BR112014010532A2 - anticorpo e métodos para inibição seletiva de respostas de célula-t - Google Patents
anticorpo e métodos para inibição seletiva de respostas de célula-tInfo
- Publication number
- BR112014010532A2 BR112014010532A2 BR112014010532A BR112014010532A BR112014010532A2 BR 112014010532 A2 BR112014010532 A2 BR 112014010532A2 BR 112014010532 A BR112014010532 A BR 112014010532A BR 112014010532 A BR112014010532 A BR 112014010532A BR 112014010532 A2 BR112014010532 A2 BR 112014010532A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- methods
- tcr
- antibodies
- cell responses
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
Abstract
resumo anticorpo e métodos para inibição seletiva de respostas de célula-t o presente invento proporciona composições, métodos e ensaios para o tratamento de uma doença inflamatória e/ou auto-imune, e/ou a rejeição de tecidos transplantados, utilizando anticorpos anti - tcr aß e fragmentos de anticorpos. os anticorpos anti - tcr aß são anticorpos que se ligam a um tcr aß. os anticorpos anti - tcr aß produzidos pela hybridomatol101 mcb também são fornecidos. os métodos para o tratamento de uma doença inflamatória, uma doença auto-imune e para a rejeição de transplantes de tecido usando regime de dosagem terapêutica de anticorpos anti - tcr aß e fragmentos de anticorpos e para hiperregular os números de células t treg também são fornecidos.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161555335P | 2011-11-03 | 2011-11-03 | |
US201161555344P | 2011-11-03 | 2011-11-03 | |
US201261589715P | 2012-01-23 | 2012-01-23 | |
US201261610348P | 2012-03-13 | 2012-03-13 | |
US201261654631P | 2012-06-01 | 2012-06-01 | |
PCT/US2012/063583 WO2013067517A2 (en) | 2011-11-03 | 2012-11-05 | Antibody and methods for selective inhibition of t-cell responses |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014010532A2 true BR112014010532A2 (pt) | 2017-04-18 |
Family
ID=48193050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014010532A BR112014010532A2 (pt) | 2011-11-03 | 2012-11-05 | anticorpo e métodos para inibição seletiva de respostas de célula-t |
Country Status (12)
Country | Link |
---|---|
US (3) | US8524234B2 (pt) |
EP (1) | EP2773670A4 (pt) |
JP (1) | JP2015504419A (pt) |
KR (1) | KR20140091038A (pt) |
CN (1) | CN104870011A (pt) |
AU (1) | AU2012332193A1 (pt) |
BR (1) | BR112014010532A2 (pt) |
CA (1) | CA2853687A1 (pt) |
HK (1) | HK1201279A1 (pt) |
IL (1) | IL232269A0 (pt) |
MX (1) | MX2014005358A (pt) |
WO (1) | WO2013067517A2 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2473565C2 (ru) | 2006-04-07 | 2013-01-27 | Аерпио Терапетикс, Инк. | АНТИТЕЛА, СВЯЗЫВАЮЩИЕ ТИРОЗИН ФОСФАТАЗУ БЕТА ЧЕЛОВЕКА (HPTPβ), И ИХ ИСПОЛЬЗОВАНИЕ |
WO2008136774A1 (en) * | 2007-05-03 | 2008-11-13 | Agency For Science, Technology And Research | Antibodies binding to an intracellular prl-1 or prl-3 polypeptide |
JP2014530244A (ja) | 2011-10-13 | 2014-11-17 | エアピオ セラピューティックス, インコーポレイテッド | 血管漏出症候群および癌を治療する方法 |
MX2016000231A (es) * | 2013-06-26 | 2016-10-05 | Guangzhou Xiangxue Pharmaceutical Co Ltd | Receptor de celulas t de la alta estabilidad y metodo de preparacion y aplicacion del mismo. |
AU2014337156A1 (en) * | 2013-10-18 | 2016-05-12 | Modernatx, Inc. | Compositions and methods for tolerizing cellular systems |
CA2929547C (en) | 2013-11-06 | 2023-02-28 | Astute Medical, Inc. | Assays for igfbp7 having improved performance in biological samples |
