DK172720B1 - Fremgangsmåde til opspaltning af en racemisk modifikation af beta-adrenerge aryl- eller heteroarylpropanolaminer i de tilsv - Google Patents

Fremgangsmåde til opspaltning af en racemisk modifikation af beta-adrenerge aryl- eller heteroarylpropanolaminer i de tilsv Download PDF

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Publication number
DK172720B1
DK172720B1 DK198304164A DK416483A DK172720B1 DK 172720 B1 DK172720 B1 DK 172720B1 DK 198304164 A DK198304164 A DK 198304164A DK 416483 A DK416483 A DK 416483A DK 172720 B1 DK172720 B1 DK 172720B1
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DK
Denmark
Prior art keywords
alkyl
urea
phenyl
lower alkyl
formula
Prior art date
Application number
DK198304164A
Other languages
Danish (da)
English (en)
Other versions
DK416483D0 (da
DK416483A (da
Inventor
Terence M Dolak
Ronald D Dennis
William E Kreighbaum
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of DK416483D0 publication Critical patent/DK416483D0/da
Publication of DK416483A publication Critical patent/DK416483A/da
Application granted granted Critical
Publication of DK172720B1 publication Critical patent/DK172720B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK198304164A 1982-09-13 1983-09-13 Fremgangsmåde til opspaltning af en racemisk modifikation af beta-adrenerge aryl- eller heteroarylpropanolaminer i de tilsv DK172720B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41779482 1982-09-13
US06/417,794 US4463176A (en) 1982-09-13 1982-09-13 Process for resolution of optical isomers

Publications (3)

Publication Number Publication Date
DK416483D0 DK416483D0 (da) 1983-09-13
DK416483A DK416483A (da) 1984-03-14
DK172720B1 true DK172720B1 (da) 1999-06-14

Family

ID=23655420

Family Applications (2)

Application Number Title Priority Date Filing Date
DK198304164A DK172720B1 (da) 1982-09-13 1983-09-13 Fremgangsmåde til opspaltning af en racemisk modifikation af beta-adrenerge aryl- eller heteroarylpropanolaminer i de tilsv
DK199701068A DK172732B1 (da) 1982-09-13 1997-09-17 Fremgangsmåde til fremstilling af urinstofderivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK199701068A DK172732B1 (da) 1982-09-13 1997-09-17 Fremgangsmåde til fremstilling af urinstofderivater

Country Status (29)

Country Link
US (1) US4463176A (no)
JP (2) JPS5980616A (no)
KR (1) KR890000616B1 (no)
AT (1) AT385032B (no)
AU (1) AU573535B2 (no)
BE (1) BE897737A (no)
CA (1) CA1250290A (no)
CH (1) CH660732A5 (no)
CY (1) CY1543A (no)
DE (1) DE3333025A1 (no)
DK (2) DK172720B1 (no)
ES (1) ES525543A0 (no)
FI (1) FI83767C (no)
FR (1) FR2540490B1 (no)
GB (2) GB2127020B (no)
GR (1) GR81546B (no)
HK (1) HK97990A (no)
HU (1) HU193183B (no)
IE (1) IE55650B1 (no)
IL (1) IL69708A (no)
IT (1) IT1170213B (no)
LU (1) LU84998A1 (no)
NL (1) NL8303154A (no)
NO (1) NO159267C (no)
NZ (1) NZ205554A (no)
PT (1) PT77331B (no)
SE (2) SE452608B (no)
YU (1) YU43327B (no)
ZA (1) ZA836795B (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849527A (en) * 1982-09-13 1989-07-18 Bristol-Myers Company Process for resolution of optical isomers
IT1163107B (it) * 1983-02-15 1987-04-08 Simes Composizioni farmaceutiche e loro uso nel trattamento del glaucoma
US5364872A (en) * 1984-04-16 1994-11-15 Yamanouchi Pharmaceutical Co., Ltd. Dihydropyridine-3,5-dicarboxylic acid ester derivatives
US5039801A (en) * 1985-12-20 1991-08-13 The United States Of America As Represented By The Department Of Health & Human Services Thermal fragmentation of methylbenzylurea disastereomers or secondary amines and preparation of optically active secondary amines
US4797498A (en) * 1986-07-18 1989-01-10 Pennwalt Corporation Flavonoxypropanolamines and esters of flavonoxypropanolamines as antiarrhythmic agents
EP0305496A4 (en) * 1987-03-17 1989-07-11 Insite Vision Inc TIMOLOL DERIVATIVES.
US4889941A (en) * 1987-04-23 1989-12-26 Fisons Corporation Synthetic flavonoids as inhibitors of leukotrienes and 5-lipoxygenase
US4806660A (en) * 1987-11-06 1989-02-21 Pennwalt Corporation Aurone oxypropanolamines
JP2801768B2 (ja) * 1990-11-17 1998-09-21 日東電工株式会社 新規な光学活性メトプロロール・酒石酸誘導体塩及びその製法、並びにこの塩を用いる光学活性メトプロロールの製法
US5082970A (en) * 1991-03-06 1992-01-21 Pfizer Inc. Process for recycling amine isomer
ES2065278B1 (es) * 1993-06-24 1995-09-01 Medichem Sa Procedimiento de obtencion enantioselectivo del levobunolol.
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
KR100332399B1 (ko) * 1999-02-22 2002-04-13 김경호 메토프롤롤 라세미체로부터 메토프롤롤 에난티오머의 제조방법
BE1012622A3 (fr) * 1999-04-21 2001-01-09 Solvay Procede pour la separation d'enantiomeres et reactif enantiopur.
US7138538B2 (en) * 2000-04-14 2006-11-21 Solvay (Societe Anonyme) Process for the separation of enantiomers and enantiopure reagent
GEP20074134B (en) 2002-08-19 2007-06-25 Pfizer Prod Inc Combination therapy for hyperproliferative diseases
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
WO2008112287A1 (en) 2007-03-12 2008-09-18 Nektar Therapeutics Oligomer-beta blocker conjugates
SG11201507496UA (en) 2013-04-17 2015-11-27 Pfizer N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
SG11202107614PA (en) 2019-01-18 2021-08-30 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US234595A (en) * 1880-11-16 Juan f
GB1211589A (en) * 1968-08-06 1970-11-11 Ici Ltd Enantiomer isolation process
BE786963A (fr) * 1971-07-30 1973-01-29 Degussa Procede pour le dedoublement racemique de d,1-phenylpropanolamine
US4314943A (en) * 1977-07-13 1982-02-09 Mead Johnson & Company Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
US4234595A (en) * 1977-07-13 1980-11-18 Mead Johnson & Company 3-Indolyl-tertiary butylaminopropanols
IT1113029B (it) * 1979-03-01 1986-01-20 Simes Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro
JPS5770884A (en) * 1980-10-21 1982-05-01 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative and its preparation
FI76551C (fi) * 1980-11-06 1988-11-10 Sandoz Ag Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3-aminopropoxifenylderivat.

