DK2606047T3 - Sammensætninger og formuleringer med lipideret immunrespons-modificerende forbindelse og fremgangsmåder dermed - Google Patents

Sammensætninger og formuleringer med lipideret immunrespons-modificerende forbindelse og fremgangsmåder dermed Download PDF

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DK2606047T3
DK2606047T3 DK11818656.8T DK11818656T DK2606047T3 DK 2606047 T3 DK2606047 T3 DK 2606047T3 DK 11818656 T DK11818656 T DK 11818656T DK 2606047 T3 DK2606047 T3 DK 2606047T3
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compound
formula
butyl
antigen
pharmaceutical composition
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DK11818656.8T
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Paul D Wightman
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3M Innovative Properties Co
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Claims (14)

1. Forbindelse med formel:
herunder ethvert farmaceutisk acceptabelt salt deraf.
2. Farmaceutisk sammensætning, der omfatter et farmaceutisk acceptabelt bæremateriale og forbindelsen ifølge krav 1.
3. Farmaceutisk sammensætning, der omfatter forbindelsen ifølge krav 1 i en formulering, der omfatter liposomer.
4. Farmaceutisk sammensætning ifølge krav 2 eller 3, der yderligere omfatter et antigen.
5. Farmaceutisk sammensætning ifølge krav 4, hvor forbindelsen og antigenet er blandet sammen i en enkelt sammensætning.
6. Farmaceutisk sammensætning ifølge krav 4, hvor forbindelsen og antigenet er til stede i separate bestanddele af sammensætningen til administration i kombination.
7. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 4 til 6, hvor antigenet er en cancervaccine.
8. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 4 til 6, hvor antigenet er en virusvaccine.
9. Anvendelse af en forbindelse med formlen N-(4 —{[4-amino-2-butyl-lA-imidazo[4,5-c]quinolin-l-yl]oxy}butyl)octadecanamid eller et farmaceutisk acceptabelt salt deraf som et vaccineadjuvans.
10. Anvendelse ifølge krav 9, hvor forbindelsen er inkorporeret i en liposomformulering.
11. Forbindelse med formlen N-(4-{[4-amino-2-butyl-lH-imidazo[4,5-c]quinolin-l-yl]oxyjbutyl)octadecanamid eller et farmaceutisk acceptabelt salt deraf til anvendelse til behandling af neoplastisk sygdom.
12. Forbindelse til anvendelse ifølge krav 11, hvor forbindelsen er i en liposomformulering.
13. Forbindelse til anvendelse ifølge krav 12, hvor formuleringen administreres direkte i en lokaliseret tumormasse.
14. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 11 til 13, hvor der yderligere administreres et cancervaccineantigen.
DK11818656.8T 2010-08-17 2011-08-16 Sammensætninger og formuleringer med lipideret immunrespons-modificerende forbindelse og fremgangsmåder dermed DK2606047T3 (da)

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Application Number Priority Date Filing Date Title
US37451210P 2010-08-17 2010-08-17
PCT/US2011/047901 WO2012024284A1 (en) 2010-08-17 2011-08-16 Lipidated immune response modifier compound compositions, formulations, and methods

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DK2606047T3 true DK2606047T3 (da) 2017-03-27

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US (9) US9242980B2 (da)
EP (2) EP3222621B1 (da)
JP (5) JP2013534248A (da)
CN (2) CN105294684B (da)
AU (1) AU2011292146B2 (da)
BR (1) BR112013003772A2 (da)
CA (2) CA2808624C (da)
CY (1) CY1118815T1 (da)
DK (1) DK2606047T3 (da)
ES (2) ES2943385T3 (da)
HK (1) HK1217942A1 (da)
HR (1) HRP20170433T1 (da)
HU (1) HUE033901T2 (da)
LT (1) LT2606047T (da)
MX (1) MX359517B (da)
PL (1) PL2606047T3 (da)
PT (1) PT2606047T (da)
RS (1) RS55819B1 (da)
SI (1) SI2606047T1 (da)
WO (1) WO2012024284A1 (da)

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