EP3160479A4 (en) * | 2014-06-30 | 2018-07-04 | Academia Sinica | Antagonists for interleukin-17 receptor b (il-17rb) and its ligand il-17b for cancer therapy |
WO2017004252A1 (en) | 2015-06-30 | 2017-01-05 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Redirected cells with mhc chimeric receptors and methods of use in immunotherapy |
WO2017049159A1 (en) * | 2015-09-16 | 2017-03-23 | Ledebur Jr Harry C | T-CELL RECEPTOR (TCR) TARGETING THERAPIES FOR IMMUNE-MEDIATED ADVERSE DRUG REACTIONS (ADRs) AND OTHER CONDITIONS |
CN109071653A (zh) * | 2016-03-29 | 2018-12-21 | 詹森生物科技公司 | 用增加的抗-il12和/或-23抗体给药间隔治疗牛皮癣 |
ES2877820T3 (es) * | 2016-08-01 | 2021-11-17 | Health Research Inc | Composiciones y métodos para la clonación rápida de receptores de células T |
WO2018165161A1 (en) * | 2017-03-06 | 2018-09-13 | Novartis Ag | Methods and compositions for determining the potency of a therapeutic cellular composition |
WO2019051164A1 (en) | 2017-09-07 | 2019-03-14 | Augusta University Research Institute, Inc. | ANTIBODIES AGAINST PROTEIN 1 OF PROGRAMMED CELL DEATH |
WO2019129850A1 (en) | 2017-12-29 | 2019-07-04 | Cellectis | Off-the-shelf engineered cells for therapy |
EP3764877A4 (en) * | 2018-03-12 | 2021-12-15 | The Regents of The University of California | EVALUATION OF TRANSPLANT REJECTION STATUS BY ANALYSIS OF DIVERSITY OF T-CELL RECEPTOR SUBUNIT REPERTOIRE |
JP7366374B2 (ja) * | 2018-10-03 | 2023-10-23 | 国立大学法人 長崎大学 | 免疫チェックポイント阻害剤の効果予測方法 |
KR102404845B1 (ko) * | 2018-10-16 | 2022-06-07 | 가톨릭대학교 산학협력단 | 인간화된 자가면역 질환 동물 모델 및 이의 용도 |
MX2021004465A (es) * | 2018-10-17 | 2021-08-24 | Janssen Biotech Inc | Método para proporcionar la administración subcutánea de anticuerpos anti-cd38. |
CN114269341A (zh) | 2019-04-29 | 2022-04-01 | 视点制药公司 | 靶向施莱姆管的Tie-2激活剂 |
WO2022011264A2 (en) * | 2020-07-10 | 2022-01-13 | The Wistar Institute Of Anatomy And Biology | Dna antibody constructs for use against rotavirus |
CN112710843B (zh) * | 2020-12-16 | 2022-11-04 | 江苏伟禾生物科技有限公司 | 一种测定群体反应性抗体检测的板式免疫荧光试剂盒及其制备方法 |
WO2023156587A1 (en) | 2022-02-18 | 2023-08-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance |
CN116836291B (zh) * | 2023-08-25 | 2023-11-07 | 宝船生物医药科技(上海)有限公司 | 抗cd47-cldn18.2双特异性抗体的抗独特型抗体及其制备方法和应用 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2018248A1 (en) * | 1989-06-07 | 1990-12-07 | Clyde W. Shearman | Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use |
CA2413866C (en) | 2000-06-19 | 2014-09-02 | Beth Israel Deaconess Medical Center | Compositions and methods of monoclonal and polyclonal antibodies specific for t cell subpopulations |
US8178098B2 (en) | 2001-04-03 | 2012-05-15 | National Jewish Health | Method to inhibit airway hyperresponsiveness using aerosolized T cell receptor antibodies |
US20050058641A1 (en) | 2002-05-22 | 2005-03-17 | Siemionow Maria Z. | Tolerance induction and maintenance in hematopoietic stem cell allografts |
US20040023885A1 (en) | 2002-06-07 | 2004-02-05 | Brand Stephen J | Compositions and methods for treating diabetes |
JP2007538000A (ja) | 2004-01-08 | 2007-12-27 | リージエンツ・オブ・ザ・ユニバーシテイ・オブ・カリフオルニア | 制御性t細胞は自己免疫を抑制する |
WO2007034489A2 (en) | 2005-09-22 | 2007-03-29 | Yeda Res & Dev | Immunogenic fragments of t-cell receptor constant domains and peptides derived therefrom |
GB0603081D0 (en) | 2006-02-15 | 2006-03-29 | Dynal Biotech Asa Oslo | Method |
