DK2371865T3 - Antistoffer, der binder human protein tyrosinphosphatase-beta (HPTP-ß) og anvendelser deraf - Google Patents
Antistoffer, der binder human protein tyrosinphosphatase-beta (HPTP-ß) og anvendelser deraf Download PDFInfo
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- DK2371865T3 DK2371865T3 DK11155518.1T DK11155518T DK2371865T3 DK 2371865 T3 DK2371865 T3 DK 2371865T3 DK 11155518 T DK11155518 T DK 11155518T DK 2371865 T3 DK2371865 T3 DK 2371865T3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Claims (8)
1. Isoleret antistof, der binder til human protein tyrosinphosphatase-beta (ΗΡΤΡβ), hvor det isolerede antistof er et monoklonalt antistof, hvor det monoklonale antistof omfatter to identiske tungkæder og to identiske letkæder, hvor det isolerede antistof opregulerer angiogenese, hvor det isolerede antistof binder den første FN3-gentagelse af ΗΡΤΡβ, hvor den første FN3-gentagelse af ΗΡΤΡβ har sekvensen som vist i SEQ ID NO: 11.
2. Det monoklonale antistof ifølge krav 1, hvor det monoklonale antistof fremstilles af hybridom-cellelinje ATCC-nummer PTA-7580.
3. Det isolerede antistof ifølge krav 1, hvor det isolerede antistof er humaniseret.
4. Det isolerede antistof ifølge krav 1, hvilket omfatter komplementaritetsbestemmende regioner fra det monoklonale antistof fremstillet af hybridom-cellelinje ATCC-nummer PTA-7580 og er humaniseret.
5. Isoleret antigenbindende fragment af et monoklonalt antistof, der binder til human protein tyrosinphosphatase-beta (ΗΡΤΡβ), hvor det antigenbindende fragment af det monoklonale antistof er et Fab-fragment, hvor det antigenbindende fragment nedregulerer angiogenese, hvor det antigenbindende fragment binder den første FN3-gentagelse af ΗΡΤΡβ, hvor den første FN3-gentagelse af ΗΡΤΡβ har sekvensen som vist i SEQ ID NO: 11.
6. Det antigenbindende fragment ifølge krav 5, det antigenbindende fragment af det monoklonale antistof fremstilles af hybridom-cellelinje ATCC-nummer PTA-7580.
7. Det antigenbindende fragment ifølge krav 5, hvor det antigenbindende fragment er humaniseret.
8. Det antigenbindende fragment ifølge krav 5, hvor det antigenbindende fragment af det monoklonale antistof omfatter komplementaritetsbestemmende regioner fra det monoklonale antistof fremstillet af hybridom-cellelinje ATCC-nummer PTA-7580 og er humaniseret.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79050606P | 2006-04-07 | 2006-04-07 | |
| US79889606P | 2006-05-09 | 2006-05-09 | |
| EP07735408A EP2004697A2 (en) | 2006-04-07 | 2007-04-05 | Antibodies that bind human protein tyrosine phosphatase beta (hptpbeta) and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2371865T3 true DK2371865T3 (da) | 2017-10-23 |
Family
ID=38325438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11155518.1T DK2371865T3 (da) | 2006-04-07 | 2007-04-05 | Antistoffer, der binder human protein tyrosinphosphatase-beta (HPTP-ß) og anvendelser deraf |
Country Status (20)
| Country | Link |
|---|---|
| US (6) | US7973142B2 (da) |
| EP (3) | EP3252079B8 (da) |
| JP (6) | JP5166398B2 (da) |
| KR (3) | KR20080113275A (da) |
| CN (2) | CN101802002B (da) |
| AU (1) | AU2007237096C1 (da) |
| BR (1) | BRPI0710645A2 (da) |
| CA (1) | CA2648284C (da) |
| DK (1) | DK2371865T3 (da) |
| ES (2) | ES2643469T3 (da) |
| IL (3) | IL194550A (da) |
| MA (1) | MA30353B1 (da) |
| MX (1) | MX2008012991A (da) |
| MY (1) | MY150400A (da) |
| NZ (1) | NZ571300A (da) |
| PL (1) | PL2371865T3 (da) |
| PT (1) | PT2371865T (da) |
| RU (2) | RU2494108C2 (da) |
| SM (1) | SMP200800060B (da) |
| WO (1) | WO2007116360A2 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080113275A (ko) | 2006-04-07 | 2008-12-29 | 더 프록터 앤드 갬블 캄파니 | 인간 단백질 타이로신 포스파타아제 베타(ｈｐｔｐ베타)에 결합하는 항체 및 그의 용도 |
| US7589212B2 (en) | 2006-06-27 | 2009-09-15 | Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US7795444B2 (en) | 2006-06-27 | 2010-09-14 | Warner Chilcott Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| WO2010126590A1 (en) * | 2009-04-27 | 2010-11-04 | Cold Spring Harbor Laboratory | Ptp1b inhibitors |
| PL2451279T3 (pl) | 2009-07-06 | 2019-09-30 | Aerpio Therapeutics, Inc. | Pochodne benzosulfonamidowe, ich kompozycje i ich zastosowanie w zapobieganiu przerzutom komórek nowotworowych |
| WO2011057115A1 (en) | 2009-11-06 | 2011-05-12 | Akebia Therapeutics Inc. | Prolyl hydroxylase inhibitors |
| US20120129847A1 (en) * | 2010-10-07 | 2012-05-24 | Kevin Gene Peters | Compositions and methods for treating ocular edema, neovascularization and related diseases |
| JP2013051957A (ja) * | 2011-08-08 | 2013-03-21 | National Institutes Of Natural Sciences | 受容体型チロシンホスファターゼＰｔｐｒｂを用いた受容体型チロシンキナーゼの活性抑制 |
| EP3505182A1 (en) | 2011-10-13 | 2019-07-03 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
| AU2012323849B2 (en) | 2011-10-13 | 2017-04-20 | EyePoint Pharmaceuticals, Inc. | Treatment of ocular disease |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| KR20150129019A (ko) | 2013-03-15 | 2015-11-18 | 에르피오 세러퓨틱스 인코포레이티드 | 안과 질환을 치료하기 위한 조성물, 제형 및 방법 |
| EP2832746B1 (en) | 2013-07-29 | 2018-07-18 | Samsung Electronics Co., Ltd | Anti-Ang2 antibody |
| KR102196450B1 (ko) | 2013-09-17 | 2020-12-30 | 삼성전자주식회사 | Tie2와 결합을 유도하는 항 Ang2 항체를 포함하는 항암제 |
| CN106232120B (zh) | 2014-02-19 | 2021-01-08 | 爱尔皮奥治疗有限公司 | 制备n-苄基-3-羟基-4-取代的-吡啶-2-(1h)-酮的方法 |
| WO2015138882A1 (en) | 2014-03-14 | 2015-09-17 | Aerpio Therapeutics, Inc. | Hptp-beta inhibitors |
| WO2016022813A1 (en) | 2014-08-07 | 2016-02-11 | Aerpio Therapeutics, Inc. | Combination of immunotherapies with activators of tie-2 |
| BR112018005499A2 (pt) | 2015-09-23 | 2018-10-09 | Aerpio Therapeutics Inc | métodos de tratamento de pressão intraocular com ativadores de tie-2. |
| WO2017070364A1 (en) * | 2015-10-21 | 2017-04-27 | Qoolabs, Inc. | Camelid hemoglobin antibodies and methods of use |
| WO2018017714A1 (en) | 2016-07-20 | 2018-01-25 | Aerpio Therapeutics, Inc. | HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-ß) |
| JP2022502367A (ja) | 2018-09-24 | 2022-01-11 | エアーピオ ファーマシューティカルズ， インコーポレイテッド | ＨＰＴＰ−β（ＶＥ−ＰＴＰ）およびＶＥＧＦを標的にする多特異性抗体 |
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| US11413242B2 (en) | 2019-06-24 | 2022-08-16 | EyePoint Pharmaceuticals, Inc. | Formulations of Tie-2 activators and methods of use thereof |
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