EP2606047A1 - Lipidated immune response modifier compound compositions, formulations, and methods - Google Patents
Lipidated immune response modifier compound compositions, formulations, and methodsInfo
- Publication number
- EP2606047A1 EP2606047A1 EP11818656.8A EP11818656A EP2606047A1 EP 2606047 A1 EP2606047 A1 EP 2606047A1 EP 11818656 A EP11818656 A EP 11818656A EP 2606047 A1 EP2606047 A1 EP 2606047A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- compound
- formula
- butyl
- antigen
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Definitions
- the present invention provides, in one aspect, a new compound useful for inducing cytokine biosynthesis.
- the compound i.e., N-(4- ⁇ [4-amino-2-butyl-lH-imidazo[4,5-c]quinolin-l- yl]oxy ⁇ butyl)octadecanamide
- formula (I) N-(4- ⁇ [4-amino-2-butyl-lH-imidazo[4,5-c]quinolin-l- yl]oxy ⁇ butyl)octadecanamide
- IFNgamma Antigen dependent interferon-gamma
- spleenocyte cultures established from the same animals for which IgG2a antibody responses were determined in Example 2.
- the spleens from the animals were removed, combined to form two pools for each group of 5 animals, minced to create single cell suspensions, and placed in culture in 96 well microtiter plates. Each pool generated three wells for a control PBS challenge and three wells for a 10 mg HA challenge.
- the cultures were then incubated at 37 °C for 72 hours.
- the medium was then removed and the interferon- gamma generated was measured (pg/ml) by an ELISA assay (Table 2).
- the IFNgamma data is reported as the geometric mean value for each pool using triplicate measurements.
- Exemplary vaccines include vaccines for cancer, BCG, cholera, plague, typhoid, hepatitis A, B, and C, influenza A and B, parainfluenza, polio, rabies, measles, mumps, rubella, yellow fever, tetanus, diphtheria, hemophilus influenza b, tuberculosis, meningococcal and pneumococcal vaccines, adenovirus, HIV, chicken pox, cytomegalovirus, dengue, feline leukemia, fowl plague, HSV- 1 and HSV-2, hog cholera, Japanese encephalitis, respiratory syncytial virus, rotavirus, papilloma virus, severe acute respiratory syndrome (SARS), anthrax, and yellow fever. See also, e.g., vaccines disclosed in International Publication No. WO 02/24225 (Thomsen et al.).
- natural killer cell activity may be stimulated, an effect that may be due to cytokine induction.
- IRM activity of the compound of Formula I also may include activating macrophages, which in turn stimulate secretion of nitric oxide and the production of additional cytokines.
- IRM activity of the compound of Formula I also may include inducing cytokine production by T cells, activating T cells specific to an antigen, and/or activating dendritic cells.
- IRM activity of the compound of Formula I may include proliferation and differentiation of B-lymphocytes. IRM activity of the compound of Formula I also may affect the acquired immune response.
Abstract
Description
Claims
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EP17152201.4A EP3222621B1 (en) | 2010-08-17 | 2011-08-16 | Lipidated immune response modifier compound and its medical use |
PL11818656T PL2606047T3 (en) | 2010-08-17 | 2011-08-16 | Lipidated immune response modifier compound compositions, formulations, and methods |
SI201131133A SI2606047T1 (en) | 2010-08-17 | 2011-08-16 | Lipidated immune response modifier compound compositions, formulations, and methods |
RS20170312A RS55819B1 (en) | 2010-08-17 | 2011-08-16 | Lipidated immune response modifier compound compositions, formulations, and methods |
HRP20170433TT HRP20170433T1 (en) | 2010-08-17 | 2017-03-17 | Lipidated immune response modifier compound compositions, formulations, and methods |
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US37451210P | 2010-08-17 | 2010-08-17 | |
PCT/US2011/047901 WO2012024284A1 (en) | 2010-08-17 | 2011-08-16 | Lipidated immune response modifier compound compositions, formulations, and methods |
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EP (2) | EP3222621B1 (en) |
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WO2004032829A2 (en) * | 2002-08-15 | 2004-04-22 | 3M Innovative Properties Company | Immunostimulatory compositions and methods of stimulating an immune response |
WO2006028962A2 (en) * | 2004-09-02 | 2006-03-16 | 3M Innovative Properties Company | 1-alkoxy 1h-imidazo ring systems and methods |
WO2012167081A1 (en) * | 2011-06-03 | 2012-12-06 | 3M Innovative Properties Company | Hydrazino 1h-imidazoquinolin-4-amines and conjugates made therefrom |
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