US7820174B2 (en) | 2006-02-24 | 2010-10-26 | The United States Of America As Represented By The Department Of Health And Human Services | T cell receptors and related materials and methods of use |
GB0605702D0 (en) | 2006-03-21 | 2006-05-03 | Biotransformations Ltd | Materials and methods for immune cell stimulation |
US8088379B2 (en) | 2006-09-26 | 2012-01-03 | The United States Of America As Represented By The Department Of Health And Human Services | Modified T cell receptors and related materials and methods |
US8216565B2 (en) | 2007-01-12 | 2012-07-10 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | GP100-specific T cell receptors and related materials and methods of use |
WO2008087219A1 (en) | 2007-01-19 | 2008-07-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for regulating t cell activity |
WO2009067375A1 (en) | 2007-11-21 | 2009-05-28 | Medical College Of Georgia Research Institute, Inc. | Selective expansion of regulatory t cells |
US9188588B2 (en) | 2008-04-07 | 2015-11-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Kit for diagnosis, prognosis, and monitoring the immune status, of patients with chronic inflammatory diseases |
WO2010042904A2 (en) | 2008-10-10 | 2010-04-15 | Trubion Pharmaceuticals, Inc. | Tcr complex immunotherapeutics |
EP2373687B1 (en) | 2008-12-03 | 2016-10-26 | Genmab A/S | Igg4 antibody variants having modifications in the constant region |
WO2010075417A1 (en) | 2008-12-23 | 2010-07-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Survivin specific t cell receptor for treating cancer |
WO2010088522A2 (en) | 2009-01-30 | 2010-08-05 | Ab Biosciences, Inc. | Novel lowered affinity antibodies and uses therefor |
WO2010099205A1 (en) | 2009-02-24 | 2010-09-02 | The Trustees Of The University Of Pennsylvania | Methods for treating progressive multifocal leukoencephalopathy (pml) |
EP2408812B1 (en) | 2009-03-17 | 2015-12-16 | CardioVax, LLC | Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis and related proteins, peptides and compositions |
GB0908613D0 (en) | 2009-05-20 | 2009-06-24 | Immunocore Ltd | T Cell Reseptors |
EP2437780B1 (en) | 2009-06-04 | 2016-03-23 | The Regents of the University of Colorado | Therapeutic compositions and methods for the prevention of autoimmune diseases |
BR112012016135A2 (pt) | 2009-12-29 | 2017-03-07 | Emergent Product Dev Seattle | proteínas de ligação de heterodímero e seus usos |
WO2012012737A2 (en) | 2010-07-23 | 2012-01-26 | The University Of Toledo | Stable tregs and related materials and methods |
CA2807127C (en) | 2010-08-02 | 2019-02-12 | Leslie S. Johnson | Covalent diabodies and uses thereof |
EP2619223B1 (en) | 2010-09-21 | 2019-04-10 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Anti-ssx-2 t cell receptors and related materials and methods of use |
CA2813268A1 (en) | 2010-09-22 | 2012-03-29 | Cardiovax, Llc | Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis and related proteins, peptides and compositions |
WO2012054825A1 (en) | 2010-10-22 | 2012-04-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mage-a3 t cell receptors and related materials and methods of use |
-
2012
- 2012-11-05 US US13/669,221 patent/US8524234B2/en active Active
- 2012-11-05 MX MX2014005358A patent/MX2014005358A/es not_active Application Discontinuation
- 2012-11-05 CN CN201280066004.9A patent/CN104870011A/zh active Pending
- 2012-11-05 BR BR112014010532A patent/BR112014010532A2/pt not_active IP Right Cessation
- 2012-11-05 WO PCT/US2012/063583 patent/WO2013067517A2/en active Application Filing