Also Published As

Publication number Publication date
AU1908183A (en) 1984-03-22
IT1170213B (it) 1987-06-03
NO833254L (no) 1984-03-14
GB2169294B (en) 1987-05-13
GB2169294A (en) 1986-07-09
GB8604515D0 (en) 1986-04-03
NZ205554A (en) 1987-09-30
CA1250290A (en) 1989-02-21
NO159267B (no) 1988-09-05
SE8304887L (sv) 1984-03-14
JPH0859597A (ja) 1996-03-05
ES8504104A1 (es) 1985-04-16
BE897737A (fr) 1984-03-12
KR890000616B1 (ko) 1989-03-22
FI83767C (fi) 1991-08-26
FI833270A (fi) 1984-03-14
SE8602724D0 (sv) 1986-06-18
GB2127020B (en) 1987-05-07
IE832134L (en) 1984-03-13
DK416483D0 (da) 1983-09-13
YU43327B (en) 1989-06-30
DE3333025C2 (no) 1992-01-23
GR81546B (no) 1984-12-11
DK172732B1 (da) 1999-06-21
GB8324536D0 (en) 1983-10-12
IT8322852A0 (it) 1983-09-12
GB2127020A (en) 1984-04-04
JPH0414086B2 (no) 1992-03-11
PT77331B (en) 1986-08-28
ZA836795B (en) 1984-04-25
HK97990A (en) 1990-11-30
JP2759184B2 (ja) 1998-05-28
IL69708A (en) 1987-02-27
DE3333025A1 (de) 1984-03-29
FR2540490B1 (fr) 1986-09-05
FI833270A0 (fi) 1983-09-13
CH660732A5 (fr) 1987-06-15
SE8602724L (sv) 1986-06-18
NL8303154A (nl) 1984-04-02
NO159267C (no) 1988-12-14
SE8304887D0 (sv) 1983-09-12
CY1543A (en) 1991-03-22
LU84998A1 (fr) 1984-04-24
IL69708A0 (en) 1983-12-30
DK106897A (da) 1997-09-17
AU573535B2 (en) 1988-06-16
ES525543A0 (es) 1985-04-16
KR840005998A (ko) 1984-11-21
IE55650B1 (en) 1990-12-05
ATA326383A (de) 1987-07-15
SE452608B (sv) 1987-12-07
US4463176A (en) 1984-07-31
HU193183B (en) 1987-08-28
AT385032B (de) 1988-02-10
JPS5980616A (ja) 1984-05-10
DK416483A (da) 1984-03-14
PT77331A (en) 1983-10-01
FI83767B (fi) 1991-05-15
YU184683A (en) 1986-02-28
FR2540490A1 (fr) 1984-08-10

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired