189B2 (en) 2019-02-14 2022-11-15 Pacific Biosciences Of California, Inc. Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes
US11680950B2 (en) 2019-02-20 2023-06-20 Pacific Biosciences Of California, Inc. Scanning apparatus and methods for detecting chemical and biological analytes
EP3931354A1 (en) 2019-02-28 2022-01-05 10X Genomics, Inc. Profiling of biological analytes with spatially barcoded oligonucleotide arrays
SG11202102530QA (en) 2019-03-01 2021-04-29 Illumina Inc High-throughput single-nuclei and single-cell libraries and methods of making and of using
WO2020190509A1 (en) 2019-03-15 2020-09-24 10X Genomics, Inc. Methods for using spatial arrays for single cell sequencing
NL2023314B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based quality scoring
NL2023311B9 (en) 2019-03-21 2021-03-12 Illumina Inc Artificial intelligence-based generation of sequencing metadata
WO2020205296A1 (en) 2019-03-21 2020-10-08 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
NL2023312B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based base calling
NL2023310B1 (en) 2019-03-21 2020-09-28 Illumina Inc Training data generation for artificial intelligence-based sequencing
NL2023316B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based sequencing
EP3887542A1 (en) 2019-03-22 2021-10-06 10X Genomics, Inc. Three-dimensional spatial analysis
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
EP3976820A1 (en) 2019-05-30 2022-04-06 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2020252186A1 (en) 2019-06-11 2020-12-17 Omniome, Inc. Calibrated focus sensing
US11377655B2 (en) 2019-07-16 2022-07-05 Pacific Biosciences Of California, Inc. Synthetic nucleic acids having non-natural structures
US10656368B1 (en) 2019-07-24 2020-05-19 Omniome, Inc. Method and system for biological imaging using a wide field objective lens
TW202124406A (zh) 2019-09-10 2021-07-01 美商歐姆尼歐美公司 核苷酸之可逆修飾
EP4038546A1 (en) 2019-10-01 2022-08-10 10X Genomics, Inc. Systems and methods for identifying morphological patterns in tissue samples
EP4045683A1 (en) 2019-10-18 2022-08-24 Omniome, Inc. Methods and compositions for capping nucleic acids
WO2021091611A1 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
EP4055155A1 (en) 2019-11-08 2022-09-14 Pacific Biosciences of California, Inc. Engineered polymerases for improved sequencing by binding
CN117078725A (zh) 2019-11-21 2023-11-17 10X基因组学有限公司 分析物的空间分析
DE202019106694U1 (de) 2019-12-02 2020-03-19 Omniome, Inc. System zur Sequenzierung von Nukleinsäuren in Fluidschaum
BR112021019640A2 (pt) 2019-12-19 2022-06-21 Illumina Inc Bibliotecas de células únicas de alto rendimento e métodos de preparo e uso
US11747262B2 (en) 2019-12-23 2023-09-05 Singular Genomics Systems, Inc. Flow cell carrier and methods of use
US11498078B2 (en) 2019-12-23 2022-11-15 Singular Genomics Systems, Inc. Flow cell receiver and methods of use
US20230054204A1 (en) 2020-02-04 2023-02-23 Pacific Biosciences Of California, Inc. Flow cells and methods for their manufacture and use
EP4107284A1 (en) 2020-02-17 2022-12-28 10X Genomics, Inc. In situ analysis of chromatin interaction
US20210265018A1 (en) 2020-02-20 2021-08-26 Illumina, Inc. Knowledge Distillation and Gradient Pruning-Based Compression of Artificial Intelligence-Based Base Caller
WO2021168287A1 (en) 2020-02-21 2021-08-26 10X Genomics, Inc. Methods and compositions for integrated in situ spatial assay
EP4114966A1 (en) 2020-03-03 2023-01-11 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing double stranded nucleic acids
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
US20230053732A1 (en) * 2020-03-16 2023-02-23 Siemens Healthcare Diagnostics Inc. Sample holders, pcr station assemblies, and methods of operating pcr testing system
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