- 2012-11-05 KR KR1020147015219A patent/KR20140091038A/ko not_active Application Discontinuation
- 2012-11-05 CA CA2853687A patent/CA2853687A1/en not_active Abandoned
- 2012-11-05 EP EP12845538.3A patent/EP2773670A4/en not_active Withdrawn
- 2012-11-05 AU AU2012332193A patent/AU2012332193A1/en not_active Abandoned
- 2012-11-05 JP JP2014540186A patent/JP2015504419A/ja not_active Ceased
-
2013
- 2013-07-19 US US13/946,450 patent/US8968739B2/en active Active
-
2014
- 2014-04-27 IL IL232269A patent/IL232269A0/en unknown
-
2015
- 2015-01-23 US US14/604,069 patent/US20150252109A1/en not_active Abandoned
- 2015-02-17 HK HK15101748.6A patent/HK1201279A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO2013067517A3 (en) | 2014-10-16 |
US20130330351A1 (en) | 2013-12-12 |
US20150252109A1 (en) | 2015-09-10 |
JP2015504419A (ja) | 2015-02-12 |
US20130122015A1 (en) | 2013-05-16 |
IL232269A0 (en) | 2014-06-30 |
CN104870011A (zh) | 2015-08-26 |
CA2853687A1 (en) | 2013-05-10 |
WO2013067517A2 (en) | 2013-05-10 |
HK1201279A1 (en) | 2015-08-28 |
US8968739B2 (en) | 2015-03-03 |
EP2773670A4 (en) | 2015-09-02 |
EP2773670A2 (en) | 2014-09-10 |
US8524234B2 (en) | 2013-09-03 |
AU2012332193A1 (en) | 2014-05-15 |
KR20140091038A (ko) | 2014-07-18 |
MX2014005358A (es) | 2014-09-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112014010532A2 (pt) | anticorpo e métodos para inibição seletiva de respostas de célula-t | |
CY1123518T1 (el) | Ανθρωπινα αντισωματα enanti-tau | |
CY1120951T1 (el) | Ανθρωπινα αντισωματα enanti-tau | |
CY1121392T1 (el) | Μορια δεσμευσης εναντι-αλφα συνουκλεϊνης | |
CY1121536T1 (el) | Ανθρωπινα αντισωματα εναντι-αλφα-συνουκλεϊνης | |
CO2018001149A2 (es) | Anticuerpos monoclonales contra bcma | |
EA201890285A1 (ru) | Антитела против pd-1, активируемые антитела против pd-1 и способы их применения | |
CL2017000278A1 (es) | Moléculas biespecíficas de unión a antígeno activadoras de células t | |
MX2019008736A (es) | Anticuerpos anti-virus del dengue y usos de los mismos. | |
CL2018000750A1 (es) | Método de redireccionamiento de linfocitos t para el tratamiento de la infección por vih | |
CU20170023A7 (es) | Anticuerpos y receptores de antígeno quiméricos específicos para cd19 | |
AR087601A1 (es) | Anticuerpos sin fc que comprenden dos fragmentos fab y metodos de utilizacion | |
ECSP11011445A (es) | Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c3b | |
EA201400447A1 (ru) | АНТИТЕЛА К CD1d | |
MX2019006362A (es) | Una combinacion de inmunoconjugado y anticuerpo para usarse en el tratamiento de cancer. | |
MX2018008680A (es) | Moleculas de union especifica a proteina de union a adn de respuesta transactiva de 43 kda (tdp-43). | |
EA201590459A1 (ru) | Специфические антитела к островковому амилоидному полипептиду человека (hiapp) и их применение | |
BR112013021562A2 (pt) | anticorpos para cd70 | |
BR112015029395A2 (pt) | Anticorpos anti-b7-h5 e seus usos | |
CO6680656A2 (es) | Anticuerpos para metaloproteinasa -9 de matriz | |
BR112021019334A2 (pt) | Anticorpos de cadeia pesada que se ligam ao psma | |
EA201590247A1 (ru) | Антитела к siglec-15 | |
MX2013009151A (es) | Inmunoterapia mejorada. | |
CO6571881A2 (es) | Nuevos anticuerpos anti-cxcr4 humanizados para el tratamiento del cáncer | |
MX2016009991A (es) | Nuevo anticuerpo anti-dengue de espectro completo. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2435 DE 05-09-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |