DK169945B1 - 25-Hydroxy-vitamin-D3-derivater, fremgangsmåde til fremstilling deraf samt lægemiddel indeholdende disse forbindelser - Google Patents
25-Hydroxy-vitamin-D3-derivater, fremgangsmåde til fremstilling deraf samt lægemiddel indeholdende disse forbindelser Download PDFInfo
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- DK169945B1 DK169945B1 DK019789A DK19789A DK169945B1 DK 169945 B1 DK169945 B1 DK 169945B1 DK 019789 A DK019789 A DK 019789A DK 19789 A DK19789 A DK 19789A DK 169945 B1 DK169945 B1 DK 169945B1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
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- 125000003118 aryl group Chemical group 0.000 claims description 9
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- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- XREXPQGDOPQPAH-QKUPJAQQSA-K trisodium;[(z)-18-[1,3-bis[[(z)-12-sulfonatooxyoctadec-9-enoyl]oxy]propan-2-yloxy]-18-oxooctadec-9-en-7-yl] sulfate Chemical compound [Na+].[Na+].[Na+].CCCCCCC(OS([O-])(=O)=O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(CCCCCC)OS([O-])(=O)=O)COC(=O)CCCCCCC\C=C/CC(CCCCCC)OS([O-])(=O)=O XREXPQGDOPQPAH-QKUPJAQQSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14593288A | 1988-01-20 | 1988-01-20 | |
| US14593288 | 1988-01-20 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK19789D0 DK19789D0 (da) | 1989-01-17 |
| DK19789A DK19789A (da) | 1989-07-21 |
| DK169945B1 true DK169945B1 (da) | 1995-04-10 |
Family
ID=22515181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK019789A DK169945B1 (da) | 1988-01-20 | 1989-01-17 | 25-Hydroxy-vitamin-D3-derivater, fremgangsmåde til fremstilling deraf samt lægemiddel indeholdende disse forbindelser |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0325279B1 (no) |
| JP (1) | JPH0764806B2 (no) |
| KR (1) | KR960009119B1 (no) |
| AR (1) | AR247551A1 (no) |
| AT (1) | ATE74350T1 (no) |
| AU (1) | AU622139B2 (no) |
| BG (1) | BG60530B2 (no) |
| CA (1) | CA1337529C (no) |
| DE (1) | DE58901056D1 (no) |
| DK (1) | DK169945B1 (no) |
| ES (1) | ES2033467T3 (no) |
| FI (1) | FI90764C (no) |
| GR (1) | GR3004786T3 (no) |
| HU (1) | HU201007B (no) |
| IE (1) | IE60921B1 (no) |
| IL (1) | IL88989A (no) |
| MC (1) | MC1998A1 (no) |
| NO (1) | NO175429C (no) |
| NZ (1) | NZ227641A (no) |
| PH (1) | PH25605A (no) |
| PT (1) | PT89486B (no) |
| YU (1) | YU47298B (no) |
| ZA (1) | ZA8923B (no) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
| EP0398217B1 (de) * | 1989-05-18 | 1994-01-12 | F. Hoffmann-La Roche Ag | Dehydrocholecalciferolderivate |
| AU650751B2 (en) * | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| ATE141914T1 (de) * | 1992-05-20 | 1996-09-15 | Hoffmann La Roche | Fluorierte analoge vitamins d3 |
| CA2096105A1 (en) * | 1992-10-07 | 1994-04-08 | Enrico Giuseppe Baggiolini (Deceased) | Vitamin d3 fluorinated analogs |
| US5753638A (en) * | 1992-10-07 | 1998-05-19 | Hoffmann-La Roche Inc. | Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs |
| TW267161B (no) * | 1992-11-20 | 1996-01-01 | Hoffmann La Roche | |
| US5401733A (en) * | 1993-10-01 | 1995-03-28 | Hoffmann-La Roche Inc. | Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol |
| US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
| TW403735B (en) * | 1995-11-22 | 2000-09-01 | Hoffmann La Roche | 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol |
| AU708679B2 (en) * | 1996-03-21 | 1999-08-12 | F. Hoffmann-La Roche Ag | 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives |
| US5939408A (en) * | 1996-05-23 | 1999-08-17 | Hoffman-La Roche Inc. | Vitamin D3 analogs |
| SG70009A1 (en) * | 1996-05-23 | 2000-01-25 | Hoffmann La Roche | Vitamin d3 analogs |
| EP0884308B1 (en) * | 1997-05-02 | 2003-04-16 | Duphar International Research B.V | A method of preparing 16-dehydro vitamin D compounds |
| US6331642B1 (en) * | 1999-07-12 | 2001-12-18 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
| WO2005074389A2 (ja) * | 2004-02-03 | 2005-08-18 | Chugai Pharmaceutical Co Ltd | ビタミンｄ化合物及びそれらの合成中間体の合成方法 |
| US8906888B2 (en) * | 2005-04-25 | 2014-12-09 | Cytochroma Inc. | Low-calcemic 16,23-diene 25-oxime analogs of 1α,25-dihydroxy vitamin D3 |
| KR20080050420A (ko) * | 2005-08-18 | 2008-06-05 | 비옥셀 에스.피.에이. | 1α-플루오로-25-히드록시-16-23Ｅ-디엔-26,27-비스호모-20-에피-콜레칼시페롤의 합성 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2812741A1 (de) * | 1977-03-24 | 1978-10-05 | Wisconsin Alumni Res Found | Vitamin d tief 3 -derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| GB2021115B (en) * | 1978-05-19 | 1982-10-06 | Wisconsin Alumni Res Found | Vitamin d derivatives |
| US4360471A (en) * | 1981-12-11 | 1982-11-23 | Wisconsin Alumni Research Foundation | 23-Dehydro-25-hydroxyvitamin D3 |
| US4508651A (en) * | 1983-03-21 | 1985-04-02 | Hoffmann-La Roche Inc. | Synthesis of 1α,25-dihydroxyergocalciferol |
| US4505906A (en) * | 1984-01-30 | 1985-03-19 | Wisconsin Alumni Research Foundation | Hydroxyvitamin D2 isomers |
| US4612308A (en) * | 1984-11-29 | 1986-09-16 | Hoffmann-La Roche Inc. | 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers |
| US4898855A (en) * | 1987-09-14 | 1990-02-06 | Hoffman-La Roche Inc. | Deuterated analogs of 1,25-dihydroxycholecalciferol |
| US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
| EP0398217B1 (de) * | 1989-05-18 | 1994-01-12 | F. Hoffmann-La Roche Ag | Dehydrocholecalciferolderivate |
-
1989
- 1989-01-03 ZA ZA8923A patent/ZA8923B/xx unknown
- 1989-01-17 NZ NZ227641A patent/NZ227641A/en unknown
- 1989-01-17 CA CA000588384A patent/CA1337529C/en not_active Expired - Fee Related
- 1989-01-17 PH PH38057A patent/PH25605A/en unknown
- 1989-01-17 DK DK019789A patent/DK169945B1/da not_active IP Right Cessation
- 1989-01-18 IL IL88989A patent/IL88989A/xx not_active IP Right Cessation
- 1989-01-18 HU HU89175A patent/HU201007B/hu not_active IP Right Cessation
- 1989-01-18 AR AR89313011A patent/AR247551A1/es active
- 1989-01-19 AU AU28644/89A patent/AU622139B2/en not_active Ceased
- 1989-01-19 MC MC902029A patent/MC1998A1/xx unknown
- 1989-01-19 IE IE15789A patent/IE60921B1/en not_active IP Right Cessation
- 1989-01-19 KR KR89000514A patent/KR960009119B1/ko not_active IP Right Cessation
- 1989-01-19 NO NO890239A patent/NO175429C/no unknown
- 1989-01-19 PT PT89486A patent/PT89486B/pt not_active IP Right Cessation
- 1989-01-19 YU YU11789A patent/YU47298B/sh unknown
- 1989-01-19 FI FI890283A patent/FI90764C/fi not_active IP Right Cessation
- 1989-01-19 JP JP1008782A patent/JPH0764806B2/ja not_active Expired - Fee Related
- 1989-01-20 AT AT89100974T patent/ATE74350T1/de not_active IP Right Cessation
- 1989-01-20 ES ES198989100974T patent/ES2033467T3/es not_active Expired - Lifetime
- 1989-01-20 EP EP89100974A patent/EP0325279B1/de not_active Expired - Lifetime
- 1989-01-20 DE DE8989100974T patent/DE58901056D1/de not_active Expired - Fee Related
-
1992
- 1992-06-03 GR GR920401138T patent/GR3004786T3/el unknown
-
1994
- 1994-02-24 BG BG98544A patent/BG60530B2/bg unknown
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