US20230183798A1 (en) 2020-05-05 2023-06-15 Pacific Biosciences Of California, Inc. Compositions and methods for modifying polymerase-nucleic acid complexes
US20230203592A1 (en) 2020-05-05 2023-06-29 Akershus Universitetssykehus Hf Compositions and methods for characterizing bowel cancer
CA3177286A1 (en) 2020-05-12 2021-11-18 Illumina Inc. Generating nucleic acids with modified bases using recombinant terminal deoxynucleotidyl transferase
EP4153775A1 (en) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
EP3916394A1 (en) * 2020-05-29 2021-12-01 Roche Diagnostics GmbH Module for an automated laboratory system
EP4162074B1 (en) 2020-06-08 2024-04-24 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
EP4165549A1 (en) 2020-06-11 2023-04-19 Nautilus Biotechnology, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
US11787831B2 (en) 2020-06-22 2023-10-17 Illumina Cambridge Limited Nucleosides and nucleotides with 3′ acetal blocking group
JP2023532231A (ja) 2020-06-30 2023-07-27 イルミナ インコーポレイテッド 傷なしdnaを生成するための触媒的に制御された合成による配列決定
AU2021306281A1 (en) 2020-07-08 2023-01-05 Illumina, Inc. Beads as transposome carriers
KR20230051508A (ko) 2020-08-18 2023-04-18 일루미나, 인코포레이티드 핵산의 서열-특이적 표적화된 전위 및 선택과 분류
GB202013141D0 (en) 2020-08-21 2020-10-07 Univ College Cardiff Consultants Ltd A screening method for the detection of DNA damage
KR20230069135A (ko) 2020-09-11 2023-05-18 일루미나 케임브리지 리미티드 헤어핀 어댑터를 사용하여 시퀀싱 라이브러리에서 표적 서열을 농축시키는 방법
KR20230118570A (ko) 2020-11-11 2023-08-11 노틸러스 서브시디어리, 인크. 강화된 결합 및 검출 특성을 갖는 친화성 시약
US20220186300A1 (en) 2020-12-11 2022-06-16 10X Genomics, Inc. Methods and compositions for multimodal in situ analysis
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
EP4153964A4 (en) 2020-12-21 2023-11-29 Singular Genomics Systems, Inc. MULTICOLOR IMAGING SYSTEMS AND METHODS
AU2021409136A1 (en) 2020-12-21 2023-06-29 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
US20220228200A1 (en) 2021-01-19 2022-07-21 10X Genomics, Inc. Methods and compositions for internally controlled in situ assays
WO2022159663A1 (en) 2021-01-21 2022-07-28 Nautilus Biotechnology, Inc. Systems and methods for biomolecule preparation
US20220235403A1 (en) 2021-01-26 2022-07-28 10X Genomics, Inc. Nucleic acid analog probes for in situ analysis
EP4301873A1 (en) 2021-03-03 2024-01-10 10X Genomics, Inc. Analyte detection in situ using nucleic acid origami
JP2024514405A (ja) 2021-03-11 2024-04-02 ノーティラス・サブシディアリー・インコーポレイテッド 生体分子保持のためのシステム及び方法
EP4263868A1 (en) 2021-03-12 2023-10-25 Singular Genomics Systems, Inc. Nanoarrays and methods of use thereof
US11884977B2 (en) 2021-03-12 2024-01-30 Singular Genomics Systems, Inc. Nanoarrays and methods of use thereof
CA3210451A1 (en) 2021-03-22 2022-09-29 Illumina Cambridge Limited Methods for improving nucleic acid cluster clonality
BR112023019894A2 (pt) 2021-03-29 2023-11-14 Illumina Inc Composições e métodos para avaliar os danos ao dna em uma biblioteca e normalizar a distorção do tamanho do amplicon
JP2024511766A (ja) 2021-03-29 2024-03-15 イルミナ インコーポレイテッド 改善されたライブラリ調製方法
WO2022213027A1 (en) 2021-04-02 2022-10-06 Illumina, Inc. Machine-learning model for detecting a bubble within a nucleotide-sample slide for sequencing
FR3121936A1 (fr) 2021-04-20 2022-10-21 Naos Institute Of Life Science Methode de criblage d’ingredients et de compositions topiques ecobiologiques, et son utilisation pour realiser un soin cosmetique de restauration du microbiote cutane
WO2022235764A1 (en) * 2021-05-05 2022-11-10 Singular Genomics Systems, Inc. Multiomic analysis device and methods of use thereof
EP4337789A1 (en) 2021-05-10 2024-03-20 Pacific Biosciences of California, Inc. Dna amplification buffer replenishment during rolling circle amplification
WO2022240764A1 (en) 2021-05-10 2022-11-17 Pacific Biosciences Of California, Inc. Single-molecule seeding and amplification on a surface
EP4347877A1 (en) 2021-06-01 2024-04-10 10X Genomics, Inc. Methods and compositions for analyte detection and probe resolution
WO2022256422A1 (en) 2021-06-02 2022-12-08 10X Genomics, Inc. Sample analysis using asymmetric circularizable probes
US20220403450A1 (en) 2021-06-03 2022-12-22 Illumina Software, Inc. Systems and methods for sequencing nucleotides using two optical channels
EP4355476A1 (en) 2021-06-15 2024-04-24 Illumina, Inc. Hydrogel-free surface functionalization for sequencing
WO2022272260A1 (en) 2021-06-23 2022-12-29 Illumina, Inc. Compositions, methods, kits, cartridges, and systems for sequencing reagents
US20220412998A1 (en) 2021-06-24 2022-12-29 Nautilus Biotechnology, Inc. Methods and systems for assay refinement
AU2022296802A1 (en) 2021-06-25 2024-01-04 Illumina, Inc. Linear fourier fiducial
US20220414853A1 (en) 2021-06-25 2022-12-29 Illumina, Inc. Fiducials for use in registration of a patterned surface
KR20240022490A (ko) 2021-06-29 2024-02-20 일루미나, 인코포레이티드 뉴클레오티드 염기 호출 및 염기 호출 품질을 결정하기 위한 신호-대-잡음비 메트릭
AU2022301321A1 (en) 2021-06-29 2024-01-18 Illumina, Inc. Machine-learning model for generating confidence classifications for genomic coordinates
CN117651855A (zh) 2021-07-13 2024-03-05 10X基因组学有限公司 用于制备具有可控厚度的聚合基质的方法
KR20240031968A (ko) 2021-07-19 2024-03-08 일루미나, 인코포레이티드 염기 호출에 대한 보간 및 적응을 갖는 강도 추출
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
US20230021577A1 (en) 2021-07-23 2023-01-26 Illumina Software, Inc. Machine-learning model for recalibrating nucleotide-base calls
US20230116852A1 (en) 2021-07-23 2023-04-13 Illumina, Inc. Methods for preparing substrate surface for dna sequencing
US20230057571A1 (en) 2021-08-03 2023-02-23 10X Genomics, Inc. Nucleic acid concatemers and methods for stabilizing and/or compacting the same
WO2023023484A1 (en) 2021-08-16 2023-02-23 10X Genomics, Inc. Probes comprising a split barcode region and methods of use
WO2023034079A1 (en) 2021-09-01 2023-03-09 Illumina Software, Inc. Amplitude modulation for accelerated base calling
WO2023038859A1 (en) 2021-09-09 2023-03-16 Nautilus Biotechnology, Inc. Characterization and localization of protein modifications
US20230088338A1 (en) 2021-09-10 2023-03-23 Illumina, Inc. Sequencer focus quality metrics and focus tracking for periodically patterned surfaces
GB202112907D0 (en) 2021-09-10 2021-10-27 Res & Innovation Uk Methods of biomolecule display
US20230080069A1 (en) * 2021-09-13 2023-03-16 Applied Materials, Inc. Flow-cell designs for biological imaging
CN117561573A (zh) 2021-09-17 2024-02-13 因美纳有限公司 从碱基判读错误模式自动鉴定核苷酸测序中的故障来源
CN117546243A (zh) 2021-09-21 2024-02-09 因美纳有限公司 使用推算的单倍型的图参考基因组和碱基检出方法
WO2023049073A1 (en) 2021-09-22 2023-03-30 Nautilus Biotechnology, Inc. Methods and systems for determining polypeptide interactions
WO2023049212A2 (en) 2021-09-22 2023-03-30 Illumina, Inc. State-based base calling
CA3232183A1 (en) 2021-10-11 2023-04-20 Nautilus Subsidiary, Inc. Highly multiplexable analysis of proteins and proteomes
WO2023069927A1 (en) 2021-10-20 2023-04-27 Illumina, Inc. Methods for capturing library dna for sequencing
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
WO2023081485A1 (en) 2021-11-08 2023-05-11 Pacific Biosciences Of California, Inc. Stepwise sequencing of a polynucleotide with a homogenous reaction mixture
EP4305195A2 (en) 2021-12-01 2024-01-17 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
CN117581303A (zh) 2021-12-02 2024-02-20 因美纳有限公司 产生用于确定核苷酸碱基检出的簇特异性信号校正
WO2023119164A1 (en) 2021-12-21 2023-06-29 Illumina Cambridge Limited Wax-microsphere matrix compositions and methods of making and using the same
WO2023122589A2 (en) * 2021-12-22 2023-06-29 Nautilus Subsidiary, Inc. Systems and methods for carrying out highly multiplexed bioanalyses
WO2023122363A1 (en) 2021-12-23 2023-06-29 Illumina Software, Inc. Dynamic graphical status summaries for nucelotide sequencing
US20230215515A1 (en) 2021-12-23 2023-07-06 Illumina Software, Inc. Facilitating secure execution of external workflows for genomic sequencing diagnostics
WO2023129898A2 (en) 2021-12-27 2023-07-06 10X Genomics, Inc. Methods and compositions for rolling circle amplification
US20230207050A1 (en) 2021-12-28 2023-06-29 Illumina Software, Inc. Machine learning model for recalibrating nucleotide base calls corresponding to target variants
WO2023129764A1 (en) 2021-12-29 2023-07-06 Illumina Software, Inc. Automatically switching variant analysis model versions for genomic analysis applications
US20230279475A1 (en) 2022-01-21 2023-09-07 10X Genomics, Inc. Multiple readout signals for analyzing a sample
WO2023164570A1 (en) 2022-02-23 2023-08-31 Insitro, Inc. Pooled optical screening and transcriptional measurements of cells comprising barcoded genetic perturbations
US20230410944A1 (en) 2022-02-25 2023-12-21 Illumina, Inc. Calibration sequences for nucelotide sequencing
CA3224595A1 (en) 2022-02-25 2023-08-31 Steven Norberg Machine-learning models for detecting and adjusting values for nucleotide methylation levels
US11795505B2 (en) 2022-03-10 2023-10-24 Singular Genomics Systems, Inc. Nucleic acid delivery scaffolds
CA3222807A1 (en) 2022-03-22 2023-09-28 Alexandra SZEMJONOV Substrate with orthogonally functional nanodomains
US20230343414A1 (en) 2022-03-25 2023-10-26 Illumina, Inc. Sequence-to-sequence base calling
WO2023192917A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
WO2023192616A1 (en) 2022-04-01 2023-10-05 10X Genomics, Inc. Compositions and methods for targeted masking of autofluorescence
WO2023196526A1 (en) 2022-04-06 2023-10-12 10X Genomics, Inc. Methods for multiplex cell analysis
WO2023196572A1 (en) 2022-04-07 2023-10-12 Illumina Singapore Pte. Ltd. Altered cytidine deaminases and methods of use
US20230360732A1 (en) 2022-04-25 2023-11-09 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
US20230340571A1 (en) 2022-04-26 2023-10-26 Illumina, Inc. Machine-learning models for selecting oligonucleotide probes for array technologies
US20230348967A1 (en) 2022-04-29 2023-11-02 Illumina Cambridge Limited Methods and systems for encapsulating lyophilised microspheres
WO2023215612A1 (en) 2022-05-06 2023-11-09 10X Genomics, Inc. Analysis of antigen and antigen receptor interactions
US20230368866A1 (en) 2022-05-10 2023-11-16 Illumina Software, Inc. Adaptive neural network for nucelotide sequencing
US20230407386A1 (en) 2022-06-09 2023-12-21 Illumina, Inc. Dependence of base calling on flow cell tilt
US20240035071A1 (en) 2022-06-17 2024-02-01 10X Genomics, Inc. Catalytic de-crosslinking of samples for in situ analysis
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
GB202209189D0 (en) 2022-06-22 2022-08-10 Broken String Biosciences Ltd Methods and compositions for nucleic acid sequencing
US20230420080A1 (en) 2022-06-24 2023-12-28 Illumina Software, Inc. Split-read alignment by intelligently identifying and scoring candidate split groups
WO2024006779A1 (en) 2022-06-27 2024-01-04 Illumina, Inc. Accelerators for a genotype imputation model
WO2024006705A1 (en) 2022-06-27 2024-01-04 Illumina Software, Inc. Improved human leukocyte antigen (hla) genotyping
US20230420082A1 (en) 2022-06-27 2023-12-28 Illumina Software, Inc. Generating and implementing a structural variation graph genome
WO2024026356A1 (en) 2022-07-26 2024-02-01 Illumina, Inc. Rapid single-cell multiomics processing using an executable file
WO2024025806A1 (en) 2022-07-27 2024-02-01 Illumina, Inc. Motion feedback using patterned flowcells
WO2024036304A1 (en) 2022-08-12 2024-02-15 10X Genomics, Inc. Puma1 polymerases and uses thereof
US20240084373A1 (en) 2022-08-16 2024-03-14 10X Genomics, Inc. Ap50 polymerases and uses thereof
DE102022209394A1 (de) * 2022-09-09 2024-03-14 Robert Bosch Gesellschaft mit beschränkter Haftung Aufnahmevorrichtung, Analysegerät und Verfahren zum Herstellen einer Aufnahmevorrichtung
WO2024059655A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024072799A1 (en) 2022-09-26 2024-04-04 Illumina, Inc. Flow cell based motion system calibration and control methods
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
US20240112753A1 (en) 2022-09-29 2024-04-04 Illumina, Inc. Target-variant-reference panel for imputing target variants
US20240120027A1 (en) 2022-09-30 2024-04-11 Illumina, Inc. Machine-learning model for refining structural variant calls
WO2024073047A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
WO2024069581A1 (en) 2022-09-30 2024-04-04 Illumina Singapore Pte. Ltd. Helicase-cytidine deaminase complexes and methods of use
WO2024073043A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides
WO2024077096A1 (en) 2022-10-05 2024-04-11 Illumina, Inc. Integrating variant calls from multiple sequencing pipelines utilizing a machine learning architecture

Family Cites Families (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4099921A (en) 1977-03-28 1978-07-11 Instrumentation Specialties Company Chemical analyzer
US4264810A (en) * 1977-12-24 1981-04-28 Nippon Kogaku K. K. Focus detecting apparatus
JPS5841358A (ja) 1981-09-04 1983-03-10 Hitachi Ltd 自動分析装置
US4478094A (en) 1983-01-21 1984-10-23 Cetus Corporation Liquid sample handling system
US4681742A (en) 1984-10-01 1987-07-21 Cetus Corporation Assay tray
DE3872341T2 (de) 1987-10-09 1992-12-10 Seiko Instr Inc Geraet zum durchfuehren einer fluessigkeitsreaktion.
US5306510A (en) 1988-01-14 1994-04-26 Cyberlab, Inc. Automated pipetting system
US4863243A (en) 1988-05-09 1989-09-05 Eastman Kodak Company Mount for an optical element including a holder with a generally semicylindrical surface
JPH02309929A (ja) * 1989-05-24 1990-12-25 Sumitomo Electric Ind Ltd 肝機能検査装置
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
DE4041905A1 (de) * 1990-12-27 1992-07-02 Boehringer Mannheim Gmbh Testtraeger-analysesystem
JP2001524926A (ja) 1991-09-18 2001-12-04 アフィマックス テクノロジーズ ナームロゼ フェンノートシャップ オリゴマーの雑多ライブラリーの集合体を合成する方法
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
DE69233331T3 (de) 1991-11-22 2007-08-30 Affymetrix, Inc., Santa Clara Kombinatorische Strategien zur Polymersynthese
US5491074A (en) 1993-04-01 1996-02-13 Affymax Technologies Nv Association peptides
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US6090555A (en) 1997-12-11 2000-07-18 Affymetrix, Inc. Scanned image alignment systems and methods
AU2360195A (en) 1994-05-05 1995-11-29 Beckman Instruments, Inc. Oligonucleotide repeat arrays
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US6090592A (en) 1994-08-03 2000-07-18 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid on supports
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5578270A (en) 1995-03-24 1996-11-26 Becton Dickinson And Company System for nucleic acid based diagnostic assay
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US6022963A (en) 1995-12-15 2000-02-08 Affymetrix, Inc. Synthesis of oligonucleotide arrays using photocleavable protecting groups
US5981956A (en) 1996-05-16 1999-11-09 Affymetrix, Inc. Systems and methods for detection of labeled materials
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US6083697A (en) 1996-11-14 2000-07-04 Affymetrix, Inc. Chemical amplification for the synthesis of patterned arrays
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
AU6846798A (en) 1997-04-01 1998-10-22 Glaxo Group Limited Method of nucleic acid sequencing
ES2563643T3 (es) 1997-04-01 2016-03-15 Illumina Cambridge Limited Método de secuenciación de ácido nucleico
AU8162498A (en) 1997-06-25 1999-01-04 Orchid Biosciences, Inc. Methods for the detection of multiple single nucleotide polymorphisms in a single reaction
EP1908832B1 (en) 1997-07-07 2012-12-26 Medical Research Council A method for increasing the concentration of a nucleic acid molecule
CN1224600A (zh) * 1997-08-06 1999-08-04 仓敷纺织株式会社 调节作用于生物体上的压力的压力调节装置和方法
US6838051B2 (en) 1999-05-03 2005-01-04 Ljl Biosystems, Inc. Integrated sample-processing system
ATE291097T1 (de) 1997-10-31 2005-04-15 Affymetrix Inc A Delaware Corp Expressionsprofile in adulten und fötalen organen
US6428752B1 (en) 1998-05-14 2002-08-06 Affymetrix, Inc. Cleaning deposit devices that form microarrays and the like
JP2002502588A (ja) 1998-02-06 2002-01-29 アフィメトリックス インコーポレイテッド 製造プロセスにおける品質管理の方法
US6132685A (en) 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
JP2000121511A (ja) 1998-10-13 2000-04-28 Hitachi Koki Co Ltd 自動分離抽出装置及びその制御方法
US20020176801A1 (en) 1999-03-23 2002-11-28 Giebeler Robert H. Fluid delivery and analysis systems
US20030207295A1 (en) 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20030108867A1 (en) 1999-04-20 2003-06-12 Chee Mark S Nucleic acid sequencing using microsphere arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
ATE553219T1 (de) 1999-04-20 2012-04-15 Illumina Inc Erkennung von nukleinsäurereaktionen auf bead- arrays
US6225109B1 (en) 1999-05-27 2001-05-01 Orchid Biosciences, Inc. Genetic analysis device
JP3640840B2 (ja) 1999-07-16 2005-04-20 アロカ株式会社 核酸断片の分離方法及び核酸シークエンス前処理装置
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US7001792B2 (en) 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
JP3638503B2 (ja) 2000-06-12 2005-04-13 アークレイ株式会社 カートリッジ式容器を用いる測定装置および測定方法並びに記録媒体
CN100462433C (zh) 2000-07-07 2009-02-18 维西根生物技术公司 实时序列测定
US20030160957A1 (en) * 2000-07-14 2003-08-28 Applera Corporation Scanning system and method for scanning a plurality of samples
US7277166B2 (en) * 2000-08-02 2007-10-02 Honeywell International Inc. Cytometer analysis cartridge optical configuration
US7000330B2 (en) 2002-08-21 2006-02-21 Honeywell International Inc. Method and apparatus for receiving a removable media member
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
GB0117706D0 (en) 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Automated semi-solid matrix assay and liquid handler apparatus for the same
CA2450676C (en) 2001-03-09 2010-03-30 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US20030059823A1 (en) 2001-09-21 2003-03-27 Juki Corporation Hybridization apparatus and method for detecting nucleic acid in sample using the same
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
JP4080208B2 (ja) 2002-01-22 2008-04-23 フジノン株式会社 反射鏡の保持構造
US6983636B2 (en) 2002-01-25 2006-01-10 Innovadyne Technologies, Inc. Apparatus and method for assessing the liquid flow performances through a small dispensing orifice
US20040002090A1 (en) 2002-03-05 2004-01-01 Pascal Mayer Methods for detecting genome-wide sequence variations associated with a phenotype
WO2003087410A1 (en) 2002-04-11 2003-10-23 Sequenom, Inc. Methods and devices for performing chemical reactions on a solid support
JP2004017212A (ja) 2002-06-17 2004-01-22 Sumitomo Heavy Ind Ltd ダイプレス抜機
JP2004028681A (ja) 2002-06-24 2004-01-29 Juki Corp 液体分注装置用ヘッド
US7125722B2 (en) 2002-07-03 2006-10-24 Abbott Laboratories Apparatus and method for handling fluids for analysis
US20050227252A1 (en) 2002-08-20 2005-10-13 Moon John A Diffraction grating-based encoded articles for multiplexed experiments
US7399643B2 (en) 2002-09-12 2008-07-15 Cyvera Corporation Method and apparatus for aligning microbeads in order to interrogate the same
SI3587433T1 (sl) 2002-08-23 2020-08-31 Illumina Cambridge Limited Modificirani nukleotidi
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
JP4016811B2 (ja) 2002-11-15 2007-12-05 日立工機株式会社 自動分注装置
US20050221281A1 (en) 2003-01-08 2005-10-06 Ho Winston Z Self-contained microfluidic biochip and apparatus
EP2159285B1 (en) 2003-01-29 2012-09-26 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
US7025935B2 (en) 2003-04-11 2006-04-11 Illumina, Inc. Apparatus and methods for reformatting liquid samples
JP3733124B2 (ja) 2003-04-14 2006-01-11 アロカ株式会社 液体貯留部
US7947512B2 (en) 2003-04-15 2011-05-24 Universal Bio Research Co., Ltd. Dispensing cylinder, large capacity dispensing device, and method of using large capacity dispensing device
JP2004325329A (ja) 2003-04-25 2004-11-18 Hitachi High-Technologies Corp 分注方法及び分注装置
TW579430B (en) 2003-05-02 2004-03-11 Dr Chip Biotechnology Inc Automatic micro-fluid hybridization chip platform
US7055695B2 (en) * 2003-06-02 2006-06-06 Caliper Life Sciencee, Inc. Container providing a controlled hydrated environment
US20050181394A1 (en) 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
EP2532745B1 (en) 2003-07-05 2015-09-09 The Johns Hopkins University Method and Compositions for Detection and Enumeration of Genetic Variations
CN100365418C (zh) 2003-09-16 2008-01-30 山东省科学院生物研究所 用于固定化酶生物传感器分析仪的流动注射装置
US20050220675A1 (en) 2003-09-19 2005-10-06 Reed Mark T High density plate filler
EP1673614A1 (en) 2003-10-01 2006-06-28 CiDra Corporation Optical reader for diffraction grating-based encoded optical identification elements
US7695952B2 (en) * 2003-11-07 2010-04-13 Nanosphere, Inc. Disposable sample processing module for detecting nucleic acids
EP2093571B1 (en) 2004-05-21 2014-07-09 Caliper Life Sciences, Inc. Automated system for handling microfluidic devices
CA2579150C (en) 2004-09-17 2014-11-25 Pacific Biosciences Of California, Inc. Apparatus and method for analysis of molecules
KR100601966B1 (ko) 2004-10-07 2006-07-18 삼성전자주식회사 마이크로 칩 유니트 및 상기 마이크로 칩 유니트를이용하여 생화학 반응을 수행하는 방법
GB0427236D0 (en) 2004-12-13 2005-01-12 Solexa Ltd Improved method of nucleotide detection
KR100657298B1 (ko) 2004-12-18 2006-12-14 삼성전자주식회사 미러 지지 장치, 이를 구비하는 광주사장치 및 전자사진방식 화상형성장치
JP2006194689A (ja) 2005-01-12 2006-07-27 Olympus Corp 分注装置、液面検出方法および培養処理装置
JP4633484B2 (ja) 2005-01-19 2011-02-16 オリンパス株式会社 光学素子の支持機構
US20060180489A1 (en) * 2005-02-02 2006-08-17 Cytyc Corporation Slide tray
US7964413B2 (en) 2005-03-10 2011-06-21 Gen-Probe Incorporated Method for continuous mode processing of multiple reaction receptacles in a real-time amplification assay
US20060275852A1 (en) 2005-06-06 2006-12-07 Montagu Jean I Assays based on liquid flow over arrays
EP2463386B1 (en) 2005-06-15 2017-04-12 Complete Genomics Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
CN1333231C (zh) 2005-07-01 2007-08-22 清华大学 一种用线阵ccd测量光束中心位置的方法
GB0514910D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
EP1910688A4 (en) * 2005-08-04 2010-03-03 Helicos Biosciences Corp MULTICHANNEL FLOW CELLS
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
JP4981295B2 (ja) 2005-10-04 2012-07-18 キヤノン株式会社 Dna処理方法およびdna処理装置
US20070179435A1 (en) 2005-12-21 2007-08-02 Braig James R Analyte detection system with periodic sample draw and body fluid analyzer
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
CN108931509B (zh) 2005-12-21 2022-04-15 梅索斯卡莱科技公司 分析装置、方法和试剂
CN1794034A (zh) 2005-12-21 2006-06-28 天津理工大学 紧凑型光学扫描检测系统
EP3121601A1 (en) * 2005-12-22 2017-01-25 Honeywell International Inc. Portable sample analyzer system
US20070154895A1 (en) 2005-12-30 2007-07-05 Caliper Life Sciences, Inc. Multi-assay microfluidic chips
JP5009533B2 (ja) 2006-01-20 2012-08-22 凸版印刷株式会社 試薬用容器
US8192698B2 (en) 2006-01-27 2012-06-05 Parker-Hannifin Corporation Sampling probe, gripper and interface for laboratory sample management systems
BE1016981A3 (fr) 2006-02-08 2007-11-06 Fn Herstal Sa Viseur ameliore a pont rouge mobile.
