FI833270A0 - Foerfarande foer avskiljning av optiska isomerer - Google Patents

Foerfarande foer avskiljning av optiska isomerer

Info

Publication number
FI833270A0
FI833270A0 FI833270A FI833270A FI833270A0 FI 833270 A0 FI833270 A0 FI 833270A0 FI 833270 A FI833270 A FI 833270A FI 833270 A FI833270 A FI 833270A FI 833270 A0 FI833270 A0 FI 833270A0
Authority
FI
Finland
Prior art keywords
optiska
isomerer
foerfarande foer
avskiljning
foer avskiljning
Prior art date
Application number
FI833270A
Other languages
English (en)
Other versions
FI833270A (fi
FI83767C (fi
FI83767B (fi
Inventor
Ronald D Dennis
Terence M Dolak
William E Kreighbaum
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of FI833270A0 publication Critical patent/FI833270A0/fi
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FI833270A publication Critical patent/FI833270A/fi
Application granted granted Critical
Publication of FI83767B publication Critical patent/FI83767B/fi
Publication of FI83767C publication Critical patent/FI83767C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI833270A 1982-09-13 1983-10-13 Foerfarande foer uppspjaelkning av en racemisk form av -adrenergiska aryl- eller heteroaryloxipropanolaminer till sina optiskt aktiva isomerer, mellanprodukt vid foerfarandet foer framstaellning av mellanprodukten. FI83767C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/417,794 US4463176A (en) 1982-09-13 1982-09-13 Process for resolution of optical isomers
US41779482 1982-09-13

Publications (4)

Publication Number Publication Date
FI833270A0 true FI833270A0 (fi) 1983-09-13
FI833270A FI833270A (fi) 1984-03-14
FI83767B FI83767B (fi) 1991-05-15
FI83767C FI83767C (fi) 1991-08-26

Family

ID=23655420

Family Applications (1)

Application Number Title Priority Date Filing Date
FI833270A FI83767C (fi) 1982-09-13 1983-10-13 Foerfarande foer uppspjaelkning av en racemisk form av -adrenergiska aryl- eller heteroaryloxipropanolaminer till sina optiskt aktiva isomerer, mellanprodukt vid foerfarandet foer framstaellning av mellanprodukten.

Country Status (29)

Country Link
US (1) US4463176A (fi)
JP (2) JPS5980616A (fi)
KR (1) KR890000616B1 (fi)
AT (1) AT385032B (fi)
AU (1) AU573535B2 (fi)
BE (1) BE897737A (fi)
CA (1) CA1250290A (fi)
CH (1) CH660732A5 (fi)
CY (1) CY1543A (fi)
DE (1) DE3333025A1 (fi)
DK (2) DK172720B1 (fi)
ES (1) ES8504104A1 (fi)
FI (1) FI83767C (fi)
FR (1) FR2540490B1 (fi)
GB (2) GB2127020B (fi)
GR (1) GR81546B (fi)
HK (1) HK97990A (fi)
HU (1) HU193183B (fi)
IE (1) IE55650B1 (fi)
IL (1) IL69708A (fi)
IT (1) IT1170213B (fi)
LU (1) LU84998A1 (fi)
NL (1) NL8303154A (fi)
NO (1) NO159267C (fi)
NZ (1) NZ205554A (fi)
PT (1) PT77331B (fi)
SE (2) SE452608B (fi)
YU (1) YU43327B (fi)
ZA (1) ZA836795B (fi)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849527A (en) * 1982-09-13 1989-07-18 Bristol-Myers Company Process for resolution of optical isomers
IT1163107B (it) * 1983-02-15 1987-04-08 Simes Composizioni farmaceutiche e loro uso nel trattamento del glaucoma
US5364872A (en) * 1984-04-16 1994-11-15 Yamanouchi Pharmaceutical Co., Ltd. Dihydropyridine-3,5-dicarboxylic acid ester derivatives
US5039801A (en) * 1985-12-20 1991-08-13 The United States Of America As Represented By The Department Of Health & Human Services Thermal fragmentation of methylbenzylurea disastereomers or secondary amines and preparation of optically active secondary amines
US4797498A (en) * 1986-07-18 1989-01-10 Pennwalt Corporation Flavonoxypropanolamines and esters of flavonoxypropanolamines as antiarrhythmic agents
EP0305496A4 (en) * 1987-03-17 1989-07-11 Insite Vision Inc TIMOLOL DERIVATIVES.
US4889941A (en) * 1987-04-23 1989-12-26 Fisons Corporation Synthetic flavonoids as inhibitors of leukotrienes and 5-lipoxygenase
US4806660A (en) * 1987-11-06 1989-02-21 Pennwalt Corporation Aurone oxypropanolamines
JP2801768B2 (ja) * 1990-11-17 1998-09-21 日東電工株式会社 新規な光学活性メトプロロール・酒石酸誘導体塩及びその製法、並びにこの塩を用いる光学活性メトプロロールの製法
US5082970A (en) * 1991-03-06 1992-01-21 Pfizer Inc. Process for recycling amine isomer
ES2065278B1 (es) * 1993-06-24 1995-09-01 Medichem Sa Procedimiento de obtencion enantioselectivo del levobunolol.
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
KR100332399B1 (ko) * 1999-02-22 2002-04-13 김경호 메토프롤롤 라세미체로부터 메토프롤롤 에난티오머의 제조방법
BE1012622A3 (fr) * 1999-04-21 2001-01-09 Solvay Procede pour la separation d'enantiomeres et reactif enantiopur.
US7138538B2 (en) * 2000-04-14 2006-11-21 Solvay (Societe Anonyme) Process for the separation of enantiomers and enantiopure reagent
ATE502635T1 (de) 2002-08-19 2011-04-15 Pfizer Kombinationstherapie gegen hyperproliferative erkrankungen
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのcetp阻害剤としてのn−((3−ベンジル)−2,2−(ビス−フェニル)−プロパン−1−アミン誘導体
US9782488B2 (en) 2007-03-12 2017-10-10 Nektar Therapeutics Oligomer-beta blocker conjugates
JP2016516804A (ja) 2013-04-17 2016-06-09 ファイザー・インク 心血管疾患を治療するためのn−ピペリジン−3−イルベンズアミド誘導体
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
JP7128969B2 (ja) 2019-01-18 2022-08-31 アストラゼネカ・アクチエボラーグ Pcsk9阻害剤及びその使用方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US234595A (en) * 1880-11-16 Juan f
GB1211589A (en) * 1968-08-06 1970-11-11 Ici Ltd Enantiomer isolation process
BE786963A (fr) * 1971-07-30 1973-01-29 Degussa Procede pour le dedoublement racemique de d,1-phenylpropanolamine
US4314943A (en) * 1977-07-13 1982-02-09 Mead Johnson & Company Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
US4234595A (en) * 1977-07-13 1980-11-18 Mead Johnson & Company 3-Indolyl-tertiary butylaminopropanols
IT1113029B (it) * 1979-03-01 1986-01-20 Simes Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro
JPS5770884A (en) * 1980-10-21 1982-05-01 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative and its preparation
FI76551C (fi) * 1980-11-06 1988-11-10 Sandoz Ag Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3-aminopropoxifenylderivat.

Also Published As

Publication number Publication date
HU193183B (en) 1987-08-28
SE8602724L (sv) 1986-06-18
PT77331B (en) 1986-08-28
ZA836795B (en) 1984-04-25
JPS5980616A (ja) 1984-05-10
NZ205554A (en) 1987-09-30
NL8303154A (nl) 1984-04-02
CY1543A (en) 1991-03-22
CH660732A5 (fr) 1987-06-15
SE8304887L (sv) 1984-03-14
KR890000616B1 (ko) 1989-03-22
IE832134L (en) 1984-03-13
JP2759184B2 (ja) 1998-05-28
DK416483D0 (da) 1983-09-13
US4463176A (en) 1984-07-31
FR2540490A1 (fr) 1984-08-10
ATA326383A (de) 1987-07-15
LU84998A1 (fr) 1984-04-24
DK172732B1 (da) 1999-06-21
SE8602724D0 (sv) 1986-06-18
IE55650B1 (en) 1990-12-05
IL69708A (en) 1987-02-27
DK172720B1 (da) 1999-06-14
ES525543A0 (es) 1985-04-16
FR2540490B1 (fr) 1986-09-05
ES8504104A1 (es) 1985-04-16
JPH0859597A (ja) 1996-03-05
DE3333025A1 (de) 1984-03-29
FI833270A (fi) 1984-03-14
NO159267C (no) 1988-12-14
GB8604515D0 (en) 1986-04-03
GB2127020A (en) 1984-04-04
GB2169294B (en) 1987-05-13
HK97990A (en) 1990-11-30
AT385032B (de) 1988-02-10
IL69708A0 (en) 1983-12-30
SE452608B (sv) 1987-12-07
DE3333025C2 (fi) 1992-01-23
GB2169294A (en) 1986-07-09
CA1250290A (en) 1989-02-21
GB2127020B (en) 1987-05-07
SE8304887D0 (sv) 1983-09-12
DK106897A (da) 1997-09-17
NO833254L (no) 1984-03-14
PT77331A (en) 1983-10-01
IT8322852A0 (it) 1983-09-12
DK416483A (da) 1984-03-14
FI83767C (fi) 1991-08-26
YU43327B (en) 1989-06-30
GR81546B (fi) 1984-12-11
YU184683A (en) 1986-02-28
KR840005998A (ko) 1984-11-21
GB8324536D0 (en) 1983-10-12
BE897737A (fr) 1984-03-12
FI83767B (fi) 1991-05-15
JPH0414086B2 (fi) 1992-03-11
NO159267B (no) 1988-09-05
IT1170213B (it) 1987-06-03
AU573535B2 (en) 1988-06-16
AU1908183A (en) 1984-03-22

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Legal Events

Date Code Title Description
MA Patent expired

Owner name: BRISTOL-MYERS SQUIBB COMPANY