IT8322852A0 - Procedimento per la risoluzione di isomeri ottici. - Google Patents

Procedimento per la risoluzione di isomeri ottici.

Info

Publication number
IT8322852A0
IT8322852A0 IT8322852A IT2285283A IT8322852A0 IT 8322852 A0 IT8322852 A0 IT 8322852A0 IT 8322852 A IT8322852 A IT 8322852A IT 2285283 A IT2285283 A IT 2285283A IT 8322852 A0 IT8322852 A0 IT 8322852A0
Authority
IT
Italy
Prior art keywords
resolution
procedure
optical isomers
isomers
optical
Prior art date
Application number
IT8322852A
Other languages
English (en)
Other versions
IT1170213B (it
Inventor
Ronald D Dennis
Terence M Dolak
William E Kreighbaum
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IT8322852A0 publication Critical patent/IT8322852A0/it
Application granted granted Critical
Publication of IT1170213B publication Critical patent/IT1170213B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
IT22852/83A 1982-09-13 1983-09-12 Procedimento per la risoluzione di isomeri ottici IT1170213B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/417,794 US4463176A (en) 1982-09-13 1982-09-13 Process for resolution of optical isomers

Publications (2)

Publication Number Publication Date
IT8322852A0 true IT8322852A0 (it) 1983-09-12
IT1170213B IT1170213B (it) 1987-06-03

Family

ID=23655420

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22852/83A IT1170213B (it) 1982-09-13 1983-09-12 Procedimento per la risoluzione di isomeri ottici

Country Status (29)

Country Link
US (1) US4463176A (it)
JP (2) JPS5980616A (it)
KR (1) KR890000616B1 (it)
AT (1) AT385032B (it)
AU (1) AU573535B2 (it)
BE (1) BE897737A (it)
CA (1) CA1250290A (it)
CH (1) CH660732A5 (it)
CY (1) CY1543A (it)
DE (1) DE3333025A1 (it)
DK (2) DK172720B1 (it)
ES (1) ES525543A0 (it)
FI (1) FI83767C (it)
FR (1) FR2540490B1 (it)
GB (2) GB2127020B (it)
GR (1) GR81546B (it)
HK (1) HK97990A (it)
HU (1) HU193183B (it)
IE (1) IE55650B1 (it)
IL (1) IL69708A (it)
IT (1) IT1170213B (it)
LU (1) LU84998A1 (it)
NL (1) NL8303154A (it)
NO (1) NO159267C (it)
NZ (1) NZ205554A (it)
PT (1) PT77331B (it)
SE (2) SE452608B (it)
YU (1) YU43327B (it)
ZA (1) ZA836795B (it)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849527A (en) * 1982-09-13 1989-07-18 Bristol-Myers Company Process for resolution of optical isomers
IT1163107B (it) * 1983-02-15 1987-04-08 Simes Composizioni farmaceutiche e loro uso nel trattamento del glaucoma
US5364872A (en) * 1984-04-16 1994-11-15 Yamanouchi Pharmaceutical Co., Ltd. Dihydropyridine-3,5-dicarboxylic acid ester derivatives
US5039801A (en) * 1985-12-20 1991-08-13 The United States Of America As Represented By The Department Of Health & Human Services Thermal fragmentation of methylbenzylurea disastereomers or secondary amines and preparation of optically active secondary amines
US4797498A (en) * 1986-07-18 1989-01-10 Pennwalt Corporation Flavonoxypropanolamines and esters of flavonoxypropanolamines as antiarrhythmic agents
WO1988007044A1 (en) * 1987-03-17 1988-09-22 Insite Vision, Inc. Timolol derivatives
US4889941A (en) * 1987-04-23 1989-12-26 Fisons Corporation Synthetic flavonoids as inhibitors of leukotrienes and 5-lipoxygenase
US4806660A (en) * 1987-11-06 1989-02-21 Pennwalt Corporation Aurone oxypropanolamines
JP2801768B2 (ja) * 1990-11-17 1998-09-21 日東電工株式会社 新規な光学活性メトプロロール・酒石酸誘導体塩及びその製法、並びにこの塩を用いる光学活性メトプロロールの製法
US5082970A (en) * 1991-03-06 1992-01-21 Pfizer Inc. Process for recycling amine isomer
ES2065278B1 (es) * 1993-06-24 1995-09-01 Medichem Sa Procedimiento de obtencion enantioselectivo del levobunolol.
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
KR100332399B1 (ko) * 1999-02-22 2002-04-13 김경호 메토프롤롤 라세미체로부터 메토프롤롤 에난티오머의 제조방법
BE1012622A3 (fr) * 1999-04-21 2001-01-09 Solvay Procede pour la separation d'enantiomeres et reactif enantiopur.
US7138538B2 (en) * 2000-04-14 2006-11-21 Solvay (Societe Anonyme) Process for the separation of enantiomers and enantiopure reagent
AP2005003232A0 (en) 2002-08-19 2005-03-31 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
WO2008112287A1 (en) * 2007-03-12 2008-09-18 Nektar Therapeutics Oligomer-beta blocker conjugates
BR112015026513A2 (pt) 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
MX2021008533A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US234595A (en) * 1880-11-16 Juan f
GB1211589A (en) * 1968-08-06 1970-11-11 Ici Ltd Enantiomer isolation process
BE786963A (fr) * 1971-07-30 1973-01-29 Degussa Procede pour le dedoublement racemique de d,1-phenylpropanolamine
US4314943A (en) * 1977-07-13 1982-02-09 Mead Johnson & Company Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
US4234595A (en) * 1977-07-13 1980-11-18 Mead Johnson & Company 3-Indolyl-tertiary butylaminopropanols
IT1113029B (it) * 1979-03-01 1986-01-20 Simes Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro
JPS5770884A (en) * 1980-10-21 1982-05-01 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative and its preparation
FI76551C (fi) * 1980-11-06 1988-11-10 Sandoz Ag Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3-aminopropoxifenylderivat.

Also Published As

Publication number Publication date
DK172732B1 (da) 1999-06-21
US4463176A (en) 1984-07-31
DE3333025C2 (it) 1992-01-23
FI833270A0 (fi) 1983-09-13
ZA836795B (en) 1984-04-25
AU573535B2 (en) 1988-06-16
YU184683A (en) 1986-02-28
SE8304887D0 (sv) 1983-09-12
SE8304887L (sv) 1984-03-14
NO159267B (no) 1988-09-05
DE3333025A1 (de) 1984-03-29
LU84998A1 (fr) 1984-04-24
IL69708A0 (en) 1983-12-30
GB2169294A (en) 1986-07-09
GB8604515D0 (en) 1986-04-03
SE8602724L (sv) 1986-06-18
GB2169294B (en) 1987-05-13
GB2127020B (en) 1987-05-07
CH660732A5 (fr) 1987-06-15
FR2540490B1 (fr) 1986-09-05
AT385032B (de) 1988-02-10
IE55650B1 (en) 1990-12-05
NZ205554A (en) 1987-09-30
DK106897A (da) 1997-09-17
KR890000616B1 (ko) 1989-03-22
IT1170213B (it) 1987-06-03
SE8602724D0 (sv) 1986-06-18
ATA326383A (de) 1987-07-15
PT77331A (en) 1983-10-01
CA1250290A (en) 1989-02-21
JPH0859597A (ja) 1996-03-05
IE832134L (en) 1984-03-13
DK172720B1 (da) 1999-06-14
FR2540490A1 (fr) 1984-08-10
YU43327B (en) 1989-06-30
HK97990A (en) 1990-11-30
CY1543A (en) 1991-03-22
FI83767C (fi) 1991-08-26
KR840005998A (ko) 1984-11-21
GB2127020A (en) 1984-04-04
GR81546B (it) 1984-12-11
JP2759184B2 (ja) 1998-05-28
FI833270A (fi) 1984-03-14
GB8324536D0 (en) 1983-10-12
ES8504104A1 (es) 1985-04-16
IL69708A (en) 1987-02-27
SE452608B (sv) 1987-12-07
JPS5980616A (ja) 1984-05-10
BE897737A (fr) 1984-03-12
AU1908183A (en) 1984-03-22
HU193183B (en) 1987-08-28
FI83767B (fi) 1991-05-15
NO159267C (no) 1988-12-14
PT77331B (en) 1986-08-28
JPH0414086B2 (it) 1992-03-11
NL8303154A (nl) 1984-04-02
DK416483D0 (da) 1983-09-13
NO833254L (no) 1984-03-14
ES525543A0 (es) 1985-04-16
DK416483A (da) 1984-03-14

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Effective date: 19970929