EP2021503A1 (en) 2006-03-17 2009-02-11 Solexa Ltd. Isothermal methods for creating clonal single molecule arrays
US7998708B2 (en) * 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP4105644A3 (en) 2006-03-31 2022-12-28 Illumina, Inc. Systems and devices for sequence by synthesis analysis
DE102006022511B3 (de) 2006-05-11 2007-08-16 Fachhochschule Jena Vorrichtung zur Fassung einer planaren ein- oder mehrteiligen Mikroreaktionskammer
JP4964518B2 (ja) 2006-06-30 2012-07-04 株式会社サカエ 自動分析装置
JP5553602B2 (ja) 2006-09-06 2014-07-16 キヤノン ユー.エス. ライフ サイエンシズ, インコーポレイテッド マイクロ流体アッセイを実施するためのチップ及びカートリッジ設計構成
JP4912096B2 (ja) * 2006-09-07 2012-04-04 ローム株式会社 マイクロチップ検査装置
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
US8343746B2 (en) 2006-10-23 2013-01-01 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
US7753095B2 (en) 2006-12-15 2010-07-13 Helicos Biosciences Corporation Storing and handling liquid reagents
US20100055666A1 (en) 2007-02-08 2010-03-04 Koninklijke Philips Electronics N.V. Biosensor with evanescent waveguide and integrated sensor
GB0704490D0 (en) * 2007-03-08 2007-04-18 Bg Res Ltd Improvements in thermal cyclers
US8105783B2 (en) * 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8133671B2 (en) * 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) * 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
EP2201352B2 (en) 2007-09-28 2018-08-29 Illumina, Inc. Fluorescence excitation and detection system and method
US8088593B2 (en) 2007-10-02 2012-01-03 Theranos, Inc. Modular point-of-care devices, systems, and uses thereof
CN101397863A (zh) 2007-12-01 2009-04-01 莫兵刚 全封闭离合式防盗锁
EP2254825A4 (en) * 2008-02-22 2016-03-02 Fluidigm Corp INTEGRATED CARRIER FOR MICROFLUIDIC DEVICE
JP2009229194A (ja) 2008-03-21 2009-10-08 Toshiba Corp 試薬容器及びこれを備える自動分析装置
CN201222492Y (zh) 2008-04-03 2009-04-15 东捷科技股份有限公司 固定装置及其系统
US8961902B2 (en) 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
US7995208B2 (en) 2008-08-06 2011-08-09 Ftrx Llc Monolithic interferometer with optics of different material
EP2331954B1 (en) 2008-08-27 2020-03-25 Life Technologies Corporation Apparatus for and method of processing biological samples
US9034257B2 (en) * 2008-10-27 2015-05-19 Nodality, Inc. High throughput flow cytometry system and method
US8169006B2 (en) 2008-11-29 2012-05-01 Electronics And Telecommunications Research Institute Bio-sensor chip for detecting target material
US20100157086A1 (en) 2008-12-15 2010-06-24 Illumina, Inc Dynamic autofocus method and system for assay imager
EP2384438A2 (en) 2008-12-30 2011-11-09 Redhorse Fluidics Systems, devices, methods and kits for fluid handling
WO2011026136A1 (en) 2009-08-31 2011-03-03 Life Technologies Corporation Low-volume sequencing system and method of use
CN201550179U (zh) 2009-10-12 2010-08-11 上海祥网瑞电子科技有限公司 带可旋转镜片平面图像采集器
CA2994889C (en) * 2009-12-07 2019-01-22 Meso Scale Technologies, Llc Assay cartridges and methods of using the same
US8574832B2 (en) 2010-02-03 2013-11-05 Massachusetts Institute Of Technology Methods for preparing sequencing libraries
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
US9115353B2 (en) 2011-01-31 2015-08-25 Illumina, Inc. Method for nucleotide detection
US8687180B2 (en) * 2012-06-07 2014-04-01 Molecular Devices, Llc System, method, and device for determining a focal position of an objective in a microscopy imaging system
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments

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PT2663402T (pt) 2021-05-07
CN103501907A (zh) 2014-01-08
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EP3714978A1 (en) 2020-09-30
US11559805B2 (en) 2023-01-24
ES2864585T3 (es) 2021-10-14
CA2824664A1 (en) 2012-07-19
US8951781B2 (en) 2015-02-10
JP3187946U (ja) 2013-12-26
US20190151845A1 (en) 2019-05-23
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EP2663402A1 (en) 2013-11-20
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US20220226819A1 (en) 2022-07-21
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US20150151297A1 (en) 2015-06-04
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US11938479B2 (en) 2024-03-26
US20230311119A1 (en) 2023-10-05
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